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Aliases for PARP12 Gene

Aliases for PARP12 Gene

  • Poly (ADP-Ribose) Polymerase Family, Member 12 2 3
  • ZC3HDC1 3 4 6
  • ADP-Ribosyltransferase Diphtheria Toxin-Like 12 3 4
  • ARTD12 3 4
  • Zinc Finger CCCH Domain-Containing Protein 1 4
  • Zinc Finger CCCH-Type Domain Containing 1 2
  • Zinc Finger CCCH Type Domain Containing 1 3
  • Poly [ADP-Ribose] Polymerase 12 3
  • EC 2.4.2.30 4
  • FLJ22693 6
  • MSTP109 3
  • PARP-12 4
  • MST109 3
  • ZC3H1 3

External Ids for PARP12 Gene

Previous Symbols for PARP12 Gene

  • ZC3HDC1

Summaries for PARP12 Gene

GeneCards Summary for PARP12 Gene

PARP12 (Poly (ADP-Ribose) Polymerase Family, Member 12) is a Protein Coding gene. GO annotations related to this gene include NAD+ ADP-ribosyltransferase activity. An important paralog of this gene is PARP14.

Tocris Summary for PARP12 Gene

  • Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to glu/asp residues on the substrate protein, and also polymerizes ADP-ribose to form long/branched chain polymers. PARP inhibitors are being developed for use in a number of pathologies including cancer, diabetes, stroke and cardiovascular disease.

Gene Wiki entry for PARP12 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PARP12 Gene

Genomics for PARP12 Gene

Genomic Location for PARP12 Gene

Start:
140,023,744 bp from pter
End:
140,064,286 bp from pter
Size:
40,543 bases
Orientation:
Minus strand

Genomic View for PARP12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PARP12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PARP12 Gene

Regulatory Elements for PARP12 Gene

Proteins for PARP12 Gene

  • Protein details for PARP12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0J9-PAR12_HUMAN
    Recommended name:
    Poly [ADP-ribose] polymerase 12
    Protein Accession:
    Q9H0J9
    Secondary Accessions:
    • Q9H610
    • Q9NP36
    • Q9NTI3

    Protein attributes for PARP12 Gene

    Size:
    701 amino acids
    Molecular mass:
    79064 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PARP12 Gene

neXtProt entry for PARP12 Gene

Proteomics data for PARP12 Gene at MOPED

Post-translational modifications for PARP12 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys256, Lys308, and Lys477

Other Protein References for PARP12 Gene

No data available for DME Specific Peptides for PARP12 Gene

Domains for PARP12 Gene

Gene Families for PARP12 Gene

HGNC:
  • PARP :Poly (ADP-ribose) polymerases
  • ZC3H :Zinc fingers, CCCH-type domain containing

Protein Domains for PARP12 Gene

UniProtKB/Swiss-Prot:

PAR12_HUMAN
Domain:
  • Contains 1 PARP catalytic domain.:
    • Q9H0J9
  • Contains 2 WWE domains.:
    • Q9H0J9
Similarity:
  • Contains 4 C3H1-type zinc fingers.:
    • Q9H0J9
genes like me logo Genes that share domains with PARP12: view

Function for PARP12 Gene

Molecular function for PARP12 Gene

UniProtKB/Swiss-Prot CatalyticActivity: NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.

Enzyme Numbers (IUBMB) for PARP12 Gene

Gene Ontology (GO) - Molecular Function for PARP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003950 NAD+ ADP-ribosyltransferase activity IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PARP12: view

Phenotypes for PARP12 Gene

GenomeRNAi human phenotypes for PARP12:
genes like me logo Genes that share phenotypes with PARP12: view

miRNA for PARP12 Gene

miRTarBase miRNAs that target PARP12

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PARP12 Gene

Localization for PARP12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PARP12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PARP12 Gene COMPARTMENTS Subcellular localization image for PARP12 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PARP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with PARP12: view

Pathways for PARP12 Gene

SuperPathways for PARP12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PARP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with PARP12: view

No data available for Pathways by source for PARP12 Gene

Compounds for PARP12 Gene

(5) Tocris Compounds for PARP12 Gene

Compound Action Cas Number
JW 55 Tankyrase inhibitor; inhibits canonical Wnt signaling [664993-53-7]
NU 1025 Potent PARP inhibitor [90417-38-2]
PJ 34 hydrochloride Potent PARP inhibitor [344458-15-7]
WIKI4 Tankyrase inhibitor; inhibits Wnt signaling [838818-26-1]
XAV 939 Tankyrase inhibitor; inhibits Wnt signaling [284028-89-3]

(1) HMDB Compounds for PARP12 Gene

Compound Synonyms Cas Number PubMed IDs
NAD
  • 3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate
53-84-9
genes like me logo Genes that share compounds with PARP12: view

Transcripts for PARP12 Gene

Unigene Clusters for PARP12 Gene

Poly (ADP-ribose) polymerase family, member 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PARP12 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b
SP1: - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - -
SP4: - - - - - - - - -
SP5: -
SP6:
SP7:
SP8: - -
SP9:
SP10:

Relevant External Links for PARP12 Gene

GeneLoc Exon Structure for
PARP12
ECgene alternative splicing isoforms for
PARP12

Expression for PARP12 Gene

mRNA expression in normal human tissues for PARP12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PARP12 Gene

SOURCE GeneReport for Unigene cluster for PARP12 Gene Hs.12646

genes like me logo Genes that share expressions with PARP12: view

Orthologs for PARP12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PARP12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PARP12 36
  • 99.14 (n)
  • 99.14 (a)
PARP12 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PARP12 36
  • 82.07 (n)
  • 74.25 (a)
PARP12 37
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PARP12 36
  • 86.12 (n)
  • 83.45 (a)
PARP12 37
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Parp12 36
  • 82.88 (n)
  • 81.31 (a)
Parp12 16
Parp12 37
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PARP12 37
  • 50 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PARP12 37
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Parp12 36
  • 82.93 (n)
  • 81.97 (a)
chicken
(Gallus gallus)
Aves PARP12 36
  • 61.96 (n)
  • 56.44 (a)
PARP12 37
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PARP12 37
  • 55 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12414 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100489821 36
  • 58.17 (n)
  • 50.09 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9609 36
zebrafish
(Danio rerio)
Actinopterygii PARP12 (2 of 2) 37
  • 34 (a)
OneToMany
parp12a 36
  • 55.61 (n)
  • 50.17 (a)
parp12a 37
  • 43 (a)
OneToMany
Species with no ortholog for PARP12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PARP12 Gene

ENSEMBL:
Gene Tree for PARP12 (if available)
TreeFam:
Gene Tree for PARP12 (if available)

Paralogs for PARP12 Gene

Paralogs for PARP12 Gene

Selected SIMAP similar genes for PARP12 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PARP12: view

Variants for PARP12 Gene

Sequence variations from dbSNP and Humsavar for PARP12 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs13760 -- 140,024,369(+) GGTTA(A/G)TCCAC utr-variant-3-prime, nc-transcript-variant
rs14250 -- 140,023,845(+) AGGGT(G/T)TCCAG utr-variant-3-prime, nc-transcript-variant
rs737321 -- 140,062,473(-) CGCCC(C/T)CACGC intron-variant
rs757833 -- 140,034,897(-) ACACT(G/T)CTAGG intron-variant
rs1044703 -- 140,023,942(-) GAAGT(A/G)CATCC utr-variant-3-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for PARP12 Gene

Variant ID Type Subtype PubMed ID
esv2735212 CNV Deletion 23290073
nsv889246 CNV Gain 21882294
esv2735237 CNV Deletion 23290073
esv2735238 CNV Deletion 23290073
esv2735240 CNV Deletion 23290073
esv2735241 CNV Deletion 23290073
nsv824318 CNV Loss 20364138

Relevant External Links for PARP12 Gene

HapMap Linkage Disequilibrium report
PARP12

Disorders for PARP12 Gene

Relevant External Links for PARP12

Genetic Association Database (GAD)
PARP12
Human Genome Epidemiology (HuGE) Navigator
PARP12
genes like me logo Genes that share disorders with PARP12: view

No data available for UniProtKB/Swiss-Prot for PARP12 Gene

Publications for PARP12 Gene

  1. Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31. (PMID: 12851707) Katoh M. … Katoh M. (Int. J. Oncol. 2003) 2 3 23
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for PARP12 Gene

Sources for PARP12 Gene

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