Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SEMG1 Gene

Aliases for SEMG1 Gene

  • Semenogelin I 2 3 4
  • Cancer/Testis Antigen 103 2 3 4
  • SemG 3 4 6
  • Semen Coagulating Protein 2 3
  • SgI 3 4
  • Semenogelin-1 3
  • DJ172H20.2 3
  • SgI-29 3
  • CT103 3

External Ids for SEMG1 Gene

Previous Symbols for SEMG1 Gene

  • SEMG

Summaries for SEMG1 Gene

Entrez Gene Summary for SEMG1 Gene

  • The protein encoded by this gene is the predominant protein in semen. The encoded secreted protein is involved in the formation of a gel matrix that encases ejaculated spermatozoa. The prostate-specific antigen (PSA) protease processes this protein into smaller peptides, with each possibly having a separate function. The proteolysis process breaks down the gel matrix and allows the spermatozoa to move more freely. The antimicrobial peptide SgI-29 is an antimicrobial peptide with antibacterial activity. [provided by RefSeq, Nov 2014]

GeneCards Summary for SEMG1 Gene

SEMG1 (Semenogelin I) is a Protein Coding gene. Among its related pathways are Disease and RNA Polymerase I Promoter Opening. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is SEMG2.

UniProtKB/Swiss-Prot for SEMG1 Gene

  • Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA.

  • Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit the secretion of pituitary follicle-stimulating hormone.

Gene Wiki entry for SEMG1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEMG1 Gene

Genomics for SEMG1 Gene

Genomic Location for SEMG1 Gene

Start:
45,206,997 bp from pter
End:
45,209,773 bp from pter
Size:
2,777 bases
Orientation:
Plus strand

Genomic View for SEMG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SEMG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEMG1 Gene

Regulatory Elements for SEMG1 Gene

Proteins for SEMG1 Gene

  • Protein details for SEMG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04279-SEMG1_HUMAN
    Recommended name:
    Semenogelin-1
    Protein Accession:
    P04279
    Secondary Accessions:
    • Q53ZV0
    • Q53ZV1
    • Q53ZV2
    • Q6X4I9
    • Q6Y809
    • Q6Y822
    • Q6Y823
    • Q86U64
    • Q96QM3

    Protein attributes for SEMG1 Gene

    Size:
    462 amino acids
    Molecular mass:
    52131 Da
    Quaternary structure:
    • Occurs in disulfide-linked complexes which may also contain two less abundant 71- and 76-kDa semenogelin-related polypeptides. Interacts with EPPIN (via C-terminus); Cys-239 is a critical amino acid for both binding to EPPIN.

    Alternative splice isoforms for SEMG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEMG1 Gene

Proteomics data for SEMG1 Gene at MOPED

Post-translational modifications for SEMG1 Gene

  • Rapidly cleaved after ejaculation by KLK3/PSA, resulting in liquefaction of the semen coagulum and the progressive release of motile spermatozoa
  • Transglutaminase substrate
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SEMG1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SEMG1 Gene

Domains for SEMG1 Gene

Protein Domains for SEMG1 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

SEMG1_HUMAN
Family:
  • Belongs to the semenogelin family.:
    • P04279
genes like me logo Genes that share domains with SEMG1: view

No data available for Gene Families for SEMG1 Gene

Function for SEMG1 Gene

Molecular function for SEMG1 Gene

GENATLAS Biochemistry: major protein of seminal fluid,semenogelin 1,(52kDa),tightly linked to SEMG2
UniProtKB/Swiss-Prot Function: Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA.
UniProtKB/Swiss-Prot Function: Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit the secretion of pituitary follicle-stimulating hormone.

Gene Ontology (GO) - Molecular Function for SEMG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IPI 15590901
genes like me logo Genes that share ontologies with SEMG1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SEMG1 Gene

Localization for SEMG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEMG1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SEMG1 Gene COMPARTMENTS Subcellular localization image for SEMG1 gene
Compartment Confidence
extracellular 5
cytoskeleton 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for SEMG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS 1517240
GO:0005634 nucleus IDA 21630459
GO:0030141 secretory granule IEA --
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with SEMG1: view

Pathways for SEMG1 Gene

SuperPathways for SEMG1 Gene

Superpath Contained pathways
1 Disease
2 RNA Polymerase I Promoter Opening
.68
genes like me logo Genes that share pathways with SEMG1: view

