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Aliases for RBM15 Gene

Aliases for RBM15 Gene

  • RNA Binding Motif Protein 15 2 3
  • RNA-Binding Motif Protein 15 3 4
  • One-Twenty Two Protein 1 3 4
  • One Twenty-Two 2 3
  • SPEN 3 6
  • OTT1 3 4
  • OTT 3 4
  • Putative RNA-Binding Protein 15 3
  • One Twenty Two Protein 3
  • Homolog Of) 6
  • Drosophila 6

External Ids for RBM15 Gene

Previous GeneCards Identifiers for RBM15 Gene

  • GC01P111298
  • GC01P109748
  • GC01P109983
  • GC01P110179
  • GC01P110180
  • GC01P110593
  • GC01P110682
  • GC01P110876
  • GC01P108753
  • GC01P110882

Summaries for RBM15 Gene

Entrez Gene Summary for RBM15 Gene

  • Members of the SPEN (Split-end) family of proteins, including RBM15, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb 2009]

GeneCards Summary for RBM15 Gene

RBM15 (RNA Binding Motif Protein 15) is a Protein Coding gene. Diseases associated with RBM15 include 'megakaryoblastic acute myeloid leukemia with t(1;22)(p13;q13)' and megakaryocytic leukemia. Among its related pathways are Notch-mediated HES/HEY network and Notch signaling pathway (Pathway Interaction Database). GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is SPEN.

UniProtKB/Swiss-Prot for RBM15 Gene

  • May function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing. High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing. May be implicated in HOX gene regulation.

Gene Wiki entry for RBM15 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM15 Gene

Genomics for RBM15 Gene

Regulatory Elements for RBM15 Gene

Genomic Location for RBM15 Gene

Start:
110,338,506 bp from pter
End:
110,346,681 bp from pter
Size:
8,176 bases
Orientation:
Plus strand

Genomic View for RBM15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RBM15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM15 Gene

Proteins for RBM15 Gene

  • Protein details for RBM15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96T37-RBM15_HUMAN
    Recommended name:
    Putative RNA-binding protein 15
    Protein Accession:
    Q96T37
    Secondary Accessions:
    • A1A693
    • Q3ZB86
    • Q4V760
    • Q5D058
    • Q5T613
    • Q86VW9
    • Q96PE4
    • Q96SC5
    • Q96SC6
    • Q96SC9
    • Q96SD0
    • Q96T38
    • Q9BRA5
    • Q9H6R8
    • Q9H9Y0

    Protein attributes for RBM15 Gene

    Size:
    977 amino acids
    Molecular mass:
    107189 Da
    Quaternary structure:
    • Interacts with Epstein-Barr virus BSFL2/BMLF1. Interacts (via SPOC domain) with SETD1B. Interacts with NXF1, the interaction is required to promote mRNA export.
    SequenceCaution:
    • Sequence=BAB14088.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15185.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for RBM15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBM15 Gene

Proteomics data for RBM15 Gene at MOPED

Post-translational modifications for RBM15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RBM15 Gene

No data available for DME Specific Peptides for RBM15 Gene

Domains for RBM15 Gene

Gene Families for RBM15 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Graphical View of Domain Structure for InterPro Entry

Q96T37

UniProtKB/Swiss-Prot:

RBM15_HUMAN :
  • Q96T37
Domain:
  • Contains 3 RRM (RNA recognition motif) domains.
  • Contains 1 SPOC domain.
Family:
  • Belongs to the RRM Spen family.
genes like me logo Genes that share domains with RBM15: view

Function for RBM15 Gene

Molecular function for RBM15 Gene

UniProtKB/Swiss-Prot Function: May function as an mRNA export factor, stimulating export and expression of RTE-containing mRNAs which are present in many retrotransposons that require to be exported prior to splicing. High affinity binding of pre-mRNA to RBM15 may allow targeting of the mRNP to the export helicase DBP5 in a manner that is independent of splicing-mediated NXF1 deposition, resulting in export prior to splicing. May be implicated in HOX gene regulation.

Gene Ontology (GO) - Molecular Function for RBM15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0005515 protein binding IPI 16129689
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with RBM15: view
genes like me logo Genes that share phenotypes with RBM15: view

Animal Models for RBM15 Gene

MGI Knock Outs for RBM15:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for RBM15 Gene

Localization for RBM15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM15 Gene

Nucleus. Nucleus membrane; Peripheral membrane protein. Note=Colocalizes at the nuclear pore with DBP5 and NXF1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RBM15 Gene COMPARTMENTS Subcellular localization image for RBM15 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for RBM15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0016020 membrane --
GO:0031965 nuclear membrane IEA --
genes like me logo Genes that share ontologies with RBM15: view

