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Aliases for POLR1E Gene

Aliases for POLR1E Gene

  • Polymerase (RNA) I Polypeptide E, 53kDa 2 3
  • DNA-Directed RNA Polymerase I Subunit E 3 4
  • Polymerase (RNA) I Associated Factor 1 2 3
  • RNA Polymerase I-Associated Factor 53 3 4
  • RNA Polymerase I Subunit A49 3 4
  • PRAF1 3 4
  • PAF53 3 4
  • DNA-Directed RNA Polymerase I Subunit RPA49 3
  • RNA Polymerase I Associated Factor 53 2
  • RNA Polymerase I-Associated Factor 1 4

External Ids for POLR1E Gene

Previous HGNC Symbols for POLR1E Gene

  • PRAF1

Previous GeneCards Identifiers for POLR1E Gene

  • GC09P037477
  • GC09P037437

Summaries for POLR1E Gene

GeneCards Summary for POLR1E Gene

POLR1E (Polymerase (RNA) I Polypeptide E, 53kDa) is a Protein Coding gene. Among its related pathways are Metabolism and TNF-alpha/NF-kB Signaling Pathway. GO annotations related to this gene include DNA-directed RNA polymerase activity.

UniProtKB/Swiss-Prot for POLR1E Gene

  • DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF (By similarity).

Gene Wiki entry for POLR1E Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for POLR1E Gene

Genomics for POLR1E Gene

Regulatory Elements for POLR1E Gene

Genomic Location for POLR1E Gene

Start:
37,485,935 bp from pter
End:
37,503,697 bp from pter
Size:
17,763 bases
Orientation:
Plus strand

Genomic View for POLR1E Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for POLR1E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for POLR1E Gene

Proteins for POLR1E Gene

  • Protein details for POLR1E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZS1-RPA49_HUMAN
    Recommended name:
    DNA-directed RNA polymerase I subunit RPA49
    Protein Accession:
    Q9GZS1
    Secondary Accessions:
    • Q5VZT3
    • Q8NBA9
    • Q96L20

    Protein attributes for POLR1E Gene

    Size:
    481 amino acids
    Molecular mass:
    53962 Da
    Quaternary structure:
    • Component of the RNA polymerase I (Pol I) complex consisting of at least 13 subunits (By similarity). Interacts with PAF49/CD3EAP. Also binds UBTF/UBF (By similarity).

    Alternative splice isoforms for POLR1E Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for POLR1E Gene

Proteomics data for POLR1E Gene at MOPED

Post-translational modifications for POLR1E Gene

  • Ubiquitination at Lys142 and Lys32
  • Modification sites at PhosphoSitePlus

Other Protein References for POLR1E Gene

Antibody Products

No data available for DME Specific Peptides for POLR1E Gene

Domains for POLR1E Gene

Gene Families for POLR1E Gene

HGNC:
  • POLR :RNA polymerase subunits

Protein Domains for POLR1E Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9GZS1

UniProtKB/Swiss-Prot:

RPA49_HUMAN :
  • Q9GZS1
Family:
  • Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.
genes like me logo Genes that share domains with POLR1E: view

Function for POLR1E Gene

Molecular function for POLR1E Gene

UniProtKB/Swiss-Prot Function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF (By similarity).

Gene Ontology (GO) - Molecular Function for POLR1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001054 contributes_to RNA polymerase I activity IBA --
GO:0001179 RNA polymerase I transcription factor binding IEA --
GO:0003677 DNA binding IEA --
GO:0003899 DNA-directed RNA polymerase activity --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with POLR1E: view

Phenotypes for POLR1E Gene

MGI mutant phenotypes for POLR1E:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with POLR1E: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for POLR1E Gene

Localization for POLR1E Gene

Subcellular locations from UniProtKB/Swiss-Prot for POLR1E Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for POLR1E Gene COMPARTMENTS Subcellular localization image for POLR1E gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for POLR1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus ISS --
GO:0005736 DNA-directed RNA polymerase I complex IBA --
genes like me logo Genes that share ontologies with POLR1E: view

Pathways for POLR1E Gene

genes like me logo Genes that share pathways with POLR1E: view

Pathways by source for POLR1E Gene

Gene Ontology (GO) - Biological Process for POLR1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001189 RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript IEA --
GO:0006351 transcription, DNA-templated --
GO:0006360 transcription from RNA polymerase I promoter TAS --
GO:0006361 transcription initiation from RNA polymerase I promoter TAS --
GO:0006362 transcription elongation from RNA polymerase I promoter TAS --
genes like me logo Genes that share ontologies with POLR1E: view

Compounds for POLR1E Gene

(6) HMDB Compounds for POLR1E Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Cytidine triphosphate
  • cytidine 5'-(tetrahydrogen triphosphate)
65-47-4
Guanosine triphosphate
  • 5'-GTP
86-01-1
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8
genes like me logo Genes that share compounds with POLR1E: view

Transcripts for POLR1E Gene

Unigene Clusters for POLR1E Gene

Polymerase (RNA) I polypeptide E, 53kDa:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for POLR1E

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for POLR1E Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: -
SP2:
SP3:

Relevant External Links for POLR1E Gene

GeneLoc Exon Structure for
POLR1E
ECgene alternative splicing isoforms for
POLR1E

Expression for POLR1E Gene

mRNA expression in normal human tissues for POLR1E Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for POLR1E Gene

SOURCE GeneReport for Unigene cluster for POLR1E Gene Hs.591087

genes like me logo Genes that share expressions with POLR1E: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for POLR1E Gene

Orthologs for POLR1E Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for POLR1E Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia POLR1E 35
  • 99.68 (n)
  • 99.76 (a)
POLR1E 36
  • 84 (a)
OneToOne
cow
(Bos Taurus)
Mammalia POLR1E 35
  • 89.02 (n)
  • 87.11 (a)
POLR1E 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia POLR1E 35
  • 89.58 (n)
  • 88.07 (a)
POLR1E 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Polr1e 35
  • 81.29 (n)
  • 77.59 (a)
Polr1e 16
Polr1e 36
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia POLR1E 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 63 (a)
OneToMany
-- 36
  • 67 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Polr1e 35
  • 82.37 (n)
  • 78.61 (a)
chicken
(Gallus gallus)
Aves POLR1E 35
  • 66.91 (n)
  • 61.17 (a)
POLR1E 36
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5852 35
tropical clawed frog
(Silurana tropicalis)
Amphibia polr1e 35
  • 61.3 (n)
  • 53.17 (a)
Str.15195 35
zebrafish
(Danio rerio)
Actinopterygii polr1e 35
  • 56.87 (n)
  • 43.97 (a)
polr1e 36
  • 41 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPA49 38
Species with no ortholog for POLR1E:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for POLR1E Gene

ENSEMBL:
Gene Tree for POLR1E (if available)
TreeFam:
Gene Tree for POLR1E (if available)

Paralogs for POLR1E Gene

No data available for Paralogs for POLR1E Gene

Variants for POLR1E Gene

Sequence variations from dbSNP and Humsavar for POLR1E Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs730282 -- 37,483,941(-) CACTG(C/G)TTTAT upstream-variant-2KB
rs731993 -- 37,487,129(+) ttttg(A/G)gccaa intron-variant
rs753968 -- 37,502,419(-) CCAGT(C/T)GGGTC intron-variant
rs753969 -- 37,502,374(-) CAGTT(A/C)CACCT intron-variant
rs754950 -- 37,493,117(+) AGATG(A/G)CAAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for POLR1E Gene

Variant ID Type Subtype PubMed ID
nsv893059 CNV Gain 21882294
esv259927 OTHER Complex 20981092
nsv824923 CNV Gain 20364138

Relevant External Links for POLR1E Gene

HapMap Linkage Disequilibrium report
POLR1E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for POLR1E Gene

Disorders for POLR1E Gene

Relevant External Links for POLR1E

Genetic Association Database (GAD)
POLR1E
Human Genome Epidemiology (HuGE) Navigator
POLR1E
genes like me logo Genes that share disorders with POLR1E: view

No data available for UniProtKB/Swiss-Prot for POLR1E Gene

Publications for POLR1E Gene

  1. Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription. (PMID: 15226435) Yamamoto K. … Muramatsu M. (Mol. Cell. Biol. 2004) 3 23
  2. RNA polymerase I associated factor 53 binds to the nucleolar transcription factor UBF and functions in specific rDNA transcription. (PMID: 8641287) Hanada K. … Muramatsu M. (EMBO J. 1996) 2 3
  3. Functional proteomic analysis of human nucleolus. (PMID: 12429849) Scherl A. … Diaz J.-J. (Mol. Biol. Cell 2002) 3 4
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for POLR1E Gene

Sources for POLR1E Gene

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