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Aliases for SELPLG Gene

Aliases for SELPLG Gene

  • Selectin P Ligand 2 3 4
  • PSGL-1 3 4
  • Cutaneous Lymphocyte-Associated Associated Antigen 3
  • CD162 Antigen 4
  • CD162 3
  • PSGL1 3
  • CLA 3

External Ids for SELPLG Gene

Previous GeneCards Identifiers for SELPLG Gene

  • GC12M108122
  • GC12M108896
  • GC12M108948
  • GC12M107518
  • GC12M109015
  • GC12M106080

Summaries for SELPLG Gene

Entrez Gene Summary for SELPLG Gene

  • This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]

GeneCards Summary for SELPLG Gene

SELPLG (Selectin P Ligand) is a Protein Coding gene. Diseases associated with SELPLG include human granulocytic anaplasmosis and colon carcinoma in situ. Among its related pathways are Hemostasis and amb2 Integrin signaling. GO annotations related to this gene include receptor binding.

UniProtKB/Swiss-Prot for SELPLG Gene

  • A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture.

  • (Microbial infection) Acts as a receptor for enterovirus 71.

Gene Wiki entry for SELPLG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELPLG Gene

Genomics for SELPLG Gene

Regulatory Elements for SELPLG Gene

Genomic Location for SELPLG Gene

Chromosome:
12
Start:
108,621,895 bp from pter
End:
108,633,959 bp from pter
Size:
12,065 bases
Orientation:
Minus strand

Genomic View for SELPLG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SELPLG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELPLG Gene

Proteins for SELPLG Gene

  • Protein details for SELPLG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14242-SELPL_HUMAN
    Recommended name:
    P-selectin glycoprotein ligand 1
    Protein Accession:
    Q14242
    Secondary Accessions:
    • A8K2Y0
    • B4DQC3
    • B7Z5C7
    • J3KMX6
    • Q12775
    • Q6GTW7
    • Q8N7J7

    Protein attributes for SELPLG Gene

    Size:
    412 amino acids
    Molecular mass:
    43201 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Interaction with P-, E- and L-selectins, through their lectin/EGF domains, is required for promoting recruitment and rolling of leukocytes. These interactions require sialyl Lewis X glycan modification but there is a differing dependence for tyrosine sulfations. Sulfation on Tyr-51 of PSGL1 is most important for high affinity L-selectin/SELL binding while P-selectin/SELP requires sulfation on Tyr-48. E-selectin/SELE binds with much lower affinity and requires the sLe(x) epitope, but apparantly not tyrosine sulfation. Dimerization appears not to be required for P-selectin/SELP binding. Interacts with SNX20. Interacts with MSN and SYK; mediates the activation of SYK by SELPLG. (Microbial infection) Interacts with enterovirus 71 capsid proteins (PubMed:19543284).

    Three dimensional structures from OCA and Proteopedia for SELPLG Gene

    Alternative splice isoforms for SELPLG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SELPLG Gene

Proteomics data for SELPLG Gene at MOPED

Post-translational modifications for SELPLG Gene

  • Displays complex, core-2, sialylated and fucosylated O-linked oligosaccharides, at least some of which appear to contain poly-N-acetyllactosamine with varying degrees of substitution. Mainly disialylated or neutral forms of the core-2 tetrasaccharide, Galbeta1-->4GlcNAcbeta1-->6(Galbeta1-->3)GalNAcOH. The GlcN:GalN ratio is approximately 2:1 and the Man:Fuc ratio 3:5. Contains about 14% fucose with alpha-1,3 linkage present in two forms: One species is a disialylated, monofucosylated glycan, and the other, a monosialylated, trifucosylated glycan with a polylactosamine backbone. The fucosylated forms carry the Lewis antigen and are important for interaction with selectins and for functioning in leukocyte rolling. The modification containing the sialyl Lewis X glycan is on Thr-57. No sulfated O-glycans. Some N-glycosylation.
  • Sulfation, in conjunction with the SLe(x)-containing glycan, is necessary for P- and L-selectin binding. High affinity P-selectin binding has a preferred requirement for the isomer sulfated on both Tyr-48 and Tyr-51, whereas L-selectin binding requires predominantly sulfation on Tyr-51 with sulfation on Tyr-48 playing only a minor role. These sulfations play an important role in L- and P-selectin-mediated neutrophil recruitment, and leukocyte rolling.
  • Ubiquitination at Lys 386
  • Glycosylation at Thr 57, Asn 65, Asn 111, Ser 287, and Asn 302
  • Modification sites at PhosphoSitePlus

Other Protein References for SELPLG Gene

Antibody Products

  • R&D Systems Antibodies for SELPLG (PSGL-1/CD162)

No data available for DME Specific Peptides for SELPLG Gene

Domains & Families for SELPLG Gene

Gene Families for SELPLG Gene

Protein Domains for SELPLG Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SELPLG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SELPLG: view

No data available for UniProtKB/Swiss-Prot for SELPLG Gene

Function for SELPLG Gene

Molecular function for SELPLG Gene

GENATLAS Biochemistry:
P-selectin glycoprotein ligand with homology to CD43 and GP1BA
UniProtKB/Swiss-Prot Function:
A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for enterovirus 71.

Gene Ontology (GO) - Molecular Function for SELPLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0005102 receptor binding NAS 7505206
GO:0005515 protein binding IPI 18196517
genes like me logo Genes that share ontologies with SELPLG: view
genes like me logo Genes that share phenotypes with SELPLG: view

Animal Models for SELPLG Gene

MGI Knock Outs for SELPLG:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SELPLG

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SELPLG Gene

Localization for SELPLG Gene

Subcellular locations from UniProtKB/Swiss-Prot for SELPLG Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SELPLG Gene COMPARTMENTS Subcellular localization image for SELPLG gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
extracellular 2
cytosol 1

Gene Ontology (GO) - Cellular Components for SELPLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001931 uropod IDA 21696602
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7505206
GO:0016020 membrane TAS 7505206
GO:0016021 integral component of membrane TAS 7541799
genes like me logo Genes that share ontologies with SELPLG: view

Pathways & Interactions for SELPLG Gene

genes like me logo Genes that share pathways with SELPLG: view

Pathways by source for SELPLG Gene

1 BioSystems pathway for SELPLG Gene
2 Reactome pathways for SELPLG Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for SELPLG Gene

Activates:

Gene Ontology (GO) - Biological Process for SELPLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 7505206
GO:0007596 blood coagulation TAS --
GO:0046718 viral entry into host cell IEA --
GO:0050900 leukocyte migration TAS --
GO:0050901 leukocyte tethering or rolling IEA --
genes like me logo Genes that share ontologies with SELPLG: view

Drugs & Compounds for SELPLG Gene

(14) Drugs for SELPLG Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Dexamethasone Approved, Investigational Pharma Agonist 1806
Heparin Approved, Investigational Pharma Antagonist 672,226
Isoflurane Approved Pharma 80
Phosphatidylserine Approved Nutra 0
cholesterol Experimental Pharma Agonist 0

(20) Additional Compounds for SELPLG Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
4-F-Glcnac
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
Carbohydrates
chlorate
  • Chlorate
  • Chlorate ion
  • Chloric acid
  • Chlorine oxide
14866-68-3
Cytochalasin B
genes like me logo Genes that share compounds with SELPLG: view

Transcripts for SELPLG Gene

Unigene Clusters for SELPLG Gene

Selectin P ligand:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SELPLG

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SELPLG Gene

No ASD Table

Relevant External Links for SELPLG Gene

GeneLoc Exon Structure for
SELPLG
ECgene alternative splicing isoforms for
SELPLG

Expression for SELPLG Gene

mRNA expression in normal human tissues for SELPLG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SELPLG Gene

This gene is overexpressed in Whole Blood (x40.2).

Protein differential expression in normal tissues from HIPED for SELPLG Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.1), Monocytes (14.8), Lymph node (10.4), Cerebral cortex (9.2), and CD8 Tcells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SELPLG Gene



SOURCE GeneReport for Unigene cluster for SELPLG Gene Hs.591014

mRNA Expression by UniProt/SwissProt for SELPLG Gene

Q14242-SELPL_HUMAN
Tissue specificity: Expressed on neutrophils, monocytes and most lymphocytes
genes like me logo Genes that share expression patterns with SELPLG: view

Protein tissue co-expression partners for SELPLG Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SELPLG Gene

This gene was present in the common ancestor of chordates.

Orthologs for SELPLG Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SELPLG 35
  • 64.15 (n)
  • 49.74 (a)
SELPLG 36
  • 46 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SELPLG 35
  • 67.85 (n)
  • 57.53 (a)
SELPLG 36
  • 48 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Selplg 35
  • 67.11 (n)
  • 53.76 (a)
Selplg 16
Selplg 36
  • 46 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SELPLG 35
  • 99.07 (n)
  • 98.36 (a)
SELPLG 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Selplg 35
  • 63.45 (n)
  • 48.3 (a)
lizard
(Anolis carolinensis)
Reptilia SELPLG 36
  • 19 (a)
OneToOne
Species with no ortholog for SELPLG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SELPLG Gene

ENSEMBL:
Gene Tree for SELPLG (if available)
TreeFam:
Gene Tree for SELPLG (if available)

Paralogs for SELPLG Gene

No data available for Paralogs for SELPLG Gene

Variants for SELPLG Gene

Sequence variations from dbSNP and Humsavar for SELPLG Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1050666 -- 108,622,992(-) CCCCA(A/T)TCCAC utr-variant-3-prime
rs2228315 - 108,624,122(-) GAAAT(A/G)CTGAG missense, reference
rs7137098 -- 108,624,642(+) AAAGA(A/C/T)TTAGT intron-variant
rs7300972 -- 108,623,488(+) TTCCA(C/T)GGACA reference, missense
rs7306237 -- 108,624,660(+) CTTCT(A/C)GTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SELPLG Gene

Variant ID Type Subtype PubMed ID
nsv883 CNV Loss 18451855
esv2746345 CNV Deletion 23290073

Variation tolerance for SELPLG Gene

Residual Variation Intolerance Score: 95.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.01; 87.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SELPLG Gene

HapMap Linkage Disequilibrium report
SELPLG
Human Gene Mutation Database (HGMD)
SELPLG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELPLG Gene

Disorders for SELPLG Gene

MalaCards: The human disease database

(5) MalaCards diseases for SELPLG Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
human granulocytic anaplasmosis
  • human granulocytic ehrlichiosis
colon carcinoma in situ
  • stage 0 colonic carcinoma
ehrlichiosis
  • human ehrlichiosis
west nile fever
pustulosis palmaris et plantaris
  • palmoplantar pustulosis
- elite association

Relevant External Links for SELPLG

Genetic Association Database (GAD)
SELPLG
Human Genome Epidemiology (HuGE) Navigator
SELPLG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SELPLG
genes like me logo Genes that share disorders with SELPLG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SELPLG Gene

Publications for SELPLG Gene

  1. Fluorinated per-acetylated GalNAc metabolically alters glycan structures on leukocyte PSGL-1 and reduces cell binding to selectins. (PMID: 19996411) Marathe D.D. … Neelamegham S. (Blood 2010) 23 67
  2. The adhesion mediated by the P-selectin P-selectin glycoprotein ligand-1 (PSGL-1) couple is stronger for shorter PSGL-1 variants. (PMID: 20051472) Barbaux S. … Deterre P. (J. Leukoc. Biol. 2010) 23 67
  3. Sulfated and non-sulfated glycopeptide recognition domains of P-selectin glycoprotein ligand 1 and their binding to P- and E-selectin. (PMID: 19322854) Baumann K. … Kunz H. (Angew. Chem. Int. Ed. Engl. 2009) 23 67
  4. SELP and SELPLG genetic variation is associated with cell surface measures of SELP and SELPLG: the Atherosclerosis Risk in Communities Carotid MRI Study. (PMID: 19395438) Volcik K.A. … Boerwinkle E. (Clin. Chem. 2009) 23 67
  5. Human P-selectin glycoprotein ligand-1 is a functional receptor for enterovirus 71. (PMID: 19543284) Nishimura Y. … Shimizu H. (Nat. Med. 2009) 23 67

Products for SELPLG Gene

Sources for SELPLG Gene

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