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Aliases for AKTIP Gene

Aliases for AKTIP Gene

  • AKT Interacting Protein 2 3
  • FT1 3 4 6
  • FTS 3 4 6
  • Fused Toes Protein Homolog 3 4
  • Fused Toes (Mouse) Homolog 2
  • Fused Toes Homolog (Mouse) 2
  • AKT-Interacting Protein 3
  • Fused Toes Homolog 3

External Ids for AKTIP Gene

Previous Symbols for AKTIP Gene

  • FTS

Summaries for AKTIP Gene

Entrez Gene Summary for AKTIP Gene

  • The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for AKTIP Gene

AKTIP (AKT Interacting Protein) is a Protein Coding gene. Diseases associated with AKTIP include balanitis xerotica obliterans and balanitis. GO annotations related to this gene include ubiquitin-like protein transferase activity.

UniProtKB/Swiss-Prot for AKTIP Gene

  • Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade.

Gene Wiki entry for AKTIP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AKTIP Gene

Genomics for AKTIP Gene

Genomic Location for AKTIP Gene

Start:
53,491,040 bp from pter
End:
53,504,411 bp from pter
Size:
13,372 bases
Orientation:
Minus strand

Genomic View for AKTIP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for AKTIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AKTIP Gene

Regulatory Elements for AKTIP Gene

Proteins for AKTIP Gene

  • Protein details for AKTIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8T0-AKTIP_HUMAN
    Recommended name:
    AKT-interacting protein
    Protein Accession:
    Q9H8T0
    Secondary Accessions:
    • Q503B1
    • Q53H38

    Protein attributes for AKTIP Gene

    Size:
    292 amino acids
    Molecular mass:
    33128 Da
    Quaternary structure:
    • Component of the FTS/Hook/FHIP complex (FHF complex), composed of AKTIP/FTS, FAM160A2, and one or more members of the Hook family of proteins HOOK1, HOOK2, and HOOK3. May interact directly with HOOK1, HOOK2 and HOOK3. The FHF complex associates with the homotypic vesicular sorting complex (the HOPS complex). Also interacts with AKT1.

    Alternative splice isoforms for AKTIP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for AKTIP Gene

Proteomics data for AKTIP Gene at MOPED

Post-translational modifications for AKTIP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for AKTIP Gene

Domains for AKTIP Gene

Gene Families for AKTIP Gene

HGNC:
  • UBE2 :Ubiquitin-conjugating enzymes E2

Protein Domains for AKTIP Gene

UniProtKB/Swiss-Prot:

AKTIP_HUMAN
Family:
  • Belongs to the ubiquitin-conjugating enzyme family. FTS subfamily.:
    • Q9H8T0
genes like me logo Genes that share domains with AKTIP: view

Function for AKTIP Gene

Molecular function for AKTIP Gene

UniProtKB/Swiss-Prot Function: Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade.

Gene Ontology (GO) - Molecular Function for AKTIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18799622
GO:0016881 acid-amino acid ligase activity --
GO:0019787 NOT ubiquitin-like protein transferase activity NAS 18799622
GO:0031625 ubiquitin protein ligase binding IBA --
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with AKTIP: view
genes like me logo Genes that share phenotypes with AKTIP: view

miRNA for AKTIP Gene

miRTarBase miRNAs that target AKTIP

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for AKTIP Gene

Localization for AKTIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for AKTIP Gene

Cytoplasm. Cell membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AKTIP Gene COMPARTMENTS Subcellular localization image for AKTIP gene
Compartment Confidence
plasma membrane 5
golgi apparatus 4
nucleus 4
cytosol 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for AKTIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
GO:0005886 plasma membrane IDA --
GO:0030897 colocalizes_with HOPS complex IDA 18799622
genes like me logo Genes that share ontologies with AKTIP: view

Pathways for AKTIP Gene

SuperPathways for AKTIP Gene

No Data Available

Gene Ontology (GO) - Biological Process for AKTIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IDA 14749367
GO:0006915 apoptotic process IEA --
GO:0007032 endosome organization IMP 18799622
GO:0007040 lysosome organization IMP 18799622
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with AKTIP: view

No data available for Pathways by source for AKTIP Gene

Transcripts for AKTIP Gene

Unigene Clusters for AKTIP Gene

AKT interacting protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AKTIP Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b ·
SP1: - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - -
SP7: - - - - - - -
SP8: - - -
SP9: - - - - - - -
SP10: - - - - -
SP11: - - - -
SP12: - -
SP13:
SP14:

ExUns: 15c · 15d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for AKTIP Gene

GeneLoc Exon Structure for
AKTIP
ECgene alternative splicing isoforms for
AKTIP

Expression for AKTIP Gene

mRNA expression in normal human tissues for AKTIP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for AKTIP Gene

SOURCE GeneReport for Unigene cluster for AKTIP Gene Hs.380897

genes like me logo Genes that share expressions with AKTIP: view

Orthologs for AKTIP Gene

This gene was present in the common ancestor of animals.

