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Aliases for SGTA Gene

Aliases for SGTA Gene

  • Small Glutamine Rich Tetratricopeptide Repeat Containing Alpha 2 3
  • Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing, Alpha 2 3 5
  • Vpu-Binding Protein 3 4
  • Alpha-SGT 3 4
  • SGT 3 4
  • UBP 3 4
  • Small Glutamine-Rich Tetratricopeptide Repeat (TPR)-Containing 2
  • Protein Containing Three Tetratricopeptide Repeats 3
  • AlphaSGT 3
  • SGT1 4
  • HSGT 3

External Ids for SGTA Gene

Previous HGNC Symbols for SGTA Gene

  • SGT

Previous GeneCards Identifiers for SGTA Gene

  • GC19M002705
  • GC19M002525

Summaries for SGTA Gene

Entrez Gene Summary for SGTA Gene

  • This gene encodes a protein which is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function. [provided by RefSeq, Jul 2008]

GeneCards Summary for SGTA Gene

SGTA (Small Glutamine Rich Tetratricopeptide Repeat Containing Alpha) is a Protein Coding gene. Diseases associated with SGTA include pontiac fever and mucocele of salivary gland. An important paralog of this gene is TTC12.

UniProtKB/Swiss-Prot for SGTA Gene

  • Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.

Gene Wiki entry for SGTA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SGTA Gene

Genomics for SGTA Gene

Regulatory Elements for SGTA Gene

Enhancers for SGTA Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SGTA on UCSC Golden Path with GeneCards custom track

Promoters for SGTA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SGTA on UCSC Golden Path with GeneCards custom track

Genomic Location for SGTA Gene

Chromosome:
19
Start:
2,754,713 bp from pter
End:
2,783,371 bp from pter
Size:
28,659 bases
Orientation:
Minus strand

Genomic View for SGTA Gene

Genes around SGTA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SGTA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SGTA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SGTA Gene

Proteins for SGTA Gene

  • Protein details for SGTA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43765-SGTA_HUMAN
    Recommended name:
    Small glutamine-rich tetratricopeptide repeat-containing protein alpha
    Protein Accession:
    O43765
    Secondary Accessions:
    • D6W610
    • Q6FIA9
    • Q9BTZ9

    Protein attributes for SGTA Gene

    Size:
    313 amino acids
    Molecular mass:
    34063 Da
    Quaternary structure:
    • Homooligomerize (By similarity). Interacts with NS1 from parvovirus H-1, with Vpu and Gag from HIV-1. Interacts with SARS-CoV accessory protein 7a. Interacts with DNAJC5 and DNAJC5B.

    Three dimensional structures from OCA and Proteopedia for SGTA Gene

neXtProt entry for SGTA Gene

Proteomics data for SGTA Gene at MOPED

Post-translational modifications for SGTA Gene

  • Ubiquitination at Lys 103, Lys 116, Lys 137, Lys 160, Lys 174, Lys 183, Lys 184, and Lys 200
  • Modification sites at PhosphoSitePlus

Other Protein References for SGTA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for SGTA (SGTA)

No data available for DME Specific Peptides for SGTA Gene

Domains & Families for SGTA Gene

Gene Families for SGTA Gene

Protein Domains for SGTA Gene

Suggested Antigen Peptide Sequences for SGTA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43765

UniProtKB/Swiss-Prot:

SGTA_HUMAN :
  • The second tetratricopeptide repeat (TPR 2) mediates the interaction with SARS-CoV accessory protein 7a.
  • Belongs to the SGT family.
  • Contains 3 TPR repeats.
Domain:
  • The second tetratricopeptide repeat (TPR 2) mediates the interaction with SARS-CoV accessory protein 7a.
Family:
  • Belongs to the SGT family.
Similarity:
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with SGTA: view

Function for SGTA Gene

Molecular function for SGTA Gene

UniProtKB/Swiss-Prot Function:
Co-chaperone that binds directly to HSC70 and HSP70 and regulates their ATPase activity.
genes like me logo Genes that share phenotypes with SGTA: view

Animal Model Products

miRNA for SGTA Gene

miRTarBase miRNAs that target SGTA

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SGTA Gene

Localization for SGTA Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SGTA Gene COMPARTMENTS Subcellular localization image for SGTA gene
Compartment Confidence
cytosol 5
nucleus 4
endoplasmic reticulum 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for SGTA Gene

Pathways & Interactions for SGTA Gene

SuperPathways for SGTA Gene

No Data Available

Gene Ontology (GO) - Biological Process for SGTA Gene

None

No data available for Pathways by source and SIGNOR curated interactions for SGTA Gene

Drugs & Compounds for SGTA Gene

(1) Drugs for SGTA Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SGTA: view

Transcripts for SGTA Gene

Unigene Clusters for SGTA Gene

Small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SGTA Gene

No ASD Table

Relevant External Links for SGTA Gene

GeneLoc Exon Structure for
SGTA
ECgene alternative splicing isoforms for
SGTA

Expression for SGTA Gene

mRNA expression in normal human tissues for SGTA Gene

Protein differential expression in normal tissues from HIPED for SGTA Gene

This gene is overexpressed in Bone (23.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for SGTA Gene



