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Aliases for IFIH1 Gene

Aliases for IFIH1 Gene

  • Interferon Induced With Helicase C Domain 1 2 3
  • Interferon Induced, With Helicase C Domain 1 2 3 5
  • Helicard 2 3 4
  • Clinically Amyopathic Dermatomyositis Autoantigen 140 KDa 3 4
  • Melanoma Differentiation-Associated Protein 5 3 4
  • Melanoma Differentiation-Associated Gene 5 2 3
  • Murabutide Down-Regulated Protein 3 4
  • RNA Helicase-DEAD Box Protein 116 3 4
  • Helicase With 2 CARD Domains 3 4
  • RIG-I-Like Receptor 2 3 4
  • CADM-140 Autoantigen 3 4
  • MDA-5 3 4
  • RLR-2 3 4
  • MDA5 3 4
  • Interferon-Induced With Helicase C Domain Protein 1 4
  • Melanoma Differentiation Associated Protein-5 3
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 3
  • EC 3.6.4.13 4
  • IDDM19 3
  • SGMRT1 3
  • RH116 4
  • AGS7 3
  • Hlcd 3

External Ids for IFIH1 Gene

Previous GeneCards Identifiers for IFIH1 Gene

  • GC02M163327
  • GC02M162949
  • GC02M162831
  • GC02M163123
  • GC02M155005

Summaries for IFIH1 Gene

Entrez Gene Summary for IFIH1 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon and a protein kinase C-activating compound, mezerein. Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation. Genetic variation in this gene is associated with diabetes mellitus insulin-dependent type 19. [provided by RefSeq, Jul 2012]

GeneCards Summary for IFIH1 Gene

IFIH1 (Interferon Induced With Helicase C Domain 1) is a Protein Coding gene. Diseases associated with IFIH1 include Aicardi-Goutieres Syndrome 7 and Singleton-Merten Syndrome 1. Among its related pathways are RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways and NF-kappaB Signaling. GO annotations related to this gene include nucleic acid binding and hydrolase activity. An important paralog of this gene is DDX58.

UniProtKB/Swiss-Prot for IFIH1 Gene

  • Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2-O-methylation at their 5 cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines.

Gene Wiki entry for IFIH1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IFIH1 Gene

Genomics for IFIH1 Gene

Regulatory Elements for IFIH1 Gene

Enhancers for IFIH1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around IFIH1 on UCSC Golden Path with GeneCards custom track

Promoters for IFIH1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around IFIH1 on UCSC Golden Path with GeneCards custom track

Genomic Location for IFIH1 Gene

Chromosome:
2
Start:
162,267,079 bp from pter
End:
162,318,764 bp from pter
Size:
51,686 bases
Orientation:
Minus strand

Genomic View for IFIH1 Gene

Genes around IFIH1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IFIH1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IFIH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IFIH1 Gene

Proteins for IFIH1 Gene

  • Protein details for IFIH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYX4-IFIH1_HUMAN
    Recommended name:
    Interferon-induced helicase C domain-containing protein 1
    Protein Accession:
    Q9BYX4
    Secondary Accessions:
    • Q2NKL6
    • Q6DC96
    • Q86X56
    • Q96MX8
    • Q9H3G6

    Protein attributes for IFIH1 Gene

    Size:
    1025 amino acids
    Molecular mass:
    116689 Da
    Quaternary structure:
    • Monomer in the absence of ligands and homodimerizes in the presence of dsRNA ligands. Can assemble into helical or linear polymeric filaments on long dsRNA. Interacts with MAVS/IPS1. Interacts (via the CARD domains) with TKFC, the interaction is inhibited by viral infection (PubMed:17600090). Interacts with PCBP2. Interacts with NLRC5. Interacts with PIAS2-beta. Interacts with DDX60. Interacts with ANKRD17. Interacts with IKBKE (PubMed:17600090). Interacts with V protein of Simian virus 5, Human parainfluenza virus 2, Mumps virus, Sendai virus and Hendra virus. Binding to paramyxoviruses V proteins prevents IFN-beta induction, and the further establishment of an antiviral state. Interacts with herpes simplex virus 1 protein US11; this interaction prevents the interaction of MAVS/IPS1 to IFIH1.
    Miscellaneous:
    • In HIV-1 infected HeLa-CD4 cells, overexpression of IFIH1 results in a great increase in the level of secreted viral p24 protein.
    SequenceCaution:
    • Sequence=AAH78180.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB71141.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for IFIH1 Gene

    Alternative splice isoforms for IFIH1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for IFIH1 Gene

Proteomics data for IFIH1 Gene at MOPED

Post-translational modifications for IFIH1 Gene

  • During apoptosis, processed into 3 cleavage products. The helicase-containing fragment, once liberated from the CARD domains, translocate from the cytoplasm to the nucleus. The processed protein significantly sensitizes cells to DNA degradation (By similarity).
  • Sumoylated. Sumoylation positively regulates its role in type I interferon induction and is enhanced by PIAS2-beta.
  • Ubiquitinated. USP17/UPS17L2-dependent deubiquitination positively regulates the receptor.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IFIH1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for IFIH1 (IFIH1)

No data available for DME Specific Peptides for IFIH1 Gene

Domains & Families for IFIH1 Gene

Suggested Antigen Peptide Sequences for IFIH1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BYX4

UniProtKB/Swiss-Prot:

IFIH1_HUMAN :
  • Contains 2 CARD domains.
  • Belongs to the helicase family. RLR subfamily.
Domain:
  • Contains 2 CARD domains.
  • Contains 1 helicase ATP-binding domain.
  • Contains 1 helicase C-terminal domain.
  • Contains 1 RLR CTR (RLR C-terminal regulatory) domain.
Family:
  • Belongs to the helicase family. RLR subfamily.
genes like me logo Genes that share domains with IFIH1: view

Function for IFIH1 Gene

Molecular function for IFIH1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2-O-methylation at their 5 cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines.
UniProtKB/Swiss-Prot Induction:
By interferon (IFN) and TNF.

Enzyme Numbers (IUBMB) for IFIH1 Gene

Gene Ontology (GO) - Molecular Function for IFIH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003725 double-stranded RNA binding TAS 17079289
GO:0005524 ATP binding IEA --
GO:0008270 zinc ion binding IDA 19380577
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with IFIH1: view
genes like me logo Genes that share phenotypes with IFIH1: view

Human Phenotype Ontology for IFIH1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for IFIH1 Gene

MGI Knock Outs for IFIH1:

Animal Model Products

  • Taconic Biosciences Mouse Models for IFIH1

CRISPR Products

miRNA for IFIH1 Gene

No data available for Transcription Factor Targets and HOMER Transcription for IFIH1 Gene

Localization for IFIH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IFIH1 Gene

Cytoplasm. Nucleus. Note=May be found in the nucleus, during apoptosis.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for IFIH1 Gene COMPARTMENTS Subcellular localization image for IFIH1 gene
Compartment Confidence
cytosol 5
nucleus 5
endosome 2
mitochondrion 2
plasma membrane 2
cytoskeleton 1
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for IFIH1 Gene

Pathways & Interactions for IFIH1 Gene

genes like me logo Genes that share pathways with IFIH1: view

Gene Ontology (GO) - Biological Process for IFIH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009597 detection of virus TAS 17079289
GO:0032480 negative regulation of type I interferon production TAS --
GO:0032727 positive regulation of interferon-alpha production TAS 17079289
GO:0032728 positive regulation of interferon-beta production TAS 17079289
GO:0034344 regulation of type III interferon production TAS 21616437
genes like me logo Genes that share ontologies with IFIH1: view

No data available for SIGNOR curated interactions for IFIH1 Gene

Drugs & Compounds for IFIH1 Gene

(1) Drugs for IFIH1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(5) Additional Compounds for IFIH1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with IFIH1: view

Transcripts for IFIH1 Gene

Unigene Clusters for IFIH1 Gene

Interferon induced with helicase C domain 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for IFIH1 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17a ·
SP1: - - - -
SP2:
SP3: -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:

ExUns: 17b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for IFIH1 Gene

GeneLoc Exon Structure for
IFIH1
ECgene alternative splicing isoforms for
IFIH1

Expression for IFIH1 Gene

mRNA expression in normal human tissues for IFIH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for IFIH1 Gene

This gene is overexpressed in Bone (21.6), Frontal cortex (15.8), Pancreas (14.7), and Esophagus (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for IFIH1 Gene



SOURCE GeneReport for Unigene cluster for IFIH1 Gene Hs.163173

mRNA Expression by UniProt/SwissProt for IFIH1 Gene

Q9BYX4-IFIH1_HUMAN
Tissue specificity: Widely expressed, at a low level. Expression is detected at slightly highest levels in placenta, pancreas and spleen and at barely levels in detectable brain, testis and lung.
genes like me logo Genes that share expression patterns with IFIH1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for IFIH1 Gene

Orthologs for IFIH1 Gene

This gene was present in the common ancestor of animals.

Orthologs for IFIH1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia IFIH1 35
  • 87.46 (n)
  • 83.89 (a)
IFIH1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia IFIH1 35
  • 86.99 (n)
  • 82.94 (a)
IFIH1 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ifih1 35
  • 81.18 (n)
  • 79.69 (a)
Ifih1 16
Ifih1 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia IFIH1 35
  • 97.57 (n)
  • 96.75 (a)
IFIH1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ifih1 35
  • 80.78 (n)
  • 79.61 (a)
oppossum
(Monodelphis domestica)
Mammalia IFIH1 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia IFIH1 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves IFIH1 35
  • 68.22 (n)
  • 63.32 (a)
IFIH1 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia IFIH1 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ifih1 35
  • 61.16 (n)
  • 56.31 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC565759 35
  • 57.07 (n)
  • 52.71 (a)
ifih1 36
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Dcr-2 36
  • 7 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea drh-1 36
  • 21 (a)
ManyToMany
drh-3 36
  • 19 (a)
ManyToMany
Species with no ortholog for IFIH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for IFIH1 Gene

