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Aliases for TINAGL1 Gene

Aliases for TINAGL1 Gene

  • Tubulointerstitial Nephritis Antigen-Like 1 2 3
  • Tubulointerstitial Nephritis Antigen-Related Protein 3 4
  • Glucocorticoid-Inducible Protein 5 3 4
  • TIN Ag-Related Protein 3 4
  • TINAG-Like 1 2 3
  • Lipocalin 7 2 3
  • TIN-Ag-RP 3 4
  • OLRG-2 3 4
  • LCN7 3 4
  • Oxidized LDL-Responsive Gene 2 Protein 4
  • Oxidized-LDL Responsive Gene 2 3
  • Androgen-Regulated Gene 1 3
  • TINAGRP 3
  • LIECG3 3
  • P3ECSL 3
  • TINAGL 4
  • OLRG2 4
  • ARG1 3
  • GIS5 4

External Ids for TINAGL1 Gene

Previous HGNC Symbols for TINAGL1 Gene

  • LCN7

Previous GeneCards Identifiers for TINAGL1 Gene

  • GC01P031712
  • GC01P031814
  • GC01P032042
  • GC01P030159

Summaries for TINAGL1 Gene

Entrez Gene Summary for TINAGL1 Gene

  • The protein encoded by this gene is similar in sequence to tubulointerstitial nephritis antigen, a secreted glycoprotein that is recognized by antibodies in some types of immune-related tubulointerstitial nephritis. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

GeneCards Summary for TINAGL1 Gene

TINAGL1 (Tubulointerstitial Nephritis Antigen-Like 1) is a Protein Coding gene. Among its related pathways are Metabolism and NgR-p75(NTR)-Mediated Signaling. GO annotations related to this gene include cysteine-type peptidase activity and scavenger receptor activity. An important paralog of this gene is CTSB.

UniProtKB/Swiss-Prot for TINAGL1 Gene

  • May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein (By similarity).

Gene Wiki entry for TINAGL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TINAGL1 Gene

Genomics for TINAGL1 Gene

Regulatory Elements for TINAGL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TINAGL1 Gene

Chromosome:
1
Start:
31,576,384 bp from pter
End:
31,587,686 bp from pter
Size:
11,303 bases
Orientation:
Plus strand

Genomic View for TINAGL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TINAGL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TINAGL1 Gene

Proteins for TINAGL1 Gene

  • Protein details for TINAGL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZM7-TINAL_HUMAN
    Recommended name:
    Tubulointerstitial nephritis antigen-like
    Protein Accession:
    Q9GZM7
    Secondary Accessions:
    • A8K9Q5
    • B4DPK6
    • D3DPN8
    • Q8TEJ9
    • Q8WZ23
    • Q96GZ4
    • Q96JW3

    Protein attributes for TINAGL1 Gene

    Size:
    467 amino acids
    Molecular mass:
    52387 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH09048.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55403.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TINAGL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TINAGL1 Gene

Proteomics data for TINAGL1 Gene at MOPED

Post-translational modifications for TINAGL1 Gene

Other Protein References for TINAGL1 Gene

Antibody Products

No data available for DME Specific Peptides for TINAGL1 Gene

Domains & Families for TINAGL1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9GZM7

UniProtKB/Swiss-Prot:

TINAL_HUMAN :
  • Contains 1 SMB (somatomedin-B) domain.
  • Belongs to the peptidase C1 family.
Domain:
  • Contains 1 SMB (somatomedin-B) domain.
Family:
  • Belongs to the peptidase C1 family.
genes like me logo Genes that share domains with TINAGL1: view

No data available for Gene Families for TINAGL1 Gene

Function for TINAGL1 Gene

Molecular function for TINAGL1 Gene

UniProtKB/Swiss-Prot Function:
May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein (By similarity).

