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Aliases for BMI1 Gene

Aliases for BMI1 Gene

  • BMI1 Proto-Oncogene, Polycomb Ring Finger 2 3
  • Polycomb Group RING Finger Protein 4 3 4
  • PCGF4 3 4
  • RNF51 3 4
  • B Lymphoma Mo-MLV Insertion Region 1 Homolog (Mouse) 2
  • Murine Leukemia Viral (Bmi-1) Oncogene Homolog 3
  • B Lymphoma Mo-MLV Insertion Region 1 Homolog 3
  • BMI1 Polycomb Ring Finger Proto-Oncogene 3
  • BMI1 Polycomb Ring Finger Oncogene 3
  • Polycomb Complex Protein BMI-1 3
  • Polycomb Group Ring Finger 4 2
  • Polycomb Group Protein Bmi1 3
  • Ring Finger Protein 51 3
  • RING Finger Protein 51 4
  • Flvi-2/Bmi-1 3
  • FLVI2/BMI1 3

External Ids for BMI1 Gene

Previous HGNC Symbols for BMI1 Gene

  • PCGF4

Previous GeneCards Identifiers for BMI1 Gene

  • GC10U990006
  • GC10P022760
  • GC10P022614
  • GC10P022650
  • GC10P022605
  • GC10P022611

Summaries for BMI1 Gene

GeneCards Summary for BMI1 Gene

BMI1 (BMI1 Proto-Oncogene, Polycomb Ring Finger) is a Protein Coding gene. Diseases associated with BMI1 include embryonal cancer and erythroplakia. Among its related pathways are MicroRNAs in cancer and Cellular Senescence. GO annotations related to this gene include RING-like zinc finger domain binding. An important paralog of this gene is PCGF3.

UniProtKB/Swiss-Prot for BMI1 Gene

  • Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.

Gene Wiki entry for BMI1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BMI1 Gene

Genomics for BMI1 Gene

Regulatory Elements for BMI1 Gene

Genomic Location for BMI1 Gene

Start:
22,321,210 bp from pter
End:
22,331,485 bp from pter
Size:
10,276 bases
Orientation:
Plus strand

Genomic View for BMI1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BMI1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BMI1 Gene

Proteins for BMI1 Gene

  • Protein details for BMI1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35226-BMI1_HUMAN
    Recommended name:
    Polycomb complex protein BMI-1
    Protein Accession:
    P35226
    Secondary Accessions:
    • Q16030
    • Q5T8Z3
    • Q96F37

    Protein attributes for BMI1 Gene

    Size:
    326 amino acids
    Molecular mass:
    36949 Da
    Quaternary structure:
    • Component of a PRC1-like complex. Interacts with RING1 and RING2 (By similarity). Interacts vwith CBX7 and CBX8. Interacts with SPOP. Part of a complex consisting of BMI1, CUL3 and SPOP. Interacts with E4F1.
    Miscellaneous:
    • The hPRC-H complex purification reported by PubMed:12167701 probably presents a mixture of different PRC1-like complexes

    Three dimensional structures from OCA and Proteopedia for BMI1 Gene

neXtProt entry for BMI1 Gene

Proteomics data for BMI1 Gene at MOPED

Post-translational modifications for BMI1 Gene

  • Monoubiquitinated (By similarity). May be polyubiquitinated; which does not lead to proteasomal degradation.
  • Ubiquitination at Lys73
  • Modification sites at PhosphoSitePlus

Other Protein References for BMI1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for BMI1 Gene

Domains for BMI1 Gene

Gene Families for BMI1 Gene

HGNC:
  • PCGF :Polycomb group ring fingers
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for BMI1 Gene

Suggested Antigen Peptide Sequences for BMI1 Gene

Graphical View of Domain Structure for InterPro Entry

P35226

UniProtKB/Swiss-Prot:

BMI1_HUMAN :
  • P35226
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with BMI1: view

Function for BMI1 Gene

Molecular function for BMI1 Gene

GENATLAS Biochemistry: bmi-1 protooncogene homolog,activated by Moloney murine leukemia proviral insertion in Emu-myc transgenic mouse,polycomb group (PcG) complexing with SSX1 and SSX2 and associating with chromatin
UniProtKB/Swiss-Prot Function: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.

