Aliases for TFB2M Gene
External Ids for TFB2M Gene
Previous GeneCards Identifiers for TFB2M Gene
GeneCards Summary for TFB2M Gene
TFB2M (Transcription Factor B2, Mitochondrial) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Gene Expression. GO annotations related to this gene include poly(A) RNA binding and rRNA methyltransferase activity.
UniProtKB/Swiss-Prot for TFB2M Gene
S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity.