Free for academic non-profit institutions. Other users need a Commercial license

Aliases for HS1BP3 Gene

Aliases for HS1BP3 Gene

  • HCLS1 Binding Protein 3 2 3
  • HS1-Binding Protein 3 3 4
  • HSP1BP-3 3 4
  • ETM2 3 6
  • HCLS1-Binding Protein 3 3
  • FLJ14249 6
  • HS1-BP3 3

External Ids for HS1BP3 Gene

Summaries for HS1BP3 Gene

Entrez Gene Summary for HS1BP3 Gene

  • The protein encoded by this gene shares similarity with mouse Hs1bp3, an Hcls1/Hs1-interacting protein that may be involved in lymphocyte activation. [provided by RefSeq, Jul 2008]

GeneCards Summary for HS1BP3 Gene

HS1BP3 (HCLS1 Binding Protein 3) is a Protein Coding gene. Diseases associated with HS1BP3 include bells palsy and essential tremor. GO annotations related to this gene include phosphatidylinositol binding.

UniProtKB/Swiss-Prot for HS1BP3 Gene

  • May be a modulator of IL-2 signaling.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for HS1BP3 Gene

Genomics for HS1BP3 Gene

Genomic Location for HS1BP3 Gene

Start:
20,560,448 bp from pter
End:
20,651,104 bp from pter
Size:
90,657 bases
Orientation:
Minus strand

Genomic View for HS1BP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for HS1BP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for HS1BP3 Gene

Regulatory Elements for HS1BP3 Gene

Proteins for HS1BP3 Gene

  • Protein details for HS1BP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53T59-H1BP3_HUMAN
    Recommended name:
    HCLS1-binding protein 3
    Protein Accession:
    Q53T59
    Secondary Accessions:
    • B2RAW2
    • D6W529
    • Q86VC2
    • Q8N367

    Protein attributes for HS1BP3 Gene

    Size:
    392 amino acids
    Molecular mass:
    42780 Da
    Quaternary structure:
    • Binds HCLS1. Interacts with the SH3 domain of HCLS1 in vitro (By similarity).

neXtProt entry for HS1BP3 Gene

Proteomics data for HS1BP3 Gene at MOPED

Post-translational modifications for HS1BP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for HS1BP3 Gene

No data available for DME Specific Peptides for HS1BP3 Gene

Domains for HS1BP3 Gene

Protein Domains for HS1BP3 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

H1BP3_HUMAN
Domain:
  • Contains 1 PX (phox homology) domain.:
    • Q53T59
genes like me logo Genes that share domains with HS1BP3: view

No data available for Gene Families for HS1BP3 Gene

Function for HS1BP3 Gene

Molecular function for HS1BP3 Gene

UniProtKB/Swiss-Prot Function: May be a modulator of IL-2 signaling.

Gene Ontology (GO) - Molecular Function for HS1BP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0035091 phosphatidylinositol binding IEA --
genes like me logo Genes that share ontologies with HS1BP3: view

miRNA for HS1BP3 Gene

miRTarBase miRNAs that target HS1BP3

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for HS1BP3 Gene

Localization for HS1BP3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for HS1BP3 Gene COMPARTMENTS Subcellular localization image for HS1BP3 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for HS1BP3 Gene

Pathways for HS1BP3 Gene

SuperPathways for HS1BP3 Gene

No Data Available

Interacting Proteins for HS1BP3 Gene

Gene Ontology (GO) - Biological Process for HS1BP3 Gene

None

No data available for Pathways by source for HS1BP3 Gene

Transcripts for HS1BP3 Gene

Unigene Clusters for HS1BP3 Gene

HCLS1 binding protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for HS1BP3 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5: - - - - - - -
SP6:

Relevant External Links for HS1BP3 Gene

GeneLoc Exon Structure for
HS1BP3
ECgene alternative splicing isoforms for
HS1BP3

Expression for HS1BP3 Gene

mRNA expression in normal human tissues for HS1BP3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for HS1BP3 Gene

