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Aliases for MMP25 Gene

Aliases for MMP25 Gene

  • Matrix Metallopeptidase 25 2 3
  • Membrane-Type Matrix Metalloproteinase 6 3 4
  • Membrane-Type-6 Matrix Metalloproteinase 3 4
  • Matrix Metallopeptidase-Like 1 2 3
  • Matrix Metalloproteinase 25 2 3
  • Leukolysin 3 4
  • MT-MMP 6 3 4
  • MT6-MMP 3 4
  • MMP-25 3 4
  • MMP20A 3 6
  • MT6MMP 3 4
  • MTMMP6 3 4
  • MMP20 3 4
  • MMPL1 3 4
  • Membrane-Type 6 Matrix Metalloproteinase 3
  • Matrix Metalloproteinase-Like 1 3
  • Matrix Metalloproteinase 20 3
  • Matrix Metalloproteinase-25 3
  • EC 3.4.24.- 4
  • MT-MMP6 3

External Ids for MMP25 Gene

Previous HGNC Symbols for MMP25 Gene

  • MMPL1
  • MMP20

Previous GeneCards Identifiers for MMP25 Gene

  • GC16U990147
  • GC16P003130
  • GC16P003097
  • GC16P003100
  • GC16P003102
  • GC16P003037
  • GC16P003038
  • GC16P003106
  • GC16P003108
  • GC16P003068
  • GC16P003109
  • GC16P003111
  • GC16P003127
  • GC16P003151

Summaries for MMP25 Gene

Entrez Gene Summary for MMP25 Gene

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. [provided by RefSeq, Jul 2008]

GeneCards Summary for MMP25 Gene

MMP25 (Matrix Metallopeptidase 25) is a Protein Coding gene. Diseases associated with MMP25 include dental fluorosis and arthritis. Among its related pathways are GPCR Pathway and Integrin Pathway. GO annotations related to this gene include calcium ion binding and metalloendopeptidase activity. An important paralog of this gene is MMP13.

UniProtKB/Swiss-Prot for MMP25 Gene

  • May activate progelatinase A

Tocris Summary for MMP25 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been identified in humans, which can be organized into six groups based on domain organization and substrate preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and -11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others (MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer. Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP25 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP25 Gene

Genomics for MMP25 Gene

Regulatory Elements for MMP25 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MMP25 Gene

3,046,681 bp from pter
3,060,726 bp from pter
14,046 bases
Plus strand

Genomic View for MMP25 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MMP25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP25 Gene

Proteins for MMP25 Gene

  • Protein details for MMP25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Matrix metalloproteinase-25
    Protein Accession:
    Secondary Accessions:
    • D3DUA8
    • Q9H3Q0

    Protein attributes for MMP25 Gene

    562 amino acids
    Molecular mass:
    62554 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available

neXtProt entry for MMP25 Gene

Proteomics data for MMP25 Gene at MOPED

Post-translational modifications for MMP25 Gene

Other Protein References for MMP25 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for MMP25 (MMP-25/MT6-MMP)

No data available for DME Specific Peptides for MMP25 Gene

Domains for MMP25 Gene

Gene Families for MMP25 Gene

Suggested Antigen Peptide Sequences for MMP25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
  • Belongs to the peptidase M10A family.
  • Contains 4 hemopexin repeats.
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
  • Belongs to the peptidase M10A family.
  • Contains 4 hemopexin repeats.
genes like me logo Genes that share domains with MMP25: view

Function for MMP25 Gene

Molecular function for MMP25 Gene

UniProtKB/Swiss-Prot Function:
May activate progelatinase A

Enzyme Numbers (IUBMB) for MMP25 Gene

Gene Ontology (GO) - Molecular Function for MMP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0008237 metallopeptidase activity --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MMP25: view

Animal Model Products

miRNA for MMP25 Gene

miRTarBase miRNAs that target MMP25

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MMP25

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MMP25 Gene

Localization for MMP25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP25 Gene

Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Jensen Localization Image for MMP25 Gene COMPARTMENTS Subcellular localization image for MMP25 gene
Compartment Confidence
extracellular 5
plasma membrane 5
endoplasmic reticulum 2
cytosol 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MMP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix NAS 10628838
GO:0005886 plasma membrane IEA --
GO:0016020 membrane NAS 11034316
GO:0016021 integral component of membrane IEA --
GO:0031012 extracellular matrix --
genes like me logo Genes that share ontologies with MMP25: view

Pathways for MMP25 Gene

genes like me logo Genes that share pathways with MMP25: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Inflammatory Response & Autoimmunity 384HT in human,mouse,rat

Gene Ontology (GO) - Biological Process for MMP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis NAS 10706098
GO:0006954 inflammatory response NAS 10628838
GO:0060022 hard palate development IEA --
genes like me logo Genes that share ontologies with MMP25: view

Compounds for MMP25 Gene

(1) Drugbank Compounds for MMP25 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • BB-2516
154039-60-8 119031 Target inhibitor approved, investigational

(5) Tocris Compounds for MMP25 Gene

Compound Action Cas Number
Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]
GI 254023X Selective ADAM10 metalloprotease inhibitor [260264-93-5]
GM 6001 Broad spectrum MMP inhibitor [142880-36-2]
Ro 32-3555 Potent, collagenase-selective MMP inhibitor [190648-49-8]
WAY 170523 Potent and selective inhibitor of MMP-13 [307002-73-9]

(1) HMDB Compounds for MMP25 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
genes like me logo Genes that share compounds with MMP25: view

Transcripts for MMP25 Gene

Unigene Clusters for MMP25 Gene

Matrix metallopeptidase 25:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MMP25

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MMP25 Gene

No ASD Table

Relevant External Links for MMP25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MMP25 Gene

mRNA expression in normal human tissues for MMP25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MMP25 Gene

This gene is overexpressed in Whole Blood (46.5).

