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Aliases for MRPS25 Gene

Aliases for MRPS25 Gene

  • Mitochondrial Ribosomal Protein S25 2 3 5
  • Mitochondrial Small Ribosomal Subunit Protein MS25 3 4
  • Mitochondrial 28S Ribosomal Protein S25 2 3
  • MRP-S25 3 4
  • RPMS25 3 4
  • S25mt 3 4
  • 28S Ribosomal Protein S25, Mitochondrial 3

External Ids for MRPS25 Gene

Previous GeneCards Identifiers for MRPS25 Gene

  • GC03M015019
  • GC03M015029
  • GC03M015065
  • GC03M015083

Summaries for MRPS25 Gene

Entrez Gene Summary for MRPS25 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

GeneCards Summary for MRPS25 Gene

MRPS25 (Mitochondrial Ribosomal Protein S25) is a Protein Coding gene. Among its related pathways are Mitochondrial translation and Organelle biogenesis and maintenance.

Gene Wiki entry for MRPS25 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS25 Gene

Genomics for MRPS25 Gene

Regulatory Elements for MRPS25 Gene

Enhancers for MRPS25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G014401 1.8 FANTOM5 ENCODE dbSUPER 12.1 +661.1 661090 5.2 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 ZNF766 SLC6A6 MRPS25 CCDC174 GC03P014418
GH03G015792 2 FANTOM5 Ensembl ENCODE dbSUPER 9.9 -732.3 -732312 9.6 HDGF PKNOX1 FOXA2 ARNT SIN3A FEZF1 ZNF2 YY1 CBX5 FOS ANKRD28 IMPDH1P8 MRPS25 EAF1 EAF1-AS1 METTL6 BTD DPH3 COLQ SH3BP5
GH03G015097 1.2 ENCODE 12.4 -33.5 -33500 2.4 MLX CREB3L1 ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 CAPN7 SH3BP5-AS1 MRPS25 ENSG00000228242 FGD5 TMEM43 FGD5-AS1 GC03M015082 RBSN
GH03G014946 1.4 Ensembl ENCODE 6.2 +116.8 116759 4.7 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 ZNF766 CAPN7 FGD5-AS1 SH3BP5-AS1 METTL6 MRPS25 RBSN RPS3AP53 PIR42856
GH03G015063 1.1 ENCODE 6.2 +0.8 802 2.9 HDGF PKNOX1 CREB3L1 MLX AGO1 ARID4B SIN3A DMAP1 YY1 SLC30A9 FGD5-AS1 MRPS25 SH3BP5-AS1 PIR50374 GC03M015052
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around MRPS25 on UCSC Golden Path with GeneCards custom track

Promoters for MRPS25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000149011 235 1800 HDGF PKNOX1 CREB3L1 MLX AGO1 ARID4B SIN3A DMAP1 YY1 SLC30A9

Genomic Location for MRPS25 Gene

Chromosome:
3
Start:
15,042,251 bp from pter
End:
15,065,335 bp from pter
Size:
23,085 bases
Orientation:
Minus strand

Genomic View for MRPS25 Gene

Genes around MRPS25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MRPS25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MRPS25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS25 Gene

Proteins for MRPS25 Gene

  • Protein details for MRPS25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P82663-RT25_HUMAN
    Recommended name:
    28S ribosomal protein S25, mitochondrial
    Protein Accession:
    P82663
    Secondary Accessions:
    • B4DFJ5
    • B4DQG6
    • Q9H7P5

    Protein attributes for MRPS25 Gene

    Size:
    173 amino acids
    Molecular mass:
    20116 Da
    Quaternary structure:
    • Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.
    SequenceCaution:
    • Sequence=BAB15723.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPS25 Gene

    Alternative splice isoforms for MRPS25 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MRPS25 Gene

Post-translational modifications for MRPS25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS25 Gene

No data available for DME Specific Peptides for MRPS25 Gene

Domains & Families for MRPS25 Gene

Gene Families for MRPS25 Gene

Protein Domains for MRPS25 Gene

Graphical View of Domain Structure for InterPro Entry

P82663

UniProtKB/Swiss-Prot:

RT25_HUMAN :
  • Belongs to the mitochondrion-specific ribosomal protein mS25 family.
Family:
  • Belongs to the mitochondrion-specific ribosomal protein mS25 family.
genes like me logo Genes that share domains with MRPS25: view

Function for MRPS25 Gene

Gene Ontology (GO) - Molecular Function for MRPS25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IBA --
genes like me logo Genes that share ontologies with MRPS25: view
genes like me logo Genes that share phenotypes with MRPS25: view

