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Aliases for PDLIM2 Gene

Aliases for PDLIM2 Gene

  • PDZ And LIM Domain 2 (Mystique) 2 3
  • MYSTIQUE 3 6
  • PDZ And LIM Domain Protein 2 3
  • PDZ-LIM Protein Mystique 4
  • Slim 3

External Ids for PDLIM2 Gene

Previous GeneCards Identifiers for PDLIM2 Gene

  • GC00U990854
  • GC08P022788
  • GC08P022256
  • GC08P022458
  • GC08P022492
  • GC08P022435
  • GC08P020978

Summaries for PDLIM2 Gene

Entrez Gene Summary for PDLIM2 Gene

  • This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for PDLIM2 Gene

PDLIM2 (PDZ And LIM Domain 2 (Mystique)) is a Protein Coding gene. Diseases associated with PDLIM2 include adult t-cell leukemia and t-cell leukemia. Among its related pathways are Cytoskeletal Signaling and Protein Stability. GO annotations related to this gene include muscle alpha-actinin binding and myosin heavy chain binding. An important paralog of this gene is PDLIM4.

UniProtKB/Swiss-Prot for PDLIM2 Gene

  • Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity.

Gene Wiki entry for PDLIM2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PDLIM2 Gene

Genomics for PDLIM2 Gene

Regulatory Elements for PDLIM2 Gene

Genomic Location for PDLIM2 Gene

Start:
22,578,279 bp from pter
End:
22,598,025 bp from pter
Size:
19,747 bases
Orientation:
Plus strand

Genomic View for PDLIM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PDLIM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PDLIM2 Gene

Proteins for PDLIM2 Gene

  • Protein details for PDLIM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JY6-PDLI2_HUMAN
    Recommended name:
    PDZ and LIM domain protein 2
    Protein Accession:
    Q96JY6
    Secondary Accessions:
    • D3DSR5
    • J3KNH4
    • Q7Z584
    • Q86WM8
    • Q8WZ29
    • Q9H4L9
    • Q9H7I2

    Protein attributes for PDLIM2 Gene

    Size:
    352 amino acids
    Molecular mass:
    37459 Da
    Quaternary structure:
    • Interacts with alpha-actinins ACTN1 and ACTN4, FLNA and MYH9.
    SequenceCaution:
    • Sequence=AAG16633.1; Type=Frameshift; Positions=131; Evidence={ECO:0000305}; Sequence=AAL55747.1; Type=Frameshift; Positions=42, 207; Evidence={ECO:0000305}; Sequence=AAL65265.1; Type=Frameshift; Positions=237; Evidence={ECO:0000305}; Sequence=BAB15788.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PDLIM2 Gene

    Alternative splice isoforms for PDLIM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PDLIM2 Gene

Proteomics data for PDLIM2 Gene at MOPED

Post-translational modifications for PDLIM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PDLIM2 (PDLIM2)

No data available for DME Specific Peptides for PDLIM2 Gene

Domains for PDLIM2 Gene

Protein Domains for PDLIM2 Gene

Suggested Antigen Peptide Sequences for PDLIM2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96JY6

UniProtKB/Swiss-Prot:

PDLI2_HUMAN :
  • Q96JY6
Domain:
  • Contains 1 LIM zinc-binding domain.
  • Contains 1 PDZ (DHR) domain.
genes like me logo Genes that share domains with PDLIM2: view

No data available for Gene Families for PDLIM2 Gene

Function for PDLIM2 Gene

Molecular function for PDLIM2 Gene

UniProtKB/Swiss-Prot Function: Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity.

Gene Ontology (GO) - Molecular Function for PDLIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0031005 filamin binding IEA --
GO:0032036 myosin heavy chain binding IEA --
GO:0051371 muscle alpha-actinin binding IEA --
genes like me logo Genes that share ontologies with PDLIM2: view

Phenotypes for PDLIM2 Gene

genes like me logo Genes that share phenotypes with PDLIM2: view

Animal Models for PDLIM2 Gene

MGI Knock Outs for PDLIM2:

Animal Model Products

CRISPR Products

miRNA for PDLIM2 Gene

miRTarBase miRNAs that target PDLIM2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PDLIM2 Gene

Localization for PDLIM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PDLIM2 Gene

Cytoplasm. Nucleus. Note=May be partially nuclear.
Isoform 1: Cytoplasm, cytoskeleton. Note=Colocalizes with beta-1 integrin (ITGB1) and alpha-actinin but not with paxillin (PXN).
Isoform 2: Cytoplasm, cytoskeleton.
Isoform 3: Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PDLIM2 Gene COMPARTMENTS Subcellular localization image for PDLIM2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for PDLIM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
GO:0005925 focal adhesion IDA --
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with PDLIM2: view