Gene Ontology (GO) - Molecular Function for TINAGL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004197 NOT cysteine-type endopeptidase activity IBA --
GO:0005044 scavenger receptor activity IEA --
GO:0005201 extracellular matrix structural constituent NAS 11170462
GO:0005515 protein binding IPI 25416956
GO:0008234 cysteine-type peptidase activity --
genes like me logo Genes that share ontologies with TINAGL1: view
genes like me logo Genes that share phenotypes with TINAGL1: view

Animal Model Products

CRISPR Products

miRNA for TINAGL1 Gene

miRTarBase miRNAs that target TINAGL1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TINAGL1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TINAGL1 Gene

Localization for TINAGL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TINAGL1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TINAGL1 Gene COMPARTMENTS Subcellular localization image for TINAGL1 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for TINAGL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 11170462
GO:0005615 extracellular space ISS 22261194
GO:0005737 cytoplasm --
GO:0005764 NOT lysosome IBA --
GO:0031012 colocalizes_with extracellular matrix IDA 20551380
genes like me logo Genes that share ontologies with TINAGL1: view

Pathways & Interactions for TINAGL1 Gene

genes like me logo Genes that share pathways with TINAGL1: view

Pathways by source for TINAGL1 Gene

Gene Ontology (GO) - Biological Process for TINAGL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis --
GO:0006898 receptor-mediated endocytosis IEA --
GO:0006955 immune response IEA --
GO:0007155 cell adhesion IBA --
GO:0016197 endosomal transport TAS 10799322
genes like me logo Genes that share ontologies with TINAGL1: view

No data available for SIGNOR curated interactions for TINAGL1 Gene

Drugs & Compounds for TINAGL1 Gene

(2) Drugs for TINAGL1 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
arachidonic acid Experimental Nutra Potentiation, Activator 27
cysteine Nutra 143
genes like me logo Genes that share compounds with TINAGL1: view

Transcripts for TINAGL1 Gene

Unigene Clusters for TINAGL1 Gene

Tubulointerstitial nephritis antigen-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TINAGL1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TINAGL1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - -
SP4: -
SP5: - -
SP6: - - - -
SP7: - - - - - - -
SP8: - - - - -
SP9: - - - - -
SP10:
SP11: - -

Relevant External Links for TINAGL1 Gene

GeneLoc Exon Structure for
TINAGL1
ECgene alternative splicing isoforms for
TINAGL1

Expression for TINAGL1 Gene

mRNA expression in normal human tissues for TINAGL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TINAGL1 Gene

This gene is overexpressed in Artery - Aorta (x4.1).

Protein differential expression in normal tissues from HIPED for TINAGL1 Gene

This gene is overexpressed in Gallbladder (14.9), Adipocyte (6.3), and Rectum (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TINAGL1 Gene



SOURCE GeneReport for Unigene cluster for TINAGL1 Gene Hs.199368

mRNA Expression by UniProt/SwissProt for TINAGL1 Gene

Q9GZM7-TINAL_HUMAN
Tissue specificity: Highly expressed in aorta, heart, placenta, kidney and a colorectal adenocarcinoma cell line. Moderately expressed in skeletal muscle, pancreas, lung, lymph nodes, adrenal gland, bone marrow and thyroid. Weakly expressed in colon, small intestine, ovary, spleen, testis and prostate. Predominantly found in vascular smooth muscle cells, but also in cardiac and skeletal muscle cells as well as kidney.
genes like me logo Genes that share expression patterns with TINAGL1: view

