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Aliases for MRPS25 Gene

Aliases for MRPS25 Gene

  • Mitochondrial Ribosomal Protein S25 2 3
  • Mitochondrial 28S Ribosomal Protein S25 2 3
  • MRP-S25 3 4
  • RPMS25 3 4
  • S25mt 3 4
  • 28S Ribosomal Protein S25, Mitochondrial 3

External Ids for MRPS25 Gene

Previous GeneCards Identifiers for MRPS25 Gene

  • GC03M015019
  • GC03M015029
  • GC03M015065
  • GC03M015083

Summaries for MRPS25 Gene

Entrez Gene Summary for MRPS25 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 4. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPS25 Gene

MRPS25 (Mitochondrial Ribosomal Protein S25) is a Protein Coding gene. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for MRPS25 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPS25 Gene

Genomics for MRPS25 Gene

Regulatory Elements for MRPS25 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRPS25 Gene

15,042,460 bp from pter
15,065,335 bp from pter
22,876 bases
Minus strand

Genomic View for MRPS25 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPS25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPS25 Gene

Proteins for MRPS25 Gene

  • Protein details for MRPS25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S25, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • B4DFJ5
    • B4DQG6
    • Q9H7P5

    Protein attributes for MRPS25 Gene

    173 amino acids
    Molecular mass:
    20116 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins
    • Sequence=BAB15723.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for MRPS25 Gene


neXtProt entry for MRPS25 Gene

Proteomics data for MRPS25 Gene at MOPED

Post-translational modifications for MRPS25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPS25 Gene

Antibody Products

No data available for DME Specific Peptides for MRPS25 Gene

Domains for MRPS25 Gene

Gene Families for MRPS25 Gene

Protein Domains for MRPS25 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein S25/L51 family.
  • Belongs to the ribosomal protein S25/L51 family.
genes like me logo Genes that share domains with MRPS25: view

Function for MRPS25 Gene

Animal Model Products

miRNA for MRPS25 Gene

miRTarBase miRNAs that target MRPS25

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS25

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPS25 Gene

Localization for MRPS25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPS25 Gene


Subcellular locations from

Jensen Localization Image for MRPS25 Gene COMPARTMENTS Subcellular localization image for MRPS25 gene
Compartment Confidence
mitochondrion 5
cytosol 3
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MRPS25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005840 ribosome IEA --
genes like me logo Genes that share ontologies with MRPS25: view

Pathways for MRPS25 Gene

SuperPathways for MRPS25 Gene

No Data Available

Gene Ontology (GO) - Biological Process for MRPS25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
genes like me logo Genes that share ontologies with MRPS25: view

No data available for Pathways by source for MRPS25 Gene

Transcripts for MRPS25 Gene

Unigene Clusters for MRPS25 Gene

Mitochondrial ribosomal protein S25:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPS25

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPS25 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b
SP1: -
SP3: - - -
SP4: - -
SP5: - - - - -

Relevant External Links for MRPS25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPS25 Gene

mRNA expression in normal human tissues for MRPS25 Gene

Protein differential expression in normal tissues for MRPS25 Gene

This gene is overexpressed in Lung (30.5) and Pancreas (10.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPS25 Gene

SOURCE GeneReport for Unigene cluster for MRPS25 Gene Hs.715617

genes like me logo Genes that share expressions with MRPS25: view

Expression partners for MRPS25 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MRPS25 Gene

Orthologs for MRPS25 Gene

This gene was present in the common ancestor of animals.

Orthologs for MRPS25 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPS25 35
  • 84.39 (n)
  • 88.44 (a)
MRPS25 36
  • 88 (a)
(Canis familiaris)
Mammalia MRPS25 35
  • 89.21 (n)
  • 90.75 (a)
MRPS25 36
  • 91 (a)
(Mus musculus)
Mammalia Mrps25 35
  • 85.77 (n)
  • 89.47 (a)
Mrps25 16
Mrps25 36
  • 89 (a)
(Pan troglodytes)
Mammalia MRPS25 35
  • 99.42 (n)
  • 100 (a)
MRPS25 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Mrps25 35
  • 85.38 (n)
  • 88.3 (a)
(Monodelphis domestica)
Mammalia MRPS25 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia MRPS25 36
  • 86 (a)
(Gallus gallus)
Aves MRPS25 35
  • 72.9 (n)
  • 80.12 (a)
MRPS25 36
  • 74 (a)
(Anolis carolinensis)
Reptilia MRPS25 36
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494871 35
  • 70.74 (n)
  • 79.65 (a)
Str.9548 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.6869 35
(Danio rerio)
Actinopterygii mrps25 35
  • 71.87 (n)
  • 73.99 (a)
mrps25 36
  • 74 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11135 35
fruit fly
(Drosophila melanogaster)
Insecta mRpS25 37
  • 54 (a)
mRpS25 35
  • 61.18 (n)
  • 55.49 (a)
mRpS25 36
  • 56 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012136 35
  • 60.98 (n)
  • 57.32 (a)
(Caenorhabditis elegans)
Secernentea mrps-25 35
  • 49.79 (n)
  • 40.74 (a)
mrps-25 36
  • 39 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4960 36
  • 32 (a)
Species with no ortholog for MRPS25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPS25 Gene

Gene Tree for MRPS25 (if available)
Gene Tree for MRPS25 (if available)

Paralogs for MRPS25 Gene Pseudogenes for MRPS25 Gene

genes like me logo Genes that share paralogs with MRPS25: view

No data available for Paralogs for MRPS25 Gene

Variants for MRPS25 Gene

Sequence variations from dbSNP and Humsavar for MRPS25 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs535524834 -- 15,061,218(+) CCTCT(C/T)CCCAC intron-variant
rs535602487 -- 15,056,475(+) GAGAG(A/G)ATCCT intron-variant
rs535246877 -- 15,062,079(+) CCGTC(C/T)GGGAG intron-variant
rs535046360 -- 15,050,398(+) TTCAG(A/G)ACATT utr-variant-3-prime, intron-variant
rs534149734 -- 15,057,970(+) ACCTC(-/T)GCCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MRPS25 Gene

Variant ID Type Subtype PubMed ID
dgv1436e1 CNV Complex 17122850
nsv834620 CNV Gain 17160897

Relevant External Links for MRPS25 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPS25 Gene

Disorders for MRPS25 Gene

Relevant External Links for MRPS25

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for MRPS25 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for MRPS25 Gene

Publications for MRPS25 Gene

  1. A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins. (PMID: 10938081) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2000) 3 4
  2. Characterization of long cDNA clones from human adult spleen. (PMID: 11214971) Hattori A. … Ohara O. (DNA Res. 2000) 3 4
  3. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PMID: 11279123) Koc E.C. … Spremulli L.L. (J. Biol. Chem. 2001) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for MRPS25 Gene

Sources for MRPS25 Gene

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