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Aliases for CENPK Gene

Aliases for CENPK Gene

  • Centromere Protein K 2 3 5
  • Interphase Centromere Complex Protein 37 3 4
  • Protein AF-5alpha 3 4
  • CENP-K 3 4
  • P33 3 4
  • SoxLZ/Sox6-Binding Protein Solt 3
  • Leucine Zipper Protein FKSG14 3
  • AF5alpha 3
  • FKSG14 3
  • ICEN37 4
  • Solt 3

External Ids for CENPK Gene

Previous GeneCards Identifiers for CENPK Gene

  • GC05M064850
  • GC05M061769

Summaries for CENPK Gene

Entrez Gene Summary for CENPK Gene

  • CENPK is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CENPK Gene

CENPK (Centromere Protein K) is a Protein Coding gene. Diseases associated with CENPK include Vertebrobasilar Insufficiency. Among its related pathways are Chromosome Maintenance and Mitotic Metaphase and Anaphase.

UniProtKB/Swiss-Prot for CENPK Gene

  • Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with KNL1 to recruit the NDC80 complex to the outer kinetochore.

Gene Wiki entry for CENPK Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CENPK Gene

Genomics for CENPK Gene

Regulatory Elements for CENPK Gene

Enhancers for CENPK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G065478 1.9 FANTOM5 Ensembl ENCODE dbSUPER 24.7 +82.2 82177 6.0 PKNOX1 FOXA2 SIN3A FEZF1 DMAP1 ZNF2 YY1 FOS ZNF263 SP3 PPWD1 CENPK TRAPPC13 ENSG00000250081 SREK1IP1 ADAMTS6 RPS2P23
GH05G065562 1.1 ENCODE 28.1 -0.2 -236 2.8 PKNOX1 ARNT WRNIP1 ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF143 ZNF207 PPWD1 CENPK RNU6-540P TRAPPC13 GC05M065605
GH05G065610 0.6 ENCODE 36.4 -48.8 -48776 3.3 SCRT1 ZNF146 ZNF280D SAP130 SCRT2 CEBPB CEBPG PRDM1 ZNF507 TEAD3 PPWD1 CENPK ADAMTS6 RNU6-540P GC05M065605 TRAPPC13
GH05G065623 1.1 ENCODE 14.1 -61.6 -61625 3.2 HDGF PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 YY1 PPWD1 CENPK RNU6-540P NLN SGTB TRAPPC13 ENSG00000253251 TRIM23
GH05G065535 0.4 ENCODE 37.9 +27.5 27481 0.2 HLF CENPK PPWD1 TRAPPC13 GC05M065490 PIR45074
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CENPK on UCSC Golden Path with GeneCards custom track

Promoters for CENPK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000181595 -111 2201 PKNOX1 ARNT WRNIP1 ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF143 ZNF207

Genomic Location for CENPK Gene

Chromosome:
5
Start:
65,508,067 bp from pter
End:
65,563,189 bp from pter
Size:
55,123 bases
Orientation:
Minus strand

Genomic View for CENPK Gene

Genes around CENPK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CENPK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CENPK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPK Gene

Proteins for CENPK Gene

  • Protein details for CENPK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BS16-CENPK_HUMAN
    Recommended name:
    Centromere protein K
    Protein Accession:
    Q9BS16
    Secondary Accessions:
    • Q9H4L0

    Protein attributes for CENPK Gene

    Size:
    269 amino acids
    Molecular mass:
    31655 Da
    Quaternary structure:
    • Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. Interacts directly with CENPH.

neXtProt entry for CENPK Gene

Post-translational modifications for CENPK Gene

  • Ubiquitination at posLast=7777 and posLast=149149
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CENPK Gene

Domains & Families for CENPK Gene

Protein Domains for CENPK Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CENPK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BS16

UniProtKB/Swiss-Prot:

CENPK_HUMAN :
  • Belongs to the CENPK family.
Family:
  • Belongs to the CENPK family.
genes like me logo Genes that share domains with CENPK: view

No data available for Gene Families for CENPK Gene

Function for CENPK Gene

Molecular function for CENPK Gene

UniProtKB/Swiss-Prot Function:
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with KNL1 to recruit the NDC80 complex to the outer kinetochore.

