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Aliases for GAL3ST2 Gene

Aliases for GAL3ST2 Gene

  • Galactose-3-O-Sulfotransferase 2 2 3 5
  • Glycoprotein Beta-Gal 3-Sulfotransferase 2 3 4
  • Gal-Beta-1, 3-GalNAc 3-Sulfotransferase 2 3 4
  • Beta-Galactose-3-O-Sulfotransferase 2 3 4
  • GAL3ST-2 3 4
  • GP3ST 3 4
  • Galbeta1-3GalNAc 3-Sulfotransferase 2 3
  • Gal 3-O-Sulphotransferase 3
  • EC 2.8.2.- 4

External Ids for GAL3ST2 Gene

Previous GeneCards Identifiers for GAL3ST2 Gene

  • GC11M068343
  • GC11M067490
  • GC11M066059
  • GC11M065585
  • GC02P243038
  • GC02P242436
  • GC02P242364
  • GC02P242716
  • GC02P234469

Summaries for GAL3ST2 Gene

Entrez Gene Summary for GAL3ST2 Gene

  • This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate group to the hydroxyl at C-3 of nonreducing beta-galactosyl residues, and it can act on both type 1 and type 2 (Galbeta 1-3/1-4GlcNAc-R) oligosaccharides with similar efficiencies, and on core 1 glycans. This enzyme has been implicated in tumor metastasis processes. This gene is different from the GAL3ST3 gene located on chromosome 11, which has also been referred to as GAL3ST2 and encodes a related enzyme with distinct tissue distribution and substrate specificities, compared to galactose-3-O-sulfotransferase 2. [provided by RefSeq, Jul 2008]

GeneCards Summary for GAL3ST2 Gene

GAL3ST2 (Galactose-3-O-Sulfotransferase 2) is a Protein Coding gene. Among its related pathways are Phase II conjugation. GO annotations related to this gene include sulfotransferase activity and galactosylceramide sulfotransferase activity. An important paralog of this gene is GAL3ST1.

UniProtKB/Swiss-Prot for GAL3ST2 Gene

  • Transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues. Acts both on type 1 (Gal-beta-1,3-GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency.

Gene Wiki entry for GAL3ST2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GAL3ST2 Gene

Genomics for GAL3ST2 Gene

Regulatory Elements for GAL3ST2 Gene

Transcription factor binding sites by QIAGEN in the GAL3ST2 gene promoter:

Genomic Location for GAL3ST2 Gene

Chromosome:
2
Start:
241,776,825 bp from pter
End:
241,804,287 bp from pter
Size:
27,463 bases
Orientation:
Plus strand

Genomic View for GAL3ST2 Gene

Genes around GAL3ST2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GAL3ST2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GAL3ST2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GAL3ST2 Gene

Proteins for GAL3ST2 Gene

  • Protein details for GAL3ST2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3Q3-G3ST2_HUMAN
    Recommended name:
    Galactose-3-O-sulfotransferase 2
    Protein Accession:
    Q9H3Q3
    Secondary Accessions:
    • Q17RK0
    • Q57Z52

    Protein attributes for GAL3ST2 Gene

    Size:
    398 amino acids
    Molecular mass:
    46110 Da
    Quaternary structure:
    No Data Available

neXtProt entry for GAL3ST2 Gene

Proteomics data for GAL3ST2 Gene at MOPED

Post-translational modifications for GAL3ST2 Gene

  • Glycosylation at Asn 79, Asn 132, Asn 179, Asn 287, Asn 330, and Asn 360
  • Modification sites at PhosphoSitePlus

Other Protein References for GAL3ST2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GAL3ST2 Gene

Domains & Families for GAL3ST2 Gene

Gene Families for GAL3ST2 Gene

Protein Domains for GAL3ST2 Gene

Suggested Antigen Peptide Sequences for GAL3ST2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H3Q3

UniProtKB/Swiss-Prot:

G3ST2_HUMAN :
  • Belongs to the galactose-3-O-sulfotransferase family.
Family:
  • Belongs to the galactose-3-O-sulfotransferase family.
genes like me logo Genes that share domains with GAL3ST2: view

Function for GAL3ST2 Gene

Molecular function for GAL3ST2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 6.0-6.5.;
UniProtKB/Swiss-Prot EnzymeRegulation:
Strongly inhibited by Cu(2+) and Zn(2+).
UniProtKB/Swiss-Prot Function:
Transfers a sulfate group to the hydroxyl group at C3 of non-reducing beta-galactosyl residues. Acts both on type 1 (Gal-beta-1,3-GlcNAc) and type 2 (Gal-beta-1,4-GlcNAc) chains with similar efficiency.

Enzyme Numbers (IUBMB) for GAL3ST2 Gene

genes like me logo Genes that share phenotypes with GAL3ST2: view

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for GAL3ST2 Gene

Localization for GAL3ST2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GAL3ST2 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GAL3ST2 Gene COMPARTMENTS Subcellular localization image for GAL3ST2 gene
Compartment Confidence
golgi apparatus 4
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for GAL3ST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with GAL3ST2: view

Pathways & Interactions for GAL3ST2 Gene

SuperPathways for GAL3ST2 Gene

Superpath Contained pathways
1 Phase II conjugation
genes like me logo Genes that share pathways with GAL3ST2: view

Pathways by source for GAL3ST2 Gene

1 BioSystems pathway for GAL3ST2 Gene

UniProtKB/Swiss-Prot Q9H3Q3-G3ST2_HUMAN

  • Pathway: Protein modification; carbohydrate sulfation.

Interacting Proteins for GAL3ST2 Gene

Selected Interacting proteins: Q9H3Q3-G3ST2_HUMAN for GAL3ST2 Gene via UniProtKB

Symbol External ID(s) Details
MTUS2

Gene Ontology (GO) - Biological Process for GAL3ST2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009058 biosynthetic process IEA --
genes like me logo Genes that share ontologies with GAL3ST2: view

No data available for SIGNOR curated interactions for GAL3ST2 Gene

Drugs & Compounds for GAL3ST2 Gene

No Compound Related Data Available

Transcripts for GAL3ST2 Gene

mRNA/cDNA for GAL3ST2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(38) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GAL3ST2 Gene

Galactose-3-O-sulfotransferase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GAL3ST2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b · 11c · 11d ^ 12a · 12b
SP1: - - - - - - - -
SP2: - -
SP3:
SP4: - - - - - - -
SP5: - - -
SP6: -
SP7: - - - -
SP8: - - -
SP9: - - - - - - - -
SP10: - - - - - - - - - - - -
SP11: - - - - - -
SP12: - - - - - - - -
SP13:

Relevant External Links for GAL3ST2 Gene

GeneLoc Exon Structure for
GAL3ST2
ECgene alternative splicing isoforms for
GAL3ST2

Expression for GAL3ST2 Gene

mRNA expression in normal human tissues for GAL3ST2 Gene

mRNA differential expression in normal tissues according to GTEx for GAL3ST2 Gene

This gene is overexpressed in Colon - Transverse (x21.4).

Protein differential expression in normal tissues from HIPED for GAL3ST2 Gene

This gene is overexpressed in Oral epithelium (63.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for GAL3ST2 Gene



SOURCE GeneReport for Unigene cluster for GAL3ST2 Gene Hs.632556

mRNA Expression by UniProt/SwissProt for GAL3ST2 Gene

Q9H3Q3-G3ST2_HUMAN
Tissue specificity: Ubiquitous. Detected in heart, stomach, colon, liver and spleen, in epithelial cells lining the lower to middle layer of the crypts in colonic mucosa, hepatocytes surrounding the central vein of the liver, extravillous cytotrophoblasts in the basal plate of the septum of the placenta, renal tubules of the kidney, and neuronal cells of the cerebral cortex.
genes like me logo Genes that share expression patterns with GAL3ST2: view

Protein tissue co-expression partners for GAL3ST2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for GAL3ST2 Gene

