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Aliases for SEMG1 Gene

Aliases for SEMG1 Gene

  • Semenogelin I 2 3 4 5
  • Cancer/Testis Antigen 103 2 3 4
  • Semen Coagulating Protein 2 3
  • SemG 3 4
  • SgI 3 4
  • Semenogelin-1 3
  • DJ172H20.2 3
  • SgI-29 3
  • CT103 3

External Ids for SEMG1 Gene

Previous HGNC Symbols for SEMG1 Gene

  • SEMG

Previous GeneCards Identifiers for SEMG1 Gene

  • GC20P043564
  • GC20P044474
  • GC20P044521
  • GC20P043269
  • GC20P043835
  • GC20P040577

Summaries for SEMG1 Gene

Entrez Gene Summary for SEMG1 Gene

  • The protein encoded by this gene is the predominant protein in semen. The encoded secreted protein is involved in the formation of a gel matrix that encases ejaculated spermatozoa. This preproprotein is proteolytically processed by the prostate-specific antigen (PSA) protease to generate multiple peptide products that exhibit distinct functions. One of these peptides, SgI-29, is an antimicrobial peptide with antibacterial activity. This proteolysis process also breaks down the gel matrix and allows the spermatozoa to move more freely. This gene and another similar semenogelin gene are present in a gene cluster on chromosome 20. [provided by RefSeq, Feb 2016]

GeneCards Summary for SEMG1 Gene

SEMG1 (Semenogelin I) is a Protein Coding gene. Diseases associated with SEMG1 include Motion Sickness. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Metabolism of proteins. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is SEMG2.

UniProtKB/Swiss-Prot for SEMG1 Gene

  • Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA.

  • Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit the secretion of pituitary follicle-stimulating hormone.

Gene Wiki entry for SEMG1 Gene

Additional gene information for SEMG1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEMG1 Gene

Genomics for SEMG1 Gene

Regulatory Elements for SEMG1 Gene

Enhancers for SEMG1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20H045209 0.4 ENCODE 0.7 +3.1 3068 0 POU5F1 SEMG1 SEMG2
GH20H045180 0.2 Ensembl 0.3 -26.7 -26697 0 WFDC5 LOC101929866 SEMG1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SEMG1 on UCSC Golden Path with GeneCards custom track

Genomic Location for SEMG1 Gene

Chromosome:
20
Start:
45,206,997 bp from pter
End:
45,209,773 bp from pter
Size:
2,777 bases
Orientation:
Plus strand

Genomic View for SEMG1 Gene

Genes around SEMG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEMG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEMG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEMG1 Gene

Proteins for SEMG1 Gene

  • Protein details for SEMG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P04279-SEMG1_HUMAN
    Recommended name:
    Semenogelin-1
    Protein Accession:
    P04279
    Secondary Accessions:
    • Q53ZV0
    • Q53ZV1
    • Q53ZV2
    • Q6X4I9
    • Q6Y809
    • Q6Y822
    • Q6Y823
    • Q86U64
    • Q96QM3

    Protein attributes for SEMG1 Gene

    Size:
    462 amino acids
    Molecular mass:
    52131 Da
    Quaternary structure:
    • Occurs in disulfide-linked complexes which may also contain two less abundant 71- and 76-kDa semenogelin-related polypeptides. Interacts with EPPIN (via C-terminus); Cys-239 is a critical amino acid for both binding to EPPIN.

    Alternative splice isoforms for SEMG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SEMG1 Gene

Post-translational modifications for SEMG1 Gene

  • Rapidly cleaved after ejaculation by KLK3/PSA, resulting in liquefaction of the semen coagulum and the progressive release of motile spermatozoa.
  • Transglutaminase substrate.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SEMG1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for SEMG1 Gene

Domains & Families for SEMG1 Gene

Gene Families for SEMG1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for SEMG1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for SEMG1 Gene

Graphical View of Domain Structure for InterPro Entry

P04279

UniProtKB/Swiss-Prot:

SEMG1_HUMAN :
  • Belongs to the semenogelin family.
Family:
  • Belongs to the semenogelin family.
genes like me logo Genes that share domains with SEMG1: view

Function for SEMG1 Gene

Molecular function for SEMG1 Gene

GENATLAS Biochemistry:
major protein of seminal fluid,semenogelin 1,(52kDa),tightly linked to SEMG2
UniProtKB/Swiss-Prot Function:
Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA.
UniProtKB/Swiss-Prot Function:
Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit the secretion of pituitary follicle-stimulating hormone.

