Aliases for SEMG1 Gene
External Ids for SEMG1 Gene
Previous HGNC Symbols for SEMG1 Gene
Previous GeneCards Identifiers for SEMG1 Gene
The protein encoded by this gene is the predominant protein in semen. The encoded secreted protein is involved in the formation of a gel matrix that encases ejaculated spermatozoa. The prostate-specific antigen (PSA) protease processes this protein into smaller peptides, with each possibly having a separate function. The proteolysis process breaks down the gel matrix and allows the spermatozoa to move more freely. The antimicrobial peptide SgI-29 is an antimicrobial peptide with antibacterial activity. [provided by RefSeq, Nov 2014]
GeneCards Summary for SEMG1 Gene
SEMG1 (Semenogelin I) is a Protein Coding gene. Diseases associated with SEMG1 include motion sickness and male infertility. Among its related pathways are Transport to the Golgi and subsequent modification and RNA Polymerase I Promoter Opening. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is SEMG2.
UniProtKB/Swiss-Prot for SEMG1 Gene
Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA.
Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit the secretion of pituitary follicle-stimulating hormone.