Aliases for GAL3ST2 Gene
Aliases for GAL3ST2 Gene
External Ids for GAL3ST2 Gene
- HGNC: 24869
- Entrez Gene: 64090
- Ensembl: ENSG00000154252
- OMIM: 608237
- UniProtKB: Q9H3Q3
Previous GeneCards Identifiers for GAL3ST2 Gene
- GC11M068343
- GC11M067490
- GC11M066059
- GC11M065585
- GC02P243038
- GC02P242436
- GC02P242364
- GC02P242716
- GC02P234469
Summaries for GAL3ST2 Gene
-
This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate group to the hydroxyl at C-3 of nonreducing beta-galactosyl residues, and it can act on both type 1 and type 2 (Galbeta 1-3/1-4GlcNAc-R) oligosaccharides with similar efficiencies, and on core 1 glycans. This enzyme has been implicated in tumor metastasis processes. This gene is different from the GAL3ST3 gene located on chromosome 11, which has also been referred to as GAL3ST2 and encodes a related enzyme with distinct tissue distribution and substrate specificities, compared to galactose-3-O-sulfotransferase 2. [provided by RefSeq, Jul 2008]
GeneCards Summary for GAL3ST2 Gene
GAL3ST2 (Galactose-3-O-Sulfotransferase 2) is a Protein Coding gene. Among its related pathways are Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include sulfotransferase activity and galactosylceramide sulfotransferase activity. An important paralog of this gene is GAL3ST4.
UniProtKB/Swiss-Prot for GAL3ST2 Gene
-
Transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues. Acts both on type 1 (Gal-beta-1,3-GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency.
Additional gene information for GAL3ST2 Gene
- Monarch Initiative
- Search for GAL3ST2 at DataMed
- Search for GAL3ST2 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAL3ST2 Gene
Genomics for GAL3ST2 Gene
GeneHancer (GH) Regulatory Elements for GAL3ST2 Gene
- Top Transcription factor binding sites by QIAGEN in the GAL3ST2 gene promoter:
Regulatory Element Products
Genomic Locations for GAL3ST2 Gene
- chr2:241,776,825-241,804,287
- (GRCh38/hg38)
- Size:
- 27,463 bases
- Orientation:
- Plus strand
- chr2:242,716,240-242,743,702
- (GRCh37/hg19)
Genomic View for GAL3ST2 Gene
- Cytogenetic band:
-
- 2q37.3 by Ensembl
- 2q37.3 by Entrez Gene
- 2q37.3 by HGNC


RefSeq DNA sequence for GAL3ST2 Gene
Proteins for GAL3ST2 Gene
-
Protein details for GAL3ST2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H3Q3-G3ST2_HUMAN
- Recommended name:
- Galactose-3-O-sulfotransferase 2
- Protein Accession:
- Q9H3Q3
- Q17RK0
- Q57Z52
Protein attributes for GAL3ST2 Gene
- Size:
- 398 amino acids
- Molecular mass:
- 46110 Da
- Quaternary structure:
- No Data Available
Protein Expression for GAL3ST2 Gene
Post-translational modifications for GAL3ST2 Gene
- Glycosylation at isoforms=79, isoforms=132, posLast=179179, posLast=287287, posLast=330330, and isoforms=360
Other Protein References for GAL3ST2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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Protein Products
- R&D Systems Proteins and Enzymes for GAL3ST2 (Galactose-3-O-sulfotransferase 2/GAL3ST2)
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-
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Assay Products
No data available for DME Specific Peptides for GAL3ST2 Gene
Domains & Families for GAL3ST2 Gene
Gene Families for GAL3ST2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
Protein Domains for GAL3ST2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for GAL3ST2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9H3Q3- Family:
-
- Belongs to the galactose-3-O-sulfotransferase family.
Function for GAL3ST2 Gene
Molecular function for GAL3ST2 Gene
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- pH dependence: Optimum pH is 6.0-6.5.;
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Strongly inhibited by Cu(2+) and Zn(2+).
- UniProtKB/Swiss-Prot Function:
- Transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues. Acts both on type 1 (Gal-beta-1,3-GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency.
