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Aliases for NCAPG Gene

Aliases for NCAPG Gene

  • Non-SMC Condensin I Complex, Subunit G 2 3
  • CAPG 3 4 6
  • Chromosome Condensation Protein G 2 3
  • Chromosome-Associated Protein G 3 4
  • Melanoma Antigen NY-MEL-3 3 4
  • Condensin Subunit CAP-G 3 4
  • XCAP-G Homolog 3 4
  • Non-SMC Condensin I Complex Subunit G 4
  • Condensin Complex Subunit 3 3
  • NY-MEL-3 3
  • NYMEL3 4
  • HCAP-G 4
  • CHCG 3
  • YCG1 3

External Ids for NCAPG Gene

Previous GeneCards Identifiers for NCAPG Gene

  • GC04P017421
  • GC04P017167

Summaries for NCAPG Gene

Entrez Gene Summary for NCAPG Gene

  • This gene encodes a subunit of the condensin complex, which is responsible for the condensation and stabilization of chromosomes during mitosis and meiosis. Phosphorylation of the encoded protein activates the condensin complex. There are pseudogenes for this gene on chromosomes 8 and 15. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for NCAPG Gene

NCAPG (Non-SMC Condensin I Complex, Subunit G) is a Protein Coding gene. Diseases associated with NCAPG include croup and melanoma. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for NCAPG Gene

  • Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

Gene Wiki entry for NCAPG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCAPG Gene

Genomics for NCAPG Gene

Regulatory Elements for NCAPG Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for NCAPG Gene

Start:
17,810,813 bp from pter
End:
17,845,719 bp from pter
Size:
34,907 bases
Orientation:
Plus strand

Genomic View for NCAPG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NCAPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCAPG Gene

Proteins for NCAPG Gene

  • Protein details for NCAPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BPX3-CND3_HUMAN
    Recommended name:
    Condensin complex subunit 3
    Protein Accession:
    Q9BPX3
    Secondary Accessions:
    • Q3MJE0
    • Q96SV9
    • Q9BUR3
    • Q9BVY1
    • Q9H914
    • Q9H9Z6
    • Q9HBI9

    Protein attributes for NCAPG Gene

    Size:
    1015 amino acids
    Molecular mass:
    114334 Da
    Quaternary structure:
    • Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG.
    Miscellaneous:
    • Overexpressed in some cancer lines and some tumor cells
    SequenceCaution:
    • Sequence=AAH00827.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14429.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB55165.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for NCAPG Gene

Proteomics data for NCAPG Gene at MOPED

Post-translational modifications for NCAPG Gene

  • Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPD2 and NCAPH subunits, activates the condensin complex and is required for chromosome condensation (By similarity).
  • Ubiquitination at Lys11, Lys235, Lys522, Lys717, and Lys852
  • Modification sites at PhosphoSitePlus

Other Protein References for NCAPG Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NCAPG Gene

Domains for NCAPG Gene

Protein Domains for NCAPG Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NCAPG Gene

Graphical View of Domain Structure for InterPro Entry

Q9BPX3

UniProtKB/Swiss-Prot:

CND3_HUMAN :
  • Q9BPX3
Family:
  • Belongs to the CND3 (condensin subunit 3) family.
Similarity:
  • Contains 10 HEAT repeats.
genes like me logo Genes that share domains with NCAPG: view

No data available for Gene Families for NCAPG Gene

Function for NCAPG Gene

Molecular function for NCAPG Gene

UniProtKB/Swiss-Prot Function: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

Gene Ontology (GO) - Molecular Function for NCAPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 12138188
genes like me logo Genes that share ontologies with NCAPG: view

Phenotypes for NCAPG Gene

GenomeRNAi human phenotypes for NCAPG:
genes like me logo Genes that share phenotypes with NCAPG: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NCAPG Gene

Localization for NCAPG Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCAPG Gene

Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensins association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCAPG Gene COMPARTMENTS Subcellular localization image for NCAPG gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 4

Gene Ontology (GO) - Cellular Components for NCAPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000793 condensed chromosome --
GO:0000796 condensin complex IDA 11136719
GO:0005634 nucleus NAS 10910072
GO:0005737 cytoplasm IDA --
GO:0005813 centrosome IDA --
genes like me logo Genes that share ontologies with NCAPG: view

Pathways for NCAPG Gene

genes like me logo Genes that share pathways with NCAPG: view

Pathways by source for NCAPG Gene

1 BioSystems pathway for NCAPG Gene
1 GeneGo (Thomson Reuters) pathway for NCAPG Gene

Gene Ontology (GO) - Biological Process for NCAPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0007076 mitotic chromosome condensation NAS 10910072
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with NCAPG: view

