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Aliases for RNF25 Gene

Aliases for RNF25 Gene

  • Ring Finger Protein 25 2 3
  • RING-Type E3 Ubiquitin Transferase RNF25 3 4
  • RING Finger Protein 25 4 5
  • E3 Ubiquitin-Protein Ligase RNF25 3
  • Ring Finger Protein AO7 3
  • EC 2.3.2.27 4
  • AO7 3

External Ids for RNF25 Gene

Previous GeneCards Identifiers for RNF25 Gene

  • GC02M217544
  • GC02M218249
  • GC02M219492
  • GC02M219731
  • GC02M219354
  • GC02M219236
  • GC02M211382
  • GC02M219528

Summaries for RNF25 Gene

Entrez Gene Summary for RNF25 Gene

  • The protein encoded by this gene contains a RING finger motif. The mouse counterpart of this protein has been shown to interact with Rela, the p65 subunit of NF-kappaB (NFKB), and modulate NFKB-mediated transcription activity. The mouse protein also binds ubiquitin-conjugating enzymes (E2s) and is a substrate for E2-dependent ubiquitination. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF25 Gene

RNF25 (Ring Finger Protein 25) is a Protein Coding gene. Diseases associated with RNF25 include Congenital Epulis. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ligase activity and NF-kappaB binding.

UniProtKB/Swiss-Prot for RNF25 Gene

  • E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NKD2 (By similarity). Stimulates transcription mediated by NF-kappa-B.

Gene Wiki entry for RNF25 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF25 Gene

Genomics for RNF25 Gene

Regulatory Elements for RNF25 Gene

Enhancers for RNF25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G219368 1.2 Ensembl ENCODE 21.7 -696.9 -696895 2.4 FOXA2 FEZF1 ZNF2 GATA2 ZNF416 KLF7 YY2 REST TSHZ1 ZNF488 RNF25 CNOT9 STK36 ANKZF1 ENSG00000269068 RESP18 ASIC4 TMEM198 PTPRN SPEG
GH02G219569 1.1 ENCODE 21.7 -899.1 -899121 4.0 PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF416 FOS INHA RNF25 SLC23A3 ENSG00000269068 NHEJ1 ASIC4 TMEM198 STK36 OBSL1
GH02G218730 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.5 -60.3 -60279 4.6 MLX CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 SLC11A1 CYP27A1 PLCD4 USP37 NHEJ1 RNF25 BCS1L ZNF142 AAMP PNKD
GH02G217987 1.5 Ensembl ENCODE dbSUPER 12.8 +683.4 683416 2.8 FOXA2 SIN3A ARID4B YBX1 ZNF2 ZNF48 ZBTB7B SLC30A9 ZNF207 ZNF143 RNF25 RUFY4 STK36 CNOT9 AAMP LOC105373878 TNS1
GH02G218269 1.4 ENCODE dbSUPER 13.4 +399.8 399772 7.1 HDGF PKNOX1 FOXA2 MLX CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 ENSG00000261338 AAMP USP37 RNF25 NHEJ1 ARPC2 STK36 PNKD TMBIM1 MIR6513
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNF25 on UCSC Golden Path with GeneCards custom track

Promoters for RNF25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000130437 511 1401 PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF143 KLF13 ZNF263 MXD4 REST

Genomic Location for RNF25 Gene

Chromosome:
2
Start:
218,663,864 bp from pter
End:
218,672,411 bp from pter
Size:
8,548 bases
Orientation:
Minus strand

Genomic View for RNF25 Gene

Genes around RNF25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF25 Gene

Proteins for RNF25 Gene

  • Protein details for RNF25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BH1-RNF25_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF25
    Protein Accession:
    Q96BH1
    Secondary Accessions:
    • A8K0D6
    • Q53HQ5
    • Q9H874

    Protein attributes for RNF25 Gene

    Size:
    459 amino acids
    Molecular mass:
    51219 Da
    Quaternary structure:
    • Interacts with UBE2D2, and may also interact with UBE2E1 and UBE2E3. Interacts with NKD2 (By similarity). Interacts with RELA.

    Three dimensional structures from OCA and Proteopedia for RNF25 Gene

neXtProt entry for RNF25 Gene

Post-translational modifications for RNF25 Gene

Other Protein References for RNF25 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF25 Gene

Domains & Families for RNF25 Gene

Gene Families for RNF25 Gene

Suggested Antigen Peptide Sequences for RNF25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96BH1

UniProtKB/Swiss-Prot:

RNF25_HUMAN :
  • The RING-type zinc finger domain interacts with an ubiquitin-conjugating enzyme (E2) and facilitates ubiquitination.
Domain:
  • The RING-type zinc finger domain interacts with an ubiquitin-conjugating enzyme (E2) and facilitates ubiquitination.
genes like me logo Genes that share domains with RNF25: view

Function for RNF25 Gene

Molecular function for RNF25 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NKD2 (By similarity). Stimulates transcription mediated by NF-kappa-B.

Enzyme Numbers (IUBMB) for RNF25 Gene

Gene Ontology (GO) - Molecular Function for RNF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity ISS --
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0051059 NF-kappaB binding IPI 12748188
genes like me logo Genes that share ontologies with RNF25: view
genes like me logo Genes that share phenotypes with RNF25: view

Animal Models for RNF25 Gene

MGI Knock Outs for RNF25:

Animal Model Products

CRISPR Products

miRNA for RNF25 Gene

miRTarBase miRNAs that target RNF25

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RNF25 Gene

Localization for RNF25 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF25 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for RNF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12748188
GO:0005829 cytosol IDA 12748188
genes like me logo Genes that share ontologies with RNF25: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RNF25 Gene

Pathways & Interactions for RNF25 Gene

genes like me logo Genes that share pathways with RNF25: view

UniProtKB/Swiss-Prot Q96BH1-RNF25_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RNF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination ISS --
GO:0051092 positive regulation of NF-kappaB transcription factor activity IDA 12748188
genes like me logo Genes that share ontologies with RNF25: view

No data available for SIGNOR curated interactions for RNF25 Gene

Transcripts for RNF25 Gene

Unigene Clusters for RNF25 Gene

Ring finger protein 25:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RNF25 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1:
SP2:
SP3:

Relevant External Links for RNF25 Gene

GeneLoc Exon Structure for
RNF25
ECgene alternative splicing isoforms for
RNF25

Expression for RNF25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RNF25 Gene

This gene is overexpressed in Rectum (25.5) and Testis (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RNF25 Gene



Protein tissue co-expression partners for RNF25 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNF25 Gene:

RNF25

SOURCE GeneReport for Unigene cluster for RNF25 Gene:

Hs.471403

Evidence on tissue expression from TISSUES for RNF25 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with RNF25: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF25 Gene

Orthologs for RNF25 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF25 34 35
  • 98.91 (n)
dog
(Canis familiaris)
Mammalia RNF25 34 35
  • 90.05 (n)
cow
(Bos Taurus)
Mammalia RNF25 34 35
  • 86.46 (n)
rat
(Rattus norvegicus)
Mammalia Rnf25 34
  • 84.88 (n)
mouse
(Mus musculus)
Mammalia Rnf25 34 16 35
  • 84.58 (n)
oppossum
(Monodelphis domestica)
Mammalia RNF25 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNF25 34 35
  • 57.96 (n)
lizard
(Anolis carolinensis)
Reptilia RNF25 35
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf25 34
  • 56.6 (n)
Str.14059 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.25335 34
zebrafish
(Danio rerio)
Actinopterygii rnf25 35
  • 31 (a)
OneToOne
-- 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9261 34
fruit fly
(Drosophila melanogaster)
Insecta CG13344 36 35
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea Y53G8AR.5 35
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8459 35
  • 29 (a)
OneToOne
Species where no ortholog for RNF25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF25 Gene

ENSEMBL:
Gene Tree for RNF25 (if available)
TreeFam:
Gene Tree for RNF25 (if available)

Paralogs for RNF25 Gene

No data available for Paralogs for RNF25 Gene

Variants for RNF25 Gene

Sequence variations from dbSNP and Humsavar for RNF25 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1057516786 Likely pathogenic 218,663,370(+) TGCTG(-/AG)TCTCT nc-transcript-variant, downstream-variant-500B, reference, frameshift-variant
rs1000024451 -- 218,665,470(+) GGCAC(A/G)GTGGC intron-variant
rs1000055970 -- 218,669,337(+) GATAA(C/T)AACAC intron-variant
rs1000621972 -- 218,667,263(+) AGTTT(-/TC)TGTGT intron-variant
rs1000909845 -- 218,666,822(+) TCTCT(C/T)TGACT intron-variant

Variation tolerance for RNF25 Gene

Residual Variation Intolerance Score: 89.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.91; 48.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNF25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RNF25 Gene

Disorders for RNF25 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RNF25 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
congenital epulis
  • congenital epulides
- elite association - COSMIC cancer census association via MalaCards
Search RNF25 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RNF25

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNF25
genes like me logo Genes that share disorders with RNF25: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNF25 Gene

Publications for RNF25 Gene

  1. RING finger protein AO7 supports NF-kappaB-mediated transcription by interacting with the transactivation domain of the p65 subunit. (PMID: 12748188) Asamitsu K. … Okamoto T. (J. Biol. Chem. 2003) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. (PMID: 10500182) Lorick K.L. … Weissman A.M. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 22 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for RNF25 Gene

Sources for RNF25 Gene

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