Protein tissue co-expression partners for TINAGL1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for TINAGL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TINAGL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TINAGL1 35
  • 88.76 (n)
  • 90.62 (a)
TINAGL1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TINAGL1 35
  • 91.42 (n)
  • 92.7 (a)
TINAGL1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tinagl1 35
  • 85.2 (n)
  • 89.91 (a)
Tinagl1 16
Tinagl1 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TINAGL1 35
  • 97.43 (n)
  • 97.64 (a)
TINAGL1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tinagl1 35
  • 85.72 (n)
  • 89.69 (a)
oppossum
(Monodelphis domestica)
Mammalia TINAGL1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TINAGL1 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves TINAGL1 35
  • 72.84 (n)
  • 69.3 (a)
TINAGL1 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TINAGL1 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tinagl1 35
  • 65.38 (n)
  • 67.95 (a)
zebrafish
(Danio rerio)
Actinopterygii tinagl1 35
  • 65.24 (n)
  • 64.94 (a)
tinagl1 36
  • 62 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007684 35
  • 52.85 (n)
  • 43.92 (a)
fruit fly
(Drosophila melanogaster)
Insecta Swim 35
  • 54.85 (n)
  • 46.43 (a)
Swim 36
  • 38 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F26E4.3 35
  • 49.22 (n)
  • 47.17 (a)
F26E4.3 36
  • 39 (a)
OneToMany
Species with no ortholog for TINAGL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TINAGL1 Gene

ENSEMBL:
Gene Tree for TINAGL1 (if available)
TreeFam:
Gene Tree for TINAGL1 (if available)

Paralogs for TINAGL1 Gene

Paralogs for TINAGL1 Gene

(1) SIMAP similar genes for TINAGL1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TINAGL1: view

Variants for TINAGL1 Gene

Sequence variations from dbSNP and Humsavar for TINAGL1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs945212 -- 31,582,465(-) gtgac(A/G)acaag intron-variant
rs945213 -- 31,582,031(-) cttat(A/C)cctgt intron-variant
rs945214 -- 31,581,704(-) cctgg(A/C/T)ccatc intron-variant
rs1107550 -- 31,582,451(-) ctgca(C/T)gctct intron-variant
rs3738005 -- 31,586,924(-) CGAAG(A/C)TCTCG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TINAGL1 Gene

Variant ID Type Subtype PubMed ID
dgv46e1 CNV Complex 17122850
nsv10062 CNV Gain+Loss 18304495
dgv26e201 CNV Deletion 23290073
esv2746419 CNV Deletion 23290073
dgv27e201 CNV Deletion 23290073
esv1695245 CNV Deletion 17803354
esv2746441 CNV Deletion 23290073
esv2746452 CNV Deletion 23290073

Variation tolerance for TINAGL1 Gene

Residual Variation Intolerance Score: 23.85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.65; 31.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TINAGL1 Gene

HapMap Linkage Disequilibrium report
TINAGL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TINAGL1 Gene

Disorders for TINAGL1 Gene

Relevant External Links for TINAGL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TINAGL1
genes like me logo Genes that share disorders with TINAGL1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TINAGL1 Gene

Publications for TINAGL1 Gene

  1. TIN-ag-RP, a novel catalytically inactive cathepsin B-related protein with EGF domains, is predominantly expressed in vascular smooth muscle cells. (PMID: 11170462) Wex T. … Broemme D. (Biochemistry 2001) 2 23 67
  2. Adrenocortical zonation factor 1 is a novel matricellular protein promoting integrin-mediated adhesion of adrenocortical and vascular smooth muscle cells. (PMID: 17425658) Li D. … Suematsu M. (FEBS J. 2007) 23 67
  3. Lipoxins and annexin-1: resolution of inflammation and regulation of phagocytosis of apoptotic cells. (PMID: 17160341) Scannell M. … Maderna P. (ScientificWorldJournal 2006) 23 67
  4. An overview of the effects of annexin 1 on cells involved in the inflammatory process. (PMID: 15962097) Kamal A.M. … Perretti M. (Mem. Inst. Oswaldo Cruz 2005) 23 67
  5. Comprehensive search for cysteine cathepsins in the human genome. (PMID: 15195995) Rossi A. … Sali A. (Biol. Chem. 2004) 23 67

Products for TINAGL1 Gene

Sources for TINAGL1 Gene

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