Aliases for CRTC3 Gene
Aliases for CRTC3 Gene
- CREB Regulated Transcription Coactivator 3 2 3 5
- TORC-3 3 4
- TORC3 3 4
- Transducer Of Regulated CAMP Response Element-Binding Protein (CREB) 3 3
- Transducer Of Regulated CAMP Response Element-Binding Protein 3 4
- CREB-Regulated Transcription Coactivator 3 3
- Transducer Of Regulated CREB Protein 3 3
- Transducer Of CREB Protein 3 4
External Ids for CRTC3 Gene
- HGNC: 26148
- Entrez Gene: 64784
- Ensembl: ENSG00000140577
- OMIM: 608986
- UniProtKB: Q6UUV7
Previous GeneCards Identifiers for CRTC3 Gene
- GC15P088875
- GC15P091073
- GC15P067184
Summaries for CRTC3 Gene
-
This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein encoded by this gene may induce mitochondrial biogenesis and attenuate catecholamine signaling in adipose tissue. A translocation event between this gene and Notch coactivator mastermind-like gene 2, which results in a fusion protein, has been reported in mucoepidermoid carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
GeneCards Summary for CRTC3 Gene
CRTC3 (CREB Regulated Transcription Coactivator 3) is a Protein Coding gene. Diseases associated with CRTC3 include Human T-Cell Leukemia Virus Type 1 and Mucoepidermoid Carcinoma. Among its related pathways are Organelle biogenesis and maintenance and Mitochondrial Gene Expression. Gene Ontology (GO) annotations related to this gene include cAMP response element binding protein binding. An important paralog of this gene is CRTC2.
UniProtKB/Swiss-Prot for CRTC3 Gene
-
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 Ser-133 phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).
Additional gene information for CRTC3 Gene
- Monarch Initiative
- Search for CRTC3 at DataMed
- Search for CRTC3 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRTC3 Gene
Genomics for CRTC3 Gene
GeneHancer (GH) Regulatory Elements for CRTC3 Gene
Promoters and enhancers for CRTC3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around CRTC3 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for CRTC3 Gene
Genomic Locations for CRTC3 Gene
- chr15:90,529,886-90,645,345
- (GRCh38/hg38)
- Size:
- 115,460 bases
- Orientation:
- Plus strand
- chr15:91,073,157-91,188,577
- (GRCh37/hg19)
Genomic View for CRTC3 Gene
Genes around CRTC3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q26.1 by Ensembl
- 15q26.1 by Entrez Gene
- 15q26.1 by HGNC
CRTC3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CRTC3 Gene
Proteins for CRTC3 Gene
-
Protein details for CRTC3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6UUV7-CRTC3_HUMAN
- Recommended name:
- CREB-regulated transcription coactivator 3
- Protein Accession:
- Q6UUV7
- Q6DK61
- Q6DK62
- Q8NF38
- Q9H6U2
Protein attributes for CRTC3 Gene
- Size:
- 619 amino acids
- Molecular mass:
- 66959 Da
- Quaternary structure:
-
- Binding, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1 enhances recruitment of TAF4 to the promoter (PubMed:14506290). Arg-314 in the bZIP domain of CREB1 is essential for this interaction (By similarity). Interaction with HTLV-1 TAX enhances its transcriptional activity (PubMed:15466468, PubMed:16809310). Interacts, via the N-terminal with the ankyrin repeats of BCL3, to form a complex with CREB1 on CRE and TxRE responsive elements and represses HTLV-1 LTR-mediated transcription (PubMed:17644518).
- SequenceCaution:
-
- Sequence=BAC03424.1; Type=Frameshift; Positions=82; Evidence={ECO:0000305};
Protein Expression for CRTC3 Gene
Post-translational modifications for CRTC3 Gene
No Post-translational modifications
Other Protein References for CRTC3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for CRTC3 (TORC3)
- Cell Signaling Technology (CST) Antibodies for CRTC3 (TORC3)
-
Custom Antibody ServicesOriGene Antibodies for CRTC3
- Novus Biologicals Antibodies for CRTC3
-
Abcam antibodies for CRTC3
-
Cloud-Clone Corp. Antibodies for CRTC3
- Invitrogen Antibodies for CRTC3
- Search GeneTex for Antibodies for CRTC3
-
Santa Cruz Biotechnology (SCBT) Antibodies for CRTC3
Protein Products
-
OriGene Purified Proteins for CRTC3
- Search Origene for MassSpec and Protein Over-expression Lysates for CRTC3
- Origene Custom Protein Services for CRTC3
- Novus Biologicals proteins for CRTC3
-
Cloud-Clone Corp. Proteins for CRTC3
- antibodies-online: Search results for 4 available CRTC3 Proteins ranked by validation data
- Compare Top CRTC3 Proteins
-
Quality Products:
- Search GeneTex for Proteins for CRTC3
-
Abcam proteins for CRTC3
Assay Products
-
Cloud-Clone Corp. Assay Kits for CRTC3
- antibodies-online: Search results for 4 available CRTC3 Elisa Kits ranked by validation data
- Compare Top CRTC3 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for CRTC3 Gene
Domains & Families for CRTC3 Gene
Gene Families for CRTC3 Gene
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for CRTC3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q6UUV7- Family:
-
- Belongs to the TORC family.
Function for CRTC3 Gene
Molecular function for CRTC3 Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 Ser-133 phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).
Phenotypes From GWAS Catalog for CRTC3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008140 | cAMP response element binding protein binding | IBA | -- |
Phenotypes for CRTC3 Gene
- MGI mutant phenotypes for CRTC3:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CRTC3:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability
- Decreased hepcidin::fluc mRNA expression
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased ionizing radiation sensitivity
- Decreased viability ratio
- Decreased p24 protein expression
- Strongly decreased CFP-tsO45G cell surface transport
- Increased G1 DNA content
- Decreased infection with West Nile virus (WNV)
- Decreased West Nile virus (WNV) infection
- Weakly decreased NFAT1-GFP nuclear translocation
- Decreased Dengue Infection
- Increased Sindbis virus (SINV) infection
- Increased cell size
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CRTC3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CRTC3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CRTC3 gene
- Search ViGene Biosciences for CRTC3
CRISPR Products
-
OriGene CRISPR knockouts for CRTC3
- genomics-online: gRNA clones - Search results for 63 available CRTC3 gene related products
- Overview of 63 available CRTC3 gene related products
- Applied Biological Materials CRISPR for CRTC3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CRTC3
- GenScript: Design CRISPR guide RNA sequences for CRTC3
miRNA for CRTC3 Gene
- miRTarBase miRNAs that target CRTC3
-
- hsa-mir-124-3p (MIRT023199)
- hsa-mir-7-5p (MIRT025919)
- hsa-mir-671-5p (MIRT039296)
- hsa-mir-92a-3p (MIRT049715)
- hsa-mir-20a-5p (MIRT440873)
- hsa-mir-106b-5p (MIRT440874)
- hsa-mir-514b-3p (MIRT691007)
- hsa-mir-514a-3p (MIRT691008)
- hsa-mir-29b-2-5p (MIRT691009)
- hsa-mir-6079 (MIRT691010)
- hsa-mir-6828-5p (MIRT691011)
- hsa-mir-4772-5p (MIRT691012)
- hsa-mir-4487 (MIRT691013)
- hsa-mir-642b-3p (MIRT691014)
- hsa-mir-642a-3p (MIRT691015)
- hsa-mir-29b-1-5p (MIRT691016)
- hsa-mir-4748 (MIRT691017)
- hsa-mir-4464 (MIRT691018)
- hsa-mir-708-5p (MIRT691019)
- hsa-mir-3139 (MIRT691020)
- hsa-mir-28-5p (MIRT691021)
- hsa-mir-129-2-3p (MIRT691022)
- hsa-mir-129-1-3p (MIRT691023)
- hsa-mir-383-5p (MIRT691024)
- hsa-mir-6768-5p (MIRT691025)
- hsa-mir-93-5p (MIRT727925)
- hsa-mir-519d-3p (MIRT727926)
- hsa-mir-20b-5p (MIRT727927)
- hsa-mir-17-5p (MIRT727928)
miRNA Products
- Search ViGene Biosciences for CRTC3
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CRTC3
- Browse OriGene Inhibitory RNA Products For CRTC3
- genomics-online: shRNA clones - Search results for 63 available CRTC3 gene related products
- Overview of 63 available CRTC3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CRTC3 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CRTC3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CRTC3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CRTC3
- Applied Biological Materials Clones for CRTC3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for CRTC3
-
ViGene Biosciences adenoviral particle packaged cDNA for CRTC3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CRTC3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CRTC3 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CRTC3 Gene
Localization for CRTC3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CRTC3 Gene
- Nucleus. Cytoplasm. Note=Appears to be mainly nuclear. {ECO:0000269 PubMed:15454081}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
- Cytosol (4)
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IBA,IEA | -- |
| GO:0005829 | cytosol | IDA | -- |
Pathways & Interactions for CRTC3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Mitochondrial Gene Expression | ||
| 2 | HTLV-I infection | ||
| 3 | Glucose / Energy Metabolism | ||
| 4 | BMAL1-CLOCK,NPAS2 activates circadian gene expression |
.68
|
|
| 5 | Organelle biogenesis and maintenance | ||
Pathways by source for CRTC3 Gene
1 Cell Signaling Technology pathway for CRTC3 Gene
4 Reactome pathways for CRTC3 Gene
1 KEGG pathway for CRTC3 Gene
Interacting Proteins for CRTC3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0016032 | viral process | IEA | -- |
| GO:0032793 | positive regulation of CREB transcription factor activity | IEA,IBA | -- |
| GO:0042116 | macrophage activation | IMP | 23033494 |
Drugs & Compounds for CRTC3 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| cyclic amp | Experimental | Pharma | 0 |
Transcripts for CRTC3 Gene
mRNA/cDNA for CRTC3 Gene
