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Aliases for MMP27 Gene

Aliases for MMP27 Gene

  • Matrix Metallopeptidase 27 2 3
  • Matrix Metalloproteinase 27 2 3
  • Matrix Metalloprotease 27 2 3
  • MMP-27 3 4
  • Matrix Metalloproteinase-27 3
  • EC 3.4.24.35 64
  • EC 3.4.24.- 4
  • EC 3.4.24 64

External Ids for MMP27 Gene

Summaries for MMP27 Gene

Entrez Gene Summary for MMP27 Gene

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. [provided by RefSeq, Jul 2008]

GeneCards Summary for MMP27 Gene

MMP27 (Matrix Metallopeptidase 27) is a Protein Coding gene. Diseases associated with MMP27 include arthritis. Among its related pathways are GPCR Pathway and Integrin Pathway. GO annotations related to this gene include calcium ion binding and metalloendopeptidase activity. An important paralog of this gene is MMP13.

UniProtKB/Swiss-Prot for MMP27 Gene

  • Matrix metalloproteinases degrade protein components of the extracellular matrix such as fibronectin, laminin, gelatins and/or collagens.

Tocris Summary for MMP27 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been identified in humans, which can be organized into six groups based on domain organization and substrate preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and -11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others (MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer. Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP27 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP27 Gene

Genomics for MMP27 Gene

Genomic Location for MMP27 Gene

Start:
102,691,487 bp from pter
End:
102,705,806 bp from pter
Size:
14,320 bases
Orientation:
Minus strand

Genomic View for MMP27 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MMP27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP27 Gene

Regulatory Elements for MMP27 Gene

Proteins for MMP27 Gene

  • Protein details for MMP27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H306-MMP27_HUMAN
    Recommended name:
    Matrix metalloproteinase-27
    Protein Accession:
    Q9H306
    Secondary Accessions:
    • Q6UWK6

    Protein attributes for MMP27 Gene

    Size:
    513 amino acids
    Molecular mass:
    59026 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 4 Ca(2+) ions per subunit.;
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.;
    Quaternary structure:
    No Data Available

neXtProt entry for MMP27 Gene

Proteomics data for MMP27 Gene at MOPED

Selected DME Specific Peptides for MMP27 Gene

Post-translational modifications for MMP27 Gene

Other Protein References for MMP27 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for MMP27 Gene

UniProtKB/Swiss-Prot:

MMP27_HUMAN
Domain:
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme:
    • Q9H306
Family:
  • Belongs to the peptidase M10A family.:
    • Q9H306
Similarity:
  • Contains 4 hemopexin repeats.:
    • Q9H306
genes like me logo Genes that share domains with MMP27: view

Function for MMP27 Gene

Molecular function for MMP27 Gene

UniProtKB/Swiss-Prot Function: Matrix metalloproteinases degrade protein components of the extracellular matrix such as fibronectin, laminin, gelatins and/or collagens.

Enzyme Numbers (IUBMB) for MMP27 Gene

Gene Ontology (GO) - Molecular Function for MMP27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0008237 metallopeptidase activity --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MMP27: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for MMP27 Gene

Localization for MMP27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP27 Gene

Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Retained in the endoplasmic reticulum. {ECO:0000269 PubMed:24548619}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MMP27 Gene COMPARTMENTS Subcellular localization image for MMP27 gene
Compartment Confidence
endoplasmic reticulum 2
extracellular 2
plasma membrane 2
golgi apparatus 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for MMP27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix --
GO:0031012 extracellular matrix IEA --
GO:0042406 extrinsic component of endoplasmic reticulum membrane IDA 24548619
genes like me logo Genes that share ontologies with MMP27: view

Pathways for MMP27 Gene

genes like me logo Genes that share pathways with MMP27: view

Pathways by source for MMP27 Gene

Interacting Proteins for MMP27 Gene

Gene Ontology (GO) - Biological Process for MMP27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0030574 collagen catabolic process IEA --
genes like me logo Genes that share ontologies with MMP27: view

Compounds for MMP27 Gene

(5) Tocris Compounds for MMP27 Gene

Compound Action Cas Number
Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]
GI 254023X Selective ADAM10 metalloprotease inhibitor [260264-93-5]
GM 6001 Broad-spectrum MMP inhibitor [142880-36-2]
Marimastat Broad spectrum MMP inhibitor [154039-60-8]
UK 383367 Potent and selective BMP-1 (PCP) inhibitor [348622-88-8]