Gene Ontology (GO) - Molecular Function for SEMG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 8665956
GO:0046872 metal ion binding IMP 15563730
genes like me logo Genes that share ontologies with SEMG1: view

Phenotypes for SEMG1 Gene

GenomeRNAi human phenotypes for SEMG1:
genes like me logo Genes that share phenotypes with SEMG1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SEMG1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SEMG1 Gene

Localization for SEMG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEMG1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEMG1 gene
Compartment Confidence
extracellular 5
nucleus 5

Gene Ontology (GO) - Cellular Components for SEMG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space TAS 1517240
GO:0005634 nucleus IDA 21630459
GO:0043234 protein complex IDA 17567961
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with SEMG1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SEMG1 Gene

Pathways & Interactions for SEMG1 Gene

genes like me logo Genes that share pathways with SEMG1: view

Pathways by source for SEMG1 Gene

Gene Ontology (GO) - Biological Process for SEMG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007320 insemination TAS 2912989
GO:0019730 antimicrobial humoral response TAS --
GO:0019731 antibacterial humoral response IDA 18714013
GO:0031640 killing of cells of other organism IDA 18314226
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with SEMG1: view

No data available for SIGNOR curated interactions for SEMG1 Gene

Drugs & Compounds for SEMG1 Gene

(2) Drugs for SEMG1 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma Target 2359
genes like me logo Genes that share compounds with SEMG1: view

Transcripts for SEMG1 Gene

mRNA/cDNA for SEMG1 Gene

Unigene Clusters for SEMG1 Gene

Semenogelin I:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for SEMG1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SEMG1 Gene

No ASD Table

Relevant External Links for SEMG1 Gene

GeneLoc Exon Structure for
SEMG1
ECgene alternative splicing isoforms for
SEMG1

Expression for SEMG1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SEMG1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SEMG1 Gene

This gene is overexpressed in Prostate (x38.7) and Whole Blood (x6.0).

Protein differential expression in normal tissues from HIPED for SEMG1 Gene

This gene is overexpressed in Prostate (58.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SEMG1 Gene



Protein tissue co-expression partners for SEMG1 Gene

NURSA nuclear receptor signaling pathways regulating expression of SEMG1 Gene:

SEMG1

SOURCE GeneReport for Unigene cluster for SEMG1 Gene:

Hs.1968

mRNA Expression by UniProt/SwissProt for SEMG1 Gene:

P04279-SEMG1_HUMAN
Tissue specificity: Seminal vesicle.

Evidence on tissue expression from TISSUES for SEMG1 Gene

  • Blood(4.2)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with SEMG1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SEMG1 Gene

Orthologs for SEMG1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for SEMG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEMG2 34
  • 59 (a)
OneToOne
Species where no ortholog for SEMG1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SEMG1 Gene

ENSEMBL:
Gene Tree for SEMG1 (if available)
TreeFam:
Gene Tree for SEMG1 (if available)

Paralogs for SEMG1 Gene

Paralogs for SEMG1 Gene

(1) SIMAP similar genes for SEMG1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SEMG1: view

Variants for SEMG1 Gene

Sequence variations from dbSNP and Humsavar for SEMG1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000979314 -- 45,206,247(+) TCACC(A/G)TGAAA upstream-variant-2KB
rs1001674760 -- 45,208,133(+) ACAGC(A/G)TGGCC reference, missense
rs1001728541 -- 45,207,804(+) GTTCA(C/T)GGACT reference, synonymous-codon
rs1002022972 -- 45,206,859(+) AAGAA(A/G)ATGCC upstream-variant-2KB
rs1002077002 -- 45,206,602(+) AGGTA(A/T)AATAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SEMG1 Gene

Variant ID Type Subtype PubMed ID
esv2663630 CNV deletion 23128226
esv3557116 CNV deletion 23714750
nsv1056102 CNV loss 25217958
nsv482068 CNV gain 20164927

Variation tolerance for SEMG1 Gene

Residual Variation Intolerance Score: 91.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.39; 54.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SEMG1 Gene

Human Gene Mutation Database (HGMD)
SEMG1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SEMG1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEMG1 Gene

Disorders for SEMG1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for SEMG1 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
motion sickness
  • travel sickness
- elite association - COSMIC cancer census association via MalaCards
Search SEMG1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for SEMG1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SEMG1
genes like me logo Genes that share disorders with SEMG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SEMG1 Gene

Publications for SEMG1 Gene

  1. Analysis of recombinant human semenogelin as an inhibitor of human sperm motility. (PMID: 19889947) Mitra A … O'Rand MG (Biology of reproduction 2010) 3 4 22 60
  2. Characterization of an eppin protein complex from human semen and spermatozoa. (PMID: 17567961) Wang Z … O'Rand MG (Biology of reproduction 2007) 3 4 22 60
  3. Semenogelins I and II bind zinc and regulate the activity of prostate-specific antigen. (PMID: 15563730) Jonsson M … Malm J (The Biochemical journal 2005) 2 3 22 60
  4. Association of eppin with semenogelin on human spermatozoa. (PMID: 15590901) Wang Z … Richardson RT (Biology of reproduction 2005) 3 4 22 60
  5. Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen. (PMID: 14629036) Jensen-Seaman MI … Li WH (Journal of molecular evolution 2003) 3 4 22 60

Products for SEMG1 Gene

Sources for SEMG1 Gene

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