- (4) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (125) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CRTC3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for CRTC3
- genomics-online: gRNA clones - Search results for 63 available CRTC3 gene related products
- Overview of 63 available CRTC3 gene related products
- Applied Biological Materials CRISPR for CRTC3
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CRTC3
- GenScript: Design CRISPR guide RNA sequences for CRTC3
miRNA Products
- Search ViGene Biosciences for CRTC3
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CRTC3
- Browse OriGene Inhibitory RNA Products For CRTC3
- genomics-online: shRNA clones - Search results for 63 available CRTC3 gene related products
- Overview of 63 available CRTC3 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CRTC3 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CRTC3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CRTC3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CRTC3
- Applied Biological Materials Clones for CRTC3
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19a | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: |
| ExUns: | 19b |
|---|---|
| SP1: | |
| SP2: | |
| SP3: | |
| SP4: | |
| SP5: | |
| SP6: | |
| SP7: | |
| SP8: | |
| SP9: |
Expression for CRTC3 Gene
This gene is overexpressed in Testis (24.8), Placenta (11.3), and CD8 Tcells (7.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CRTC3 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of CRTC3 Gene:
CRTC3SOURCE GeneReport for Unigene cluster for CRTC3 Gene:
Hs.567572mRNA Expression by UniProt/SwissProt for CRTC3 Gene:
Q6UUV7-CRTC3_HUMAN
Tissue specificity:
Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach.
Evidence on tissue expression from TISSUES for CRTC3 Gene
- Nervous system(4.6)
- Spleen(4.3)
Primer Products
-
OriGene qPCR primer pairs for CRTC3
-
OriGene qPCR primer pairs and template standards for CRTC3
- genomics-online: primer clones - Search results for 63 available CRTC3 gene related products
- Overview of 63 available CRTC3 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CRTC3 Gene
Orthologs for CRTC3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CRTC3 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Crtc3 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Crtc3 33 16 34 |
|
||
| cow (Bos Taurus) |
Mammalia | CRTC3 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | CRTC3 33 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CRTC3 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CRTC3 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | crtc3 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | crtc3 33 34 |
|
- Species where no ortholog for CRTC3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CRTC3 Gene
(3) SIMAP similar genes for CRTC3 Gene using alignment to 3 proteins:
Variants for CRTC3 Gene
| SNP ID | Clin | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs193921108 | uncertain-significance, Malignant tumor of prostate | 90,638,566(+) | C/A/G/T | coding_sequence_variant, missense_variant | |
| rs1000027365 | -- | 90,600,560(+) | T/C | intron_variant | |
| rs1000038445 | -- | 90,535,551(+) | G/C | intron_variant | |
| rs1000042469 | -- | 90,573,441(+) | C/G | intron_variant | |
| rs1000076197 | -- | 90,595,426(+) | G/A | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1259n106 | CNV | deletion | 24896259 |
| esv1007679 | CNV | deletion | 20482838 |
| esv1236283 | CNV | deletion | 17803354 |
| esv2234796 | CNV | deletion | 18987734 |
| esv2512119 | CNV | deletion | 19546169 |
| esv2750011 | CNV | deletion | 23290073 |
| esv3217123 | CNV | deletion | 24192839 |
| esv33061 | CNV | loss | 17666407 |
| esv3552839 | CNV | deletion | 23714750 |
| esv3569875 | CNV | gain | 25503493 |
| esv3955 | CNV | loss | 18987735 |
| esv5649 | CNV | gain | 19470904 |
| esv8010 | CNV | loss | 19470904 |
| nsv1045042 | CNV | gain | 25217958 |
| nsv1069883 | CNV | deletion | 25765185 |
| nsv1078211 | CNV | insertion | 25765185 |
| nsv1127452 | CNV | deletion | 24896259 |
| nsv1142183 | CNV | tandem duplication | 24896259 |
| nsv1148246 | CNV | deletion | 26484159 |
| nsv1662 | CNV | insertion | 18451855 |
| nsv475139 | CNV | novel sequence insertion | 20440878 |
| nsv479235 | CNV | novel sequence insertion | 20440878 |
| nsv509582 | CNV | insertion | 20534489 |
| nsv570396 | CNV | gain | 21841781 |
| nsv833088 | CNV | loss | 17160897 |
| nsv94691 | CNV | deletion | 16902084 |
| nsv957961 | CNV | deletion | 24416366 |
| nsv984108 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
37.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
9.81;
