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Aliases for PARP12 Gene

Aliases for PARP12 Gene

  • Poly(ADP-Ribose) Polymerase Family Member 12 2 3 5
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 12 3 4
  • ZC3HDC1 3 4
  • ARTD12 3 4
  • Poly (ADP-Ribose) Polymerase Family, Member 12 3
  • Zinc Finger CCCH Domain-Containing Protein 1 4
  • Zinc Finger CCCH-Type Domain Containing 1 2
  • Zinc Finger CCCH Type Domain Containing 1 3
  • EC 4
  • MSTP109 3
  • PARP-12 4
  • MST109 3
  • ZC3H1 3

External Ids for PARP12 Gene

Previous HGNC Symbols for PARP12 Gene

  • ZC3HDC1

Previous GeneCards Identifiers for PARP12 Gene

  • GC07M139177
  • GC07M139370
  • GC07M139723
  • GC07M134017

Summaries for PARP12 Gene

GeneCards Summary for PARP12 Gene

PARP12 (Poly(ADP-Ribose) Polymerase Family Member 12) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP14.

Tocris Summary for PARP12 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

Gene Wiki entry for PARP12 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARP12 Gene

Genomics for PARP12 Gene

Regulatory Elements for PARP12 Gene

Enhancers for PARP12 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PARP12 on UCSC Golden Path with GeneCards custom track

Promoters for PARP12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PARP12 on UCSC Golden Path with GeneCards custom track

Genomic Location for PARP12 Gene

140,023,744 bp from pter
140,063,828 bp from pter
40,085 bases
Minus strand

Genomic View for PARP12 Gene

Genes around PARP12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARP12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARP12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP12 Gene

Proteins for PARP12 Gene

  • Protein details for PARP12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Poly [ADP-ribose] polymerase 12
    Protein Accession:
    Secondary Accessions:
    • Q9H610
    • Q9NP36
    • Q9NTI3

    Protein attributes for PARP12 Gene

    701 amino acids
    Molecular mass:
    79064 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PARP12 Gene

neXtProt entry for PARP12 Gene

Proteomics data for PARP12 Gene at MOPED

Post-translational modifications for PARP12 Gene

  • Ubiquitination at Lys 256, Lys 308, and Lys 477
  • Modification sites at PhosphoSitePlus

Other Protein References for PARP12 Gene

No data available for DME Specific Peptides for PARP12 Gene

Domains & Families for PARP12 Gene

Protein Domains for PARP12 Gene

Suggested Antigen Peptide Sequences for PARP12 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 PARP catalytic domain.
  • Contains 4 C3H1-type zinc fingers.
  • Contains 1 PARP catalytic domain.
  • Contains 2 WWE domains.
  • Contains 4 C3H1-type zinc fingers.
genes like me logo Genes that share domains with PARP12: view

Function for PARP12 Gene

Molecular function for PARP12 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.

Enzyme Numbers (IUBMB) for PARP12 Gene

Gene Ontology (GO) - Molecular Function for PARP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with PARP12: view

Phenotypes for PARP12 Gene

genes like me logo Genes that share phenotypes with PARP12: view

Animal Models for PARP12 Gene

MGI Knock Outs for PARP12:

Animal Model Products

miRNA for PARP12 Gene

miRTarBase miRNAs that target PARP12

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PARP12 Gene

Localization for PARP12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARP12 Gene

Subcellular locations from

Jensen Localization Image for PARP12 Gene COMPARTMENTS Subcellular localization image for PARP12 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for PARP12 Gene

Pathways & Interactions for PARP12 Gene

SuperPathways for PARP12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PARP12 Gene


No data available for Pathways by source and SIGNOR curated interactions for PARP12 Gene

Drugs & Compounds for PARP12 Gene

(3) Drugs for PARP12 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Experimental Nutra 850,854
NU1025 Experimental Pharma Potent PARP inhibitor 0
NAD Pharma Full agonist, Agonist 0

(4) Additional Compounds for PARP12 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
DR 2313
PJ 34 hydrochloride

(5) Tocris Compounds for PARP12 Gene

Compound Action Cas Number
3-Aminobenzamide PARP inhibitor 3544-24-9
4-HQN PARP inhibitor 491-36-1
DR 2313 PARP-1 and PARP-2 inhibitor 284028-90-6
NU 1025 Potent PARP inhibitor 90417-38-2
PJ 34 hydrochloride Potent PARP inhibitor 344458-15-7
genes like me logo Genes that share compounds with PARP12: view