Pathways for RBM15 Gene

genes like me logo Genes that share pathways with RBM15: view

Pathways by source for RBM15 Gene

1 R&D Systems pathway for RBM15 Gene

Gene Ontology (GO) - Biological Process for RBM15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter --
GO:0001569 patterning of blood vessels IEA --
GO:0007221 positive regulation of transcription of Notch receptor target IEA --
GO:0016032 viral process IEA --
GO:0045638 negative regulation of myeloid cell differentiation IEA --
genes like me logo Genes that share ontologies with RBM15: view

Transcripts for RBM15 Gene

Unigene Clusters for RBM15 Gene

RNA binding motif protein 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RBM15 Gene

No ASD Table

Relevant External Links for RBM15 Gene

GeneLoc Exon Structure for
RBM15
ECgene alternative splicing isoforms for
RBM15

Expression for RBM15 Gene

mRNA expression in normal human tissues for RBM15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RBM15 Gene

SOURCE GeneReport for Unigene cluster for RBM15 Gene Hs.435947

genes like me logo Genes that share expressions with RBM15: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RBM15 Gene

Orthologs for RBM15 Gene

This gene was present in the common ancestor of animals.

Orthologs for RBM15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBM15 35
  • 98.9 (n)
  • 98.76 (a)
RBM15 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RBM15 35
  • 93.37 (n)
  • 97.38 (a)
RBM15 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RBM15 35
  • 91.76 (n)
  • 96.59 (a)
RBM15 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rbm15 35
  • 90.31 (n)
  • 95.07 (a)
Rbm15 16
Rbm15 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RBM15 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RBM15 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rbm15 35
  • 90.9 (n)
  • 94.9 (a)
chicken
(Gallus gallus)
Aves LOC100859595 35
  • 73.04 (n)
  • 81.65 (a)
RBM15 36
  • 69 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.19505 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rbm15 35
  • 63.77 (n)
  • 66.3 (a)
Str.7059 35
zebrafish
(Danio rerio)
Actinopterygii Dr.15490 35
rbm15 35
  • 62.45 (n)
  • 67.66 (a)
rbm15 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta nito 36
  • 36 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea grld-1 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToMany
Species with no ortholog for RBM15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RBM15 Gene

ENSEMBL:
Gene Tree for RBM15 (if available)
TreeFam:
Gene Tree for RBM15 (if available)

Paralogs for RBM15 Gene

Paralogs for RBM15 Gene

Selected SIMAP similar genes for RBM15 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for RBM15 Gene

genes like me logo Genes that share paralogs with RBM15: view

Variants for RBM15 Gene

Sequence variations from dbSNP and Humsavar for RBM15 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1572263 -- 110,343,114(-) AGTTT(C/T)GAAAT intron-variant
rs3738751 -- 110,341,295(-) AGATC(C/T)CGATC reference, synonymous-codon
rs3768460 -- 110,344,453(-) AAACA(C/T)AGTAC intron-variant
rs4839342 -- 110,343,916(+) AGCAC(A/G)AAAGT intron-variant
rs4839343 -- 110,344,151(+) CTGTG(C/G)TTGGT intron-variant

Relevant External Links for RBM15 Gene

HapMap Linkage Disequilibrium report
RBM15
Human Gene Mutation Database (HGMD)
RBM15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RBM15 Gene

Disorders for RBM15 Gene

UniProtKB/Swiss-Prot

RBM15_HUMAN
  • Note=A chromosomal aberration involving RBM15 may be a cause of acute megakaryoblastic leukemia. Translocation t(1;22)(p13;q13) with MKL1. Although both reciprocal fusion transcripts are detected in acute megakaryoblastic leukemia (AMKL, FAB-M7), the RBM15-MKL1 chimeric protein has all the putative functional domains encoded by each gene and is the candidate oncogene.

(1) University of Copenhagen DISEASES for RBM15 Gene

genes like me logo Genes that share disorders with RBM15: view

Publications for RBM15 Gene

  1. Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. (PMID: 11431691) Ma Z. … Hitzler J.K. (Nat. Genet. 2001) 2 3 4 23
  2. Interaction of the Epstein-Barr virus mRNA export factor EB2 with human Spen proteins SHARP, OTT1, and a novel member of the family, OTT3, links Spen proteins with splicing regulation and mRNA export. (PMID: 16129689) Hiriart E. … Manet E. (J. Biol. Chem. 2005) 3 4 23
  3. Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia. (PMID: 11344311) Mercher T. … Bernard O.A. (Proc. Natl. Acad. Sci. U.S.A. 2001) 2 3 4
  4. The RNA-binding motif protein 15B (RBM15B/OTT3) acts as cofactor of the nuclear export receptor NXF1. (PMID: 19586903) Uranishi H. … Felber B.K. (J. Biol. Chem. 2009) 3 23
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for RBM15 Gene

Sources for RBM15 Gene

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