Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SFRP2 Gene

Aliases for SFRP2 Gene

  • Secreted Frizzled-Related Protein 2 2 3
  • SARP1 3 4 6
  • Secreted Apoptosis-Related Protein 1 3 4
  • SARP-1 3 4
  • SFRP-2 3 4
  • FRP-2 3 4
  • Secreted Apoptosis Related Protein 1 3
  • SDF-5 3
  • FRP2 4

External Ids for SFRP2 Gene

Previous GeneCards Identifiers for SFRP2 Gene

  • GC04M155550
  • GC04M155090
  • GC04M155279
  • GC04M155059
  • GC04M154921
  • GC04M154701
  • GC04M150432

Summaries for SFRP2 Gene

Entrez Gene Summary for SFRP2 Gene

  • This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq, Jul 2008]

GeneCards Summary for SFRP2 Gene

SFRP2 (Secreted Frizzled-Related Protein 2) is a Protein Coding gene. Diseases associated with SFRP2 include synpolydactyly and colorectal cancer. Among its related pathways are Wnt signaling pathway (KEGG) and Wnt signaling pathway (KEGG). GO annotations related to this gene include integrin binding and Wnt-protein binding. An important paralog of this gene is FZD10.

UniProtKB/Swiss-Prot for SFRP2 Gene

  • Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis

Gene Wiki entry for SFRP2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFRP2 Gene

Genomics for SFRP2 Gene

Regulatory Elements for SFRP2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SFRP2 Gene

Start:
153,780,590 bp from pter
End:
153,789,120 bp from pter
Size:
8,531 bases
Orientation:
Minus strand

Genomic View for SFRP2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SFRP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFRP2 Gene

Proteins for SFRP2 Gene

  • Protein details for SFRP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HF1-SFRP2_HUMAN
    Recommended name:
    Secreted frizzled-related protein 2
    Protein Accession:
    Q96HF1
    Secondary Accessions:
    • B3KQR2
    • O14778
    • Q9HAP5

    Protein attributes for SFRP2 Gene

    Size:
    295 amino acids
    Molecular mass:
    33490 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SFRP2 Gene

Proteomics data for SFRP2 Gene at MOPED

Post-translational modifications for SFRP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SFRP2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Protein Products

  • Novus Biologicals lysates for SFRP2

No data available for DME Specific Peptides for SFRP2 Gene

Domains for SFRP2 Gene

Gene Families for SFRP2 Gene

HGNC:
  • SFRP :Secreted frizzled-related proteins

Protein Domains for SFRP2 Gene

Suggested Antigen Peptide Sequences for SFRP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96HF1

UniProtKB/Swiss-Prot:

SFRP2_HUMAN :
  • Q96HF1
Domain:
  • The FZ domain is involved in binding with Wnt ligands.
  • Contains 1 FZ (frizzled) domain.
  • Contains 1 NTR domain.
Family:
  • Belongs to the secreted frizzled-related protein (sFRP) family.
genes like me logo Genes that share domains with SFRP2: view

Function for SFRP2 Gene

Molecular function for SFRP2 Gene

GENATLAS Biochemistry: Drosophila frizzled polarity homolog,secreted related protein 2,mouse sfrp 2 homolog,likely involved in WNT binding and signal transduction,expressed in inner nuclear layer of the retina
UniProtKB/Swiss-Prot Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis

Gene Ontology (GO) - Molecular Function for SFRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001968 fibronectin binding ISS --
GO:0004930 NOT G-protein coupled receptor activity IBA --
GO:0005178 integrin binding ISS --
GO:0005515 protein binding --
GO:0010577 metalloenzyme activator activity IEA --
genes like me logo Genes that share ontologies with SFRP2: view
genes like me logo Genes that share phenotypes with SFRP2: view

Animal Models for SFRP2 Gene

MGI Knock Outs for SFRP2:

Animal Model Products

CRISPR Products

miRNA for SFRP2 Gene

miRTarBase miRNAs that target SFRP2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SFRP2 Gene

Localization for SFRP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFRP2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SFRP2 Gene COMPARTMENTS Subcellular localization image for SFRP2 gene
Compartment Confidence
extracellular 5
plasma membrane 3
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for SFRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space ISS --
GO:0005737 cytoplasm --
GO:0005886 plasma membrane --
GO:0016021 NOT integral component of membrane IBA --
GO:0031012 extracellular matrix ISS --
genes like me logo Genes that share ontologies with SFRP2: view

Pathways for SFRP2 Gene

genes like me logo Genes that share pathways with SFRP2: view

Pathways by source for SFRP2 Gene

2 Sino Biological pathways for SFRP2 Gene
1 BioSystems pathway for SFRP2 Gene
1 KEGG pathway for SFRP2 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for SFRP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001569 patterning of blood vessels ISS --
GO:0001756 somitogenesis --
GO:0001843 neural tube closure IEA --
GO:0001944 vasculature development --
GO:0002063 chondrocyte development IEA --
genes like me logo Genes that share ontologies with SFRP2: view

