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Aliases for ZNF106 Gene

Aliases for ZNF106 Gene

  • Zinc Finger Protein 106 2 3 5
  • SH3-Domain Binding Protein 3 2 3
  • Zinc Finger Protein 474 3 4
  • ZFP106 3 4
  • SH3BP3 3 4
  • ZNF474 3 4
  • Zinc Finger Protein 106 Homolog (Mouse) 2
  • Zfp-106 4

External Ids for ZNF106 Gene

Previous HGNC Symbols for ZNF106 Gene

  • ZFP106

Previous GeneCards Identifiers for ZNF106 Gene

  • GC19U990126
  • GC15M042707

Summaries for ZNF106 Gene

GeneCards Summary for ZNF106 Gene

ZNF106 (Zinc Finger Protein 106) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and opioid peptide activity. An important paralog of this gene is TRAF7.

Gene Wiki entry for ZNF106 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF106 Gene

Genomics for ZNF106 Gene

Regulatory Elements for ZNF106 Gene

Promoters for ZNF106 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ZNF106 on UCSC Golden Path with GeneCards custom track

Genomic Location for ZNF106 Gene

Chromosome:
15
Start:
42,412,437 bp from pter
End:
42,491,197 bp from pter
Size:
78,761 bases
Orientation:
Minus strand

Genomic View for ZNF106 Gene

Genes around ZNF106 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF106 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF106 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF106 Gene

Proteins for ZNF106 Gene

  • Protein details for ZNF106 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H2Y7-ZN106_HUMAN
    Recommended name:
    Zinc finger protein 106
    Protein Accession:
    Q9H2Y7
    Secondary Accessions:
    • B4DZ40
    • E9PE29
    • Q6NSD9
    • Q6PEK1
    • Q86T43
    • Q86T45
    • Q86T50
    • Q86T58
    • Q86TA9
    • Q96M37
    • Q9H7B8

    Protein attributes for ZNF106 Gene

    Size:
    1883 amino acids
    Molecular mass:
    208883 Da
    Quaternary structure:
    • Interacts with KNOP1.
    SequenceCaution:
    • Sequence=AAH58023.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH70244.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB14976.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAD91134.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF106 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF106 Gene

Proteomics data for ZNF106 Gene at MOPED

Post-translational modifications for ZNF106 Gene

  • Ubiquitination at Lys 243, Lys 356, Lys 539, and Lys 775
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF106 Gene

Domains & Families for ZNF106 Gene

Gene Families for ZNF106 Gene

Suggested Antigen Peptide Sequences for ZNF106 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H2Y7

UniProtKB/Swiss-Prot:

ZN106_HUMAN :
  • Contains 2 C2H2-type zinc fingers.
Similarity:
  • Contains 2 C2H2-type zinc fingers.
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with ZNF106: view

Function for ZNF106 Gene

Gene Ontology (GO) - Molecular Function for ZNF106 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with ZNF106: view
genes like me logo Genes that share phenotypes with ZNF106: view

Animal Models for ZNF106 Gene

MGI Knock Outs for ZNF106:

Animal Model Products

CRISPR Products

miRNA for ZNF106 Gene

miRTarBase miRNAs that target ZNF106

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF106 Gene

Localization for ZNF106 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF106 Gene

Nucleus, nucleolus.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ZNF106 Gene

Pathways & Interactions for ZNF106 Gene

SuperPathways for ZNF106 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF106 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZNF106 Gene

Drugs & Compounds for ZNF106 Gene

No Compound Related Data Available

Transcripts for ZNF106 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF106 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a ·
SP1: -
SP2: -
SP3:
SP4: -
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10: -
SP11:
SP12: - - -
SP13: - - - - -
SP14:

ExUns: 18b ^ 19 ^ 20a · 20b ^ 21a · 21b · 21c ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25
SP1: - -
SP2: - -
SP3: - -
SP4: - - -
SP5:
SP6:
SP7:
SP8:
SP9: - -
SP10:
SP11: -
SP12:
SP13:
SP14:

Relevant External Links for ZNF106 Gene

GeneLoc Exon Structure for
ZNF106
ECgene alternative splicing isoforms for
ZNF106

Expression for ZNF106 Gene

mRNA expression in normal human tissues for ZNF106 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF106 Gene

This gene is overexpressed in Muscle - Skeletal (x12.3) and Heart - Left Ventricle (x6.9).

Protein differential expression in normal tissues from HIPED for ZNF106 Gene

This gene is overexpressed in Bone (31.0), Lung (23.4), and Monocytes (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ZNF106 Gene



genes like me logo Genes that share expression patterns with ZNF106: view

Protein tissue co-expression partners for ZNF106 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ZNF106 Gene

Orthologs for ZNF106 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF106 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ZNF106 35
  • 89.84 (n)
  • 88.25 (a)
ZNF106 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF106 35
  • 89.81 (n)
  • 89.45 (a)
ZNF106 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp106 35
  • 82.67 (n)
  • 78.28 (a)
Zfp106 16
Zfp106 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ZFP106 35
  • 99.75 (n)
  • 99.91 (a)
ZNF106 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC688018 35
  • 81.93 (n)
  • 78.19 (a)
oppossum
(Monodelphis domestica)
Mammalia ZNF106 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZFP106 35
  • 66.87 (n)
  • 62.68 (a)
ZNF106 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF106 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16042 35
znf106 35
  • 59.08 (n)
  • 53.57 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.9777 35
zebrafish
(Danio rerio)
Actinopterygii znf106a 36
  • 40 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14322 36
  • 18 (a)
OneToMany
Species with no ortholog for ZNF106:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF106 Gene

ENSEMBL:
Gene Tree for ZNF106 (if available)
TreeFam:
Gene Tree for ZNF106 (if available)

Paralogs for ZNF106 Gene

Paralogs for ZNF106 Gene

(2) SIMAP similar genes for ZNF106 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for ZNF106 Gene

genes like me logo Genes that share paralogs with ZNF106: view

Variants for ZNF106 Gene

Sequence variations from dbSNP and Humsavar for ZNF106 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs12440118 - 42,451,896(+) TCTCC(A/G)TTGGG intron-variant, reference, missense
rs12101559 - 42,450,266(+) GAACT(A/G)TGGGA intron-variant, reference, missense
rs34792942 - 42,450,237(+) TGTCA(C/T)TTGTA intron-variant, reference, missense
rs34983340 - 42,442,283(+) TGGAG(A/G/T)CTCCA reference, missense
rs1139100 -- 42,415,807(-) TAAGC(C/T)GAGAT utr-variant-3-prime

Variation tolerance for ZNF106 Gene

Residual Variation Intolerance Score: 4.95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.14; 69.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ZNF106 Gene

HapMap Linkage Disequilibrium report
ZNF106

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF106 Gene

Disorders for ZNF106 Gene

Relevant External Links for ZNF106

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ZNF106

No disorders were found for ZNF106 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF106 Gene

Publications for ZNF106 Gene

  1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 67
  2. Dual promoter structure of ZFP106: regulation by myogenin and nuclear respiratory factor-1. (PMID: 15656981) Grasberger H. … Bell G.I. (Gene 2005) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 3

Products for ZNF106 Gene

Sources for ZNF106 Gene

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