ENSEMBL:
Gene Tree for IFIH1 (if available)
TreeFam:
Gene Tree for IFIH1 (if available)

Paralogs for IFIH1 Gene

Paralogs for IFIH1 Gene

(2) SIMAP similar genes for IFIH1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for IFIH1 Gene

genes like me logo Genes that share paralogs with IFIH1: view

Variants for IFIH1 Gene

Sequence variations from dbSNP and Humsavar for IFIH1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs3747517 - 162,272,314(-) CGAAC(A/G)TGAGA reference, missense
rs1990760 - 162,267,541(+) CAGTG(C/T)TTTGT reference, missense
rs10930046 - 162,281,473(+) AATAA(C/T)GCCTC reference, missense
VAR_071375 Aicardi-Goutieres syndrome 7 (AGS7)
VAR_071376 Aicardi-Goutieres syndrome 7 (AGS7)

Structural Variations from Database of Genomic Variants (DGV) for IFIH1 Gene

Variant ID Type Subtype PubMed ID
nsv834440 CNV Gain 17160897
dgv4353n71 CNV Loss 21882294
nsv875354 CNV Loss 21882294

Variation tolerance for IFIH1 Gene

Residual Variation Intolerance Score: 93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.41; 95.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for IFIH1 Gene

Human Gene Mutation Database (HGMD)
IFIH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IFIH1 Gene

Disorders for IFIH1 Gene

MalaCards: The human disease database

(20) MalaCards diseases for IFIH1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search IFIH1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

IFIH1_HUMAN
  • Aicardi-Goutieres syndrome 7 (AGS7) [MIM:615846]: A form of Aicardi-Goutieres syndrome, a genetically heterogeneous disease characterized by cerebral atrophy, leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon, and negative serologic investigations for common prenatal infection. Clinical features as thrombocytopenia, hepatosplenomegaly and elevated hepatic transaminases along with intermittent fever may erroneously suggest an infective process. Severe neurological dysfunctions manifest in infancy as progressive microcephaly, spasticity, dystonic posturing and profound psychomotor retardation. Death often occurs in early childhood. {ECO:0000269 PubMed:24686847, ECO:0000269 PubMed:24995871}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Diabetes mellitus, insulin-dependent, 19 (IDDM19) [MIM:610155]: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269 PubMed:16699517}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry.
  • Note=IFIH1 is the CADM-140 autoantigen, involved in clinically amyopathic dermatomyositis (CADM). This is a chronic inflammatory disorder that shows typical skin manifestations of dermatomyositis but has no or little evidence of clinical myositis. Anti-CADM-140 antibodies appear to be specific to dermatomyositis, especially CADM. Patients with anti-CADM-140 antibodies frequently develop life-threatening acute progressive interstitial lung disease (ILD). {ECO:0000269 PubMed:19565506, ECO:0000269 PubMed:20015976}.
  • Singleton-Merten syndrome 1 (SGMRT1) [MIM:182250]: An autosomal dominant disorder with variable expression. Core features are marked aortic calcification, dental anomalies, osteopenia, acro-osteolysis, and to a lesser extend glaucoma, psoriasis, muscle weakness, and joint laxity. Dental anomalies include delayed eruption and immature root formation of anterior permanent teeth, early loss of permanent teeth due to short roots, acute root resorption, high caries, and aggressive alveolar bone loss. Additional clinical manifestations include particular facial characteristics and abnormal joint and muscle ligaments. {ECO:0000269 PubMed:25620204}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for IFIH1

Genetic Association Database (GAD)
IFIH1
Human Genome Epidemiology (HuGE) Navigator
IFIH1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
IFIH1
genes like me logo Genes that share disorders with IFIH1: view

No data available for Genatlas for IFIH1 Gene

Publications for IFIH1 Gene

  1. A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region. (PMID: 16699517) Smyth D.J. … Todd J.A. (Nat. Genet. 2006) 3 4 23 48 67
  2. The interferon-induced helicase IFIH1 Ala946Thr polymorphism is associated with type 1 diabetes in both the high-incidence Finnish and the medium-incidence Hungarian populations. (PMID: 19841890) Jermendy A. … . (Diabetologia 2010) 3 23
  3. Both RIG-I and MDA5 RNA helicases contribute to the induction of alpha/beta interferon in measles virus-infected human cells. (PMID: 19846522) Ikegame S. … Yanagi Y. (J. Virol. 2010) 3 23
  4. Polyinosinic-polycytidylic acid liposome induces human hepatoma cells apoptosis which correlates to the up-regulation of RIG-I like receptors. (PMID: 19154402) Peng S. … Wei H. (Cancer Sci. 2009) 3 23
  5. Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria. (PMID: 19164550) Xu L. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23

Products for IFIH1 Gene

Sources for IFIH1 Gene

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