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Aliases for SFRP1 Gene

Aliases for SFRP1 Gene

  • Secreted Frizzled-Related Protein 1 2 3
  • SARP2 3 4 6
  • FRP 3 4 6
  • Secreted Apoptosis-Related Protein 2 3 4
  • SARP-2 3 4
  • SFRP-1 3 4
  • FRP-1 3 4
  • FRP1 3 4
  • FrzA 3

External Ids for SFRP1 Gene

Summaries for SFRP1 Gene

Entrez Gene Summary for SFRP1 Gene

  • This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq, Sep 2009]

GeneCards Summary for SFRP1 Gene

SFRP1 (Secreted Frizzled-Related Protein 1) is a Protein Coding gene. Diseases associated with SFRP1 include hepatocellular carcinoma. Among its related pathways are Wnt signaling pathway (KEGG) and Wnt / Hedgehog / Notch. GO annotations related to this gene include identical protein binding and PDZ domain binding. An important paralog of this gene is FZD10.

UniProtKB/Swiss-Prot for SFRP1 Gene

  • Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription.

Gene Wiki entry for SFRP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SFRP1 Gene

Genomics for SFRP1 Gene

Genomic Location for SFRP1 Gene

Start:
41,261,957 bp from pter
End:
41,309,497 bp from pter
Size:
47,541 bases
Orientation:
Minus strand

Genomic View for SFRP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SFRP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SFRP1 Gene

Regulatory Elements for SFRP1 Gene

Proteins for SFRP1 Gene

  • Protein details for SFRP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N474-SFRP1_HUMAN
    Recommended name:
    Secreted frizzled-related protein 1
    Protein Accession:
    Q8N474
    Secondary Accessions:
    • O00546
    • O14779

    Protein attributes for SFRP1 Gene

    Size:
    314 amino acids
    Molecular mass:
    35386 Da
    Quaternary structure:
    • Interacts with WNT1, WNT2 and FRZD6. Interacts with WNT4, WNT8 and MYOC (By similarity).
    Miscellaneous:
    • May have therapeutic use in cardiac surgery

neXtProt entry for SFRP1 Gene

Proteomics data for SFRP1 Gene at MOPED

Post-translational modifications for SFRP1 Gene

Other Protein References for SFRP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SFRP1 Gene

Domains for SFRP1 Gene

Gene Families for SFRP1 Gene

HGNC:
  • SFRP :Secreted frizzled-related proteins

Protein Domains for SFRP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N474

UniProtKB/Swiss-Prot:

SFRP1_HUMAN
Domain:
  • The FZ domain is involved in binding with Wnt ligands.:
    • Q8N474
  • Contains 1 FZ (frizzled) domain.:
    • Q8N474
  • Contains 1 NTR domain.:
    • Q8N474
Family:
  • Belongs to the secreted frizzled-related protein (sFRP) family.:
    • Q8N474
genes like me logo Genes that share domains with SFRP1: view

Function for SFRP1 Gene

Molecular function for SFRP1 Gene

GENATLAS Biochemistry: Drosophila frizzled polarity homolog,secreted related protein 1,mouse sfrp 1 homolog,likely involved in WNT binding and signal transduction,deleted in breast carcinomas (see TSG8D)
UniProtKB/Swiss-Prot Function: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription.
UniProtKB/Swiss-Prot Induction: Down-regulated in colorectal and breast tumors. Up-regulated in uterine leiomyomas under high estrogenic conditions. Expression, in leiomyomal cells, also increased both under hypoxic and serum deprivation conditions.

LifeMap Function Summary for SFRP1 Gene

SFRP1 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:

Gene Ontology (GO) - Molecular Function for SFRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 cysteine-type endopeptidase activity IMP 14581477
GO:0004930 NOT G-protein coupled receptor activity IBA --
GO:0005109 frizzled binding IPI 10347172
GO:0005515 protein binding IPI 10347172
GO:0008144 drug binding IDA 19072540
genes like me logo Genes that share ontologies with SFRP1: view
genes like me logo Genes that share phenotypes with SFRP1: view

Animal Models for SFRP1 Gene

MGI Knock Outs for SFRP1:

miRNA for SFRP1 Gene

miRTarBase miRNAs that target SFRP1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SFRP1 Gene

Localization for SFRP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SFRP1 Gene

Secreted. Note=Cell membrane or extracellular matrix-associated. Released by heparin-binding.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SFRP1 Gene COMPARTMENTS Subcellular localization image for SFRP1 gene
Compartment Confidence
cytosol 5
extracellular 5
plasma membrane 4
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for SFRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IDA 9192640
GO:0005615 extracellular space IDA 10980594
GO:0005622 intracellular IDA 17500071
GO:0005829 cytosol IDA 14581477
genes like me logo Genes that share ontologies with SFRP1: view

Pathways for SFRP1 Gene

genes like me logo Genes that share pathways with SFRP1: view

Pathways by source for SFRP1 Gene

2 Sino Biological pathways for SFRP1 Gene
1 Cell Signaling Technology pathway for SFRP1 Gene
1 KEGG pathway for SFRP1 Gene

Gene Ontology (GO) - Biological Process for SFRP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001649 osteoblast differentiation IEP 16149051
GO:0001657 ureteric bud development IEA --
GO:0001756 somitogenesis --
GO:0001843 neural tube closure IEA --
GO:0001944 vasculature development --
genes like me logo Genes that share ontologies with SFRP1: view

