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Aliases for SGTA Gene

Aliases for SGTA Gene

  • Small Glutamine Rich Tetratricopeptide Repeat Containing Alpha 2 3 5
  • Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing, Alpha 2 3
  • Vpu-Binding Protein 3 4
  • Alpha-SGT 3 4
  • SGT 3 4
  • UBP 3 4
  • Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Alpha 3
  • Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing 2
  • Protein Containing Three Tetratricopeptide Repeats 3
  • AlphaSGT 3
  • SGT1 4
  • HSGT 3

External Ids for SGTA Gene

Previous HGNC Symbols for SGTA Gene

  • SGT

Previous GeneCards Identifiers for SGTA Gene

  • GC19M002705
  • GC19M002525

Summaries for SGTA Gene

Entrez Gene Summary for SGTA Gene

  • This gene encodes a protein which is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function. [provided by RefSeq, Jul 2008]

GeneCards Summary for SGTA Gene

SGTA (Small Glutamine Rich Tetratricopeptide Repeat Containing Alpha) is a Protein Coding gene. Diseases associated with SGTA include Mucocele Of Salivary Gland and Pontiac Fever. An important paralog of this gene is SGTB.

UniProtKB/Swiss-Prot for SGTA Gene

  • Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892). Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892). Probably functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:28104892). It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605). Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484). Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:18759457).

  • (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection via interaction with DNAJB12, DNAJB14 and HSPA8/Hsc70 (PubMed:24675744).

Gene Wiki entry for SGTA Gene

Additional gene information for SGTA Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SGTA Gene

Genomics for SGTA Gene

Regulatory Elements for SGTA Gene

Enhancers for SGTA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H003093 1.3 ENCODE dbSUPER 11.9 -313.8 -313792 6 PKNOX1 ARID4B SIN3A ZNF2 ZNF416 ZNF143 FOS ATF7 RUNX3 SP3 CACTIN ZNF77 SGTA LMNB2 THOP1 ENSG00000261342 GNA11 GC19M003098
GH19H002701 1.2 ENCODE dbSUPER 12 +81.1 81145 2 PKNOX1 ATF1 ZFP64 ZNF76 KLF17 GTF3C2 GLIS2 ZNF354C SCRT2 ZNF143 SF3A2 LOC100288123 CACTIN CACTIN-AS1 ZNF77 ENSG00000267139 DOT1L ZNF555 SGTA ATP8B3
GH19H002773 1.7 FANTOM5 Ensembl ENCODE dbSUPER 6.4 +8.0 7998 2 ATF1 ARID4B RARA YY1 ZNF548 ATF7 RUNX3 CREM THAP11 ZHX2 THOP1 SF3A2 CACTIN-AS1 ZNF77 APBA3 GADD45B CACTIN LOC100288123 GNA15 SGTA
GH19H003034 2 FANTOM5 Ensembl ENCODE dbSUPER 2.4 -252.5 -252459 3 HDGF PKNOX1 MLX ARNT SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 CACTIN ZNF77 SF3A2 CACTIN-AS1 ZNF554 AP3D1 APBA3 DOHH THOP1 SGTA
GH19H002487 1.6 FANTOM5 Ensembl ENCODE dbSUPER 1.7 +294.5 294461 2 ZSCAN5A ZNF792 CHD4 KLF17 ZNF2 ZKSCAN1 E2F1 ZFHX2 EZH2 ZBTB10 ATP8B3 BTBD2 MOB3A PLEKHJ1 TIMM13 SGTA SF3A2 GC19P002492 PIR42747
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SGTA on UCSC Golden Path with GeneCards custom track

Promoters for SGTA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000105940 371 1201 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for SGTA Gene

Chromosome:
19
Start:
2,754,713 bp from pter
End:
2,783,371 bp from pter
Size:
28,659 bases
Orientation:
Minus strand

Genomic View for SGTA Gene

Genes around SGTA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SGTA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SGTA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGTA Gene

Proteins for SGTA Gene

  • Protein details for SGTA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43765-SGTA_HUMAN
    Recommended name:
    Small glutamine-rich tetratricopeptide repeat-containing protein alpha
    Protein Accession:
    O43765
    Secondary Accessions:
    • D6W610
    • Q6FIA9
    • Q9BTZ9

    Protein attributes for SGTA Gene

    Size:
    313 amino acids
    Molecular mass:
    34063 Da
    Quaternary structure:
    • Homodimer (PubMed:15708368). Homooligomer (By similarity). Interacts with DNAJC5 and DNAJC5B. Interacts (via TPR repeats) with HSP90AA1 (PubMed:15708368). Interacts (via Gln-rich region) with SLC2A1 (PubMed:15708368). Interacts with HSP90AB1 (PubMed:16580629). Interacts (via TPR repeats) with HSPA8/Hsc70; the interaction is direct (PubMed:24675744). Interacts with BAG6 (via ubiquitin-like domain); interaction prevents interaction between BAG6 and RNF126 (PubMed:23129660, PubMed:25179605, PubMed:27193484). Forms a multiprotein complex, at least composed of DNAJB12, DNAJB14, HSPA8/Hsc70 and SGTA; interaction with DNAJB14 and HSPA8/Hsc70 is direct (PubMed:24675744).
    • (Microbial infection) Interacts with NS1 from parvovirus H-1, with Vpu and Gag from HIV-1. Interacts with SARS-CoV accessory protein 7a.

    Three dimensional structures from OCA and Proteopedia for SGTA Gene

neXtProt entry for SGTA Gene

Post-translational modifications for SGTA Gene

  • Ubiquitination at Lys103, Lys116, isoforms=137, isoforms=160, isoforms=174, isoforms=183, isoforms=184, and isoforms=200
  • Modification sites at PhosphoSitePlus

Other Protein References for SGTA Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SGTA (SGTA)
  • Abcam antibodies for SGTA

No data available for DME Specific Peptides for SGTA Gene

Domains & Families for SGTA Gene

Gene Families for SGTA Gene

Protein Domains for SGTA Gene

Suggested Antigen Peptide Sequences for SGTA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43765

UniProtKB/Swiss-Prot:

SGTA_HUMAN :
  • The second tetratricopeptide repeat (TPR 2) mediates the interaction with SARS-CoV accessory protein 7a.
  • Belongs to the SGT family.
Domain:
  • The second tetratricopeptide repeat (TPR 2) mediates the interaction with SARS-CoV accessory protein 7a.
Family:
  • Belongs to the SGT family.
genes like me logo Genes that share domains with SGTA: view

Function for SGTA Gene

Molecular function for SGTA Gene

UniProtKB/Swiss-Prot Function:
Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892). Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892). Probably functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:28104892). It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605). Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484). Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:18759457).
UniProtKB/Swiss-Prot Function:
(Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection via interaction with DNAJB12, DNAJB14 and HSPA8/Hsc70 (PubMed:24675744).

Gene Ontology (GO) - Molecular Function for SGTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14667819
GO:0043621 protein self-association IDA 15708368
GO:1904288 BAT3 complex binding IPI 23246001
genes like me logo Genes that share ontologies with SGTA: view
genes like me logo Genes that share phenotypes with SGTA: view

Animal Models for SGTA Gene

MGI Knock Outs for SGTA:

Animal Model Products

CRISPR Products

miRNA for SGTA Gene

miRTarBase miRNAs that target SGTA

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SGTA
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SGTA Gene

Localization for SGTA Gene

Subcellular locations from UniProtKB/Swiss-Prot for SGTA Gene

Cytoplasm. Nucleus. Note=Co-localizes with HSP90AB1 in the cytoplasm. Increased nuclear accumulation seen during cell apoptosis. {ECO:0000269 PubMed:16580629}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SGTA gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for SGTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 16580629
GO:0005737 cytoplasm IDA,IEA 16580629
GO:0005829 cytosol IDA 23246001
GO:0016020 membrane IDA 23246001
genes like me logo Genes that share ontologies with SGTA: view

Pathways & Interactions for SGTA Gene

No Data Available

Gene Ontology (GO) - Biological Process for SGTA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0016032 viral process IEA --
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process IDA 23129660
GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process IDA 23129660
GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process IMP 23246001
genes like me logo Genes that share ontologies with SGTA: view

No data available for Pathways by source and SIGNOR curated interactions for SGTA Gene

Drugs & Compounds for SGTA Gene

(1) Drugs for SGTA Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SGTA: view

Transcripts for SGTA Gene

Unigene Clusters for SGTA Gene

Small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SGTA
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SGTA Gene

No ASD Table

Relevant External Links for SGTA Gene

GeneLoc Exon Structure for
SGTA
ECgene alternative splicing isoforms for
SGTA

Expression for SGTA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SGTA Gene

Protein differential expression in normal tissues from HIPED for SGTA Gene

This gene is overexpressed in Bone (23.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SGTA Gene



Protein tissue co-expression partners for SGTA Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SGTA Gene:

SGTA

SOURCE GeneReport for Unigene cluster for SGTA Gene:

Hs.203910

mRNA Expression by UniProt/SwissProt for SGTA Gene:

