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Aliases for CRLF2 Gene

Aliases for CRLF2 Gene

  • Cytokine Receptor-Like Factor 2 2 3
  • Thymic Stromal Lymphopoietin Protein Receptor 3 4
  • TSLP Receptor 3 4
  • IL-XR 3 4
  • TSLPR 3 4
  • CRL2 3 4
  • Thymic Stromal-Derived Lymphopoietin Receptor 3
  • Cytokine Receptor CRL2 Precusor 3
  • Cytokine Receptor-Like 2 4
  • CRLF2Y 3
  • ILXR 4

External Ids for CRLF2 Gene

Summaries for CRLF2 Gene

Entrez Gene Summary for CRLF2 Gene

  • This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

GeneCards Summary for CRLF2 Gene

CRLF2 (Cytokine Receptor-Like Factor 2) is a Protein Coding gene. Diseases associated with CRLF2 include eczema herpeticum. Among its related pathways are PEDF Induced Signaling and Jak-STAT signaling pathway.

UniProtKB/Swiss-Prot for CRLF2 Gene

  • Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system.

Gene Wiki entry for CRLF2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CRLF2 Gene

Genomics for CRLF2 Gene

Genomic Location for CRLF2 Gene

Start:
1,187,538 bp from pter
End:
1,212,750 bp from pter
Size:
25,213 bases
Orientation:
Minus strand

Genomic View for CRLF2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CRLF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CRLF2 Gene

No data available for Regulatory Elements for CRLF2 Gene

Proteins for CRLF2 Gene

  • Protein details for CRLF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HC73-CRLF2_HUMAN
    Recommended name:
    Cytokine receptor-like factor 2
    Protein Accession:
    Q9HC73
    Secondary Accessions:
    • J3QKD1
    • Q5G7M1
    • Q9H5R3

    Protein attributes for CRLF2 Gene

    Size:
    371 amino acids
    Molecular mass:
    42013 Da
    Quaternary structure:
    • Heterodimer of CRLF2 and IL7R
    Miscellaneous:
    • The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes

    Alternative splice isoforms for CRLF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CRLF2 Gene

Proteomics data for CRLF2 Gene at MOPED

Post-translational modifications for CRLF2 Gene

  • Glycosylation at Asn47, Asn55, Asn101, and Asn169

Other Protein References for CRLF2 Gene

No data available for DME Specific Peptides for CRLF2 Gene

Domains for CRLF2 Gene

Gene Families for CRLF2 Gene

HGNC:
  • PAR1 :Pseudoautosomal regions / PAR1
IUPHAR :

Protein Domains for CRLF2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

CRLF2_HUMAN
Domain:
  • The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding:
    • Q9HC73
  • The box 1 motif is important for association with JAKs:
    • Q9HC73
  • Contains 1 fibronectin type-III domain.:
    • Q9HC73
Family:
  • Belongs to the type I cytokine receptor family. Type 5 subfamily.:
    • Q9HC73
genes like me logo Genes that share domains with CRLF2: view

Function for CRLF2 Gene

Molecular function for CRLF2 Gene

UniProtKB/Swiss-Prot Function: Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system.
UniProtKB/Swiss-Prot Induction: Up-regulated in activated peripheral monocytes and THP-1 cells

Gene Ontology (GO) - Molecular Function for CRLF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CRLF2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CRLF2 Gene

Localization for CRLF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CRLF2 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CRLF2 Gene COMPARTMENTS Subcellular localization image for CRLF2 gene
Compartment Confidence
plasma membrane 5
extracellular 4
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CRLF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CRLF2: view

Pathways for CRLF2 Gene

genes like me logo Genes that share pathways with CRLF2: view

Pathways by source for CRLF2 Gene

1 BioSystems pathway for CRLF2 Gene

Gene Ontology (GO) - Biological Process for CRLF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002380 immunoglobulin secretion involved in immune response IEA --
GO:0006954 inflammatory response IEA --
GO:0035745 T-helper 2 cell cytokine production IEA --
genes like me logo Genes that share ontologies with CRLF2: view

Transcripts for CRLF2 Gene

mRNA/cDNA for CRLF2 Gene

(6) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CRLF2 Gene

No ASD Table

Relevant External Links for CRLF2 Gene

GeneLoc Exon Structure for
CRLF2
ECgene alternative splicing isoforms for
CRLF2

Expression for CRLF2 Gene

mRNA expression in normal human tissues for CRLF2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CRLF2 Gene

SOURCE GeneReport for Unigene cluster for CRLF2 Gene Hs.287729

mRNA Expression by UniProt/SwissProt for CRLF2 Gene

Q9HC73-CRLF2_HUMAN
Tissue specificity: Expressed in heart, skeletal muscle, kidney and adult and fetal liver. Primarily expressed in dendrites and monocytes. Weakly expressed in T-cells
genes like me logo Genes that share expressions with CRLF2: view

Orthologs for CRLF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CRLF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CRLF2 36
  • 98.76 (n)
  • 99.25 (a)
cow
(Bos Taurus)
Mammalia CRLF2 37
  • 37 (a)
OneToOne
LOC529792 36
  • 67.86 (n)
  • 58.68 (a)
dog
(Canis familiaris)
Mammalia CRLF2 36
  • 71.32 (n)
  • 61.37 (a)
CRLF2 37
  • 39 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Crlf2 36
  • 50.1 (n)
  • 37.28 (a)
Crlf2 37
  • 22 (a)
OneToOne
57914 16
oppossum
(Monodelphis domestica)
Mammalia CRLF2 37
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CRLF2 37
  • 28 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Crlf2 36
  • 49.23 (n)
  • 38.39 (a)
chicken
(Gallus gallus)
Aves CRLF2 37
  • 25 (a)
OneToOne
LOC418668 36
  • 49.11 (n)
  • 37.54 (a)
Species with no ortholog for CRLF2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CRLF2 Gene

ENSEMBL:
Gene Tree for CRLF2 (if available)
TreeFam:
Gene Tree for CRLF2 (if available)

Paralogs for CRLF2 Gene

Selected SIMAP similar genes for CRLF2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CRLF2: view

No data available for Paralogs for CRLF2 Gene

Variants for CRLF2 Gene

Structural Variations from Database of Genomic Variants (DGV) for CRLF2 Gene

Variant ID Type Subtype PubMed ID
esv29996 CNV Loss 17803354
esv21933 CNV Gain+Loss 19812545
esv2739630 CNV Deletion 23290073
esv2739631 CNV Deletion 23290073
esv2739632 CNV Deletion 23290073
esv2739633 CNV Deletion 23290073
esv2739634 CNV Deletion 23290073

Relevant External Links for CRLF2 Gene

HapMap Linkage Disequilibrium report
CRLF2

No data available for Sequence variations from dbSNP and Humsavar for CRLF2 Gene

Disorders for CRLF2 Gene

(1) MalaCards Diseases for CRLF2 Gene

Search for CRLF2 Gene in MalaCards »

(3) University of Copenhagen DISEASES for CRLF2 Gene

(1) Novoseek inferred disease relationships for CRLF2 Gene

Disease -log(P) Hits PubMed IDs
asthma allergic 42 1

Relevant External Links for CRLF2

Genetic Association Database (GAD)
CRLF2
Human Genome Epidemiology (HuGE) Navigator
CRLF2
genes like me logo Genes that share disorders with CRLF2: view

No data available for UniProtKB/Swiss-Prot for CRLF2 Gene

Publications for CRLF2 Gene

  1. Identification of a novel type I cytokine receptor CRL2 preferentially expressed by human dendritic cells and activated monocytes. (PMID: 11237741) Zhang W. … Cao X. (Biochem. Biophys. Res. Commun. 2001) 2 3 4 23
  2. Molecular cloning of a human novel type I cytokine receptor related to delta1/TSLPR. (PMID: 11474172) Tonozuka Y. … Kitamura T. (Cytogenet. Cell Genet. 2001) 2 3 4 23
  3. Cloning of rat thymic stromal lymphopoietin receptor (TSLPR) and characterization of genomic structure of murine Tslpr gene. (PMID: 11891057) Blagoev B. … Pandey A. (Gene 2002) 3 23
  4. Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia. (PMID: 19641190) Russell L.J. … Harrison C.J. (Blood 2009) 3 23
  5. Signal transduction by the atopy-associated human thymic stromal lymphopoietin (TSLP) receptor depends on Janus kinase function. (PMID: 20128689) Wohlmann A. … Friedrich K. (Biol. Chem. 2010) 3 23

Products for CRLF2 Gene

Sources for CRLF2 Gene

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