Aliases for SFRP5 Gene
External Ids for SFRP5 Gene
Previous GeneCards Identifiers for SFRP5 Gene
Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas. [provided by RefSeq, Jul 2008]
GeneCards Summary for SFRP5 Gene
SFRP5 (Secreted Frizzled-Related Protein 5) is a Protein Coding gene. Diseases associated with SFRP5 include esophageal basaloid squamous cell carcinoma. Among its related pathways are Wnt signaling pathway (KEGG) and Wnt Signaling Pathways: beta-Catenin-independent Wnt/PCP Signaling Pathways. GO annotations related to this gene include G-protein coupled receptor activity and Wnt-protein binding. An important paralog of this gene is FZD10.
UniProtKB/Swiss-Prot for SFRP5 Gene
Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina.