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Aliases for SELPLG Gene

Aliases for SELPLG Gene

  • Selectin P Ligand 2 3 4 5
  • PSGL-1 3 4
  • Cutaneous Lymphocyte-Associated Associated Antigen 3
  • P-Selectin Glycoprotein Ligand 1 3
  • CD162 Antigen 4
  • CD162 3
  • PSGL1 3
  • CLA 3

External Ids for SELPLG Gene

Previous GeneCards Identifiers for SELPLG Gene

  • GC12M108122
  • GC12M108896
  • GC12M108948
  • GC12M107518
  • GC12M109015
  • GC12M106080

Summaries for SELPLG Gene

Entrez Gene Summary for SELPLG Gene

  • This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]

GeneCards Summary for SELPLG Gene

SELPLG (Selectin P Ligand) is a Protein Coding gene. Diseases associated with SELPLG include Human Granulocytic Anaplasmosis and Ehrlichiosis. Among its related pathways are Cell surface interactions at the vascular wall and Response to elevated platelet cytosolic Ca2+. GO annotations related to this gene include receptor binding.

UniProtKB/Swiss-Prot for SELPLG Gene

  • A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture.

  • (Microbial infection) Acts as a receptor for enterovirus 71.

Gene Wiki entry for SELPLG Gene

Additional gene information for SELPLG Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELPLG Gene

Genomics for SELPLG Gene

Regulatory Elements for SELPLG Gene

Enhancers for SELPLG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H108820 2.1 FANTOM5 Ensembl ENCODE dbSUPER 13.2 -197.8 -197752 23.4 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 YY1 ZNF766 CBX5 ZNF143 SART3 UBE3B SSH1 CORO1C LINC01486 LOC644746 RNU4-32P SELPLG ALKBH2 ACACB
GH12H108663 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.9 -32.1 -32058 5.8 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 YY1 ZNF143 FOS CORO1C SELPLG SSH1 ISCU SART3 ENSG00000257221 MVK ACACB RNU7-169P GC12P108645
GH12H108626 2 FANTOM5 Ensembl ENCODE dbSUPER 11.8 -4.9 -4905 24.2 HDGF PKNOX1 ARNT FEZF1 ZNF766 CBX5 ZNF207 ZNF143 ZNF548 FOS PWP1 SART3 PRDM4 UBE3B RNU4-32P CORO1C FICD LOC101929162 SELPLG TMEM119
GH12H108720 1.5 FANTOM5 ENCODE dbSUPER 12.2 -89.5 -89465 5.5 PKNOX1 KLF17 SIN3A FEZF1 RAD21 YY1 ZNF366 FOS RUNX3 USF2 SELPLG RNU7-169P ENSG00000257221 MVK CORO1C SSH1 GC12M108717
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SELPLG on UCSC Golden Path with GeneCards custom track

Promoters for SELPLG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000057075 259 201 PKNOX1 TBL1XR1 RB1 BMI1 BATF ZNF143 ZNF207 ATF7 ETV6 RUNX3

Genomic Locations for SELPLG Gene

Genomic Locations for SELPLG Gene
12,065 bases
Minus strand

Genomic View for SELPLG Gene

Genes around SELPLG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELPLG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELPLG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELPLG Gene

Proteins for SELPLG Gene

  • Protein details for SELPLG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    P-selectin glycoprotein ligand 1
    Protein Accession:
    Secondary Accessions:
    • A8K2Y0
    • B4DQC3
    • B7Z5C7
    • J3KMX6
    • Q12775
    • Q6GTW7
    • Q8N7J7

    Protein attributes for SELPLG Gene

    412 amino acids
    Molecular mass:
    43201 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Interaction with P-, E- and L-selectins, through their lectin/EGF domains, is required for promoting recruitment and rolling of leukocytes. These interactions require sialyl Lewis X glycan modification but there is a differing dependence for tyrosine sulfations. Sulfation on Tyr-51 of PSGL1 is most important for high affinity L-selectin/SELL binding while P-selectin/SELP requires sulfation on Tyr-48. E-selectin/SELE binds with much lower affinity and requires the sLe(x) epitope, but apparantly not tyrosine sulfation. Dimerization appears not to be required for P-selectin/SELP binding. Interacts with SNX20. Interacts with MSN and SYK; mediates the activation of SYK by SELPLG.
    • (Microbial infection) Interacts with enterovirus 71 capsid proteins.

    Three dimensional structures from OCA and Proteopedia for SELPLG Gene

    Alternative splice isoforms for SELPLG Gene


neXtProt entry for SELPLG Gene

Post-translational modifications for SELPLG Gene

  • Displays complex, core-2, sialylated and fucosylated O-linked oligosaccharides, at least some of which appear to contain poly-N-acetyllactosamine with varying degrees of substitution. Mainly disialylated or neutral forms of the core-2 tetrasaccharide, Galbeta1-->4GlcNAcbeta1-->6(Galbeta1-->3)GalNAcOH. The GlcN:GalN ratio is approximately 2:1 and the Man:Fuc ratio 3:5. Contains about 14% fucose with alpha-1,3 linkage present in two forms: One species is a disialylated, monofucosylated glycan, and the other, a monosialylated, trifucosylated glycan with a polylactosamine backbone. The fucosylated forms carry the Lewis antigen and are important for interaction with selectins and for functioning in leukocyte rolling. The modification containing the sialyl Lewis X glycan is on Thr-57. No sulfated O-glycans. Some N-glycosylation.
  • Sulfation, in conjunction with the SLe(x)-containing glycan, is necessary for P- and L-selectin binding. High affinity P-selectin binding has a preferred requirement for the isomer sulfated on both Tyr-48 and Tyr-51, whereas L-selectin binding requires predominantly sulfation on Tyr-51 with sulfation on Tyr-48 playing only a minor role. These sulfations play an important role in L- and P-selectin-mediated neutrophil recruitment, and leukocyte rolling.
  • Ubiquitination at isoforms=2386
  • Glycosylation at isoforms=257, Asn65, Asn111, isoforms=2287, and isoforms=2302
  • Modification sites at PhosphoSitePlus

Other Protein References for SELPLG Gene

No data available for DME Specific Peptides for SELPLG Gene

Domains & Families for SELPLG Gene

Gene Families for SELPLG Gene

Human Protein Atlas (HPA):
  • Candidate cardiovascular disease genes
  • CD markers
  • Plasma proteins
  • Predicted membrane proteins

Protein Domains for SELPLG Gene


Suggested Antigen Peptide Sequences for SELPLG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SELPLG: view

No data available for UniProtKB/Swiss-Prot for SELPLG Gene

Function for SELPLG Gene

Molecular function for SELPLG Gene

GENATLAS Biochemistry:
P-selectin glycoprotein ligand with homology to CD43 and GP1BA
UniProtKB/Swiss-Prot Function:
A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for enterovirus 71.

Phenotypes From GWAS Catalog for SELPLG Gene

Gene Ontology (GO) - Molecular Function for SELPLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0005102 receptor binding NAS 7505206
GO:0005515 protein binding IPI 11081633
genes like me logo Genes that share ontologies with SELPLG: view
genes like me logo Genes that share phenotypes with SELPLG: view

Animal Models for SELPLG Gene

MGI Knock Outs for SELPLG:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SELPLG Gene

Localization for SELPLG Gene

Subcellular locations from UniProtKB/Swiss-Prot for SELPLG Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SELPLG gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytoskeleton 2
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SELPLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001931 uropod IDA 21696602
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7505206
GO:0016020 membrane IEA,TAS 7505206
GO:0016021 integral component of membrane IEA,TAS 7541799
genes like me logo Genes that share ontologies with SELPLG: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SELPLG Gene

Pathways & Interactions for SELPLG Gene

genes like me logo Genes that share pathways with SELPLG: view

Pathways by source for SELPLG Gene

1 BioSystems pathway for SELPLG Gene
2 Reactome pathways for SELPLG Gene

SIGNOR curated interactions for SELPLG Gene


Gene Ontology (GO) - Biological Process for SELPLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 7505206
GO:0016032 viral process IEA --
GO:0046718 viral entry into host cell IEA --
GO:0050900 leukocyte migration TAS,IDA --
GO:0050901 leukocyte tethering or rolling IDA 25425738
genes like me logo Genes that share ontologies with SELPLG: view

Drugs & Compounds for SELPLG Gene

(15) Drugs for SELPLG Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(19) Additional Compounds for SELPLG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SELPLG: view

Transcripts for SELPLG Gene

Unigene Clusters for SELPLG Gene

Selectin P ligand:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SELPLG Gene

No ASD Table

Relevant External Links for SELPLG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SELPLG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SELPLG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SELPLG Gene

This gene is overexpressed in Whole Blood (x40.2).