(1) HMDB Compounds for MMP27 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Drugbank Compounds for MMP27 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Marimastat
154039-60-8 target inhibitor
genes like me logo Genes that share compounds with MMP27: view

Transcripts for MMP27 Gene

mRNA/cDNA for MMP27 Gene

(5) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MMP27 Gene

Matrix metallopeptidase 27:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MMP27 Gene

No ASD Table

Relevant External Links for MMP27 Gene

GeneLoc Exon Structure for
MMP27
ECgene alternative splicing isoforms for
MMP27

Expression for MMP27 Gene

mRNA expression in normal human tissues for MMP27 Gene

mRNA differential expression in normal tissues according to GTEx for MMP27 Gene

This gene is overexpressed in Minor Salivary Gland (10.9), Skin - Sun Exposed (Lower leg) (10.6), Skin - Not Sun Exposed (Suprapubic) (8.5), and Adipose - Subcutaneous (6.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for MMP27 Gene

SOURCE GeneReport for Unigene cluster for MMP27 Gene Hs.534479

mRNA Expression by UniProt/SwissProt for MMP27 Gene

Q9H306-MMP27_HUMAN
Tissue specificity: Expressed in B-cells (PubMed:14506071). Expressed in a subset of endometrial macrophages related to menstruation and in ovarian and peritoneal endometriotic lesions (at protein level)(PubMed:24810263).
genes like me logo Genes that share expressions with MMP27: view

Orthologs for MMP27 Gene

This gene was present in the common ancestor of chordates.

Orthologs for MMP27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MMP27 36
  • 99.22 (n)
  • 98.64 (a)
MMP27 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MMP27 36
  • 85.96 (n)
  • 82.63 (a)
MMP27 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MMP27 36
  • 86.59 (n)
  • 83.2 (a)
MMP27 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mmp27 36
  • 81.76 (n)
  • 77.17 (a)
Mmp27 16
Mmp27 37
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MMP27 37
  • 68 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mmp27 36
  • 81.44 (n)
  • 78.14 (a)
chicken
(Gallus gallus)
Aves MMP27 36
  • 65.73 (n)
  • 59.14 (a)
MMP27 37
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MMP27 37
  • 51 (a)
OneToOne
Species with no ortholog for MMP27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for MMP27 Gene

ENSEMBL:
Gene Tree for MMP27 (if available)
TreeFam:
Gene Tree for MMP27 (if available)

Paralogs for MMP27 Gene

Selected SIMAP similar genes for MMP27 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MMP27: view

Variants for MMP27 Gene

Sequence variations from dbSNP and Humsavar for MMP27 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs495910 -- 102,702,534(+) GGGTG(C/T)ATGAA intron-variant
rs947875 -- 102,706,938(-) TAAAC(A/T)ATTTA upstream-variant-2KB
rs1276286 - 102,696,476(-) TAAGG(A/T)ACCTG reference, missense
rs1276287 -- 102,694,545(-) TCATT(C/G)TTTAC intron-variant
rs1276288 -- 102,693,535(-) AAAGT(A/G)CTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MMP27 Gene

Variant ID Type Subtype PubMed ID
nsv832252 CNV Gain 17160897
esv2660550 CNV Deletion 23128226
nsv819435 CNV Loss 19587683

Relevant External Links for MMP27 Gene

HapMap Linkage Disequilibrium report
MMP27

Disorders for MMP27 Gene

(1) MalaCards Diseases for MMP27 Gene

Search for MMP27 Gene in MalaCards »

Relevant External Links for MMP27

Genetic Association Database (GAD)
MMP27
Human Genome Epidemiology (HuGE) Navigator
MMP27
genes like me logo Genes that share disorders with MMP27: view

No data available for UniProtKB/Swiss-Prot for MMP27 Gene

Publications for MMP27 Gene

  1. Matrix metalloproteinases. (PMID: 10419448) Nagase H. … Woessner J.F. (J. Biol. Chem. 1999) 2 3
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 49
  4. A unique C-terminal domain allows retention of matrix metalloproteinase-27 in the endoplasmic reticulum. (PMID: 24548619) Cominelli A. … Henriet P. (Traffic 2014) 3 4
  5. Matrix metalloproteinase-27 is expressed in CD163+/CD206+ M2 macrophages in the cycling human endometrium and in superficial endometriotic lesions. (PMID: 24810263) Cominelli A. … Henriet P. (Mol. Hum. Reprod. 2014) 3 4

Products for MMP27 Gene

Sources for MMP27 Gene

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