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Aliases for SCG5 Gene

Aliases for SCG5 Gene

  • Secretogranin V 2 3 4 5
  • Secretory Granule, Neuroendocrine Protein 1 (7B2 Protein) 2 3
  • Secretory Granule Endocrine Protein I 3 4
  • Prohormone Convertase Chaperone 2 3
  • Pituitary Polypeptide 3 4
  • Secretogranin-5 3 4
  • SGNE1 3 4
  • Secretogranin V (7B2 Protein) 3
  • P7B2 3
  • 7B2 3
  • SgV 3

External Ids for SCG5 Gene

Previous HGNC Symbols for SCG5 Gene

  • SGNE1

Previous GeneCards Identifiers for SCG5 Gene

  • GC15P030722
  • GC15P032933
  • GC15P009796

Summaries for SCG5 Gene

GeneCards Summary for SCG5 Gene

SCG5 (Secretogranin V) is a Protein Coding gene. Diseases associated with SCG5 include Pseudotumor Cerebri and Non-Secretory Myeloma. GO annotations related to this gene include GTP binding and enzyme inhibitor activity.

UniProtKB/Swiss-Prot for SCG5 Gene

  • Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.

Gene Wiki entry for SCG5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCG5 Gene

Genomics for SCG5 Gene

Regulatory Elements for SCG5 Gene

Enhancers for SCG5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around SCG5 on UCSC Golden Path with GeneCards custom track

Promoters for SCG5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around SCG5 on UCSC Golden Path with GeneCards custom track

Genomic Location for SCG5 Gene

Chromosome:
15
Start:
32,641,669 bp from pter
End:
32,697,098 bp from pter
Size:
55,430 bases
Orientation:
Plus strand

Genomic View for SCG5 Gene

Genes around SCG5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCG5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCG5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCG5 Gene

Proteins for SCG5 Gene

  • Protein details for SCG5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05408-7B2_HUMAN
    Recommended name:
    Neuroendocrine protein 7B2
    Protein Accession:
    P05408
    Secondary Accessions:
    • P01164
    • Q6FHD0
    • Q9BS38

    Protein attributes for SCG5 Gene

    Size:
    212 amino acids
    Molecular mass:
    23730 Da
    Quaternary structure:
    • Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages.

    Alternative splice isoforms for SCG5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SCG5 Gene

Proteomics data for SCG5 Gene at MOPED

Post-translational modifications for SCG5 Gene

  • Proteolytically cleaved in the Golgi by a furin-like convertase to generate bioactive peptides.
  • Sulfated on tyrosine residues.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SCG5 Gene

No data available for DME Specific Peptides for SCG5 Gene

Domains & Families for SCG5 Gene

Gene Families for SCG5 Gene

Protein Domains for SCG5 Gene

Suggested Antigen Peptide Sequences for SCG5 Gene

Graphical View of Domain Structure for InterPro Entry

P05408

UniProtKB/Swiss-Prot:

7B2_HUMAN :
  • Belongs to the 7B2 family.
Family:
  • Belongs to the 7B2 family.
genes like me logo Genes that share domains with SCG5: view

Function for SCG5 Gene

Molecular function for SCG5 Gene

UniProtKB/Swiss-Prot Function:
Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.

Gene Ontology (GO) - Molecular Function for SCG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 7913882
GO:0051082 unfolded protein binding IDA 7913882
genes like me logo Genes that share ontologies with SCG5: view
genes like me logo Genes that share phenotypes with SCG5: view

Animal Models for SCG5 Gene

MGI Knock Outs for SCG5:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for SCG5 Gene

Localization for SCG5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCG5 Gene

Secreted. Note=Neuroendocrine and endocrine secretory granules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCG5 Gene COMPARTMENTS Subcellular localization image for SCG5 gene
Compartment Confidence
extracellular 5
mitochondrion 3
cytoskeleton 2
cytosol 2
golgi apparatus 2
plasma membrane 2
chloroplast 1
endoplasmic reticulum 1
lysosome 1
nucleus 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for SCG5 Gene

Pathways & Interactions for SCG5 Gene

SuperPathways for SCG5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SCG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007218 neuropeptide signaling pathway IEA --
GO:0016486 peptide hormone processing ISS --
GO:0043086 negative regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with SCG5: view

No data available for Pathways by source and SIGNOR curated interactions for SCG5 Gene

Drugs & Compounds for SCG5 Gene

(29) Drugs for SCG5 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(30) Additional Compounds for SCG5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SCG5: view

Transcripts for SCG5 Gene

Unigene Clusters for SCG5 Gene

Secretogranin V (7B2 protein):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SCG5 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - -
SP6: - -
SP7:

Relevant External Links for SCG5 Gene

GeneLoc Exon Structure for
SCG5
ECgene alternative splicing isoforms for
SCG5

Expression for SCG5 Gene

mRNA expression in normal human tissues for SCG5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCG5 Gene

This gene is overexpressed in Pituitary (x6.7), Brain - Frontal Cortex (BA9) (x4.9), Brain - Anterior cingulate cortex (BA24) (x4.3), and Brain - Nucleus accumbens (basal ganglia) (x4.1).