Protein differential expression in normal tissues from HIPED for SELPLG Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.1), Monocytes (14.8), Lymph node (10.4), Cerebral cortex (9.2), and CD8 Tcells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SELPLG Gene

Protein tissue co-expression partners for SELPLG Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SELPLG Gene:


SOURCE GeneReport for Unigene cluster for SELPLG Gene:


mRNA Expression by UniProt/SwissProt for SELPLG Gene:

Tissue specificity: Expressed on neutrophils, monocytes and most lymphocytes.

Evidence on tissue expression from TISSUES for SELPLG Gene

  • Blood(4.9)
  • Nervous system(4.9)
  • Spleen(3.4)
  • Lymph node(2.5)
  • Intestine(2.4)
  • Heart(2.3)
  • Lung(2.3)
  • Bone marrow(2.2)
genes like me logo Genes that share expression patterns with SELPLG: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SELPLG Gene

Orthologs for SELPLG Gene

This gene was present in the common ancestor of chordates.

Orthologs for SELPLG Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SELPLG 33 34
  • 99.07 (n)
(Canis familiaris)
Mammalia SELPLG 33 34
  • 67.85 (n)
(Mus musculus)
Mammalia Selplg 33 16 34
  • 67.11 (n)
(Bos Taurus)
Mammalia SELPLG 33 34
  • 64.15 (n)
(Rattus norvegicus)
Mammalia Selplg 33
  • 63.45 (n)
(Anolis carolinensis)
Reptilia SELPLG 34
  • 19 (a)
Species where no ortholog for SELPLG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SELPLG Gene

Gene Tree for SELPLG (if available)
Gene Tree for SELPLG (if available)

Paralogs for SELPLG Gene

No data available for Paralogs for SELPLG Gene

Variants for SELPLG Gene

Sequence variations from dbSNP and Humsavar for SELPLG Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000128794 -- 108,634,327(+) TTCTC(A/G)CAGGA intron-variant, upstream-variant-2KB
rs1000325370 -- 108,626,706(+) CTGTT(G/T)TCCAG intron-variant, upstream-variant-2KB
rs1000405654 -- 108,628,905(+) CTCTC(A/T)AAGCC intron-variant
rs1000775473 -- 108,624,687(+) ACTCC(-/TTTTTTCTTT)TTTTT intron-variant
rs1000874064 -- 108,627,761(+) AGTGA(C/G)ATCCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SELPLG Gene

Variant ID Type Subtype PubMed ID
nsv883 CNV deletion 18451855
nsv560114 CNV gain 21841781
nsv560113 CNV loss 21841781
esv3630708 CNV loss 21293372
esv2746345 CNV deletion 23290073

Variation tolerance for SELPLG Gene

Residual Variation Intolerance Score: 95.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.01; 87.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SELPLG Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELPLG Gene

Disorders for SELPLG Gene

MalaCards: The human disease database

(6) MalaCards diseases for SELPLG Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
human granulocytic anaplasmosis
  • hge
  • human ehrlichiosis
hydrops, lactic acidosis, and sideroblastic anemia
  • hlasa
pustulosis palmaris et plantaris
  • palmoplantar pustulosis
colon carcinoma in situ
  • carcinoma in situ of colon
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SELPLG

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SELPLG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SELPLG Gene

Publications for SELPLG Gene

  1. SELP and SELPLG genetic variation is associated with cell surface measures of SELP and SELPLG: the Atherosclerosis Risk in Communities Carotid MRI Study. (PMID: 19395438) Volcik KA … Boerwinkle E (Clinical chemistry 2009) 3 22 45 60
  2. Human P-selectin glycoprotein ligand-1 is a functional receptor for enterovirus 71. (PMID: 19543284) Nishimura Y … Shimizu H (Nature medicine 2009) 3 4 22 60
  3. SLIC-1/sorting nexin 20: a novel sorting nexin that directs subcellular distribution of PSGL-1. (PMID: 18196517) Schaff UY … Simon SI (European journal of immunology 2008) 3 4 22 60
  4. Specific P-selectin and P-selectin glycoprotein ligand-1 genotypes/haplotypes are associated with risk of incident CHD and ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) study. (PMID: 17420019) Volcik KA … Boerwinkle E (Atherosclerosis 2007) 3 22 45 60
  5. Turkish population data on the factor XIII Val34Leu,glycoprotein (GP)Ibalpha Kozak and P-selectin glycoprotein ligand 1 (PSGL-1) loci. (PMID: 15386532) Hancer VS … Nalcaci M (Cell biochemistry and function 2005) 3 22 45 60

Products for SELPLG Gene

Sources for SELPLG Gene

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