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Aliases for SEMG2 Gene

Aliases for SEMG2 Gene

  • Semenogelin II 2 3 4
  • Semenogelin 2 2 3
  • SGII 3 4
  • Semenogelin-2 3

External Ids for SEMG2 Gene

Previous GeneCards Identifiers for SEMG2 Gene

  • GC20P043578
  • GC20P044488
  • GC20P044535
  • GC20P043283
  • GC20P043849
  • GC20P040591

Summaries for SEMG2 Gene

Entrez Gene Summary for SEMG2 Gene

  • The secreted protein encoded by this gene is involved in the formation of a gel matrix that encases ejaculated spermatozoa. Proteolysis by the prostate-specific antigen (PSA) breaks down the gel matrix and allows the spermatozoa to move more freely. The encoded protein is found in lesser abundance than a similar semenogelin protein. An antibacterial activity has been found for a antimicrobial peptide isolated from this protein. The genes encoding these two semenogelin proteins are found in a cluster on chromosome 20. [provided by RefSeq, Jan 2015]

GeneCards Summary for SEMG2 Gene

SEMG2 (Semenogelin II) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is SEMG1.

UniProtKB/Swiss-Prot for SEMG2 Gene

  • Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa

Gene Wiki entry for SEMG2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEMG2 Gene

Genomics for SEMG2 Gene

Regulatory Elements for SEMG2 Gene

Genomic Location for SEMG2 Gene

45,221,300 bp from pter
45,224,458 bp from pter
3,159 bases
Plus strand

Genomic View for SEMG2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEMG2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEMG2 Gene

Proteins for SEMG2 Gene

  • Protein details for SEMG2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q53ZU2
    • Q6X2M5
    • Q6X2M6

    Protein attributes for SEMG2 Gene

    582 amino acids
    Molecular mass:
    65444 Da
    Quaternary structure:
    • Interacts with SERPINA5.

neXtProt entry for SEMG2 Gene

Proteomics data for SEMG2 Gene at MOPED

Post-translational modifications for SEMG2 Gene

  • Semenogelin-2 is thought to form both the 71 kDa polypeptide and, in its glycosylated form, the 76 kDa polypeptide.
  • Glycosylation at Asn272
  • Modification sites at PhosphoSitePlus

Other Protein References for SEMG2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SEMG2 Gene

Domains for SEMG2 Gene

Protein Domains for SEMG2 Gene


Suggested Antigen Peptide Sequences for SEMG2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q02383
  • Belongs to the semenogelin family.
genes like me logo Genes that share domains with SEMG2: view

No data available for Gene Families for SEMG2 Gene

Function for SEMG2 Gene

Molecular function for SEMG2 Gene

GENATLAS Biochemistry: major protein of seminal fluid,semenogelin 2 (71 and 76 kDa)
UniProtKB/Swiss-Prot Function: Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa

Gene Ontology (GO) - Molecular Function for SEMG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with SEMG2: view

Animal Model Products

miRNA for SEMG2 Gene

miRTarBase miRNAs that target SEMG2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEMG2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for SEMG2 Gene

Localization for SEMG2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEMG2 Gene


Subcellular locations from

Jensen Localization Image for SEMG2 Gene COMPARTMENTS Subcellular localization image for SEMG2 gene
Compartment Confidence
extracellular 5
cytosol 1
endoplasmic reticulum 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SEMG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space TAS 1517240
GO:0005634 nucleus IDA 21630459
GO:0030141 secretory granule IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with SEMG2: view

Pathways for SEMG2 Gene

SuperPathways for SEMG2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for SEMG2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019953 sexual reproduction IEA --
genes like me logo Genes that share ontologies with SEMG2: view

No data available for Pathways by source for SEMG2 Gene

Compounds for SEMG2 Gene

(3) Novoseek inferred chemical compound relationships for SEMG2 Gene

Compound -log(P) Hits PubMed IDs
dextran sulfate 51.5 1
heparin 29 1
serine 24.9 1
genes like me logo Genes that share compounds with SEMG2: view

Transcripts for SEMG2 Gene

mRNA/cDNA for SEMG2 Gene

(344) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SEMG2 Gene

Semenogelin II:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SEMG2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for SEMG2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SEMG2 Gene

No ASD Table

Relevant External Links for SEMG2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SEMG2 Gene

mRNA expression in normal human tissues for SEMG2 Gene

mRNA differential expression in normal tissues according to GTEx for SEMG2 Gene

This gene is overexpressed in Prostate (32.5), Kidney - Cortex (9.0), and Testis (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SEMG2 Gene

SOURCE GeneReport for Unigene cluster for SEMG2 Gene Hs.537218

mRNA Expression by UniProt/SwissProt for SEMG2 Gene

Tissue specificity: Seminal vesicles, and to a much lesser extent, epididymis
genes like me logo Genes that share expressions with SEMG2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for SEMG2 Gene

Orthologs for SEMG2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SEMG2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SEMG2 35
  • 98.03 (n)
  • 96.06 (a)
Species with no ortholog for SEMG2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SEMG2 Gene

Gene Tree for SEMG2 (if available)
Gene Tree for SEMG2 (if available)

Paralogs for SEMG2 Gene

Paralogs for SEMG2 Gene

Selected SIMAP similar genes for SEMG2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SEMG2: view

Variants for SEMG2 Gene

Sequence variations from dbSNP and Humsavar for SEMG2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs2071650 - 45,222,734(+) AGAAA(C/G)GTGTA missense, reference
rs2071651 -- 45,224,512(+) TGAGG(G/T)CATTT downstream-variant-500B
rs2233891 -- 45,220,638(+) GCCTC(A/G)CCTCT upstream-variant-2KB
rs2233892 -- 45,220,814(+) TACAT(C/T)TGACA upstream-variant-2KB
rs2233893 -- 45,221,294(+) CAGTG(C/T)CTTTT upstream-variant-2KB

Relevant External Links for SEMG2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for SEMG2 Gene

Disorders for SEMG2 Gene

No disorders were found for SEMG2 Gene.

No data available for UniProtKB/Swiss-Prot for SEMG2 Gene

Publications for SEMG2 Gene

  1. Molecular cloning of epididymal and seminal vesicular transcripts encoding a semenogelin-related protein. (PMID: 1584792) Lundwall A. … Lilja H. (Proc. Natl. Acad. Sci. U.S.A. 1992) 3 4 23
  2. Isolation and characterization of the major gel proteins in human semen, semenogelin I and semenogelin II. (PMID: 8665951) Malm J. … Lilja H. (Eur. J. Biochem. 1996) 3 4 23
  3. Characterization of semenogelin II and its molecular interaction with prostate-specific antigen and protein C inhibitor. (PMID: 8665956) Kise H. … Suzuki K. (Eur. J. Biochem. 1996) 3 4 23
  4. Semenogelin I and semenogelin II, the major gel-forming proteins in human semen, are substrates for transglutaminase. (PMID: 9523691) Peter A. … Malm J. (Eur. J. Biochem. 1998) 2 3 23
  5. Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen. (PMID: 14629036) Jensen-Seaman M.I. … Li W.-H. (J. Mol. Evol. 2003) 3 4 23

Products for SEMG2 Gene

Sources for SEMG2 Gene

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