Pathways by source for SEMG1 Gene

2 Reactome pathways for SEMG1 Gene

Gene Ontology (GO) - Biological Process for SEMG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007320 insemination TAS 2912989
GO:0019953 sexual reproduction --
GO:0090281 negative regulation of calcium ion import IDA 22075473
GO:1901318 negative regulation of sperm motility IDA 22075473
genes like me logo Genes that share ontologies with SEMG1: view

Compounds for SEMG1 Gene

(2) Novoseek inferred chemical compound relationships for SEMG1 Gene

Compound -log(P) Hits PubMed IDs
serine 49.7 2
zinc 39.8 7
genes like me logo Genes that share compounds with SEMG1: view

Transcripts for SEMG1 Gene

mRNA/cDNA for SEMG1 Gene

Unigene Clusters for SEMG1 Gene

Semenogelin I:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SEMG1 Gene

No ASD Table

Relevant External Links for SEMG1 Gene

GeneLoc Exon Structure for
SEMG1
ECgene alternative splicing isoforms for
SEMG1

Expression for SEMG1 Gene

mRNA expression in normal human tissues for SEMG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SEMG1 Gene

This gene is overexpressed in Prostate (38.7) and Whole Blood (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SEMG1 Gene

SOURCE GeneReport for Unigene cluster for SEMG1 Gene Hs.1968

mRNA Expression by UniProt/SwissProt for SEMG1 Gene

P04279-SEMG1_HUMAN
Tissue specificity: Seminal vesicle
genes like me logo Genes that share expressions with SEMG1: view

Orthologs for SEMG1 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for SEMG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEMG2 37
  • 59 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Svs2 16
Species with no ortholog for SEMG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SEMG1 Gene

ENSEMBL:
Gene Tree for SEMG1 (if available)
TreeFam:
Gene Tree for SEMG1 (if available)

Paralogs for SEMG1 Gene

Paralogs for SEMG1 Gene

Selected SIMAP similar genes for SEMG1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SEMG1: view

Variants for SEMG1 Gene

Sequence variations from dbSNP and Humsavar for SEMG1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1804436 -- 45,209,701(+) TGCTT(A/C)CTTGA utr-variant-3-prime
rs2233879 -- 45,206,642(+) AAGGA(A/G)GTATG upstream-variant-2KB
rs2233880 -- 45,206,812(+) TGATG(A/G)TCTAA upstream-variant-2KB
rs2233881 -- 45,206,816(+) GATCT(A/G)AAAGG upstream-variant-2KB
rs2233882 -- 45,207,042(+) AAGGT(A/T)TTCCA utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SEMG1 Gene

Variant ID Type Subtype PubMed ID
nsv482068 CNV Gain 20164927
esv2663630 CNV Deletion 23128226

Relevant External Links for SEMG1 Gene

HapMap Linkage Disequilibrium report
SEMG1
Human Gene Mutation Database (HGMD)
SEMG1

Disorders for SEMG1 Gene

(1) University of Copenhagen DISEASES for SEMG1 Gene

(1) Novoseek inferred disease relationships for SEMG1 Gene

Disease -log(P) Hits PubMed IDs
infertility male 55.6 2
genes like me logo Genes that share disorders with SEMG1: view

No data available for UniProtKB/Swiss-Prot for SEMG1 Gene

Publications for SEMG1 Gene

  1. Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20. (PMID: 1517240) Ulvsbaeck M. … Lundwall A. (J. Biol. Chem. 1992) 3 4 23
  2. Semenogelin I: a coagulum forming, multifunctional seminal vesicle protein. (PMID: 10412373) Robert M. … Gagnon C. (Cell. Mol. Life Sci. 1999) 3 4 23
  3. Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen. (PMID: 14629036) Jensen-Seaman M.I. … Li W.-H. (J. Mol. Evol. 2003) 3 4 23
  4. Semenogelins I and II bind zinc and regulate the activity of prostate-specific antigen. (PMID: 15563730) Jonsson M. … Malm J. (Biochem. J. 2005) 2 3 23
  5. Association of eppin with semenogelin on human spermatozoa. (PMID: 15590901) Wang Z. … Richardson R.T. (Biol. Reprod. 2005) 3 4 23

Products for SEMG1 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate SEMG1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for SEMG1
    • Block miRNA regulation of SEMG1 using miScript Target Protectors

    Sources for SEMG1 Gene

    Back to Top

    Content