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Aliases for PARP12 Gene

Aliases for PARP12 Gene

  • Poly(ADP-Ribose) Polymerase Family Member 12 2 3 5
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 12 3 4
  • ZC3HDC1 3 4
  • ARTD12 3 4
  • Zinc Finger CCCH Domain-Containing Protein 1 4
  • Zinc Finger CCCH-Type Domain Containing 1 2
  • Zinc Finger CCCH Type Domain Containing 1 3
  • Poly [ADP-Ribose] Polymerase 12 3
  • EC 2.4.2.30 4
  • MSTP109 3
  • PARP-12 4
  • MST109 3
  • ZC3H1 3

External Ids for PARP12 Gene

Previous HGNC Symbols for PARP12 Gene

  • ZC3HDC1

Previous GeneCards Identifiers for PARP12 Gene

  • GC07M139177
  • GC07M139370
  • GC07M139723
  • GC07M134017

Summaries for PARP12 Gene

GeneCards Summary for PARP12 Gene

PARP12 (Poly(ADP-Ribose) Polymerase Family Member 12) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is ZC3HAV1.

Tocris Summary for PARP12 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to Glu/Asp residues on the substrate protein.

Gene Wiki entry for PARP12 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARP12 Gene

Genomics for PARP12 Gene

Regulatory Elements for PARP12 Gene

Enhancers for PARP12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G140058 1.4 ENCODE dbSUPER 17.7 +2.4 2382 5.1 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A FEZF1 YY1 ZNF766 ZNF143 PARP12 GC07P140023 GC07P140024
GH07G139101 2.1 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +956.3 956342 11.2 CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 ZNF143 SP3 TBX21 MEF2D ZC3HAV1 TTC26 ZC3HAV1L PARP12 UBN2 LUC7L2 RPL17P28
GH07G139724 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +331.7 331685 15.0 HDGF FOXA2 PKNOX1 ZFP64 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF143 TBXAS1 HIPK2 FCF1P11 TTC26 ZC3HAV1L PARP12 KDM7A TMEM213 KIAA1549 LUC7L2
GH07G140041 0.9 Ensembl dbSUPER 19.5 +21.7 21704 1.1 ESRRA CEBPB CEBPG FEZF1 NR2F2 OSR2 PRDM6 GATA2 CEBPA GLIS1 PARP12 KDM7A RNU6-797P HIPK2 TBXAS1 GC07P140023 GC07P140024
GH07G139773 1.3 ENCODE dbSUPER 9.8 +287.7 287657 5.4 HDGF PKNOX1 CREB3L1 SIN3A ZNF2 YY1 ZNF207 FOS ZNF263 SP3 ZC3HAV1L PARP12 TBXAS1 PIR36040
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PARP12 on UCSC Golden Path with GeneCards custom track

Promoters for PARP12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000219033 1128 1801 CREB3L1 ARID4B SIN3A YY1 ZNF766 ZNF143 ZNF207 KLF13 SP5 MXD4

Genomic Location for PARP12 Gene

Chromosome:
7
Start:
140,023,744 bp from pter
End:
140,063,828 bp from pter
Size:
40,085 bases
Orientation:
Minus strand

Genomic View for PARP12 Gene

Genes around PARP12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PARP12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PARP12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP12 Gene

Proteins for PARP12 Gene

  • Protein details for PARP12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0J9-PAR12_HUMAN
    Recommended name:
    Poly [ADP-ribose] polymerase 12
    Protein Accession:
    Q9H0J9
    Secondary Accessions:
    • Q9H610
    • Q9NP36
    • Q9NTI3

    Protein attributes for PARP12 Gene

    Size:
    701 amino acids
    Molecular mass:
    79064 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PARP12 Gene

neXtProt entry for PARP12 Gene

Post-translational modifications for PARP12 Gene

  • Ubiquitination at posLast=256256, Lys308, and posLast=477477
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PARP12 Gene

Domains & Families for PARP12 Gene

Protein Domains for PARP12 Gene

Suggested Antigen Peptide Sequences for PARP12 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PARP12: view

No data available for UniProtKB/Swiss-Prot for PARP12 Gene

Function for PARP12 Gene

Molecular function for PARP12 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.

Enzyme Numbers (IUBMB) for PARP12 Gene

Gene Ontology (GO) - Molecular Function for PARP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0003950 NAD+ ADP-ribosyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PARP12: view

Phenotypes for PARP12 Gene

genes like me logo Genes that share phenotypes with PARP12: view

Animal Models for PARP12 Gene

MGI Knock Outs for PARP12:

Animal Model Products

CRISPR Products

miRNA for PARP12 Gene

miRTarBase miRNAs that target PARP12

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PARP12 Gene

Localization for PARP12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARP12 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PARP12 gene
Compartment Confidence
nucleus 4
cytosol 3
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PARP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with PARP12: view

Pathways & Interactions for PARP12 Gene

SuperPathways for PARP12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PARP12 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PARP12 Gene

Drugs & Compounds for PARP12 Gene

(6) Drugs for PARP12 Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Nicotinamide Approved Nutra 919,923
NAD Pharma Full agonist, Agonist 0
BYK 204165 Pharma PARP-1 inhibitor,potent and selective, Selective PARP-1 inhibitor 0
EB 47 Pharma Potent PARP-1 inhibitor 0
JW 55 Pharma PARP domain inhibitor, Tankyrase inhibitor 0

(1) Additional Compounds for PARP12 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PJ 34 hydrochloride
344458-15-7

(5) Tocris Compounds for PARP12 Gene

Compound Action Cas Number
BYK 204165 Selective PARP-1 inhibitor 1104546-89-5
EB 47 Potent PARP-1 inhibitor 1190332-25-2
JW 55 Tankyrase inhibitor 664993-53-7
PJ 34 hydrochloride Potent PARP inhibitor 344458-15-7
XAV 939 Potent tankyrase inhibitor 284028-89-3
genes like me logo Genes that share compounds with PARP12: view

Transcripts for PARP12 Gene

Unigene Clusters for PARP12 Gene

Poly (ADP-ribose) polymerase family, member 12:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PARP12 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b
SP1: - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - -
SP5: -
SP6:
SP7:
SP8: - -
SP9:
SP10:

Relevant External Links for PARP12 Gene

GeneLoc Exon Structure for
PARP12
ECgene alternative splicing isoforms for
PARP12

Expression for PARP12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PARP12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PARP12 Gene

This gene is overexpressed in Lymph node (21.8) and Peripheral blood mononuclear cells (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PARP12 Gene



Protein tissue co-expression partners for PARP12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PARP12 Gene:

PARP12

SOURCE GeneReport for Unigene cluster for PARP12 Gene:

Hs.12646

Evidence on tissue expression from TISSUES for PARP12 Gene

  • Intestine(4.3)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with PARP12: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PARP12 Gene

Orthologs for PARP12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PARP12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PARP12 34 35
  • 99.14 (n)
dog
(Canis familiaris)
Mammalia PARP12 34 35
  • 86.12 (n)
rat
(Rattus norvegicus)
Mammalia Parp12 34
  • 82.93 (n)
mouse
(Mus musculus)
Mammalia Parp12 34 16 35
  • 82.88 (n)
cow
(Bos Taurus)
Mammalia PARP12 34 35
  • 82.07 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PARP12 35
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PARP12 35
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves PARP12 34 35
  • 61.96 (n)
lizard
(Anolis carolinensis)
Reptilia PARP12 35
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489821 34
  • 58.17 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12414 34
zebrafish
(Danio rerio)
Actinopterygii parp12a 34 35
  • 55.61 (n)
PARP12 (2 of 2) 35
  • 34 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9609 34
Species where no ortholog for PARP12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PARP12 Gene

ENSEMBL:
Gene Tree for PARP12 (if available)
TreeFam:
Gene Tree for PARP12 (if available)

Paralogs for PARP12 Gene

Paralogs for PARP12 Gene

(4) SIMAP similar genes for PARP12 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PARP12: view

Variants for PARP12 Gene

Sequence variations from dbSNP and Humsavar for PARP12 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000224259 -- 140,027,177(+) AACTG(A/C)CGCTC intron-variant
rs1000255674 -- 140,045,859(+) CCCAT(C/T)TGGAG intron-variant
rs1000360009 -- 140,060,998(+) GAACA(A/C)CACCC intron-variant
rs1000480471 -- 140,040,545(+) CTGGC(A/T)ATGCA intron-variant
rs1000524017 -- 140,063,117(+) CCGGA(A/G)CGCGG nc-transcript-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for PARP12 Gene

Variant ID Type Subtype PubMed ID
esv2735212 CNV deletion 23290073
esv2735237 CNV deletion 23290073
esv2735238 CNV deletion 23290073
esv2735240 CNV deletion 23290073
esv2735241 CNV deletion 23290073
nsv1076005 CNV deletion 25765185
nsv1119141 CNV deletion 24896259
nsv824318 CNV loss 20364138

Variation tolerance for PARP12 Gene

Residual Variation Intolerance Score: 38.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.74; 78.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PARP12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PARP12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PARP12 Gene

Disorders for PARP12 Gene

Relevant External Links for PARP12

Genetic Association Database (GAD)
PARP12
Human Genome Epidemiology (HuGE) Navigator
PARP12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PARP12

No disorders were found for PARP12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PARP12 Gene

Publications for PARP12 Gene

  1. Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31. (PMID: 12851707) Katoh M. … Katoh M. (Int. J. Oncol. 2003) 2 3 22 64
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 64
  3. Candidate gene polymorphisms for ischemic stroke. (PMID: 19729601) Matarin M. … Meschia J.F. (Stroke 2009) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for PARP12 Gene

Sources for PARP12 Gene

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