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Aliases for MLST8 Gene

Aliases for MLST8 Gene

  • MTOR Associated Protein, LST8 Homolog (S. Cerevisiae) 2 3
  • LST8 3 4 6
  • GBL 3 4 6
  • Mammalian Lethal With SEC13 Protein 8 3 4
  • TORC Subunit LST8 3 4
  • Protein GbetaL 3 4
  • Gable 3 4
  • POP3 3 6
  • WAT1 3 6
  • Target Of Rapamycin Complex Subunit LST8 3
  • G Protein Beta Subunit Like 2
  • G Protein Beta Subunit-Like 4
  • GbetaL 3
  • MLST8 4

External Ids for MLST8 Gene

Summaries for MLST8 Gene

GeneCards Summary for MLST8 Gene

MLST8 (MTOR Associated Protein, LST8 Homolog (S. Cerevisiae)) is a Protein Coding gene. Diseases associated with MLST8 include schizophrenia. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade.

UniProtKB/Swiss-Prot for MLST8 Gene

  • Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at Thr-389, which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 Ser-473 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on Thr-308 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at Ser-422. mTORC2 also modulates the phosphorylation of PRKCA on Ser-657.

Gene Wiki entry for MLST8 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MLST8 Gene

Genomics for MLST8 Gene

Genomic Location for MLST8 Gene

Start:
2,204,248 bp from pter
End:
2,209,417 bp from pter
Size:
5,170 bases
Orientation:
Plus strand

Genomic View for MLST8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MLST8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MLST8 Gene

No data available for Regulatory Elements for MLST8 Gene

Proteins for MLST8 Gene

  • Protein details for MLST8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVC4-LST8_HUMAN
    Recommended name:
    Target of rapamycin complex subunit LST8
    Protein Accession:
    Q9BVC4
    Secondary Accessions:
    • B3KMM4
    • B4DY00
    • D3DU88
    • Q5M800
    • Q86Y18
    • Q8WUI5
    • Q9HA66
    • Q9UJV6

    Protein attributes for MLST8 Gene

    Size:
    326 amino acids
    Molecular mass:
    35876 Da
    Quaternary structure:
    • Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts directly with MTOR and RPTOR. Interacts with RHEB.
    SequenceCaution:
    • Sequence=EAW85539.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MLST8 Gene

    Alternative splice isoforms for MLST8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MLST8 Gene

Proteomics data for MLST8 Gene at MOPED

Post-translational modifications for MLST8 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys86, Lys245, and Lys305

No data available for DME Specific Peptides for MLST8 Gene

Domains for MLST8 Gene

Gene Families for MLST8 Gene

HGNC:
  • WDR :WD repeat domain containing

UniProtKB/Swiss-Prot:

LST8_HUMAN
Family:
  • Belongs to the WD repeat LST8 family.:
    • Q9BVC4
Similarity:
  • Contains 7 WD repeats.:
    • Q9BVC4
genes like me logo Genes that share domains with MLST8: view

Function for MLST8 Gene

Molecular function for MLST8 Gene

UniProtKB/Swiss-Prot Function: Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at Thr-389, which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 Ser-473 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on Thr-308 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at Ser-422. mTORC2 also modulates the phosphorylation of PRKCA on Ser-657.

Gene Ontology (GO) - Molecular Function for MLST8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12408816
genes like me logo Genes that share ontologies with MLST8: view
genes like me logo Genes that share phenotypes with MLST8: view

miRNA for MLST8 Gene

miRTarBase miRNAs that target MLST8

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for MLST8 Gene

Localization for MLST8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MLST8 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MLST8 Gene COMPARTMENTS Subcellular localization image for MLST8 gene
Compartment Confidence
cytosol 4
cytoskeleton 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for MLST8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MLST8: view

Pathways for MLST8 Gene

SuperPathways for MLST8 Gene

Superpath Contained pathways
1 Insulin receptor signalling cascade
2 PI-3K cascade
3 Signaling by FGFR
4 CD28 co-stimulation
5 Downstream Signaling Events Of B Cell Receptor (BCR)
genes like me logo Genes that share pathways with MLST8: view

Gene Ontology (GO) - Biological Process for MLST8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0007050 cell cycle arrest TAS --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0008286 insulin receptor signaling pathway TAS --
GO:0008543 fibroblast growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with MLST8: view

Compounds for MLST8 Gene

(6) Novoseek inferred chemical compound relationships for MLST8 Gene

Compound -log(P) Hits PubMed IDs
adenylate 30.1 1
pge1 23.5 1
isoproterenol 19.4 1
calcium 15.8 7
atp 0 1
genes like me logo Genes that share compounds with MLST8: view

Transcripts for MLST8 Gene

Unigene Clusters for MLST8 Gene

MTOR associated protein, LST8 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MLST8 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10a · 10b · 10c ^ 11a ·
SP1: - - - - - - -
SP2: - - - -
SP3: - - - - - - - -
SP4: - - - -
SP5: - - - - - - - - -
SP6: - - - -
SP7: - -
SP8: - - - - - - - -
SP9: - - - - -
SP10: - - - -
SP11: - - - - -
SP12: - - - - -
SP13: - -
SP14: - -
SP15: - - -
SP16: - - - - - -
SP17: - - - - - - -
SP18: - -
SP19: - - - - -
SP20:
SP21: - - - -

ExUns: 11b · 11c · 11d ^ 12a · 12b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:

Relevant External Links for MLST8 Gene

GeneLoc Exon Structure for
MLST8
ECgene alternative splicing isoforms for
MLST8

Expression for MLST8 Gene

mRNA expression in normal human tissues for MLST8 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MLST8 Gene

SOURCE GeneReport for Unigene cluster for MLST8 Gene Hs.29203

mRNA Expression by UniProt/SwissProt for MLST8 Gene

Q9BVC4-LST8_HUMAN
Tissue specificity: Broadly expressed, with highest levels in skeletal muscle, heart and kidney.
genes like me logo Genes that share expressions with MLST8: view

Orthologs for MLST8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MLST8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MLST8 36
  • 99.69 (n)
  • 99.69 (a)
MLST8 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MLST8 36
  • 91.46 (n)
  • 98.75 (a)
MLST8 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MLST8 36
  • 90.39 (n)
  • 99.08 (a)
MLST8 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mlst8 36
  • 87.63 (n)
  • 97.85 (a)
Mlst8 16
Mlst8 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MLST8 37
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MLST8 37
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mlst8 36
  • 88.96 (n)
  • 97.85 (a)
chicken
(Gallus gallus)
Aves MLST8 36
  • 84.66 (n)
  • 93.87 (a)
MLST8 37
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MLST8 37
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68713 36
tropical clawed frog
(Silurana tropicalis)
Amphibia mlst8 36
  • 79.96 (n)
  • 91.1 (a)
Str.15148 36
zebrafish
(Danio rerio)
Actinopterygii -- 36
mlst8 36
  • 78.22 (n)
  • 92.33 (a)
mlst8 37
  • 92 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001036 36
  • 61.43 (n)
  • 54.18 (a)
fruit fly
(Drosophila melanogaster)
Insecta Lst8 36
  • 58.25 (n)
  • 50.82 (a)
Lst8 37
  • 48 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C10H11.8 37
  • 22 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL009C 36
  • 53.69 (n)
  • 49.33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LST8 36
  • 50.78 (n)
  • 49.66 (a)
LST8 37
  • 48 (a)
OneToOne
LST8 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D04840g 36
  • 51.45 (n)
  • 50 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G18140 36
  • 51.39 (n)
  • 47.16 (a)
rice
(Oryza sativa)
Liliopsida Os03g0681700 36
  • 52.51 (n)
  • 49.83 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04281 36
  • 52.94 (n)
  • 45.42 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pop3 36
  • 51.33 (n)
  • 47.33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 63 (a)
OneToOne
Species with no ortholog for MLST8:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MLST8 Gene

ENSEMBL:
Gene Tree for MLST8 (if available)
TreeFam:
Gene Tree for MLST8 (if available)

Paralogs for MLST8 Gene

Selected SIMAP similar genes for MLST8 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with MLST8: view

No data available for Paralogs for MLST8 Gene

Variants for MLST8 Gene

Sequence variations from dbSNP and Humsavar for MLST8 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs26860 -- 2,208,037(-) CCCAA(C/G)CAAGG intron-variant
rs26861 -- 2,207,373(-) TGCCC(A/G)CACCC intron-variant
rs26862 -- 2,207,104(+) CACCC(C/G)AACCA reference, synonymous-codon, nc-transcript-variant
rs26863 -- 2,206,460(-) GTGCT(C/G)AGGTC intron-variant
rs26864 -- 2,203,917(-) caggc(A/G)tgagc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MLST8 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
dgv2540n71 CNV Loss 21882294
dgv2544n71 CNV Loss 21882294
dgv2545n71 CNV Loss 21882294
dgv2546n71 CNV Loss 21882294
dgv2550n71 CNV Loss 21882294
nsv471072 CNV Loss 18288195
dgv2556n71 CNV Loss 21882294
dgv2557n71 CNV Loss 21882294
dgv2558n71 CNV Loss 21882294
dgv2562n71 CNV Loss 21882294
dgv2563n71 CNV Loss 21882294
nsv457351 CNV Loss 19166990
nsv905132 CNV Loss 21882294
dgv2565n71 CNV Loss 21882294
dgv2566n71 CNV Loss 21882294
nsv1711 CNV Insertion 18451855
nsv905138 CNV Loss 21882294

Relevant External Links for MLST8 Gene

HapMap Linkage Disequilibrium report
MLST8

Disorders for MLST8 Gene

(1) MalaCards Diseases for MLST8 Gene

Search for MLST8 Gene in MalaCards »

(1) Novoseek inferred disease relationships for MLST8 Gene

Disease -log(P) Hits PubMed IDs
schizophrenia 0 1

Relevant External Links for MLST8

Human Genome Epidemiology (HuGE) Navigator
MLST8
genes like me logo Genes that share disorders with MLST8: view

No data available for UniProtKB/Swiss-Prot for MLST8 Gene

Publications for MLST8 Gene

  1. Identification of Protor as a novel Rictor-binding component of mTOR complex-2. (PMID: 17461779) Pearce L.R. … Alessi D.R. (Biochem. J. 2007) 3 4
  2. Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. (PMID: 12408816) Loewith R. … Hall M.N. (Mol. Cell 2002) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  4. GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. (PMID: 12718876) Kim D.-H. … Sabatini D.M. (Mol. Cell 2003) 3 4
  5. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. (PMID: 15467718) Jacinto E. … Hall M.N. (Nat. Cell Biol. 2004) 3 4

Products for MLST8 Gene

  • Addgene plasmids for MLST8

Sources for MLST8 Gene

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