89.56% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CRTC3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CRTC3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CRTC3 Gene
Disorders for CRTC3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| human t-cell leukemia virus type 1 |
|
|
| mucoepidermoid carcinoma |
|
|
| warthin tumor |
|
|
Search CRTC3 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CRTC3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for CRTC3 Gene
Publications for CRTC3 Gene
- Enhanced activation of tax-dependent transcription of human T-cell leukemia virus type I (HTLV-I) long terminal repeat by TORC3. (PMID: 15466468) Koga H … Shimotohno K (The Journal of biological chemistry 2004) 3 4 22 58
- TORCs: transducers of regulated CREB activity. (PMID: 14536081) Conkright MD … Montminy M (Molecular cell 2003) 2 3 4 58
- Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. (PMID: 14506290) Iourgenko V … Labow MA (Proceedings of the National Academy of Sciences of the United States of America 2003) 2 3 4 58
- Whole genome association scan for genetic polymorphisms influencing information processing speed. (PMID: 21130836) Luciano M … Deary IJ (Biological psychology 2011) 3 44 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
Products for CRTC3 Gene
- R&D Systems Antibodies for CRTC3 (TORC3)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for CRTC3
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CRTC3
- Search Origene for MassSpec and Protein Over-expression Lysates for CRTC3
- Origene Custom Protein Services for CRTC3
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CRTC3
- Browse OriGene Inhibitory RNA Products For CRTC3
- OriGene qPCR primer pairs and template standards for CRTC3
- OriGene qPCR primer pairs for CRTC3
- OriGene CRISPR knockouts for CRTC3
- OriGene ORF clones in human for CRTC3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CRTC3
- GenScript: Next-day shipping of latest version cDNA ORF clones for CRTC3 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CRTC3
- GenScript Custom Assay Services for CRTC3
- GenScript Custom overexpressing Cell Line Services for CRTC3
- GenScript: Design CRISPR guide RNA sequences for CRTC3
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for CRTC3
- Cell Signaling Technology (CST) Antibodies for CRTC3 (TORC3)
- Search for Antibodies & Assays
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for CRTC3
- Novus Biologicals proteins for CRTC3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for CRTC3
- Abcam proteins for CRTC3
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Cloud-Clone Corp. Antibodies for CRTC3
- Cloud-Clone Corp. Proteins for CRTC3
- Cloud-Clone Corp. Assay Kits for CRTC3
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for CRTC3
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for CRTC3
- VectorBuilder custom plasmid, inducible vectors for CRTC3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CRTC3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for CRTC3
- antibodies-online: Search results for 36 available CRTC3 Antibodies ranked by validation data
- Compare Top CRTC3 Antibodies
- antibodies-online: Search results for 4 available CRTC3 Elisa Kits ranked by validation data
- Compare Top CRTC3 Elisa Kits
- Quality Products:
- antibodies-online: Search results for 4 available CRTC3 Proteins ranked by validation data
- Compare Top CRTC3 Proteins
- Quality Products:
- Search GeneTex for Antibodies for CRTC3
- Search GeneTex for Proteins for CRTC3
- ViGene Biosciences adenoviral particle packaged cDNA for CRTC3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CRTC3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CRTC3 gene
- Search ViGene Biosciences for CRTC3
- Santa Cruz Biotechnology (SCBT) Antibodies for CRTC3
- Search Santa Cruz Biotechnology (SCBT) for CRTC3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CRTC3
- Horizon Cell Lines for CRTC3
- genomics-online: cdna clones - Search results for 63 available CRTC3 gene related products
- Overview of 63 available CRTC3 gene related products
- orf clones - Search results for 63 available CRTC3 gene related products
- Overview of 63 available CRTC3 gene related products
- genomics-online: gRNA clones - Search results for 63 available CRTC3 gene related products
- Overview of 63 available CRTC3 gene related products
- genomics-online: primer clones - Search results for 63 available CRTC3 gene related products
- Overview of 63 available CRTC3 gene related products
- genomics-online: shRNA clones - Search results for 63 available CRTC3 gene related products
- Overview of 63 available CRTC3 gene related products
Sources for CRTC3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew