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Aliases for GAL3ST2 Gene

Aliases for GAL3ST2 Gene

  • Galactose-3-O-Sulfotransferase 2 2 3
  • GP3ST 3 4 6
  • Glycoprotein Beta-Gal 3-Sulfotransferase 2 3 4
  • Gal-Beta-1, 3-GalNAc 3-Sulfotransferase 2 3 4
  • Beta-Galactose-3-O-Sulfotransferase 2 3 4
  • GAL3ST-2 3 4
  • Galbeta1-3GalNAc 3-Sulfotransferase 2 3
  • Gal 3-O-Sulphotransferase 3
  • EC 2.8.2.- 4

External Ids for GAL3ST2 Gene

Previous GeneCards Identifiers for GAL3ST2 Gene

  • GC11M068343
  • GC11M067490
  • GC11M066059
  • GC11M065585
  • GC02P243038
  • GC02P242436
  • GC02P242364
  • GC02P242716
  • GC02P234469

Summaries for GAL3ST2 Gene

Entrez Gene Summary for GAL3ST2 Gene

  • This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate group to the hydroxyl at C-3 of nonreducing beta-galactosyl residues, and it can act on both type 1 and type 2 (Galbeta 1-3/1-4GlcNAc-R) oligosaccharides with similar efficiencies, and on core 1 glycans. This enzyme has been implicated in tumor metastasis processes. This gene is different from the GAL3ST3 gene located on chromosome 11, which has also been referred to as GAL3ST2 and encodes a related enzyme with distinct tissue distribution and substrate specificities, compared to galactose-3-O-sulfotransferase 2. [provided by RefSeq, Jul 2008]

GeneCards Summary for GAL3ST2 Gene

GAL3ST2 (Galactose-3-O-Sulfotransferase 2) is a Protein Coding gene. Among its related pathways are Biological oxidations. GO annotations related to this gene include sulfotransferase activity and galactosylceramide sulfotransferase activity. An important paralog of this gene is GAL3ST1.

UniProtKB/Swiss-Prot for GAL3ST2 Gene

  • Transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues. Acts both on type 1 (Gal-beta-1,3-GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency

Gene Wiki entry for GAL3ST2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAL3ST2 Gene

Genomics for GAL3ST2 Gene

Regulatory Elements for GAL3ST2 Gene

Transcription factor binding sites by QIAGEN in the GAL3ST2 gene promoter:

Genomic Location for GAL3ST2 Gene

241,776,825 bp from pter
241,804,287 bp from pter
27,463 bases
Plus strand

Genomic View for GAL3ST2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GAL3ST2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAL3ST2 Gene

Proteins for GAL3ST2 Gene

  • Protein details for GAL3ST2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Galactose-3-O-sulfotransferase 2
    Protein Accession:
    Secondary Accessions:
    • Q17RK0
    • Q57Z52

    Protein attributes for GAL3ST2 Gene

    398 amino acids
    Molecular mass:
    46110 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GAL3ST2 Gene

Proteomics data for GAL3ST2 Gene at MOPED

Post-translational modifications for GAL3ST2 Gene

  • Glycosylation at Asn79, Asn132, Asn179, Asn287, Asn330, and Asn360
  • Modification sites at PhosphoSitePlus

Other Protein References for GAL3ST2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GAL3ST2 Gene

Domains for GAL3ST2 Gene

Gene Families for GAL3ST2 Gene

Protein Domains for GAL3ST2 Gene

Suggested Antigen Peptide Sequences for GAL3ST2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the galactose-3-O-sulfotransferase family.
  • Belongs to the galactose-3-O-sulfotransferase family.
genes like me logo Genes that share domains with GAL3ST2: view

Function for GAL3ST2 Gene

Molecular function for GAL3ST2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 6.0-6.5.;
UniProtKB/Swiss-Prot EnzymeRegulation:
Strongly inhibited by Cu(2+) and Zn(2+).
UniProtKB/Swiss-Prot Function:
Transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues. Acts both on type 1 (Gal-beta-1,3-GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency

Enzyme Numbers (IUBMB) for GAL3ST2 Gene

Gene Ontology (GO) - Molecular Function for GAL3ST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001733 galactosylceramide sulfotransferase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008146 sulfotransferase activity IDA 11029462
genes like me logo Genes that share ontologies with GAL3ST2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GAL3ST2

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GAL3ST2 Gene

Localization for GAL3ST2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GAL3ST2 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.

Subcellular locations from

Jensen Localization Image for GAL3ST2 Gene COMPARTMENTS Subcellular localization image for GAL3ST2 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GAL3ST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus --
GO:0016020 membrane TAS 11029462
GO:0016021 integral component of membrane IEA --
GO:0032580 Golgi cisterna membrane IEA --
genes like me logo Genes that share ontologies with GAL3ST2: view

Pathways for GAL3ST2 Gene

SuperPathways for GAL3ST2 Gene

Superpath Contained pathways
1 Biological oxidations
genes like me logo Genes that share pathways with GAL3ST2: view

Pathways by source for GAL3ST2 Gene

1 BioSystems pathway for GAL3ST2 Gene

UniProtKB/Swiss-Prot Q9H3Q3-G3ST2_HUMAN

  • Pathway: Protein modification; carbohydrate sulfation

Interacting Proteins for GAL3ST2 Gene

Selected Interacting proteins: Q9H3Q3-G3ST2_HUMAN for GAL3ST2 Gene via UniProtKB

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for GAL3ST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0009058 biosynthetic process IEA --
genes like me logo Genes that share ontologies with GAL3ST2: view

Transcripts for GAL3ST2 Gene

mRNA/cDNA for GAL3ST2 Gene

(38) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GAL3ST2 Gene

Galactose-3-O-sulfotransferase 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for GAL3ST2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GAL3ST2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d ^ 12a · 12b
SP1: - - - - - - - -
SP2: - -
SP4: - - - - - - -
SP5: - - -
SP6: -
SP7: - - - -
SP8: - - -
SP9: - - - - - - - -
SP10: - - - - - - - - - - - -
SP11: - - - - - -
SP12: - - - - - - - -

Relevant External Links for GAL3ST2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GAL3ST2 Gene

mRNA expression in normal human tissues for GAL3ST2 Gene

mRNA differential expression in normal tissues according to GTEx for GAL3ST2 Gene

This gene is overexpressed in Colon - Transverse (21.4).

Protein differential expression in normal tissues for GAL3ST2 Gene

This gene is overexpressed in Oral epithelium (63.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for GAL3ST2 Gene

SOURCE GeneReport for Unigene cluster for GAL3ST2 Gene Hs.632556

mRNA Expression by UniProt/SwissProt for GAL3ST2 Gene

Tissue specificity: Ubiquitous. Detected in heart, stomach, colon, liver and spleen, in epithelial cells lining the lower to middle layer of the crypts in colonic mucosa, hepatocytes surrounding the central vein of the liver, extravillous cytotrophoblasts in the basal plate of the septum of the placenta, renal tubules of the kidney, and neuronal cells of the cerebral cortex.
genes like me logo Genes that share expressions with GAL3ST2: view

Expression partners for GAL3ST2 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GAL3ST2 Gene

Orthologs for GAL3ST2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GAL3ST2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GAL3ST2 35
  • 82.24 (n)
  • 75.25 (a)
GAL3ST2 36
  • 73 (a)
(Canis familiaris)
Mammalia GAL3ST2 35
  • 83.8 (n)
  • 78.49 (a)
GAL3ST2 36
  • 74 (a)
(Mus musculus)
Mammalia Gm9994 35
  • 73.63 (n)
  • 70.6 (a)
Gm6086 16
Gal3st2 36
  • 68 (a)
Gm6086 36
  • 67 (a)
Gm9994 36
  • 68 (a)
(Pan troglodytes)
Mammalia GAL3ST2 35
  • 99.03 (n)
  • 97.81 (a)
GAL3ST2 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Gal3st2 35
  • 73.43 (n)
  • 68.53 (a)
(Monodelphis domestica)
Mammalia GAL3ST2 36
  • 60 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 43 (a)
-- 36
  • 60 (a)
(Gallus gallus)
Aves GAL3ST2 35
  • 62.67 (n)
  • 54.09 (a)
GAL3ST2 36
  • 45 (a)
(Anolis carolinensis)
Reptilia GAL3ST2 36
  • 50 (a)
(Danio rerio)
Actinopterygii LOC556126 35
  • 56.63 (n)
  • 53.69 (a)
CABZ01079005.1 36
  • 33 (a)
si:dkey-246m18.2 36
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
-- 36
  • 33 (a)
-- 36
  • 25 (a)
Species with no ortholog for GAL3ST2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GAL3ST2 Gene

Gene Tree for GAL3ST2 (if available)
Gene Tree for GAL3ST2 (if available)

Paralogs for GAL3ST2 Gene

Paralogs for GAL3ST2 Gene

(2) SIMAP similar genes for GAL3ST2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GAL3ST2: view

Variants for GAL3ST2 Gene

Sequence variations from dbSNP and Humsavar for GAL3ST2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs7421513 -- 241,779,075(+) CCCCC(A/G)TTttc intron-variant
rs7423193 -- 241,779,029(+) agctt(A/G)tagtg intron-variant
rs7573250 -- 241,780,975(+) tcacc(A/G)ttcca intron-variant
rs7576068 -- 241,778,664(+) ggacg(C/T)gcacc intron-variant
rs9973663 -- 241,786,337(+) aacaa(A/G)caatc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for GAL3ST2 Gene

Variant ID Type Subtype PubMed ID
nsv876226 CNV Loss 21882294
dgv4493n71 CNV Loss 21882294
dgv4494n71 CNV Loss 21882294
dgv4495n71 CNV Loss 21882294
dgv165e55 CNV Loss 17911159
dgv4496n71 CNV Loss 21882294
nsv876242 CNV Loss 21882294
dgv4497n71 CNV Loss 21882294
nsv876250 CNV Gain 21882294
nsv876254 CNV Loss 21882294
nsv876255 CNV Loss 21882294
nsv10232 CNV Gain+Loss 18304495

Relevant External Links for GAL3ST2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAL3ST2 Gene

Disorders for GAL3ST2 Gene

No disorders were found for GAL3ST2 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for GAL3ST2 Gene

Publications for GAL3ST2 Gene

  1. Molecular cloning and characterization of a human beta-Gal-3'- sulfotransferase that acts on both type 1 and type 2 (Galbeta 1-3/1- 4GlcNAc-R) oligosaccharides. (PMID: 11029462) Honke K. … Taniguchi N. (J. Biol. Chem. 2001) 2 3 4 23
  2. Gal3ST-2 involved in tumor metastasis process by regulation of adhesion ability to selectins and expression of integrins. (PMID: 15921657) Shi B.Z. … Wu X.Z. (Biochem. Biophys. Res. Commun. 2005) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Porcine, mouse and human galactose 3-O-sulphotransferase-2 enzymes have different substrate specificities; the porcine enzyme requires basic compounds for its catalytic activity. (PMID: 15926885) Seko A. … Yamashita K. (Biochem. J. 2005) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for GAL3ST2 Gene

Sources for GAL3ST2 Gene

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