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Aliases for RNF25 Gene

Aliases for RNF25 Gene

  • Ring Finger Protein 25 2 3
  • RING-Type E3 Ubiquitin Transferase RNF25 3 4
  • RING Finger Protein 25 4 5
  • E3 Ubiquitin-Protein Ligase RNF25 3
  • Ring Finger Protein AO7 3
  • EC 2.3.2.27 4
  • AO7 3

External Ids for RNF25 Gene

Previous GeneCards Identifiers for RNF25 Gene

  • GC02M217544
  • GC02M218249
  • GC02M219492
  • GC02M219731
  • GC02M219354
  • GC02M219236
  • GC02M211382
  • GC02M219528

Summaries for RNF25 Gene

Entrez Gene Summary for RNF25 Gene

  • The protein encoded by this gene contains a RING finger motif. The mouse counterpart of this protein has been shown to interact with Rela, the p65 subunit of NF-kappaB (NFKB), and modulate NFKB-mediated transcription activity. The mouse protein also binds ubiquitin-conjugating enzymes (E2s) and is a substrate for E2-dependent ubiquitination. [provided by RefSeq, Jul 2008]

GeneCards Summary for RNF25 Gene

RNF25 (Ring Finger Protein 25) is a Protein Coding gene. Diseases associated with RNF25 include Congenital Epulis. Among its related pathways are superpathway of tryptophan utilization and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ligase activity and NF-kappaB binding.

UniProtKB/Swiss-Prot for RNF25 Gene

  • E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NKD2 (By similarity). Stimulates transcription mediated by NF-kappa-B.

Gene Wiki entry for RNF25 Gene

Additional gene information for RNF25 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RNF25 Gene

Genomics for RNF25 Gene

Regulatory Elements for RNF25 Gene

Enhancers for RNF25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H219368 1.2 Ensembl ENCODE 38.3 -696.9 -696895 2 FOXA2 FEZF1 ZNF2 GATA2 ZNF416 KLF7 YY2 REST TSHZ1 ZNF488 ZNF142 RNF25 STK36 CNOT9 ENSG00000269068 STK11IP ENSG00000268896 ANKZF1 OBSL1 GLB1L
GH02H219569 1.1 ENCODE 38.3 -899.1 -899121 4 PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF416 FOS ZNF142 RNF25 NHEJ1 INHA SLC23A3 STK36 STK11IP GLB1L DNPEP BCS1L
GH02H219495 1.4 ENCODE dbSUPER 20 -825.6 -825615 5 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZNF142 STK36 RNF25 CNOT9 USP37 NHEJ1 STK11IP ENSG00000268603 ASIC4 DNPEP
GH02H218908 2 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -237.2 -237188 2 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B CNOT9 STK36 ZNF142 USP37 AAMP OBSL1 NHEJ1 CDK5R2 ENSG00000235024 ENSG00000269068
GH02H218393 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +271.4 271405 14 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC SSRP1 CNOT9 AAMP USP37 STK36 ANKZF1 TNS1 BCS1L ENSG00000273466 NHEJ1 TMBIM1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RNF25 on UCSC Golden Path with GeneCards custom track

Promoters for RNF25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000130437 511 1401 PKNOX1 ARID4B SIN3A DMAP1 YY1 ETS1 GLIS2 ELK1 ZNF143 ATF7

Genomic Location for RNF25 Gene

Chromosome:
2
Start:
218,663,864 bp from pter
End:
218,672,411 bp from pter
Size:
8,548 bases
Orientation:
Minus strand

Genomic View for RNF25 Gene

Genes around RNF25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RNF25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RNF25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RNF25 Gene

Proteins for RNF25 Gene

  • Protein details for RNF25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96BH1-RNF25_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RNF25
    Protein Accession:
    Q96BH1
    Secondary Accessions:
    • A8K0D6
    • Q53HQ5
    • Q9H874

    Protein attributes for RNF25 Gene

    Size:
    459 amino acids
    Molecular mass:
    51219 Da
    Quaternary structure:
    • Interacts with UBE2D2, and may also interact with UBE2E1 and UBE2E3. Interacts with NKD2 (By similarity). Interacts with RELA.

    Three dimensional structures from OCA and Proteopedia for RNF25 Gene

neXtProt entry for RNF25 Gene

Post-translational modifications for RNF25 Gene

Other Protein References for RNF25 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RNF25 Gene

Domains & Families for RNF25 Gene

Gene Families for RNF25 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RNF25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96BH1

UniProtKB/Swiss-Prot:

RNF25_HUMAN :
  • The RING-type zinc finger domain interacts with an ubiquitin-conjugating enzyme (E2) and facilitates ubiquitination.
Domain:
  • The RING-type zinc finger domain interacts with an ubiquitin-conjugating enzyme (E2) and facilitates ubiquitination.
genes like me logo Genes that share domains with RNF25: view

Function for RNF25 Gene

Molecular function for RNF25 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of NKD2 (By similarity). Stimulates transcription mediated by NF-kappa-B.