Transcripts for NCAPG Gene

Unigene Clusters for NCAPG Gene

Non-SMC condensin I complex, subunit G:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for NCAPG

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for NCAPG Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^
SP1: - - - -
SP2:
SP3:
SP4:
SP5:

ExUns: 21
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for NCAPG Gene

GeneLoc Exon Structure for
NCAPG
ECgene alternative splicing isoforms for
NCAPG

Expression for NCAPG Gene

mRNA expression in normal human tissues for NCAPG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NCAPG Gene

This gene is overexpressed in Testis (5.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NCAPG Gene

SOURCE GeneReport for Unigene cluster for NCAPG Gene Hs.567567

mRNA Expression by UniProt/SwissProt for NCAPG Gene

Q9BPX3-CND3_HUMAN
Tissue specificity: Highly expressed in testis.
genes like me logo Genes that share expressions with NCAPG: view

In Situ Assay Products

Orthologs for NCAPG Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NCAPG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NCAPG 35
  • 99.87 (n)
  • 99.8 (a)
NCAPG 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia HCAP-G 36
  • 89 (a)
OneToOne
NCAPG 35
  • 90.17 (n)
  • 88.46 (a)
dog
(Canis familiaris)
Mammalia NCAPG 35
  • 88.52 (n)
  • 85.98 (a)
NCAPG 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ncapg 35
  • 86.45 (n)
  • 83.07 (a)
Ncapg 16
Ncapg 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NCAPG 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NCAPG 36
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ncapg 35
  • 86.03 (n)
  • 83 (a)
chicken
(Gallus gallus)
Aves NCAPG 35
  • 70.79 (n)
  • 65.25 (a)
NCAPG 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCAPG 36
  • 60 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398088 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76110 35
ncapg 35
  • 64.65 (n)
  • 61.88 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13920 35
zebrafish
(Danio rerio)
Actinopterygii ncapg 35
  • 59.07 (n)
  • 53.2 (a)
ncapg 36
  • 52 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007568 35
  • 39.45 (n)
  • 28.89 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cap-G 35
  • 40.69 (n)
  • 27.55 (a)
Cap-G 36
  • 16 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YCG1 36
  • 20 (a)
OneToOne
YCG1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToOne
Species with no ortholog for NCAPG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NCAPG Gene

ENSEMBL:
Gene Tree for NCAPG (if available)
TreeFam:
Gene Tree for NCAPG (if available)

Paralogs for NCAPG Gene

Pseudogenes.org Pseudogenes for NCAPG Gene

genes like me logo Genes that share paralogs with NCAPG: view

No data available for Paralogs for NCAPG Gene

Variants for NCAPG Gene

Sequence variations from dbSNP and Humsavar for NCAPG Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1911606 -- 17,813,282(+) AAAAC(C/T)TAAGT intron-variant
rs1911607 -- 17,813,352(+) TGTCC(C/T)TCAGA intron-variant
rs1911608 -- 17,813,373(+) AAATC(C/T)TCAGT intron-variant
rs2286534 -- 17,840,325(-) AAAAA(A/T)TTTCA intron-variant
rs2286535 -- 17,840,225(-) TTCTG(G/T)TCAGT intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for NCAPG Gene

Variant ID Type Subtype PubMed ID
nsv878721 CNV Loss 21882294
esv2645526 CNV Deletion 19546169
nsv819190 CNV Gain 19587683
esv2425595 CNV Deletion 19546169

Relevant External Links for NCAPG Gene

HapMap Linkage Disequilibrium report
NCAPG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NCAPG Gene

Disorders for NCAPG Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for NCAPG Gene including...

Search for NCAPG Gene in MalaCards »

(1) University of Copenhagen DISEASES for NCAPG Gene

Relevant External Links for NCAPG

Genetic Association Database (GAD)
NCAPG
Human Genome Epidemiology (HuGE) Navigator
NCAPG
genes like me logo Genes that share disorders with NCAPG: view

No data available for UniProtKB/Swiss-Prot for NCAPG Gene

Publications for NCAPG Gene

  1. Serological cloning of a melanocyte rab guanosine 5'-triphosphate- binding protein and a chromosome condensation protein from a melanoma complementary DNA library. (PMID: 10910072) Jaeger D. … Chen Y.-T. (Cancer Res. 2000) 2 3 4 23
  2. Chromosome condensation by a human condensin complex in Xenopus egg extracts. (PMID: 11136719) Kimura K. … Hirano T. (J. Biol. Chem. 2001) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  5. A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. (PMID: 20189936) Okada Y. … Kamatani N. (Hum. Mol. Genet. 2010) 3 48

Products for NCAPG Gene

Sources for NCAPG Gene

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