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Aliases for SFRP5 Gene

Aliases for SFRP5 Gene

  • Secreted Frizzled-Related Protein 5 2 3
  • SARP3 3 4 6
  • Secreted Apoptosis Related Protein 3 2 3
  • Secreted Apoptosis-Related Protein 3 3 4
  • Frizzled-Related Protein 1b 3 4
  • FRP-1b 3 4
  • SARP-3 3 4
  • SFRP-5 3 4
  • FRP1B 4

External Ids for SFRP5 Gene

Summaries for SFRP5 Gene

Entrez Gene Summary for SFRP5 Gene

  • Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas. [provided by RefSeq, Jul 2008]

GeneCards Summary for SFRP5 Gene

SFRP5 (Secreted Frizzled-Related Protein 5) is a Protein Coding gene. Among its related pathways are Wnt signaling pathway (KEGG) and Non-Canonical Wnt Pathway. GO annotations related to this gene include PDZ domain binding and Wnt-activated receptor activity. An important paralog of this gene is FZD10.

UniProtKB/Swiss-Prot for SFRP5 Gene

  • Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina

Gene Wiki entry for SFRP5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFRP5 Gene

Genomics for SFRP5 Gene

Genomic Location for SFRP5 Gene

Start:
97,766,751 bp from pter
End:
97,771,999 bp from pter
Size:
5,249 bases
Orientation:
Minus strand

Genomic View for SFRP5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SFRP5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFRP5 Gene

Regulatory Elements for SFRP5 Gene

Proteins for SFRP5 Gene

  • Protein details for SFRP5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T4F7-SFRP5_HUMAN
    Recommended name:
    Secreted frizzled-related protein 5
    Protein Accession:
    Q5T4F7
    Secondary Accessions:
    • O14780
    • Q86TH7

    Protein attributes for SFRP5 Gene

    Size:
    317 amino acids
    Molecular mass:
    35563 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SFRP5 Gene

Proteomics data for SFRP5 Gene at MOPED

Post-translational modifications for SFRP5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SFRP5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SFRP5 Gene

Domains for SFRP5 Gene

Gene Families for SFRP5 Gene

HGNC:
  • SFRP :Secreted frizzled-related proteins

Protein Domains for SFRP5 Gene

UniProtKB/Swiss-Prot:

SFRP5_HUMAN
Domain:
  • The FZ domain is involved in binding with Wnt ligands.:
    • Q5T4F7
  • Contains 1 FZ (frizzled) domain.:
    • Q5T4F7
  • Contains 1 NTR domain.:
    • Q5T4F7
Family:
  • Belongs to the secreted frizzled-related protein (sFRP) family.:
    • Q5T4F7
genes like me logo Genes that share domains with SFRP5: view

Function for SFRP5 Gene

Molecular function for SFRP5 Gene

GENATLAS Biochemistry: Drosophila frizzled polarity homolog,secreted related protein 5,mouse sfrp 5 homolog,likely involved in WNT binding and signal transduction,expressed in the retinal epithelium and pancreas
UniProtKB/Swiss-Prot Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina

Gene Ontology (GO) - Molecular Function for SFRP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 NOT G-protein coupled receptor activity IBA --
GO:0005515 protein binding --
GO:0017147 Wnt-protein binding IBA --
GO:0030165 PDZ domain binding --
GO:0042813 NOT Wnt-activated receptor activity IBA --
genes like me logo Genes that share ontologies with SFRP5: view
genes like me logo Genes that share phenotypes with SFRP5: view

Animal Models for SFRP5 Gene

MGI Knock Outs for SFRP5:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for SFRP5 Gene

Localization for SFRP5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFRP5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SFRP5 Gene COMPARTMENTS Subcellular localization image for SFRP5 gene
Compartment Confidence
extracellular 4
plasma membrane 3
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for SFRP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space TAS 10072424
GO:0005737 cytoplasm --
GO:0005886 plasma membrane --
GO:0016021 NOT integral component of membrane IBA --
genes like me logo Genes that share ontologies with SFRP5: view

Pathways for SFRP5 Gene

genes like me logo Genes that share pathways with SFRP5: view

Pathways by source for SFRP5 Gene

1 Sino Biological pathway for SFRP5 Gene
1 KEGG pathway for SFRP5 Gene

Gene Ontology (GO) - Biological Process for SFRP5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001944 vasculature development --
GO:0006915 apoptotic process TAS 9391078
GO:0007163 establishment or maintenance of cell polarity TAS 10072424
GO:0007165 signal transduction TAS 10072424
GO:0007420 brain development --
genes like me logo Genes that share ontologies with SFRP5: view

Compounds for SFRP5 Gene

(1) PharmGKB related drug/compound annotations for SFRP5 Gene

Drug/compound Annotation
Bisphosphonates CA
genes like me logo Genes that share compounds with SFRP5: view