SOURCE GeneReport for Unigene cluster for MMP25 Gene Hs.654979

mRNA Expression by UniProt/SwissProt for MMP25 Gene

Tissue specificity: Expressed predominantly in leukocytes, lung and spleen. Expressed also in colon carcinoma, astrocytoma and glioblastomas
genes like me logo Genes that share expressions with MMP25: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Expression partners for MMP25 Gene

Orthologs for MMP25 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP25 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MMP25 35
  • 85.63 (n)
  • 86.02 (a)
MMP25 36
  • 81 (a)
(Canis familiaris)
Mammalia MMP25 35
  • 83.36 (n)
  • 82.29 (a)
MMP25 36
  • 77 (a)
(Mus musculus)
Mammalia Mmp25 35
  • 79.43 (n)
  • 78.53 (a)
Mmp25 16
Mmp25 36
  • 69 (a)
(Pan troglodytes)
Mammalia MMP25 35
  • 99.53 (n)
  • 99.11 (a)
MMP25 36
  • 99 (a)
(Monodelphis domestica)
Mammalia MMP25 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia MMP25 36
  • 70 (a)
(Anolis carolinensis)
Reptilia MMP25 36
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mmp25 35
  • 56.21 (n)
  • 52.43 (a)
(Danio rerio)
Actinopterygii LOC100333601 35
  • 52.71 (n)
  • 47.48 (a)
CABZ01030094.1 36
  • 44 (a)
MMP25 (2 of 2) 36
  • 39 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mmp1 37
  • 34 (a)
Mmp2 37
  • 36 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003929 35
  • 51.31 (n)
  • 41.87 (a)
(Caenorhabditis elegans)
Secernentea C31B8.8 37
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
Species with no ortholog for MMP25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MMP25 Gene

Gene Tree for MMP25 (if available)
Gene Tree for MMP25 (if available)

Paralogs for MMP25 Gene

(11) SIMAP similar genes for MMP25 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MMP25: view

Variants for MMP25 Gene

Sequence variations from dbSNP and Humsavar for MMP25 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs879734 -- 3,047,294(-) CCCCG(A/G)ATGCC intron-variant
rs909408 -- 3,047,073(+) GAAGC(C/T)GGGCC intron-variant
rs909409 -- 3,047,394(+) TTCAC(A/C)TGCCC intron-variant
rs2142477 -- 3,047,455(+) CCACC(C/G)TGCCC reference, missense
rs2247226 -- 3,049,441(+) CTCAA(C/T)AAATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MMP25 Gene

Variant ID Type Subtype PubMed ID
nsv905162 CNV Gain 21882294
nsv905170 CNV Loss 21882294
dgv2575n71 CNV Loss 21882294
dgv2576n71 CNV Loss 21882294
nsv905185 CNV Loss 21882294
dgv2577n71 CNV Loss 21882294
dgv2578n71 CNV Loss 21882294
dgv2579n71 CNV Loss 21882294
nsv833125 CNV Loss 17160897
nsv509589 CNV Insertion 20534489
nsv905198 CNV Loss 21882294
esv2750390 CNV Deletion 23290073
dgv360e201 CNV Deletion 23290073
esv2750392 CNV Deletion 23290073
nsv905199 CNV Loss 21882294

Relevant External Links for MMP25 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP25 Gene

Disorders for MMP25 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MMP25 Gene in MalaCards »

(2) Diseases for MMP25 Gene

(2) University of Copenhagen DISEASES for MMP25 Gene

(2) Novoseek inferred disease relationships for MMP25 Gene

Disease -log(P) Hits PubMed IDs
cancer 0.388 2
tumors 0 2

Relevant External Links for MMP25

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MMP25: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for MMP25 Gene

Publications for MMP25 Gene

  1. Leukolysin/MMP25/MT6-MMP: a novel matrix metalloproteinase specifically expressed in the leukocyte lineage. (PMID: 10628838) Pei D.Q. (Cell Res. 1999) 2 3 4 23
  2. Membrane-type 6 matrix metalloproteinase (MT6-MMP, MMP-25) is the second glycosyl-phosphatidyl inositol (GPI)-anchored MMP. (PMID: 11034316) Kojima S. … Seiki M. (FEBS Lett. 2000) 3 4 23
  3. Human MT6-matrix metalloproteinase: identification, progelatinase A activation, and expression in brain tumors. (PMID: 10706098) Velasco G. … Lopez-Otin C. (Cancer Res. 2000) 2 3 4
  4. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler H.E. … Kim S.K. (PLoS Genet. 2009) 3 48
  5. Identification and role of the homodimerization interface of the glycosylphosphatidylinositol-anchored membrane type 6 matrix metalloproteinase (MMP25). (PMID: 18936094) Zhao H. … Fridman R. (J. Biol. Chem. 2008) 3 23

Products for MMP25 Gene

Sources for MMP25 Gene

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