Animal Models for MRPS25 Gene

MGI Knock Outs for MRPS25:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for MRPS25 Gene

Localization for MRPS25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS25 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for MRPS25 gene
Compartment Confidence
mitochondrion 5
extracellular 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for MRPS25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005840 ribosome IEA --
GO:0030529 intracellular ribonucleoprotein complex IEA --
genes like me logo Genes that share ontologies with MRPS25: view

Pathways & Interactions for MRPS25 Gene

genes like me logo Genes that share pathways with MRPS25: view

Gene Ontology (GO) - Biological Process for MRPS25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS25: view

No data available for SIGNOR curated interactions for MRPS25 Gene

Transcripts for MRPS25 Gene

Unigene Clusters for MRPS25 Gene

Mitochondrial ribosomal protein S25:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS25 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b
SP1: -
SP2:
SP3: - - -
SP4: - -
SP5: - - - - -

Relevant External Links for MRPS25 Gene

GeneLoc Exon Structure for
MRPS25
ECgene alternative splicing isoforms for
MRPS25

Expression for MRPS25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for MRPS25 Gene

Protein differential expression in normal tissues from HIPED for MRPS25 Gene

This gene is overexpressed in Lung (30.5) and Pancreas (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for MRPS25 Gene



Protein tissue co-expression partners for MRPS25 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of MRPS25 Gene:

MRPS25

SOURCE GeneReport for Unigene cluster for MRPS25 Gene:

Hs.715617

Evidence on tissue expression from TISSUES for MRPS25 Gene

  • Nervous system(4.8)
  • Spleen(4.3)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with MRPS25: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for MRPS25 Gene

Orthologs for MRPS25 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MRPS25 34 35
  • 99.42 (n)
dog
(Canis familiaris)
Mammalia MRPS25 34 35
  • 89.21 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia MRPS25 35
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mrps25 34 16 35
  • 85.77 (n)
rat
(Rattus norvegicus)
Mammalia Mrps25 34
  • 85.38 (n)
cow
(Bos Taurus)
Mammalia MRPS25 34 35
  • 84.39 (n)
oppossum
(Monodelphis domestica)
Mammalia MRPS25 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves MRPS25 34 35
  • 72.9 (n)
lizard
(Anolis carolinensis)
Reptilia MRPS25 35
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494871 34
  • 70.74 (n)
Str.9548 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.6869 34
zebrafish
(Danio rerio)
Actinopterygii mrps25 34 35
  • 71.87 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11135 34
fruit fly
(Drosophila melanogaster)
Insecta mRpS25 36 34 35
  • 61.18 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012136 34
  • 60.98 (n)
worm
(Caenorhabditis elegans)
Secernentea mrps-25 34 35
  • 49.79 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4960 35
  • 32 (a)
OneToOne
Species where no ortholog for MRPS25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS25 Gene

ENSEMBL:
Gene Tree for MRPS25 (if available)
TreeFam:
Gene Tree for MRPS25 (if available)

Paralogs for MRPS25 Gene

Pseudogenes.org Pseudogenes for MRPS25 Gene

genes like me logo Genes that share paralogs with MRPS25: view

No data available for Paralogs for MRPS25 Gene

Variants for MRPS25 Gene

Sequence variations from dbSNP and Humsavar for MRPS25 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000017575 -- 15,042,951(+) CCCTA(C/T)ATCCT nc-transcript-variant, reference, synonymous-codon
rs1000050366 -- 15,058,703(+) TTGAT(G/T)CTCAT intron-variant
rs1000267875 -- 15,063,525(+) AACCC(A/G)CGGGT intron-variant
rs1000498217 -- 15,044,423(+) TAAAT(C/T)GTAGC intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1000550003 -- 15,051,978(+) ACTGA(A/G)CGGAG nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MRPS25 Gene

Variant ID Type Subtype PubMed ID
dgv4687n100 CNV gain 25217958
esv2759130 CNV gain 17122850
nsv834620 CNV gain 17160897

Variation tolerance for MRPS25 Gene

Residual Variation Intolerance Score: 76.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.57; 12.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPS25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
MRPS25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS25 Gene

Disorders for MRPS25 Gene

Relevant External Links for MRPS25

Genetic Association Database (GAD)
MRPS25
Human Genome Epidemiology (HuGE) Navigator
MRPS25
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MRPS25

No disorders were found for MRPS25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPS25 Gene

Publications for MRPS25 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3 64
  5. A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins. (PMID: 10938081) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2000) 3 4 64

Products for MRPS25 Gene

Sources for MRPS25 Gene

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