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Aliases for CENPK Gene

Aliases for CENPK Gene

  • Centromere Protein K 2 3
  • Interphase Centromere Complex Protein 37 3 4
  • Protein AF-5alpha 3 4
  • CENP-K 3 4
  • Solt 3 6
  • P33 3 4
  • SoxLZ/Sox6-Binding Protein Solt 3
  • Leucine Zipper Protein FKSG14 3
  • AF5alpha 3
  • FKSG14 3
  • ICEN37 4
  • CEMPK 6

External Ids for CENPK Gene

Previous GeneCards Identifiers for CENPK Gene

  • GC05M064850
  • GC05M061769

Summaries for CENPK Gene

Entrez Gene Summary for CENPK Gene

  • CENPK is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CENPK Gene

CENPK (Centromere Protein K) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for CENPK Gene

  • Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with CASC5/KNL1 to recruit the NDC80 complex to the outer kinetochore.

Gene Wiki entry for CENPK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CENPK Gene

Genomics for CENPK Gene

Regulatory Elements for CENPK Gene

Genomic Location for CENPK Gene

Start:
65,517,766 bp from pter
End:
65,563,188 bp from pter
Size:
45,423 bases
Orientation:
Minus strand

Genomic View for CENPK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CENPK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPK Gene

Proteins for CENPK Gene

  • Protein details for CENPK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BS16-CENPK_HUMAN
    Recommended name:
    Centromere protein K
    Protein Accession:
    Q9BS16
    Secondary Accessions:
    • Q9H4L0

    Protein attributes for CENPK Gene

    Size:
    269 amino acids
    Molecular mass:
    31655 Da
    Quaternary structure:
    • Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. Interacts directly with CENPH.

neXtProt entry for CENPK Gene

Proteomics data for CENPK Gene at MOPED

Post-translational modifications for CENPK Gene

  • Ubiquitination at Lys77 and Lys149
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CENPK Gene

Domains for CENPK Gene

Protein Domains for CENPK Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CENPK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BS16

UniProtKB/Swiss-Prot:

CENPK_HUMAN :
  • Q9BS16
Family:
  • Belongs to the CENPK family.
genes like me logo Genes that share domains with CENPK: view

No data available for Gene Families for CENPK Gene

Function for CENPK Gene

Molecular function for CENPK Gene

UniProtKB/Swiss-Prot Function: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with CASC5/KNL1 to recruit the NDC80 complex to the outer kinetochore.

Gene Ontology (GO) - Molecular Function for CENPK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CENPK: view

miRNA for CENPK Gene

miRTarBase miRNAs that target CENPK

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CENPK Gene

Localization for CENPK Gene

Subcellular locations from UniProtKB/Swiss-Prot for CENPK Gene

Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CENPK Gene COMPARTMENTS Subcellular localization image for CENPK gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CENPK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CENPK: view

Pathways for CENPK Gene

genes like me logo Genes that share pathways with CENPK: view

Pathways by source for CENPK Gene

Gene Ontology (GO) - Biological Process for CENPK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0006334 nucleosome assembly TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0034080 CENP-A containing nucleosome assembly TAS --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with CENPK: view

Transcripts for CENPK Gene

Unigene Clusters for CENPK Gene

Centromere protein K:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CENPK Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1:
SP2:
SP3: - -
SP4:

Relevant External Links for CENPK Gene

GeneLoc Exon Structure for
CENPK
ECgene alternative splicing isoforms for
CENPK

Expression for CENPK Gene

mRNA expression in normal human tissues for CENPK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CENPK Gene

SOURCE GeneReport for Unigene cluster for CENPK Gene Hs.529778

mRNA Expression by UniProt/SwissProt for CENPK Gene

Q9BS16-CENPK_HUMAN
Tissue specificity: Detected in several fetal organs with highest levels in fetal liver. In adults, it is weakly expressed in lung and placenta.
genes like me logo Genes that share expressions with CENPK: view

No data available for mRNA differential expression in normal tissues for CENPK Gene

Orthologs for CENPK Gene

This gene was present in the common ancestor of chordates.

Orthologs for CENPK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CENPK 35
  • 99.88 (n)
  • 99.63 (a)
CENPK 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CENPK 35
  • 89.1 (n)
  • 85.13 (a)
CENPK 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CENPK 35
  • 88.48 (n)
  • 81.41 (a)
CENPK 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cenpk 35
  • 83.96 (n)
  • 75.37 (a)
Cenpk 16
Cenpk 36
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CENPK 36
  • 53 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CENPK 36
  • 57 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cenpk 35
  • 79.97 (n)
  • 73.82 (a)
chicken
(Gallus gallus)
Aves CENPK 35
  • 68.76 (n)
  • 56.9 (a)
CENPK 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CENPK 36
  • 49 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.13103 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cenpk 35
  • 61.42 (n)
  • 56.18 (a)
Str.15747 35
zebrafish
(Danio rerio)
Actinopterygii cenpk 35
  • 53.07 (n)
  • 42.11 (a)
cenpk 36
  • 33 (a)
OneToOne
Species with no ortholog for CENPK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CENPK Gene

ENSEMBL:
Gene Tree for CENPK (if available)
TreeFam:
Gene Tree for CENPK (if available)

Paralogs for CENPK Gene

Selected SIMAP similar genes for CENPK Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with CENPK: view

No data available for Paralogs for CENPK Gene

Variants for CENPK Gene

Sequence variations from dbSNP and Humsavar for CENPK Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs149514 -- 65,555,910(+) GTCTG(A/C)AGTTG intron-variant
rs155061 -- 65,555,319(+) ttcag(A/G)cagag intron-variant
rs155062 -- 65,555,585(+) aagga(C/T)agaag intron-variant
rs155063 -- 65,556,359(+) agccc(A/G)agctg intron-variant
rs195094 -- 65,554,392(+) tgatc(C/G)cccag intron-variant

Relevant External Links for CENPK Gene

HapMap Linkage Disequilibrium report
CENPK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CENPK Gene

Disorders for CENPK Gene

UniProtKB/Swiss-Prot

CENPK_HUMAN
  • Note=Chromosomal aberrations involving CENPK are a cause of acute leukemias. Translocation t(5;11)(q12;q23) with KMT2A/MLL1.

No disorders were found for CENPK Gene.

Publications for CENPK Gene

  1. Fusion of the MLL gene with two different genes, AF-6 and AF-5alpha, by a complex translocation involving chromosomes 5, 6, 8 and 11 in infant leukemia. (PMID: 8950979) Taki T. … Morishita K. (Oncogene 1996) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The human CENP-A centromeric nucleosome-associated complex. (PMID: 16622419) Foltz D.R. … Cleveland D.W. (Nat. Cell Biol. 2006) 3 4
  4. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. (PMID: 16622420) Okada M. … Fukagawa T. (Nat. Cell Biol. 2006) 3 4
  5. Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. (PMID: 16716197) Izuta H. … Yoda K. (Genes Cells 2006) 3 4

Products for CENPK Gene

Sources for CENPK Gene

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