Compounds for SFRP1 Gene

(6) Novoseek inferred chemical compound relationships for SFRP1 Gene

Compound -log(P) Hits PubMed IDs
5-aza-2deoxycytidine 70.3 6
retinoic acid 17.2 2
glycogen 9.19 1
tyrosine 4.28 1
testosterone 2.87 3
genes like me logo Genes that share compounds with SFRP1: view

Transcripts for SFRP1 Gene

mRNA/cDNA for SFRP1 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(311) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SFRP1 Gene

Secreted frizzled-related protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SFRP1 Gene

No ASD Table

Relevant External Links for SFRP1 Gene

GeneLoc Exon Structure for
SFRP1
ECgene alternative splicing isoforms for
SFRP1

Expression for SFRP1 Gene

mRNA expression in normal human tissues for SFRP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SFRP1 Gene

This gene is overexpressed in Cervix - Ectocervix (4.7) and Vagina (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for SFRP1 Gene

SOURCE GeneReport for Unigene cluster for SFRP1 Gene Hs.213424

mRNA Expression by UniProt/SwissProt for SFRP1 Gene

Q8N474-SFRP1_HUMAN
Tissue specificity: Widely expressed. Absent from lung, liver and peripheral blood leukocytes. Highest levels in heart and fetal kidney. Also expressed in testis, ovary, fetal brain and lung, leiomyomal cells, myometrial cells and vascular smooth muscle cells. Expressed in foreskin fibroblasts and in keratinocytes.
genes like me logo Genes that share expressions with SFRP1: view

Orthologs for SFRP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for SFRP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SFRP1 35
  • 98.94 (n)
  • 99.36 (a)
SFRP1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SFRP1 35
  • 93.85 (n)
  • 98.23 (a)
SFRP1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SFRP1 35
  • 93.68 (n)
  • 97.58 (a)
SFRP1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sfrp1 35
  • 92.46 (n)
  • 94.9 (a)
Sfrp1 16
Sfrp1 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SFRP1 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sfrp1 35
  • 91.59 (n)
  • 93.93 (a)
chicken
(Gallus gallus)
Aves SFRP1 35
  • 84.82 (n)
  • 85.35 (a)
SFRP1 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia sfrp1-A-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia sfrp1 35
  • 71.48 (n)
  • 71.48 (a)
Str.11327 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
sfrp1a 35
  • 68.84 (n)
  • 68.2 (a)
sfrp1a 36
  • 63 (a)
OneToMany
sfrp1b 36
  • 59 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea sfrp-1 36
  • 29 (a)
OneToMany
Y73B6BL.21 37
  • 36 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8698 36
  • 36 (a)
OneToMany
Species with no ortholog for SFRP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SFRP1 Gene

ENSEMBL:
Gene Tree for SFRP1 (if available)
TreeFam:
Gene Tree for SFRP1 (if available)

Paralogs for SFRP1 Gene

Paralogs for SFRP1 Gene

Selected SIMAP similar genes for SFRP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SFRP1: view

Variants for SFRP1 Gene

Sequence variations from dbSNP and Humsavar for SFRP1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs3242 -- 41,262,035(-) CCGTA(C/T)GTGTT utr-variant-3-prime
rs12914 -- 41,262,633(-) TTACA(A/G)TAATC utr-variant-3-prime
rs13635 -- 41,264,740(-) CTAAT(A/G)ATTGG utr-variant-3-prime
rs730648 -- 41,293,133(-) AGCTG(C/T)GAGGG intron-variant
rs747417 -- 41,300,485(-) GATAC(A/C)CTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SFRP1 Gene

Variant ID Type Subtype PubMed ID
nsv890843 CNV Gain 21882294
nsv831298 CNV Gain+Loss 17160897
esv33397 CNV Loss 17666407
esv1509288 CNV Insertion 17803354

Relevant External Links for SFRP1 Gene

HapMap Linkage Disequilibrium report
SFRP1
Human Gene Mutation Database (HGMD)
SFRP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SFRP1 Gene

Disorders for SFRP1 Gene

(1) MalaCards Diseases for SFRP1 Gene

Search for SFRP1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for SFRP1 Gene

(22) Novoseek inferred disease relationships for SFRP1 Gene

Disease -log(P) Hits PubMed IDs
colorectal tumors 39.6 4
cancer 37.2 9
tumors 34.8 39
carcinoma renal cell 31.8 6
adenoma 28.5 4

Relevant External Links for SFRP1

Genetic Association Database (GAD)
SFRP1
Human Genome Epidemiology (HuGE) Navigator
SFRP1
genes like me logo Genes that share disorders with SFRP1: view

No data available for UniProtKB/Swiss-Prot for SFRP1 Gene

Publications for SFRP1 Gene

  1. Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. (PMID: 9192640) Finch P.W. … Rubin J.S. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 23
  2. Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling. (PMID: 10347172) Bafico A. … Aaronson S.A. (J. Biol. Chem. 1999) 3 4 23
  3. Disulfide bond assignments of secreted Frizzled-related protein-1 provide insights about Frizzled homology and netrin modules. (PMID: 11741940) Chong J.M. … Speicher D.W. (J. Biol. Chem. 2002) 3 4 23
  4. Association of single nucleotide polymorphisms in secreted frizzled-related protein 1 gene with bone mineral density in Japanese women. (PMID: 19702942) Ohnaka K. … Takayanagi R. (Geriatr Gerontol Int 2009) 3 23 48
  5. SARPs: a family of secreted apoptosis-related proteins. (PMID: 9391078) Melkonyan H.S. … Umansky S.R. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4

Products for SFRP1 Gene

Sources for SFRP1 Gene

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