Aliases for MOAP1 Gene
External Ids for MOAP1 Gene
Previous GeneCards Identifiers for MOAP1 Gene
The protein encoded by this gene was identified by its interaction with apoptosis regulator BAX protein. This protein contains a Bcl-2 homology 3 (BH3)-like motif, which is required for the association with BAX. When overexpressed, this gene has been shown to mediate caspase-dependent apoptosis. [provided by RefSeq, Jul 2008]
GeneCards Summary for MOAP1 Gene
MOAP1 (Modulator Of Apoptosis 1) is a Protein Coding gene. Diseases associated with MOAP1 include villonodular synovitis and pigmented villonodular synovitis. Among its related pathways are Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins. GO annotations related to this gene include protein homodimerization activity. An important paralog of this gene is ZCCHC12.
UniProtKB/Swiss-Prot for MOAP1 Gene
Required for death receptor-dependent apoptosis. When associated with RASSF1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation.