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Aliases for MMP25 Gene

Aliases for MMP25 Gene

  • Matrix Metallopeptidase 25 2 3
  • Membrane-Type Matrix Metalloproteinase 6 3 4
  • Membrane-Type-6 Matrix Metalloproteinase 3 4
  • Matrix Metallopeptidase-Like 1 2 3
  • Matrix Metalloproteinase 25 2 3
  • Leukolysin 3 4
  • MT-MMP 6 3 4
  • MT6-MMP 3 4
  • MMP-25 3 4
  • MMP20A 3 6
  • MT6MMP 3 4
  • MTMMP6 3 4
  • MMP20 3 4
  • MMPL1 3 4
  • Membrane-Type 6 Matrix Metalloproteinase 3
  • Matrix Metalloproteinase-Like 1 3
  • Matrix Metalloproteinase 20 3
  • Matrix Metalloproteinase-25 3
  • EC 3.4.24.- 4
  • MT-MMP6 3

External Ids for MMP25 Gene

Previous Symbols for MMP25 Gene

  • MMPL1
  • MMP20

Summaries for MMP25 Gene

Entrez Gene Summary for MMP25 Gene

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. [provided by RefSeq, Jul 2008]

GeneCards Summary for MMP25 Gene

MMP25 (Matrix Metallopeptidase 25) is a Protein Coding gene. Diseases associated with MMP25 include dental fluorosis and arthritis. Among its related pathways are GPCR Pathway and Integrin Pathway. GO annotations related to this gene include calcium ion binding and metalloendopeptidase activity. An important paralog of this gene is MMP13.

UniProtKB/Swiss-Prot for MMP25 Gene

  • May activate progelatinase A

Tocris Summary for MMP25 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been identified in humans, which can be organized into six groups based on domain organization and substrate preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and -11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others (MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer. Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP25 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP25 Gene

Genomics for MMP25 Gene

Genomic Location for MMP25 Gene

Start:
3,046,681 bp from pter
End:
3,060,726 bp from pter
Size:
14,046 bases
Orientation:
Plus strand

Genomic View for MMP25 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MMP25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP25 Gene

Regulatory Elements for MMP25 Gene

Proteins for MMP25 Gene

  • Protein details for MMP25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPA2-MMP25_HUMAN
    Recommended name:
    Matrix metalloproteinase-25
    Protein Accession:
    Q9NPA2
    Secondary Accessions:
    • D3DUA8
    • Q9H3Q0

    Protein attributes for MMP25 Gene

    Size:
    562 amino acids
    Molecular mass:
    62554 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available

neXtProt entry for MMP25 Gene

Proteomics data for MMP25 Gene at MOPED

Post-translational modifications for MMP25 Gene

Other Protein References for MMP25 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for MMP25 Gene

Domains for MMP25 Gene

UniProtKB/Swiss-Prot:

MMP25_HUMAN
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme:
    • Q9NPA2
Family:
  • Belongs to the peptidase M10A family.:
    • Q9NPA2
Similarity:
  • Contains 4 hemopexin repeats.:
    • Q9NPA2
genes like me logo Genes that share domains with MMP25: view

Function for MMP25 Gene

Molecular function for MMP25 Gene

UniProtKB/Swiss-Prot Function: May activate progelatinase A

Enzyme Numbers (IUBMB) for MMP25 Gene

Gene Ontology (GO) - Molecular Function for MMP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0008237 metallopeptidase activity --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MMP25: view

miRNA for MMP25 Gene

miRTarBase miRNAs that target MMP25

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MMP25 Gene

Localization for MMP25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP25 Gene

Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MMP25 Gene COMPARTMENTS Subcellular localization image for MMP25 gene
Compartment Confidence
extracellular 5
plasma membrane 5
endoplasmic reticulum 2
cytosol 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MMP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix NAS 10628838
GO:0005886 plasma membrane IEA --
GO:0016020 membrane NAS 11034316
GO:0016021 integral component of membrane IEA --
GO:0031012 extracellular matrix --
genes like me logo Genes that share ontologies with MMP25: view

Pathways for MMP25 Gene

genes like me logo Genes that share pathways with MMP25: view

Gene Ontology (GO) - Biological Process for MMP25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis NAS 10706098
GO:0006954 inflammatory response NAS 10628838
GO:0060022 hard palate development IEA --
genes like me logo Genes that share ontologies with MMP25: view

Compounds for MMP25 Gene

(5) Tocris Compounds for MMP25 Gene

Compound Action Cas Number
Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]
GI 254023X Selective ADAM10 metalloprotease inhibitor [260264-93-5]
GM 6001 Broad-spectrum MMP inhibitor [142880-36-2]
Marimastat Broad spectrum MMP inhibitor [154039-60-8]
UK 383367 Potent and selective BMP-1 (PCP) inhibitor [348622-88-8]

(1) HMDB Compounds for MMP25 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Drugbank Compounds for MMP25 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Marimastat
154039-60-8 target inhibitor
genes like me logo Genes that share compounds with MMP25: view

Transcripts for MMP25 Gene

Unigene Clusters for MMP25 Gene

Matrix metallopeptidase 25:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MMP25 Gene

No ASD Table

Relevant External Links for MMP25 Gene

GeneLoc Exon Structure for
MMP25
ECgene alternative splicing isoforms for
MMP25

Expression for MMP25 Gene

mRNA expression in normal human tissues for MMP25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MMP25 Gene

This gene is overexpressed in Whole Blood (46.5).