Gene Ontology (GO) - Molecular Function for CENPK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CENPK: view

Phenotypes for CENPK Gene

genes like me logo Genes that share phenotypes with CENPK: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CENPK

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CENPK Gene

Localization for CENPK Gene

Subcellular locations from UniProtKB/Swiss-Prot for CENPK Gene

Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CENPK gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for CENPK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IEA --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with CENPK: view

Pathways & Interactions for CENPK Gene

genes like me logo Genes that share pathways with CENPK: view

Gene Ontology (GO) - Biological Process for CENPK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007062 sister chromatid cohesion TAS --
GO:0034080 CENP-A containing nucleosome assembly TAS --
genes like me logo Genes that share ontologies with CENPK: view

No data available for SIGNOR curated interactions for CENPK Gene

Transcripts for CENPK Gene

Unigene Clusters for CENPK Gene

Centromere protein K:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CENPK

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CENPK Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1:
SP2:
SP3: - -
SP4:

Relevant External Links for CENPK Gene

GeneLoc Exon Structure for
CENPK
ECgene alternative splicing isoforms for
CENPK

Expression for CENPK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CENPK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CENPK Gene

This gene is overexpressed in Plasma (50.2) and Fetal ovary (16.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CENPK Gene



Protein tissue co-expression partners for CENPK Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CENPK Gene:

CENPK

SOURCE GeneReport for Unigene cluster for CENPK Gene:

Hs.529778

mRNA Expression by UniProt/SwissProt for CENPK Gene:

Q9BS16-CENPK_HUMAN
Tissue specificity: Detected in several fetal organs with highest levels in fetal liver. In adults, it is weakly expressed in lung and placenta.

Evidence on tissue expression from TISSUES for CENPK Gene

  • Gall bladder(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with CENPK: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CENPK Gene

Orthologs for CENPK Gene

This gene was present in the common ancestor of chordates.

Orthologs for CENPK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CENPK 34 35
  • 99.88 (n)
cow
(Bos Taurus)
Mammalia CENPK 34 35
  • 89.1 (n)
dog
(Canis familiaris)
Mammalia CENPK 34 35
  • 88.48 (n)
mouse
(Mus musculus)
Mammalia Cenpk 34 16 35
  • 83.96 (n)
rat
(Rattus norvegicus)
Mammalia Cenpk 34
  • 79.97 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CENPK 35
  • 57 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CENPK 35
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves CENPK 34 35
  • 68.76 (n)
lizard
(Anolis carolinensis)
Reptilia CENPK 35
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cenpk 34
  • 61.42 (n)
Str.15747 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.13103 34
zebrafish
(Danio rerio)
Actinopterygii cenpk 34 35
  • 53.07 (n)
Species where no ortholog for CENPK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CENPK Gene

ENSEMBL:
Gene Tree for CENPK (if available)
TreeFam:
Gene Tree for CENPK (if available)

Paralogs for CENPK Gene

(3) SIMAP similar genes for CENPK Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with CENPK: view

No data available for Paralogs for CENPK Gene

Variants for CENPK Gene

Sequence variations from dbSNP and Humsavar for CENPK Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000008039 -- 65,543,873(+) AGCTA(C/T)GAAGA intron-variant
rs1000045031 -- 65,541,946(+) AGCTA(C/G)GAAGT intron-variant
rs1000045914 -- 65,532,005(+) AAAAT(C/T)AGATT intron-variant
rs1000112355 -- 65,496,026(+) CCAAG(A/G)TGAGT intron-variant
rs1000189265 -- 65,553,849(+) TTCAA(A/G)AACAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CENPK Gene

Variant ID Type Subtype PubMed ID
esv3570175 CNV loss 25503493

Variation tolerance for CENPK Gene

Residual Variation Intolerance Score: 77.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.33; 26.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CENPK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CENPK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CENPK Gene

Disorders for CENPK Gene

MalaCards: The human disease database

(1) MalaCards diseases for CENPK Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
vertebrobasilar insufficiency
  • vertebro-basilar insufficiency
- elite association - COSMIC cancer census association via MalaCards
Search CENPK in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CENPK_HUMAN
  • Note=Chromosomal aberrations involving CENPK are a cause of acute leukemias. Translocation t(5;11)(q12;q23) with KMT2A/MLL1. {ECO:0000269 PubMed:8950979}.

Relevant External Links for CENPK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CENPK
genes like me logo Genes that share disorders with CENPK: view

No data available for Genatlas for CENPK Gene

Publications for CENPK Gene

  1. Fusion of the MLL gene with two different genes, AF-6 and AF-5alpha, by a complex translocation involving chromosomes 5, 6, 8 and 11 in infant leukemia. (PMID: 8950979) Taki T. … Morishita K. (Oncogene 1996) 2 3 4 64
  2. KNL1 and the CENP-H/I/K complex coordinately direct kinetochore assembly in vertebrates. (PMID: 18045986) Cheeseman I.M. … Desai A. (Mol. Biol. Cell 2008) 3 4 64
  3. The human CENP-A centromeric nucleosome-associated complex. (PMID: 16622419) Foltz D.R. … Cleveland D.W. (Nat. Cell Biol. 2006) 3 4 64
  4. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. (PMID: 16622420) Okada M. … Fukagawa T. (Nat. Cell Biol. 2006) 3 4 64
  5. Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. (PMID: 16716197) Izuta H. … Yoda K. (Genes Cells 2006) 3 4 64

Products for CENPK Gene

Sources for CENPK Gene

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