Gene Ontology (GO) - Molecular Function for BMI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding --
GO:0004842 ubiquitin-protein transferase activity --
GO:0005515 protein binding IPI 15386022
GO:0008270 zinc ion binding IDA 16714294
GO:0043565 sequence-specific DNA binding --
genes like me logo Genes that share ontologies with BMI1: view
genes like me logo Genes that share phenotypes with BMI1: view

Animal Models for BMI1 Gene

MGI Knock Outs for BMI1:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for BMI1 Gene

Localization for BMI1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BMI1 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BMI1 Gene COMPARTMENTS Subcellular localization image for BMI1 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for BMI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex IDA 16714294
GO:0000792 heterochromatin --
GO:0005634 nucleus IDA 10445843
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with BMI1: view

Pathways for BMI1 Gene

genes like me logo Genes that share pathways with BMI1: view

Gene Ontology (GO) - Biological Process for BMI1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IMP 19636380
GO:0001501 skeletal system development --
GO:0001701 in utero embryonic development --
GO:0006306 DNA methylation --
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with BMI1: view

Compounds for BMI1 Gene

(2) Novoseek inferred chemical compound relationships for BMI1 Gene

Compound -log(P) Hits PubMed IDs
zinc 0 2
estrogen 0 2
genes like me logo Genes that share compounds with BMI1: view

Transcripts for BMI1 Gene

Unigene Clusters for BMI1 Gene

BMI1 polycomb ring finger oncogene:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BMI1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13
SP1: - - - - -
SP2: - - -
SP3: - - - - - -
SP4: - -
SP5: - -
SP6: - -
SP7: - - -
SP8: -
SP9:
SP10: - -

Relevant External Links for BMI1 Gene

GeneLoc Exon Structure for
BMI1
ECgene alternative splicing isoforms for
BMI1

Expression for BMI1 Gene

mRNA expression in normal human tissues for BMI1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for BMI1 Gene

SOURCE GeneReport for Unigene cluster for BMI1 Gene Hs.380403

genes like me logo Genes that share expressions with BMI1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for BMI1 Gene

Orthologs for BMI1 Gene

This gene was present in the common ancestor of animals.

Orthologs for BMI1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 100 (a)
OneToMany
BMI1 35
  • 99.8 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia BMI1 36
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia BMI1 36
  • 99 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Bmi1 16
Bmi1 36
  • 98 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 82 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 98 (a)
OneToMany
chicken
(Gallus gallus)
Aves BMI1 36
  • 95 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 88 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii bmi1a 35
  • 73.33 (n)
  • 82.5 (a)
bmi1a 36
  • 82 (a)
ManyToMany
bmi1b 36
  • 76 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Psc 36
  • 7 (a)
ManyToMany
Su(z)2 36
  • 7 (a)
ManyToMany
Psc 37
  • 44 (a)
Species with no ortholog for BMI1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BMI1 Gene

ENSEMBL:
Gene Tree for BMI1 (if available)
TreeFam:
Gene Tree for BMI1 (if available)

Paralogs for BMI1 Gene

Paralogs for BMI1 Gene

Pseudogenes.org Pseudogenes for BMI1 Gene

genes like me logo Genes that share paralogs with BMI1: view

Variants for BMI1 Gene

Sequence variations from dbSNP and Humsavar for BMI1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
VAR_052087 -

Structural Variations from Database of Genomic Variants (DGV) for BMI1 Gene

Variant ID Type Subtype PubMed ID
dgv136n67 CNV Gain 20364138
dgv137n67 CNV Gain 20364138
dgv624n71 CNV Loss 21882294
dgv625n71 CNV Loss 21882294
nsv894959 CNV Loss 21882294
esv27808 CNV Gain 19812545
nsv825300 CNV Gain 20364138

Relevant External Links for BMI1 Gene

HapMap Linkage Disequilibrium report
BMI1
Human Gene Mutation Database (HGMD)
BMI1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BMI1 Gene

Disorders for BMI1 Gene

(1) University of Copenhagen DISEASES for BMI1 Gene

(35) Novoseek inferred disease relationships for BMI1 Gene

Disease -log(P) Hits PubMed IDs
lymphoma mantle-cell 61.7 2
tumors 52 82
cancer 51.1 51
leukemia 48 21
leukemogenesis 42.8 1
genes like me logo Genes that share disorders with BMI1: view

No data available for UniProtKB/Swiss-Prot for BMI1 Gene

Publications for BMI1 Gene

  1. Characterization and chromosomal localization of the human proto- oncogene BMI-1. (PMID: 8268912) Alkema M.J. … van Lohuizen M. (Hum. Mol. Genet. 1993) 2 3 4 23
  2. Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic. (PMID: 9121482) Gunster M.J. … Otte A.P. (Mol. Cell. Biol. 1997) 3 4 23
  3. The Bmi-1 oncoprotein is overexpressed in human colorectal cancer and correlates with the reduced p16INK4a/p14ARF proteins. (PMID: 14732230) Kim J.H. … Kim J.W. (Cancer Lett. 2004) 3 23
  4. BMI-1 is highly expressed in M0-subtype acute myeloid leukemia. (PMID: 16105758) Sawa M. … Naoe T. (Int. J. Hematol. 2005) 3 23
  5. CALM-AF10+ T-ALL expression profiles are characterized by overexpression of HOXA and BMI1 oncogenes. (PMID: 16107895) Dik W.A. … Delabesse E. (Leukemia 2005) 3 23

Products for BMI1 Gene

  • Addgene plasmids for BMI1

Sources for BMI1 Gene

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