SOURCE GeneReport for Unigene cluster for MMP25 Gene Hs.654979

mRNA Expression by UniProt/SwissProt for MMP25 Gene

Q9NPA2-MMP25_HUMAN
Tissue specificity: Expressed predominantly in leukocytes, lung and spleen. Expressed also in colon carcinoma, astrocytoma and glioblastomas
genes like me logo Genes that share expressions with MMP25: view

Orthologs for MMP25 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MMP25 36
  • 99.53 (n)
  • 99.11 (a)
MMP25 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MMP25 36
  • 85.63 (n)
  • 86.02 (a)
MMP25 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MMP25 36
  • 83.36 (n)
  • 82.29 (a)
MMP25 37
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mmp25 36
  • 79.43 (n)
  • 78.53 (a)
Mmp25 16
Mmp25 37
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MMP25 37
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MMP25 37
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MMP25 37
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mmp25 36
  • 56.21 (n)
  • 52.43 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01030094.1 37
  • 44 (a)
OneToMany
LOC100333601 36
  • 52.71 (n)
  • 47.48 (a)
MMP25 (2 of 2) 37
  • 39 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003929 36
  • 51.31 (n)
  • 41.87 (a)
fruit fly
(Drosophila melanogaster)
Insecta Mmp2 38
  • 36 (a)
Mmp1 38
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea C31B8.8 38
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 35 (a)
OneToMany
Species with no ortholog for MMP25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MMP25 Gene

ENSEMBL:
Gene Tree for MMP25 (if available)
TreeFam:
Gene Tree for MMP25 (if available)

Paralogs for MMP25 Gene

Selected SIMAP similar genes for MMP25 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with MMP25: view

Variants for MMP25 Gene

Sequence variations from dbSNP and Humsavar for MMP25 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs879734 -- 3,047,294(-) CCCCG(A/G)ATGCC intron-variant
rs909408 -- 3,047,073(+) GAAGC(C/T)GGGCC intron-variant
rs909409 -- 3,047,394(+) TTCAC(A/C)TGCCC intron-variant
rs2142477 -- 3,047,455(+) CCACC(C/G)TGCCC reference, missense
rs2247226 -- 3,049,441(+) CTCAA(C/T)AAATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MMP25 Gene

Variant ID Type Subtype PubMed ID
nsv905162 CNV Gain 21882294
nsv905170 CNV Loss 21882294
dgv2575n71 CNV Loss 21882294
dgv2576n71 CNV Loss 21882294
nsv905185 CNV Loss 21882294
dgv2577n71 CNV Loss 21882294
dgv2578n71 CNV Loss 21882294
dgv2579n71 CNV Loss 21882294
nsv833125 CNV Loss 17160897
nsv509589 CNV Insertion 20534489
nsv905198 CNV Loss 21882294
esv2750390 CNV Deletion 23290073
dgv360e201 CNV Deletion 23290073
esv2750392 CNV Deletion 23290073
nsv905199 CNV Loss 21882294

Relevant External Links for MMP25 Gene

HapMap Linkage Disequilibrium report
MMP25

Disorders for MMP25 Gene

(2) MalaCards Diseases for MMP25 Gene

Search for MMP25 Gene in MalaCards »

(2) University of Copenhagen DISEASES for MMP25 Gene

(2) Novoseek inferred disease relationships for MMP25 Gene

Disease -log(P) Hits PubMed IDs
cancer 0.388 2
tumors 0 2

Relevant External Links for MMP25

Genetic Association Database (GAD)
MMP25
Human Genome Epidemiology (HuGE) Navigator
MMP25
genes like me logo Genes that share disorders with MMP25: view

No data available for UniProtKB/Swiss-Prot for MMP25 Gene

Publications for MMP25 Gene

  1. Leukolysin/MMP25/MT6-MMP: a novel matrix metalloproteinase specifically expressed in the leukocyte lineage. (PMID: 10628838) Pei D.Q. (Cell Res. 1999) 2 3 4 23
  2. Membrane-type 6 matrix metalloproteinase (MT6-MMP, MMP-25) is the second glycosyl-phosphatidyl inositol (GPI)-anchored MMP. (PMID: 11034316) Kojima S. … Seiki M. (FEBS Lett. 2000) 3 4 23
  3. Human MT6-matrix metalloproteinase: identification, progelatinase A activation, and expression in brain tumors. (PMID: 10706098) Velasco G. … Lopez-Otin C. (Cancer Res. 2000) 2 3 4
  4. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PMID: 19834535) Wheeler H.E. … Kim S.K. (PLoS Genet. 2009) 3 49
  5. Identification and role of the homodimerization interface of the glycosylphosphatidylinositol-anchored membrane type 6 matrix metalloproteinase (MMP25). (PMID: 18936094) Zhao H. … Fridman R. (J. Biol. Chem. 2008) 3 23

Products for MMP25 Gene

Sources for MMP25 Gene

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