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Aliases for MRPS25 Gene

Aliases for MRPS25 Gene

  • Mitochondrial Ribosomal Protein S25 2 3
  • Mitochondrial 28S Ribosomal Protein S25 2 3
  • MRP-S25 3 4
  • RPMS25 3 4
  • S25mt 3 4
  • 28S Ribosomal Protein S25, Mitochondrial 3

External Ids for MRPS25 Gene

Previous GeneCards Identifiers for MRPS25 Gene

  • GC03M015019
  • GC03M015029
  • GC03M015065
  • GC03M015083

Summaries for MRPS25 Gene

Entrez Gene Summary for MRPS25 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 4. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS25 Gene

MRPS25 (Mitochondrial Ribosomal Protein S25) is a Protein Coding gene. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPS25 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS25 Gene

Genomics for MRPS25 Gene

Regulatory Elements for MRPS25 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRPS25 Gene

Start:
15,042,460 bp from pter
End:
15,065,335 bp from pter
Size:
22,876 bases
Orientation:
Minus strand

Genomic View for MRPS25 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPS25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS25 Gene

Proteins for MRPS25 Gene

  • Protein details for MRPS25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P82663-RT25_HUMAN
    Recommended name:
    28S ribosomal protein S25, mitochondrial
    Protein Accession:
    P82663
    Secondary Accessions:
    • B4DFJ5
    • B4DQG6
    • Q9H7P5

    Protein attributes for MRPS25 Gene

    Size:
    173 amino acids
    Molecular mass:
    20116 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins
    SequenceCaution:
    • Sequence=BAB15723.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MRPS25 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPS25 Gene

Proteomics data for MRPS25 Gene at MOPED

Post-translational modifications for MRPS25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS25 Gene

No data available for DME Specific Peptides for MRPS25 Gene

Domains for MRPS25 Gene

Gene Families for MRPS25 Gene

HGNC:
  • MRPS :Mitochondrial ribosomal proteins / small subunits

Protein Domains for MRPS25 Gene

Graphical View of Domain Structure for InterPro Entry

P82663

UniProtKB/Swiss-Prot:

RT25_HUMAN :
  • P82663
Family:
  • Belongs to the ribosomal protein S25/L51 family.
genes like me logo Genes that share domains with MRPS25: view

Function for MRPS25 Gene

Animal Model Products

CRISPR Products

miRNA for MRPS25 Gene

miRTarBase miRNAs that target MRPS25

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS25

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MRPS25 Gene

Localization for MRPS25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS25 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MRPS25 Gene COMPARTMENTS Subcellular localization image for MRPS25 gene
Compartment Confidence
mitochondrion 5
cytosol 3
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MRPS25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPS25: view

Pathways for MRPS25 Gene

SuperPathways for MRPS25 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MRPS25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS25: view

No data available for Pathways by source for MRPS25 Gene

Transcripts for MRPS25 Gene

Unigene Clusters for MRPS25 Gene

Mitochondrial ribosomal protein S25:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS25

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS25 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b
SP1: -
SP2:
SP3: - - -
SP4: - -
SP5: - - - - -

Relevant External Links for MRPS25 Gene

GeneLoc Exon Structure for
MRPS25
ECgene alternative splicing isoforms for
MRPS25

Expression for MRPS25 Gene

mRNA expression in normal human tissues for MRPS25 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS25 Gene

SOURCE GeneReport for Unigene cluster for MRPS25 Gene Hs.715617

genes like me logo Genes that share expressions with MRPS25: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS25 Gene

Orthologs for MRPS25 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPS25 35
  • 99.42 (n)
  • 100 (a)
MRPS25 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MRPS25 35
  • 84.39 (n)
  • 88.44 (a)
MRPS25 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MRPS25 35
  • 89.21 (n)
  • 90.75 (a)
MRPS25 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrps25 35
  • 85.77 (n)
  • 89.47 (a)
Mrps25 16
Mrps25 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MRPS25 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MRPS25 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mrps25 35
  • 85.38 (n)
  • 88.3 (a)
chicken
(Gallus gallus)
Aves MRPS25 35
  • 72.9 (n)
  • 80.12 (a)
MRPS25 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MRPS25 36
  • 63 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6869 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494871 35
  • 70.74 (n)
  • 79.65 (a)
Str.9548 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11135 35
zebrafish
(Danio rerio)
Actinopterygii mrps25 35
  • 71.87 (n)
  • 73.99 (a)
mrps25 36
  • 74 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012136 35
  • 60.98 (n)
  • 57.32 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpS25 35
  • 61.18 (n)
  • 55.49 (a)
mRpS25 36
  • 56 (a)
OneToOne
mRpS25 37
  • 54 (a)
worm
(Caenorhabditis elegans)
Secernentea mrps-25 35
  • 49.79 (n)
  • 40.74 (a)
mrps-25 36
  • 39 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4960 36
  • 32 (a)
OneToOne
Species with no ortholog for MRPS25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS25 Gene

ENSEMBL:
Gene Tree for MRPS25 (if available)
TreeFam:
Gene Tree for MRPS25 (if available)

Paralogs for MRPS25 Gene

Pseudogenes.org Pseudogenes for MRPS25 Gene

genes like me logo Genes that share paralogs with MRPS25: view

No data available for Paralogs for MRPS25 Gene

Variants for MRPS25 Gene

Sequence variations from dbSNP and Humsavar for MRPS25 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs2592 -- 15,050,901(+) CCGTA(A/G)GTATG utr-variant-3-prime, intron-variant
rs12497 -- 15,052,554(+) CTCCC(A/G)CAGGC reference, missense, intron-variant
rs540600 -- 15,054,965(-) agaac(C/T)atgag intron-variant
rs939549 -- 15,065,302(-) TGGAA(C/T)CTGGC utr-variant-5-prime
rs939550 -- 15,065,292(-) CTCTG(C/G/T)GGAGA utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for MRPS25 Gene

Variant ID Type Subtype PubMed ID
dgv1436e1 CNV Complex 17122850
nsv834620 CNV Gain 17160897

Relevant External Links for MRPS25 Gene

HapMap Linkage Disequilibrium report
MRPS25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS25 Gene

Disorders for MRPS25 Gene

Relevant External Links for MRPS25

Genetic Association Database (GAD)
MRPS25
Human Genome Epidemiology (HuGE) Navigator
MRPS25
genes like me logo Genes that share disorders with MRPS25: view

No data available for UniProtKB/Swiss-Prot for MRPS25 Gene

Publications for MRPS25 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  4. A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins. (PMID: 10938081) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2000) 3 4
  5. Characterization of long cDNA clones from human adult spleen. (PMID: 11214971) Hattori A. … Ohara O. (DNA Res. 2000) 3 4

Products for MRPS25 Gene

  • antibodies-online proteins for MRPS25
  • antibodies-online antibodies for MRPS25
  • antibodies-online kits for MRPS25

Sources for MRPS25 Gene

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