Pathways for PDLIM2 Gene

genes like me logo Genes that share pathways with PDLIM2: view

Pathways by source for PDLIM2 Gene

3 Cell Signaling Technology pathways for PDLIM2 Gene
1 GeneGo (Thomson Reuters) pathway for PDLIM2 Gene

Gene Ontology (GO) - Biological Process for PDLIM2 Gene

None

Transcripts for PDLIM2 Gene

Unigene Clusters for PDLIM2 Gene

PDZ and LIM domain 2 (mystique):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PDLIM2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PDLIM2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b · 15c · 15d · 15e ^ 16
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - - - - - -
SP6: - - -
SP7: - - - -
SP8: - - - -
SP9: - - -
SP10: - -
SP11: - - - - - - - -
SP12:

Relevant External Links for PDLIM2 Gene

GeneLoc Exon Structure for
PDLIM2
ECgene alternative splicing isoforms for
PDLIM2

Expression for PDLIM2 Gene

mRNA expression in normal human tissues for PDLIM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PDLIM2 Gene

This gene is overexpressed in Spleen (8.3) and Whole Blood (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PDLIM2 Gene

SOURCE GeneReport for Unigene cluster for PDLIM2 Gene Hs.632034

genes like me logo Genes that share expressions with PDLIM2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PDLIM2 Gene

Orthologs for PDLIM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PDLIM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PDLIM2 35
  • 99.45 (n)
  • 99.34 (a)
PDLIM2 36
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PDLIM2 35
  • 82.75 (n)
  • 82.46 (a)
PDLIM2 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PDLIM2 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pdlim2 35
  • 79.15 (n)
  • 79.54 (a)
Pdlim2 16
Pdlim2 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PDLIM2 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PDLIM2 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pdlim2 35
  • 78.48 (n)
  • 78.1 (a)
lizard
(Anolis carolinensis)
Reptilia PDLIM2 36
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii pdlim2 35
  • 50.74 (n)
  • 44.81 (a)
pdlim2 36
  • 43 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3932 36
  • 24 (a)
OneToOne
Species with no ortholog for PDLIM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PDLIM2 Gene

ENSEMBL:
Gene Tree for PDLIM2 (if available)
TreeFam:
Gene Tree for PDLIM2 (if available)

Paralogs for PDLIM2 Gene

Paralogs for PDLIM2 Gene

Selected SIMAP similar genes for PDLIM2 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for PDLIM2 Gene

genes like me logo Genes that share paralogs with PDLIM2: view

Variants for PDLIM2 Gene

Sequence variations from dbSNP and Humsavar for PDLIM2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs3064 -- 22,594,175(-) ACCCT(C/G)GCACA utr-variant-3-prime, intron-variant
rs755244 -- 22,582,224(+) CACCT(C/T)TTGCA intron-variant
rs922810 -- 22,580,800(+) GGAGC(C/T)AGGGA intron-variant
rs1038310 -- 22,586,616(-) CAAAG(C/G)TTCCC intron-variant
rs1482335 -- 22,580,043(+) CGGCC(A/T)CACCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PDLIM2 Gene

Variant ID Type Subtype PubMed ID
essv19243 CNV CNV 17122850
essv21913 CNV CNV 17122850
nsv890673 CNV Loss 21882294
dgv7762n71 CNV Loss 21882294
esv2736748 CNV Deletion 23290073

Relevant External Links for PDLIM2 Gene

HapMap Linkage Disequilibrium report
PDLIM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PDLIM2 Gene

Disorders for PDLIM2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for PDLIM2 Gene including...

Search for PDLIM2 Gene in MalaCards »
genes like me logo Genes that share disorders with PDLIM2: view

No data available for UniProtKB/Swiss-Prot for PDLIM2 Gene

Publications for PDLIM2 Gene

  1. Mystique is a new IGF-I regulated PDZ-LIM domain protein that promotes cell attachment and migration and suppresses anchorage independent growth. (PMID: 15659642) Loughran G. … O'connor R. (Mol. Biol. Cell 2005) 3 4 23
  2. Human T-cell leukemia virus type I-mediated repression of PDZ-LIM domain-containing protein 2 involves DNA methylation but independent of the viral oncoprotein tax. (PMID: 19794962) Yan P. … Xiao G. (Neoplasia 2009) 3 23
  3. Epigenetic repression of PDZ-LIM domain-containing protein 2: implications for the biology and treatment of breast cancer. (PMID: 20185823) Qu Z. … Xiao G. (J. Biol. Chem. 2010) 3 23
  4. Characterization of long cDNA clones from human adult spleen. (PMID: 11214971) Hattori A. … Ohara O. (DNA Res. 2000) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for PDLIM2 Gene

  • antibodies-online proteins for PDLIM2
  • antibodies-online antibodies for PDLIM2
  • antibodies-online kits for PDLIM2

Sources for PDLIM2 Gene

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