Orthologs for AKTIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AKTIP 36
  • 99.66 (n)
  • 100 (a)
AKTIP 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AKTIP 36
  • 94.29 (n)
  • 98.63 (a)
AKTIP 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia AKTIP 36
  • 94.29 (n)
  • 97.26 (a)
AKTIP 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aktip 36
  • 89.61 (n)
  • 96.23 (a)
Aktip 16
Aktip 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia AKTIP 37
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia AKTIP 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aktip 36
  • 90.41 (n)
  • 95.89 (a)
chicken
(Gallus gallus)
Aves AKTIP 36
  • 80.71 (n)
  • 87.67 (a)
AKTIP 37
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia AKTIP 37
  • 87 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33930 36
tropical clawed frog
(Silurana tropicalis)
Amphibia aktip 36
  • 75.26 (n)
  • 83.85 (a)
Str.2976 36
zebrafish
(Danio rerio)
Actinopterygii aktip 36
  • 74.06 (n)
  • 81.32 (a)
aktip 37
  • 78 (a)
OneToOne
fts 36
African malaria mosquito
(Anopheles gambiae)
Insecta AKTIP_ANOGA 36
  • 47.99 (n)
  • 38.65 (a)
fruit fly
(Drosophila melanogaster)
Insecta cbx 36
  • 50.08 (n)
  • 39.34 (a)
cbx 37
  • 36 (a)
OneToMany
CG16894 37
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ubc-19 37
  • 28 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6708 36
Species with no ortholog for AKTIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for AKTIP Gene

ENSEMBL:
Gene Tree for AKTIP (if available)
TreeFam:
Gene Tree for AKTIP (if available)

Paralogs for AKTIP Gene

Selected SIMAP similar genes for AKTIP Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for AKTIP Gene

genes like me logo Genes that share paralogs with AKTIP: view

No data available for Paralogs for AKTIP Gene

Variants for AKTIP Gene

Sequence variations from dbSNP and Humsavar for AKTIP Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1111486 -- 53,497,403(+) CTGCC(C/T)TTGGG intron-variant
rs1861350 -- 53,499,430(-) CTAGG(A/G)GAACA intron-variant
rs1861351 -- 53,499,315(-) CTGAA(G/T)TCAGG intron-variant
rs2388116 -- 53,497,152(-) AATTC(G/T)TAATT intron-variant
rs2892438 -- 53,492,390(-) TGCAC(C/T)ATGCA utr-variant-3-prime

Relevant External Links for AKTIP Gene

HapMap Linkage Disequilibrium report
AKTIP
Human Gene Mutation Database (HGMD)
AKTIP

No data available for Structural Variations from Database of Genomic Variants (DGV) for AKTIP Gene

Disorders for AKTIP Gene

(1) University of Copenhagen DISEASES for AKTIP Gene

Relevant External Links for AKTIP

Genetic Association Database (GAD)
AKTIP
Human Genome Epidemiology (HuGE) Navigator
AKTIP
genes like me logo Genes that share disorders with AKTIP: view

No data available for UniProtKB/Swiss-Prot for AKTIP Gene

Publications for AKTIP Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt. (PMID: 14749367) Remy I. … Michnick S.W. (Mol. Cell. Biol. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Association between AKT1 but not AKTIP genetic variants and increased risk for suicidal behavior in bipolar patients. (PMID: 20132317) Magno L.A. … Romano-Silva M.A. (Genes Brain Behav. 2010) 3 49
  5. Ft1, a novel gene related to ubiquitin-conjugating enzymes, is deleted in the Fused toes mouse mutation. (PMID: 9383278) Lesche R. … RA1ther U. (Mamm. Genome 1997) 3 23

Products for AKTIP Gene

Sources for AKTIP Gene

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