Enzyme Numbers (IUBMB) for RNF25 Gene

Phenotypes From GWAS Catalog for RNF25 Gene

Gene Ontology (GO) - Molecular Function for RNF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity ISS --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0051059 NF-kappaB binding IPI 12748188
GO:0061630 ubiquitin protein ligase activity IBA,IEA --
genes like me logo Genes that share ontologies with RNF25: view
genes like me logo Genes that share phenotypes with RNF25: view

Animal Models for RNF25 Gene

MGI Knock Outs for RNF25:

Animal Model Products

CRISPR Products

miRNA for RNF25 Gene

miRTarBase miRNAs that target RNF25

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RNF25
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RNF25 Gene

Localization for RNF25 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RNF25 gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RNF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12748188
GO:0005829 cytosol IDA 12748188
genes like me logo Genes that share ontologies with RNF25: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RNF25 Gene

Pathways & Interactions for RNF25 Gene

genes like me logo Genes that share pathways with RNF25: view

UniProtKB/Swiss-Prot Q96BH1-RNF25_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RNF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination ISS --
GO:0051092 positive regulation of NF-kappaB transcription factor activity IDA 12748188
genes like me logo Genes that share ontologies with RNF25: view

No data available for SIGNOR curated interactions for RNF25 Gene

Drugs & Compounds for RNF25 Gene

No Compound Related Data Available

Transcripts for RNF25 Gene

Unigene Clusters for RNF25 Gene

Ring finger protein 25:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RNF25
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RNF25 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1:
SP2:
SP3:

Relevant External Links for RNF25 Gene

GeneLoc Exon Structure for
RNF25
ECgene alternative splicing isoforms for
RNF25

Expression for RNF25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RNF25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RNF25 Gene

This gene is overexpressed in Rectum (25.5) and Testis (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RNF25 Gene



Protein tissue co-expression partners for RNF25 Gene

NURSA nuclear receptor signaling pathways regulating expression of RNF25 Gene:

RNF25

SOURCE GeneReport for Unigene cluster for RNF25 Gene:

Hs.471403

Evidence on tissue expression from TISSUES for RNF25 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with RNF25: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RNF25 Gene

Orthologs for RNF25 Gene

This gene was present in the common ancestor of animals.

Orthologs for RNF25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RNF25 33 34
  • 98.91 (n)
dog
(Canis familiaris)
Mammalia RNF25 33 34
  • 90.05 (n)
cow
(Bos Taurus)
Mammalia RNF25 33 34
  • 86.46 (n)
rat
(Rattus norvegicus)
Mammalia Rnf25 33
  • 84.88 (n)
mouse
(Mus musculus)
Mammalia Rnf25 33 16 34
  • 84.58 (n)
oppossum
(Monodelphis domestica)
Mammalia RNF25 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves RNF25 33 34
  • 57.96 (n)
lizard
(Anolis carolinensis)
Reptilia RNF25 34
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rnf25 33
  • 56.6 (n)
Str.14059 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.25335 33
zebrafish
(Danio rerio)
Actinopterygii rnf25 34
  • 31 (a)
OneToOne
-- 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9261 33
fruit fly
(Drosophila melanogaster)
Insecta CG13344 34 35
  • 31 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y53G8AR.5 34
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8459 34
  • 29 (a)
OneToOne
Species where no ortholog for RNF25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RNF25 Gene

ENSEMBL:
Gene Tree for RNF25 (if available)
TreeFam:
Gene Tree for RNF25 (if available)

Paralogs for RNF25 Gene

No data available for Paralogs for RNF25 Gene

Variants for RNF25 Gene

Sequence variations from dbSNP and Humsavar for RNF25 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1057516786 Likely pathogenic 218,663,370(+) TGCTG(-/AG)TCTCT nc-transcript-variant, downstream-variant-500B, reference, frameshift-variant
rs1000024451 -- 218,665,470(+) GGCAC(A/G)GTGGC intron-variant
rs1000055970 -- 218,669,337(+) GATAA(C/T)AACAC intron-variant
rs1000621972 -- 218,667,263(+) AGTTT(-/TC)TGTGT intron-variant
rs1000909845 -- 218,666,822(+) TCTCT(C/T)TGACT intron-variant

Variation tolerance for RNF25 Gene

Residual Variation Intolerance Score: 89.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.91; 48.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RNF25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RNF25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RNF25 Gene

Disorders for RNF25 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RNF25 Gene - From: DISEASES

Disorder Aliases PubMed IDs
congenital epulis
  • congenital epulides
- elite association - COSMIC cancer census association via MalaCards
Search RNF25 in MalaCards View complete list of genes associated with diseases

Relevant External Links for RNF25

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RNF25
genes like me logo Genes that share disorders with RNF25: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RNF25 Gene

Publications for RNF25 Gene

  1. RING finger protein AO7 supports NF-kappaB-mediated transcription by interacting with the transactivation domain of the p65 subunit. (PMID: 12748188) Asamitsu K … Okamoto T (The Journal of biological chemistry 2003) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. (PMID: 10500182) Lorick KL … Weissman AM (Proceedings of the National Academy of Sciences of the United States of America 1999) 3 22 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for RNF25 Gene

Sources for RNF25 Gene

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