Protein differential expression in normal tissues from HIPED for SCG5 Gene

This gene is overexpressed in Cerebrospinal fluid (22.8), Frontal cortex (17.4), Vitreous humor (11.0), and Islet of Langerhans (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SCG5 Gene



SOURCE GeneReport for Unigene cluster for SCG5 Gene Hs.156540

genes like me logo Genes that share expression patterns with SCG5: view

Protein tissue co-expression partners for SCG5 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for SCG5 Gene

Orthologs for SCG5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SCG5 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Scg5 35
  • 87.74 (n)
  • 91.98 (a)
Scg5 16
Scg5 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SCG5 35
  • 99.37 (n)
  • 100 (a)
SCG5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scg5 35
  • 87.3 (n)
  • 92.38 (a)
cow
(Bos Taurus)
Mammalia SCG5 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCG5 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SCG5 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCG5 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCG5 35
  • 75.67 (n)
  • 81.99 (a)
SCG5 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCG5 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scg5 35
  • 73.13 (n)
  • 81.63 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC397865 35
zebrafish
(Danio rerio)
Actinopterygii scg5 35
  • 70.24 (n)
  • 78.54 (a)
zgc73132 35
scg5 36
  • 73 (a)
OneToMany
scg5 36
  • 73 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9417 35
Species with no ortholog for SCG5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCG5 Gene

ENSEMBL:
Gene Tree for SCG5 (if available)
TreeFam:
Gene Tree for SCG5 (if available)

Paralogs for SCG5 Gene

No data available for Paralogs for SCG5 Gene

Variants for SCG5 Gene

Sequence variations from dbSNP and Humsavar for SCG5 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs13850 -- 32,641,754(-) CCTAC(A/T)GCGGT utr-variant-5-prime
rs5811696 -- 32,641,172(+) GAAAT(-/A)AACAC upstream-variant-2KB
rs6494576 -- 32,677,942(+) TCAGA(A/G)TAGGT intron-variant
rs6494577 -- 32,678,061(+) ACACT(A/G)AAATA intron-variant
rs6494581 -- 32,680,326(+) GAGTA(C/G)CTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SCG5 Gene

Variant ID Type Subtype PubMed ID
dgv723e1 CNV Complex 17122850
nsv428302 CNV Gain+Loss 18775914
esv33337 CNV Gain+Loss 17666407
nsv517740 CNV Gain+Loss 19592680
dgv728e1 CNV Complex 17122850
dgv729e1 CNV Complex 17122850
esv2422296 CNV Duplication 17116639
nsv469587 CNV Loss 16826518
nsv483039 CNV Gain 15286789
nsv456785 CNV Gain 19166990
nsv1481 CNV Loss 18451855
esv271798 CNV Insertion 20981092

Variation tolerance for SCG5 Gene

Residual Variation Intolerance Score: 45.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.91; 18.83% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for SCG5 Gene

Disorders for SCG5 Gene

MalaCards: The human disease database

(5) MalaCards diseases for SCG5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pseudotumor cerebri
  • benign intracran. hypt.
non-secretory myeloma
rheumatic myocarditis
  • active rheumatic fever with myocarditis
xanthogranulomatous pyelonephritis
  • pyelonephritis, xanthogranulomatous
rheumatoid lung disease
  • rheumatoid lung
- elite association - COSMIC cancer census association via MalaCards
Search SCG5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SCG5

Genetic Association Database (GAD)
SCG5
Human Genome Epidemiology (HuGE) Navigator
SCG5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCG5
genes like me logo Genes that share disorders with SCG5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCG5 Gene

Publications for SCG5 Gene

  1. Secretory granule neuroendocrine protein 1 (SGNE1) genetic variation and glucose intolerance in severe childhood and adult obesity. (PMID: 17617923) Bouatia-Naji N. … Meyre D. (BMC Med. Genet. 2007) 3 23 48 67
  2. The chromogranin-secretogranin family. (PMID: 12646671) Taupenot L. … O'Connor D.T. (N. Engl. J. Med. 2003) 2 3
  3. Structural organization of the gene encoding the neuroendocrine chaperone 7B2. (PMID: 8617287) Braks J.A. … Martens G.J.M. (Eur. J. Biochem. 1996) 3 23
  4. 7B2 is a specific intracellular binding protein of the prohormone convertase PC2. (PMID: 7722516) Benjannet S. … Seidah N.G. (J. Neurochem. 1995) 3 23
  5. Analysis of chromogranin/secretogranin messenger RNAs in human pituitary adenomas. (PMID: 8162254) Lloyd R.V. … Jin L. (Diagn. Mol. Pathol. 1994) 2 3

Products for SCG5 Gene

Sources for SCG5 Gene

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