Transcripts for PARP12 Gene

Unigene Clusters for PARP12 Gene

Poly (ADP-ribose) polymerase family, member 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PARP12 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b
SP1: - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - -
SP5: -
SP8: - -

Relevant External Links for PARP12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PARP12 Gene

mRNA expression in normal human tissues for PARP12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PARP12 Gene

This gene is overexpressed in Lymph node (21.8) and Peripheral blood mononuclear cells (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PARP12 Gene

SOURCE GeneReport for Unigene cluster for PARP12 Gene Hs.12646

genes like me logo Genes that share expression patterns with PARP12: view

Protein tissue co-expression partners for PARP12 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PARP12 Gene

Orthologs for PARP12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PARP12 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PARP12 35
  • 82.07 (n)
  • 74.25 (a)
PARP12 36
  • 74 (a)
(Canis familiaris)
Mammalia PARP12 35
  • 86.12 (n)
  • 83.45 (a)
PARP12 36
  • 84 (a)
(Mus musculus)
Mammalia Parp12 35
  • 82.88 (n)
  • 81.31 (a)
Parp12 16
Parp12 36
  • 80 (a)
(Pan troglodytes)
Mammalia PARP12 35
  • 99.14 (n)
  • 99.14 (a)
PARP12 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Parp12 35
  • 82.93 (n)
  • 81.97 (a)
(Monodelphis domestica)
Mammalia PARP12 36
  • 50 (a)
(Ornithorhynchus anatinus)
Mammalia PARP12 36
  • 58 (a)
(Gallus gallus)
Aves PARP12 35
  • 61.96 (n)
  • 56.44 (a)
PARP12 36
  • 46 (a)
(Anolis carolinensis)
Reptilia PARP12 36
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489821 35
  • 58.17 (n)
  • 50.09 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12414 35
(Danio rerio)
Actinopterygii parp12a 35
  • 55.61 (n)
  • 50.17 (a)
PARP12 (2 of 2) 36
  • 34 (a)
parp12a 36
  • 43 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9609 35
Species with no ortholog for PARP12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PARP12 Gene

Gene Tree for PARP12 (if available)
Gene Tree for PARP12 (if available)

Paralogs for PARP12 Gene

Paralogs for PARP12 Gene

(4) SIMAP similar genes for PARP12 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PARP12: view

Variants for PARP12 Gene

Sequence variations from dbSNP and Humsavar for PARP12 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs34111764 - 140,046,993(+) ATGAA(C/G/T)TCTAT nc-transcript-variant, reference, missense
rs35456446 - 140,034,269(+) AGACA(A/C/T)GTATT nc-transcript-variant, reference, synonymous-codon, missense
rs17161356 - 140,024,807(+) CCCGG(A/G)CCAGG nc-transcript-variant, reference, missense, utr-variant-3-prime
rs6948746 -- 140,064,393(+) aaaaa(C/T)gtaaa upstream-variant-2KB
rs1044703 -- 140,023,942(-) GAAGT(A/G)CATCC nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PARP12 Gene

Variant ID Type Subtype PubMed ID
esv2735212 CNV Deletion 23290073
nsv889246 CNV Gain 21882294
esv2735237 CNV Deletion 23290073
esv2735238 CNV Deletion 23290073
esv2735240 CNV Deletion 23290073
esv2735241 CNV Deletion 23290073
nsv824318 CNV Loss 20364138

Variation tolerance for PARP12 Gene

Residual Variation Intolerance Score: 38.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.74; 78.82% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PARP12 Gene

Disorders for PARP12 Gene

Relevant External Links for PARP12

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PARP12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PARP12 Gene

Publications for PARP12 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31. (PMID: 12851707) Katoh M. … Katoh M. (Int. J. Oncol. 2003) 2 3 23
  3. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3
  4. PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. (PMID: 24332808) Marechal A. … Zou L. (Mol. Cell 2014) 3
  5. The central role of EED in the orchestration of polycomb group complexes. (PMID: 24457600) Cao Q. … Chinnaiyan A.M. (Nat Commun 2014) 3

Products for PARP12 Gene

Sources for PARP12 Gene