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Aliases for NCAPG Gene

Aliases for NCAPG Gene

  • Non-SMC Condensin I Complex Subunit G 2 3 4 5
  • Non-SMC Condensin I Complex, Subunit G 2 3
  • Chromosome Condensation Protein G 2 3
  • Chromosome-Associated Protein G 3 4
  • Melanoma Antigen NY-MEL-3 3 4
  • Condensin Subunit CAP-G 3 4
  • XCAP-G Homolog 3 4
  • CAPG 3 4
  • NY-MEL-3 3
  • NYMEL3 4
  • HCAP-G 4
  • CHCG 3
  • YCG1 3

External Ids for NCAPG Gene

Previous GeneCards Identifiers for NCAPG Gene

  • GC04P017421
  • GC04P017167

Summaries for NCAPG Gene

Entrez Gene Summary for NCAPG Gene

  • This gene encodes a subunit of the condensin complex, which is responsible for the condensation and stabilization of chromosomes during mitosis and meiosis. Phosphorylation of the encoded protein activates the condensin complex. There are pseudogenes for this gene on chromosomes 8 and 15. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

GeneCards Summary for NCAPG Gene

NCAPG (Non-SMC Condensin I Complex Subunit G) is a Protein Coding gene. Among its related pathways are Aurora B signaling and Cell Cycle, Mitotic. GO annotations related to this gene include binding.

UniProtKB/Swiss-Prot for NCAPG Gene

  • Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

Gene Wiki entry for NCAPG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NCAPG Gene

Genomics for NCAPG Gene

Regulatory Elements for NCAPG Gene

Enhancers for NCAPG Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around NCAPG on UCSC Golden Path with GeneCards custom track

Promoters for NCAPG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around NCAPG on UCSC Golden Path with GeneCards custom track

Genomic Location for NCAPG Gene

Chromosome:
4
Start:
17,810,813 bp from pter
End:
17,844,865 bp from pter
Size:
34,053 bases
Orientation:
Plus strand

Genomic View for NCAPG Gene

Genes around NCAPG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NCAPG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NCAPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NCAPG Gene

Proteins for NCAPG Gene

  • Protein details for NCAPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BPX3-CND3_HUMAN
    Recommended name:
    Condensin complex subunit 3
    Protein Accession:
    Q9BPX3
    Secondary Accessions:
    • Q3MJE0
    • Q96SV9
    • Q9BUR3
    • Q9BVY1
    • Q9H914
    • Q9H9Z6
    • Q9HBI9

    Protein attributes for NCAPG Gene

    Size:
    1015 amino acids
    Molecular mass:
    114334 Da
    Quaternary structure:
    • Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG.
    Miscellaneous:
    • Overexpressed in some cancer lines and some tumor cells.
    SequenceCaution:
    • Sequence=AAH00827.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14429.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB55165.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for NCAPG Gene

Proteomics data for NCAPG Gene at MOPED

Post-translational modifications for NCAPG Gene

  • Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPD2 and NCAPH subunits, activates the condensin complex and is required for chromosome condensation (By similarity).
  • Ubiquitination at Lys 11, Lys 235, Lys 522, Lys 717, and Lys 852
  • Modification sites at PhosphoSitePlus

Other Protein References for NCAPG Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for NCAPG Gene

Domains & Families for NCAPG Gene

Protein Domains for NCAPG Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for NCAPG Gene

Graphical View of Domain Structure for InterPro Entry

Q9BPX3

UniProtKB/Swiss-Prot:

CND3_HUMAN :
  • Belongs to the CND3 (condensin subunit 3) family.
  • Contains 10 HEAT repeats.
Family:
  • Belongs to the CND3 (condensin subunit 3) family.
Similarity:
  • Contains 10 HEAT repeats.
genes like me logo Genes that share domains with NCAPG: view

No data available for Gene Families for NCAPG Gene

Function for NCAPG Gene

Molecular function for NCAPG Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

Phenotypes for NCAPG Gene

GenomeRNAi human phenotypes for NCAPG:
genes like me logo Genes that share phenotypes with NCAPG: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for NCAPG Gene

Localization for NCAPG Gene

Subcellular locations from UniProtKB/Swiss-Prot for NCAPG Gene

Nucleus. Cytoplasm. Chromosome. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensins association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NCAPG Gene COMPARTMENTS Subcellular localization image for NCAPG gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for NCAPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000796 condensin complex IEA,IDA 11136719
GO:0005634 nucleus NAS 10910072
GO:0005829 cytosol TAS --
GO:0015629 actin cytoskeleton IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with NCAPG: view

Pathways & Interactions for NCAPG Gene

genes like me logo Genes that share pathways with NCAPG: view

Pathways by source for NCAPG Gene

1 BioSystems pathway for NCAPG Gene
1 GeneGo (Thomson Reuters) pathway for NCAPG Gene

Gene Ontology (GO) - Biological Process for NCAPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with NCAPG: view