O43765-SGTA_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for SGTA Gene

  • Lung(4.5)
  • Muscle(4.5)
  • Liver(4.4)
  • Nervous system(4.3)
  • Eye(2.4)
genes like me logo Genes that share expression patterns with SGTA: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for SGTA Gene

Orthologs for SGTA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SGTA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SGTA 33 34
  • 98.94 (n)
dog
(Canis familiaris)
Mammalia SGTA 33 34
  • 89.78 (n)
cow
(Bos Taurus)
Mammalia SGTA 33 34
  • 88.39 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 84 (a)
OneToMany
-- 34
  • 66 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SGTA 34
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sgta 33
  • 83.92 (n)
mouse
(Mus musculus)
Mammalia Sgta 33 16 34
  • 82.96 (n)
chicken
(Gallus gallus)
Aves SGTA 33 34
  • 74.06 (n)
lizard
(Anolis carolinensis)
Reptilia SGTA 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sgta 33
  • 68.49 (n)
LOC394994 33
zebrafish
(Danio rerio)
Actinopterygii sgta 34
  • 69 (a)
OneToMany
SGTA (1 of 2) 34
  • 67 (a)
OneToMany
zgc:55741 33
  • 66.56 (n)
fruit fly
(Drosophila melanogaster)
Insecta Sgt 34
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sgt-1 33 34
  • 50.72 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SGT2 34 36
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10634 34
  • 40 (a)
OneToMany
Species where no ortholog for SGTA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SGTA Gene

ENSEMBL:
Gene Tree for SGTA (if available)
TreeFam:
Gene Tree for SGTA (if available)

Paralogs for SGTA Gene

Paralogs for SGTA Gene

(2) SIMAP similar genes for SGTA Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SGTA: view

Variants for SGTA Gene

Sequence variations from dbSNP and Humsavar for SGTA Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000078349 -- 2,769,687(+) ACTTC(C/T)TGGGG intron-variant
rs1000135778 -- 2,776,035(+) CAGTC(C/G)CAGAA intron-variant
rs1000139430 -- 2,783,182(+) GGCCC(C/G)GAGCC intron-variant, upstream-variant-2KB
rs1000218494 -- 2,758,889(+) AAGTT(A/C/T)ACGCA intron-variant
rs1000261457 -- 2,780,579(+) GAGAA(A/T)CTAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SGTA Gene

Variant ID Type Subtype PubMed ID
esv1158443 CNV deletion 17803354
esv1403577 CNV deletion 17803354
esv2363232 CNV deletion 18987734
esv2605105 CNV deletion 19546169
esv29323 CNV loss 19812545
nsv509714 CNV insertion 20534489
nsv578412 CNV gain 21841781
nsv828397 CNV gain 20364138

Variation tolerance for SGTA Gene

Residual Variation Intolerance Score: 24.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SGTA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SGTA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SGTA Gene

Disorders for SGTA Gene

MalaCards: The human disease database

(3) MalaCards diseases for SGTA Gene - From: DISEASES

Disorder Aliases PubMed IDs
mucocele of salivary gland
  • mucous retention cyst of salivary gland
pontiac fever
otomycosis
  • singapore ear
- elite association - COSMIC cancer census association via MalaCards
Search SGTA in MalaCards View complete list of genes associated with diseases

Relevant External Links for SGTA

Genetic Association Database (GAD)
SGTA
Human Genome Epidemiology (HuGE) Navigator
SGTA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SGTA
genes like me logo Genes that share disorders with SGTA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SGTA Gene

Publications for SGTA Gene

  1. Isolation and characterization of human SGT and identification of homologues in Saccharomyces cerevisiae and Caenorhabditis elegans. (PMID: 9740675) Kordes E … Cziepluch C (Genomics 1998) 2 3 4 22 60
  2. Structural and functional characterization of human SGT and its interaction with Vpu of the human immunodeficiency virus type 1. (PMID: 18759457) Dutta S … Tan YJ (Biochemistry 2008) 3 4 22 60
  3. Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA), a candidate gene for polycystic ovary syndrome. (PMID: 18332089) Goodarzi MO … Azziz R (Human reproduction (Oxford, England) 2008) 3 22 45 60
  4. SGT, a Hsp90beta binding partner, is accumulated in the nucleus during cell apoptosis. (PMID: 16580629) Yin H … Gu J (Biochemical and biophysical research communications 2006) 3 4 22 60
  5. Small glutamine-rich tetratricopeptide repeat-containing protein is composed of three structural units with distinct functions. (PMID: 15708368) Liou ST … Wang C (Archives of biochemistry and biophysics 2005) 3 4 22 60

Products for SGTA Gene

Sources for SGTA Gene

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