SOURCE GeneReport for Unigene cluster for HS1BP3 Gene Hs.531785

genes like me logo Genes that share expressions with HS1BP3: view

Orthologs for HS1BP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for HS1BP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia HS1BP3 36
  • 98.72 (n)
  • 97.7 (a)
HS1BP3 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HS1BP3 36
  • 83.68 (n)
  • 80.77 (a)
HS1BP3 37
  • 51 (a)
OneToOne
dog
(Canis familiaris)
Mammalia HS1BP3 36
  • 84.9 (n)
  • 84.37 (a)
HS1BP3 37
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Hs1bp3 36
  • 82.38 (n)
  • 77.46 (a)
Hs1bp3 16
Hs1bp3 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia HS1BP3 37
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia HS1BP3 37
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Hs1bp3 36
  • 82.82 (n)
  • 79.02 (a)
chicken
(Gallus gallus)
Aves HS1BP3 36
  • 62.1 (n)
  • 58.53 (a)
HS1BP3 37
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia HS1BP3 37
  • 53 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.32792 36
tropical clawed frog
(Silurana tropicalis)
Amphibia hs1bp3 36
  • 57.35 (n)
  • 50.14 (a)
zebrafish
(Danio rerio)
Actinopterygii HS1BP3 37
  • 40 (a)
OneToOne
LOC553223 36
  • 52.22 (n)
  • 43.64 (a)
Species with no ortholog for HS1BP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for HS1BP3 Gene

ENSEMBL:
Gene Tree for HS1BP3 (if available)
TreeFam:
Gene Tree for HS1BP3 (if available)

Paralogs for HS1BP3 Gene

No data available for Paralogs for HS1BP3 Gene

Variants for HS1BP3 Gene

Sequence variations from dbSNP and Humsavar for HS1BP3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs734889 -- 20,645,971(+) GGGAC(A/G)AGCAC intron-variant
rs744663 -- 20,621,141(-) TGCCC(A/G)GCCCT intron-variant
rs870309 -- 20,619,531(+) ACCCC(A/G)CTTGA intron-variant
rs875672 -- 20,632,968(-) CTAAA(C/G)AGGTC intron-variant
rs896733 -- 20,619,556(-) AGCCC(A/C)CTACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for HS1BP3 Gene

Variant ID Type Subtype PubMed ID
dgv56n68 CNV Loss 17160897
nsv508828 CNV Insertion 20534489
nsv517472 CNV Loss 19592680
nsv873725 CNV Loss 21882294
nsv527901 CNV Loss 19592680
dgv4069n71 CNV Loss 21882294
esv272408 CNV Insertion 20981092

Relevant External Links for HS1BP3 Gene

HapMap Linkage Disequilibrium report
HS1BP3
Human Gene Mutation Database (HGMD)
HS1BP3

Disorders for HS1BP3 Gene

(2) University of Copenhagen DISEASES for HS1BP3 Gene

Relevant External Links for HS1BP3

Genetic Association Database (GAD)
HS1BP3
Human Genome Epidemiology (HuGE) Navigator
HS1BP3
genes like me logo Genes that share disorders with HS1BP3: view

No data available for UniProtKB/Swiss-Prot for HS1BP3 Gene

Publications for HS1BP3 Gene

  1. A variant in the HS1-BP3 gene is associated with familial essential tremor. (PMID: 15699368) Higgins J.J. … Rooney J.P. (Neurology 2005) 2 3 23
  2. Isolation and characterization of a novel HS1 SH3 domain binding protein, HS1BP3. (PMID: 10590261) Takemoto Y. … Hashimoto Y. (Int. Immunol. 1999) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. DRD3 Ser9Gly and HS1BP3 Ala265Gly are not associated with Parkinson disease. (PMID: 19524641) Keeling B.H. … Farrer M.J. (Neurosci. Lett. 2009) 3 49
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for HS1BP3 Gene

Sources for HS1BP3 Gene

Back to Top

Content