Aliases for CRTC3 Gene
External Ids for CRTC3 Gene
Previous GeneCards Identifiers for CRTC3 Gene
This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein encoded by this gene may induce mitochondrial biogenesis and attenuate catecholamine signaling in adipose tissue. A translocation event between this gene and Notch coactivator mastermind-like gene 2, which results in a fusion protein, has been reported in mucoepidermoid carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
GeneCards Summary for CRTC3 Gene
CRTC3 (CREB Regulated Transcription Coactivator 3) is a Protein Coding gene. Diseases associated with CRTC3 include warthin tumor and human t-cell leukemia virus type 1. Among its related pathways are Glucose / Energy Metabolism and HTLV-I infection. GO annotations related to this gene include cAMP response element binding protein binding. An important paralog of this gene is CRTC2.
UniProtKB/Swiss-Prot for CRTC3 Gene
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 Ser-133 phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).