SOURCE GeneReport for Unigene cluster for SGTA Gene Hs.203910

mRNA Expression by UniProt/SwissProt for SGTA Gene

O43765-SGTA_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with SGTA: view

Protein tissue co-expression partners for SGTA Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for SGTA Gene

Orthologs for SGTA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SGTA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SGTA 35
  • 88.39 (n)
  • 95.21 (a)
SGTA 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SGTA 35
  • 89.78 (n)
  • 95.85 (a)
SGTA 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sgta 35
  • 82.96 (n)
  • 88.82 (a)
Sgta 16
Sgta 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SGTA 35
  • 98.94 (n)
  • 100 (a)
SGTA 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sgta 35
  • 83.92 (n)
  • 88.82 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 66 (a)
OneToMany
-- 36
  • 84 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SGTA 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves SGTA 35
  • 74.06 (n)
  • 81.67 (a)
SGTA 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SGTA 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC394994 35
sgta 35
  • 68.49 (n)
  • 75.81 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:55741 35
  • 66.56 (n)
  • 70.32 (a)
sgta 36
  • 69 (a)
OneToMany
SGTA (1 of 2) 36
  • 67 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Sgt 36
  • 30 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sgt-1 35
  • 50.72 (n)
  • 46.76 (a)
sgt-1 36
  • 37 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SGT2 36
  • 31 (a)
OneToMany
SGT2 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10634 36
  • 40 (a)
OneToMany
Species with no ortholog for SGTA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SGTA Gene

ENSEMBL:
Gene Tree for SGTA (if available)
TreeFam:
Gene Tree for SGTA (if available)

Paralogs for SGTA Gene

Paralogs for SGTA Gene

(2) SIMAP similar genes for SGTA Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SGTA: view

Variants for SGTA Gene

Sequence variations from dbSNP and Humsavar for SGTA Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs759066 -- 2,775,339(+) CGTGG(G/T)CTGCC intron-variant
rs759067 -- 2,775,670(+) GGTGC(C/T)GGGGC intron-variant
rs7256139 -- 2,761,934(+) GTGTT(G/T)ATTTC intron-variant
rs7257204 -- 2,761,681(+) ATCGC(A/C)ACCGC intron-variant
rs7259681 -- 2,762,343(+) CTCAC(A/G)ACACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SGTA Gene

Variant ID Type Subtype PubMed ID
nsv509714 CNV Insertion 20534489
nsv910675 CNV Loss 21882294
dgv3641n71 CNV Loss 21882294
nsv910678 CNV Loss 21882294
nsv828397 CNV Gain 20364138
dgv3642n71 CNV Loss 21882294
dgv3643n71 CNV Loss 21882294
nsv910691 CNV Loss 21882294
nsv910692 CNV Loss 21882294
esv2605105 CNV Deletion 19546169
esv2363232 CNV Deletion 18987734
esv29323 CNV Loss 19812545
esv1403577 CNV Deletion 17803354
esv1158443 CNV Deletion 17803354
nsv910693 CNV Loss 21882294

Variation tolerance for SGTA Gene

Residual Variation Intolerance Score: 24.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SGTA Gene

HapMap Linkage Disequilibrium report
SGTA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SGTA Gene

Disorders for SGTA Gene

MalaCards: The human disease database

(2) MalaCards diseases for SGTA Gene - From: DISEASES

Disorder Aliases PubMed IDs
pontiac fever
mucocele of salivary gland
  • mucocele of salivary gland unspecified
- elite association - COSMIC cancer census association via MalaCards
Search SGTA in MalaCards View complete list of genes associated with diseases

Relevant External Links for SGTA

Genetic Association Database (GAD)
SGTA
Human Genome Epidemiology (HuGE) Navigator
SGTA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SGTA
genes like me logo Genes that share disorders with SGTA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SGTA Gene

Publications for SGTA Gene

  1. Isolation and characterization of human SGT and identification of homologues in Saccharomyces cerevisiae and Caenorhabditis elegans. (PMID: 9740675) Kordes E. … Cziepluch C. (Genomics 1998) 2 3 4 23 67
  2. Small glutamine-rich tetratricopeptide repeat-containing protein (SGT) interacts with the ubiquitin-dependent endocytosis (UbE) motif of the growth hormone receptor. (PMID: 12735788) Schantl J.A. … Strous G.J. (Biochem. J. 2003) 2 3 23
  3. Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA), a candidate gene for polycystic ovary syndrome. (PMID: 18332089) Goodarzi M.O. … Azziz R. (Hum. Reprod. 2008) 3 23
  4. Expression, purification and preliminary crystallographic analysis of recombinant human small glutamine-rich tetratricopeptide-repeat protein. (PMID: 18607086) Dutta S. … Tan Y.J. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2008) 3 23
  5. Structural and functional characterization of human SGT and its interaction with Vpu of the human immunodeficiency virus type 1. (PMID: 18759457) Dutta S. … Tan Y.J. (Biochemistry 2008) 3 23

Products for SGTA Gene

Sources for SGTA Gene

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