Transcripts for SFRP2 Gene

mRNA/cDNA for SFRP2 Gene

(292) Selected AceView cDNA sequences:
(6) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SFRP2 Gene

Secreted frizzled-related protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SFRP2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SFRP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4
SP1:
SP2:

Relevant External Links for SFRP2 Gene

GeneLoc Exon Structure for
SFRP2
ECgene alternative splicing isoforms for
SFRP2

Expression for SFRP2 Gene

mRNA expression in normal human tissues for SFRP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SFRP2 Gene

This gene is overexpressed in Artery - Tibial (8.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SFRP2 Gene

SOURCE GeneReport for Unigene cluster for SFRP2 Gene Hs.481022

mRNA Expression by UniProt/SwissProt for SFRP2 Gene

Q96HF1-SFRP2_HUMAN
Tissue specificity: Expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in adipose tissue, small intestine and colon.
genes like me logo Genes that share expressions with SFRP2: view

In Situ Assay Products

Orthologs for SFRP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for SFRP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SFRP2 35
  • 99.44 (n)
  • 100 (a)
SFRP2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SFRP2 35
  • 94.1 (n)
  • 96.6 (a)
SFRP2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SFRP2 35
  • 95.01 (n)
  • 98.3 (a)
SFRP2 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sfrp2 35
  • 93.79 (n)
  • 97.97 (a)
Sfrp2 16
Sfrp2 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SFRP2 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SFRP2 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sfrp2 35
  • 93.9 (n)
  • 97.63 (a)
chicken
(Gallus gallus)
Aves SFRP2 35
  • 79.84 (n)
  • 81.1 (a)
SFRP2 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SFRP2 36
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia sfrp2-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75789 35
sfrp2 35
  • 78.94 (n)
  • 83.68 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6215 35
zebrafish
(Danio rerio)
Actinopterygii sfrp2 35
  • 70.96 (n)
  • 72.82 (a)
sfrp2 36
  • 72 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea sfrp-1 35
  • 47 (n)
  • 41 (a)
sfrp-1 36
  • 31 (a)
OneToMany
Y73B6BL.21 37
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToOne
Species with no ortholog for SFRP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SFRP2 Gene

ENSEMBL:
Gene Tree for SFRP2 (if available)
TreeFam:
Gene Tree for SFRP2 (if available)

Paralogs for SFRP2 Gene

Paralogs for SFRP2 Gene

Selected SIMAP similar genes for SFRP2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with SFRP2: view

Variants for SFRP2 Gene

Sequence variations from dbSNP and Humsavar for SFRP2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs2405201 -- 153,783,978(+) AGGAG(A/G)GAGCA intron-variant
rs2405202 -- 153,783,980(+) GAGGG(A/G)GCACA intron-variant
rs2405203 -- 153,783,999(+) CACAG(A/G)CATCC intron-variant
rs2405204 -- 153,784,096(+) TGTGC(A/G)TGTTT intron-variant
rs2405205 -- 153,784,362(+) GCTCT(C/T)AGCCA intron-variant

Relevant External Links for SFRP2 Gene

HapMap Linkage Disequilibrium report
SFRP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SFRP2 Gene

Disorders for SFRP2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for SFRP2 Gene including...

Search for SFRP2 Gene in MalaCards »

(10) Novoseek inferred disease relationships for SFRP2 Gene

Disease -log(P) Hits PubMed IDs
precancerous lesions 42.3 2
myeloma 41.3 3
mammary tumor 40.5 3
retinal degeneration 38.5 1
retinitis pigmentosa 35.2 2

Relevant External Links for SFRP2

Genetic Association Database (GAD)
SFRP2
Human Genome Epidemiology (HuGE) Navigator
SFRP2
genes like me logo Genes that share disorders with SFRP2: view

No data available for UniProtKB/Swiss-Prot for SFRP2 Gene

Publications for SFRP2 Gene

  1. SARPs: a family of secreted apoptosis-related proteins. (PMID: 9391078) Melkonyan H.S. … Umansky S.R. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4
  2. Tissue restricted expression of two human Frzbs in preadipocytes and pancreas. (PMID: 9642118) Hu E. … Brooks D. (Biochem. Biophys. Res. Commun. 1998) 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae. (PMID: 19389651) Smith J.G. … Newton-Cheh C. (Heart Rhythm 2009) 3 48
  5. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PMID: 19453261) Yerges L.M. … Zmuda J.M. (J. Bone Miner. Res. 2009) 3 48

Products for SFRP2 Gene

Sources for SFRP2 Gene

Back to Top

Content