Enzyme Numbers (IUBMB) for GAL3ST2 Gene
Phenotypes From GWAS Catalog for GAL3ST2 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0001733 | galactosylceramide sulfotransferase activity | IEA | -- |
GO:0005515 | protein binding | IPI | 25416956 |
GO:0008146 | sulfotransferase activity | IDA | 11029462 |
GO:0016740 | transferase activity | IEA | -- |
Phenotypes for GAL3ST2 Gene
- GenomeRNAi human phenotypes for GAL3ST2:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability
- shRNA abundance <= 50%
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased viability ratio
- Dynamic nuclei (hole, folded or small irregular)
- Decreased IL-8 secretion
- Decreased shRNA abundance
- Decreased infection with West Nile virus (WNV)
- Decreased West Nile virus (WNV) infection
- Upregulation of RLR pathway after Sendai virus (SeV) infection
Animal Model Products
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-
-
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CRISPR Products
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Inhibitory RNA Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
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-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
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No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GAL3ST2 Gene
Localization for GAL3ST2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for GAL3ST2 Gene
- Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005794 | Golgi apparatus | IEA | -- |
GO:0016020 | membrane | TAS | 11029462 |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0032580 | Golgi cisterna membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for GAL3ST2 Gene
Pathways & Interactions for GAL3ST2 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cytochrome P450 - arranged by substrate type |
Pathways by source for GAL3ST2 Gene
1 BioSystems pathway for GAL3ST2 Gene
UniProtKB/Swiss-Prot Q9H3Q3-G3ST2_HUMAN
- Pathway: Protein modification; carbohydrate sulfation.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0008150 | biological_process | ND | -- |
GO:0009247 | glycolipid biosynthetic process | IEA | -- |
No data available for SIGNOR curated interactions for GAL3ST2 Gene
Transcripts for GAL3ST2 Gene
mRNA/cDNA for GAL3ST2 Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (38) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for GAL3ST2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for GAL3ST2
- genomics-online: gRNA clones - Search results for available GAL3ST2 gene related products
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-
Vectors and viruses for KO, Activation, Repression, and more
-
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miRNA Products
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Inhibitory RNA Products
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-
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available GAL3ST2 gene related products
- orf clones - Search results for available GAL3ST2 gene related products
- Applied Biological Materials Clones for GAL3ST2
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | · | 11c | · | 11d | ^ | 12a | · | 12b |
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SP2: | - | - | |||||||||||||||||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | ||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP9: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||
SP11: | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
SP12: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP13: |
Expression for GAL3ST2 Gene
mRNA differential expression in normal tissues according to GTEx for GAL3ST2 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GAL3ST2 Gene
NURSA nuclear receptor signaling pathways regulating expression of GAL3ST2 Gene:
GAL3ST2SOURCE GeneReport for Unigene cluster for GAL3ST2 Gene:
Hs.632556mRNA Expression by UniProt/SwissProt for GAL3ST2 Gene:
Q9H3Q3-G3ST2_HUMANEvidence on tissue expression from TISSUES for GAL3ST2 Gene
- Intestine(4.4)
Primer Products
-
OriGene qPCR primer pairs for GAL3ST2
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No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for GAL3ST2 Gene
Orthologs for GAL3ST2 Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | GAL3ST2 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | GAL3ST2 33 34 |
|
||
cow (Bos Taurus) |
Mammalia | GAL3ST2 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Gm9994 33 34 |
|
||
Gal3st2 34 |
|
OneToMany | |||
Gm6086 34 |
|
OneToMany | |||
Gal3st2c 16 |
|
|
|||
rat (Rattus norvegicus) |
Mammalia | Gal3st2 33 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | GAL3ST2 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
-- 34 |
|
OneToMany | |||
chicken (Gallus gallus) |
Aves | GAL3ST2 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | GAL3ST2 34 |
|
OneToOne | |
zebrafish (Danio rerio) |
Actinopterygii | LOC556126 33 |
|
||
CABZ01079005.1 34 |
|
ManyToMany | |||
si:dkey-246m18.2 34 |
|
ManyToMany | |||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany | |
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany |
- Species where no ortholog for GAL3ST2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for GAL3ST2 Gene
Variants for GAL3ST2 Gene
SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs372108744 | likely-pathogenic, not provided | 241,801,858(+) | C/T | coding_sequence_variant, missense_variant | |
rs78620448 | uncertain-significance, not specified | 241,776,985(+) | G/A | splice_donor_variant | |
rs1000026073 | -- | 241,798,307(+) | C/T | intron_variant | |
rs1000152829 | -- | 241,803,511(+) | G/A | coding_sequence_variant, missense_variant | |
rs1000301134 | -- | 241,800,655(+) | A/T | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv165e55 | CNV | loss | 17911159 |
dgv4200n100 | CNV | loss | 25217958 |
dgv4201n100 | CNV | gain | 25217958 |
esv3594840 | CNV | loss | 21293372 |
esv3594841 | CNV | loss | 21293372 |
esv3594842 | CNV | gain | 21293372 |
esv3893578 | CNV | loss | 25118596 |
nsv1002941 | CNV | gain | 25217958 |
nsv1006733 | CNV | gain | 25217958 |
nsv10232 | CNV | gain+loss | 18304495 |
nsv584982 | CNV | loss | 21841781 |
nsv955300 | CNV | deletion | 24416366 |
nsv955301 | CNV | deletion | 24416366 |
nsv997984 | CNV | gain | 25217958 |
Additional Variant Information for GAL3ST2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAL3ST2 Gene
Disorders for GAL3ST2 Gene
Additional Disease Information for GAL3ST2
No disorders were found for GAL3ST2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAL3ST2 Gene
Publications for GAL3ST2 Gene
- Molecular cloning and characterization of a human beta-Gal-3'-sulfotransferase that acts on both type 1 and type 2 (Gal beta 1-3/1-4GlcNAc-R) oligosaccharides. (PMID: 11029462) Honke K … Taniguchi N (The Journal of biological chemistry 2001) 2 3 4 22 58
- Gal3ST-2 involved in tumor metastasis process by regulation of adhesion ability to selectins and expression of integrins. (PMID: 15921657) Shi BZ … Wu XZ (Biochemical and biophysical research communications 2005) 3 22 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Recurrent cis-SAGe chimeric RNA, D2HGDH-GAL3ST2, in prostate cancer. (PMID: 27322736) Qin F … Li H (Cancer letters 2016) 3 58
- GAL3ST2 from mammary gland epithelial cells affects differentiation of 3T3-L1 preadipocytes. (PMID: 25532485) Guerra LN … Calvo JC (Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2015) 3 58
Products for GAL3ST2 Gene
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for available GAL3ST2 related products ranked by validation data
- antibodies-online: Search results for available GAL3ST2 related products ranked by validation data
- antibodies-online: Search results for 4 available GAL3ST2 Proteins ranked by validation data
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Sources for GAL3ST2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
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