Transcripts for SFRP5 Gene

mRNA/cDNA for SFRP5 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(30) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SFRP5 Gene

Secreted frizzled-related protein 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SFRP5 Gene

No ASD Table

Relevant External Links for SFRP5 Gene

GeneLoc Exon Structure for
SFRP5
ECgene alternative splicing isoforms for
SFRP5

Expression for SFRP5 Gene

mRNA expression in normal human tissues for SFRP5 Gene

mRNA differential expression in normal tissues according to GTEx for SFRP5 Gene

This gene is overexpressed in Nerve - Tibial (18.7), Pancreas (10.7), and Heart - Atrial Appendage (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SFRP5 Gene

SOURCE GeneReport for Unigene cluster for SFRP5 Gene Hs.279565

mRNA Expression by UniProt/SwissProt for SFRP5 Gene

Q5T4F7-SFRP5_HUMAN
Tissue specificity: Highly expressed in the retinal pigment epithelium (RPE) and pancreas. Weak expression in heart, liver and muscle.
genes like me logo Genes that share expressions with SFRP5: view

Orthologs for SFRP5 Gene

This gene was present in the common ancestor of animals.

Orthologs for SFRP5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SFRP5 36
  • 95.09 (n)
  • 98.63 (a)
SFRP5 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SFRP5 36
  • 94.2 (n)
  • 97.56 (a)
SFRP5 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sfrp5 36
  • 92.01 (n)
  • 96.23 (a)
Sfrp5 16
Sfrp5 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SFRP5 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SFRP5 37
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sfrp5 36
  • 91.08 (n)
  • 95.22 (a)
chicken
(Gallus gallus)
Aves SFRP5 36
  • 78.78 (n)
  • 74.39 (a)
SFRP5 37
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SFRP5 37
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.21815 36
tropical clawed frog
(Silurana tropicalis)
Amphibia sfrp5 36
  • 69.82 (n)
  • 72 (a)
zebrafish
(Danio rerio)
Actinopterygii sfrp5 36
  • 72.12 (n)
  • 67.97 (a)
sfrp5 37
  • 63 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea sfrp-1 37
  • 33 (a)
OneToMany
Y73B6BL.21 38
  • 38 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5649 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8698 37
  • 37 (a)
OneToMany
Species with no ortholog for SFRP5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SFRP5 Gene

ENSEMBL:
Gene Tree for SFRP5 (if available)
TreeFam:
Gene Tree for SFRP5 (if available)

Paralogs for SFRP5 Gene

Paralogs for SFRP5 Gene

Selected SIMAP similar genes for SFRP5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SFRP5: view

Variants for SFRP5 Gene

Sequence variations from dbSNP and Humsavar for SFRP5 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1556971 -- 97,768,089(-) CCTCA(A/T)TTCCC intron-variant
rs1934562 -- 97,773,887(-) CCATC(A/G)TCTGC upstream-variant-2KB
rs2039826 -- 97,766,911(-) GCCCG(C/T)GGCTC utr-variant-3-prime
rs2185365 -- 97,766,750(-) AATAA(C/T)TGGTT downstream-variant-500B
rs4244330 -- 97,771,094(+) AGCCG(A/C)CGGGA intron-variant

Relevant External Links for SFRP5 Gene

HapMap Linkage Disequilibrium report
SFRP5

No data available for Structural Variations from Database of Genomic Variants (DGV) for SFRP5 Gene

Disorders for SFRP5 Gene

(3) Novoseek inferred disease relationships for SFRP5 Gene

Disease -log(P) Hits PubMed IDs
gastric cancer 29.3 5
cancer 29.2 1
tumors 27.7 1

Relevant External Links for SFRP5

Genetic Association Database (GAD)
SFRP5
Human Genome Epidemiology (HuGE) Navigator
SFRP5
genes like me logo Genes that share disorders with SFRP5: view

No data available for UniProtKB/Swiss-Prot for SFRP5 Gene

Publications for SFRP5 Gene

  1. SARPs: a family of secreted apoptosis-related proteins. (PMID: 9391078) Melkonyan H.S. … Umansky S.R. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4
  2. Tissue restricted expression of two human Frzbs in preadipocytes and pancreas. (PMID: 9642118) Hu E. … Brooks D. (Biochem. Biophys. Res. Commun. 1998) 3 4
  3. Cloning and characterization of a secreted frizzled-related protein that is expressed by the retinal pigment epithelium. (PMID: 10072424) Chang J.T. … Zack D.J. (Hum. Mol. Genet. 1999) 3 4
  4. Sfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and noncanonical Wnt11 signaling. (PMID: 18981481) Li Y. … Zorn A.M. (Genes Dev. 2008) 3 23
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4

Products for SFRP5 Gene

Sources for SFRP5 Gene

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