Aliases for RBM15 Gene
External Ids for RBM15 Gene
Previous GeneCards Identifiers for RBM15 Gene
Members of the SPEN (Split-end) family of proteins, including RBM15, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb 2009]
GeneCards Summary for RBM15 Gene
RBM15 (RNA Binding Motif Protein 15) is a Protein Coding gene. Diseases associated with RBM15 include megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13) and pancreatic cystadenoma. Among its related pathways are Notch signaling pathway (KEGG) and Notch signaling pathway (Pathway Interaction Database). GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RBM15B.
UniProtKB/Swiss-Prot for RBM15 Gene
May function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing. High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing. May be implicated in HOX gene regulation.