Orthologs for GAL3ST2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GAL3ST2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GAL3ST2 35
  • 82.24 (n)
  • 75.25 (a)
GAL3ST2 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GAL3ST2 35
  • 83.8 (n)
  • 78.49 (a)
GAL3ST2 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm9994 35
  • 73.63 (n)
  • 70.6 (a)
Gm9994 16
Gal3st2 36
  • 68 (a)
OneToMany
Gm6086 36
  • 67 (a)
OneToMany
Gm9994 36
  • 68 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia GAL3ST2 35
  • 99.03 (n)
  • 97.81 (a)
GAL3ST2 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gal3st2 35
  • 73.43 (n)
  • 68.53 (a)
oppossum
(Monodelphis domestica)
Mammalia GAL3ST2 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 43 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
chicken
(Gallus gallus)
Aves GAL3ST2 35
  • 62.67 (n)
  • 54.09 (a)
GAL3ST2 36
  • 45 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GAL3ST2 36
  • 50 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii LOC556126 35
  • 56.63 (n)
  • 53.69 (a)
CABZ01079005.1 36
  • 33 (a)
ManyToMany
si:dkey-246m18.2 36
  • 30 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
Species with no ortholog for GAL3ST2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GAL3ST2 Gene

ENSEMBL:
Gene Tree for GAL3ST2 (if available)
TreeFam:
Gene Tree for GAL3ST2 (if available)

Paralogs for GAL3ST2 Gene

Paralogs for GAL3ST2 Gene

(2) SIMAP similar genes for GAL3ST2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GAL3ST2: view

Variants for GAL3ST2 Gene

Sequence variations from dbSNP and Humsavar for GAL3ST2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs12469459 - 241,776,965(+) TGTCC(A/T)TGCTG reference, missense
rs741776 -- 241,804,528(-) AGCCC(A/C)AGTGC downstream-variant-500B
rs744986 -- 241,804,236(+) GGCCG(A/G)GGATC utr-variant-3-prime
rs909142 -- 241,802,579(-) cacct(C/T)tcccc intron-variant
rs2142091 -- 241,803,711(-) CACCA(C/T)GTTGT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for GAL3ST2 Gene

Variant ID Type Subtype PubMed ID
nsv876226 CNV Loss 21882294
dgv4493n71 CNV Loss 21882294
dgv4494n71 CNV Loss 21882294
dgv4495n71 CNV Loss 21882294
dgv165e55 CNV Loss 17911159
dgv4496n71 CNV Loss 21882294
nsv876242 CNV Loss 21882294
dgv4497n71 CNV Loss 21882294
nsv876250 CNV Gain 21882294
nsv876254 CNV Loss 21882294
nsv876255 CNV Loss 21882294
nsv10232 CNV Gain+Loss 18304495

Variation tolerance for GAL3ST2 Gene

Residual Variation Intolerance Score: 90.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.73; 73.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GAL3ST2 Gene

HapMap Linkage Disequilibrium report
GAL3ST2
Human Gene Mutation Database (HGMD)
GAL3ST2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GAL3ST2 Gene

Disorders for GAL3ST2 Gene

Relevant External Links for GAL3ST2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GAL3ST2

No disorders were found for GAL3ST2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GAL3ST2 Gene

Publications for GAL3ST2 Gene

  1. Molecular cloning and characterization of a human beta-Gal-3'- sulfotransferase that acts on both type 1 and type 2 (Galbeta 1-3/1- 4GlcNAc-R) oligosaccharides. (PMID: 11029462) Honke K. … Taniguchi N. (J. Biol. Chem. 2001) 2 3 4 23 67
  2. Gal3ST-2 involved in tumor metastasis process by regulation of adhesion ability to selectins and expression of integrins. (PMID: 15921657) Shi B.Z. … Wu X.Z. (Biochem. Biophys. Res. Commun. 2005) 3 23
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Polyoxometalates as effective inhibitors for sialyl- and sulfotransferases. (PMID: 19508952) Seko A. … Yamashita K. (J. Inorg. Biochem. 2009) 23
  5. Porcine, mouse and human galactose 3-O-sulphotransferase-2 enzymes have different substrate specificities; the porcine enzyme requires basic compounds for its catalytic activity. (PMID: 15926885) Seko A. … Yamashita K. (Biochem. J. 2005) 3

Products for GAL3ST2 Gene

Sources for GAL3ST2 Gene

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