No data available for SIGNOR curated interactions for NCAPG Gene

Drugs & Compounds for NCAPG Gene

No Compound Related Data Available

Transcripts for NCAPG Gene

Unigene Clusters for NCAPG Gene

Non-SMC condensin I complex, subunit G:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NCAPG Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^
SP1: - - - -
SP2:
SP3:
SP4:
SP5:

ExUns: 21
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for NCAPG Gene

GeneLoc Exon Structure for
NCAPG
ECgene alternative splicing isoforms for
NCAPG

Expression for NCAPG Gene

mRNA expression in normal human tissues for NCAPG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for NCAPG Gene

This gene is overexpressed in Testis (x5.9).

Protein differential expression in normal tissues from HIPED for NCAPG Gene

This gene is overexpressed in Bone (38.3), Breast (8.7), and Pancreas (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for NCAPG Gene



SOURCE GeneReport for Unigene cluster for NCAPG Gene Hs.567567

mRNA Expression by UniProt/SwissProt for NCAPG Gene

Q9BPX3-CND3_HUMAN
Tissue specificity: Highly expressed in testis.
genes like me logo Genes that share expression patterns with NCAPG: view

Protein tissue co-expression partners for NCAPG Gene

- Elite partner

Primer Products

Orthologs for NCAPG Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for NCAPG Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NCAPG 35
  • 90.17 (n)
  • 88.46 (a)
HCAP-G 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NCAPG 35
  • 88.52 (n)
  • 85.98 (a)
NCAPG 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ncapg 35
  • 86.45 (n)
  • 83.07 (a)
Ncapg 16
Ncapg 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia NCAPG 35
  • 99.87 (n)
  • 99.8 (a)
NCAPG 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ncapg 35
  • 86.03 (n)
  • 83 (a)
oppossum
(Monodelphis domestica)
Mammalia NCAPG 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NCAPG 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves NCAPG 35
  • 70.79 (n)
  • 65.25 (a)
NCAPG 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NCAPG 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76110 35
ncapg 35
  • 64.65 (n)
  • 61.88 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC398088 35
zebrafish
(Danio rerio)
Actinopterygii ncapg 35
  • 59.07 (n)
  • 53.2 (a)
ncapg 36
  • 52 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13920 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007568 35
  • 39.45 (n)
  • 28.89 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cap-G 35
  • 40.69 (n)
  • 27.55 (a)
Cap-G 36
  • 16 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YCG1 36
  • 20 (a)
OneToOne
YCG1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToOne
Species with no ortholog for NCAPG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NCAPG Gene

ENSEMBL:
Gene Tree for NCAPG (if available)
TreeFam:
Gene Tree for NCAPG (if available)

Paralogs for NCAPG Gene

Pseudogenes.org Pseudogenes for NCAPG Gene

genes like me logo Genes that share paralogs with NCAPG: view

No data available for Paralogs for NCAPG Gene

Variants for NCAPG Gene

Sequence variations from dbSNP and Humsavar for NCAPG Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_036125 A colorectal cancer sample
VAR_053041 -
rs3795243 - 17,828,367(+) ACCAT(C/G)AATGG nc-transcript-variant, reference, missense
rs2286534 -- 17,840,325(-) AAAAA(A/T)TTTCA intron-variant
rs2286535 -- 17,840,225(-) TTCTG(A/C/G/T)TCAGT intron-variant, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for NCAPG Gene

Variant ID Type Subtype PubMed ID
nsv878721 CNV Loss 21882294
esv2645526 CNV Deletion 19546169
nsv819190 CNV Gain 19587683
esv2425595 CNV Deletion 19546169

Variation tolerance for NCAPG Gene

Residual Variation Intolerance Score: 24.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.86; 79.40% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for NCAPG Gene

Disorders for NCAPG Gene

Relevant External Links for NCAPG

Genetic Association Database (GAD)
NCAPG
Human Genome Epidemiology (HuGE) Navigator
NCAPG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
NCAPG

No disorders were found for NCAPG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for NCAPG Gene

Publications for NCAPG Gene

  1. Serological cloning of a melanocyte rab guanosine 5'-triphosphate- binding protein and a chromosome condensation protein from a melanoma complementary DNA library. (PMID: 10910072) Jaeger D. … Chen Y.-T. (Cancer Res. 2000) 2 3 4 23 67
  2. Chromosome condensation by a human condensin complex in Xenopus egg extracts. (PMID: 11136719) Kimura K. … Hirano T. (J. Biol. Chem. 2001) 2 3
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  4. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. (PMID: 25429064) He M. … Qi L. (Hum. Mol. Genet. 2015) 3
  5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3

Products for NCAPG Gene

Sources for NCAPG Gene

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