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Aliases for SELPLG Gene

Aliases for SELPLG Gene

  • Selectin P Ligand 2 3 4 5
  • PSGL-1 3 4
  • Cutaneous Lymphocyte-Associated Associated Antigen 3
  • P-Selectin Glycoprotein Ligand 1 3
  • CD162 Antigen 4
  • CD162 3
  • PSGL1 3
  • CLA 3

External Ids for SELPLG Gene

Previous GeneCards Identifiers for SELPLG Gene

  • GC12M108122
  • GC12M108896
  • GC12M108948
  • GC12M107518
  • GC12M109015
  • GC12M106080

Summaries for SELPLG Gene

Entrez Gene Summary for SELPLG Gene

  • This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]

GeneCards Summary for SELPLG Gene

SELPLG (Selectin P Ligand) is a Protein Coding gene. Diseases associated with SELPLG include Ehrlichiosis and Human Granulocytic Anaplasmosis. Among its related pathways are amb2 Integrin signaling and Cell surface interactions at the vascular wall. GO annotations related to this gene include receptor binding.

UniProtKB/Swiss-Prot for SELPLG Gene

  • A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture.

  • (Microbial infection) Acts as a receptor for enterovirus 71.

Gene Wiki entry for SELPLG Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELPLG Gene

Genomics for SELPLG Gene

Regulatory Elements for SELPLG Gene

Enhancers for SELPLG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G108820 2.1 FANTOM5 Ensembl ENCODE dbSUPER 13.2 -197.8 -197752 23.4 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A FEZF1 YY1 ZNF766 CBX5 SART3 SSH1 CORO1C RNU4-32P SELPLG UBE3B ACACB CMKLR1 FICD ENSG00000274598
GH12G108626 2.1 FANTOM5 Ensembl ENCODE dbSUPER 11.8 -4.9 -4905 24.2 CREB3L1 MLX ZFP64 DMAP1 FEZF1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 PWP1 CORO1C SART3 PRDM4 UBE3B FICD KCTD10 SELPLG TMEM119 RPL17P38
GH12G108663 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.9 -32.1 -32058 5.8 HDGF PKNOX1 FOXA2 ARNT WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 CORO1C SELPLG SSH1 SART3 ISCU ENSG00000257221 MVK ACACB RNU7-169P GC12P108645
GH12G108684 2 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -57.7 -57677 13.6 CREB3L1 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC TBX21 MEF2D SSRP1 CORO1C RNU7-169P SELPLG ENSG00000257221 MVK SSH1 GC12P108678 GC12P108720
GH12G108720 1.7 FANTOM5 ENCODE dbSUPER 12.2 -89.5 -89465 5.5 PKNOX1 MLX ZFP64 SIN3A ARID4B DMAP1 FEZF1 ZNF48 YY1 ZNF121 SELPLG RNU7-169P ENSG00000257221 MVK CORO1C SSH1 GC12M108717
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SELPLG on UCSC Golden Path with GeneCards custom track

Promoters for SELPLG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000057075 259 201 PKNOX1 WRNIP1 ELK1 ZNF143 ZNF207 TBX21 ZNF592 MEF2D CREB3 NBN

Genomic Location for SELPLG Gene

Chromosome:
12
Start:
108,621,895 bp from pter
End:
108,633,959 bp from pter
Size:
12,065 bases
Orientation:
Minus strand

Genomic View for SELPLG Gene

Genes around SELPLG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELPLG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELPLG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELPLG Gene

Proteins for SELPLG Gene

  • Protein details for SELPLG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14242-SELPL_HUMAN
    Recommended name:
    P-selectin glycoprotein ligand 1
    Protein Accession:
    Q14242
    Secondary Accessions:
    • A8K2Y0
    • B4DQC3
    • B7Z5C7
    • J3KMX6
    • Q12775
    • Q6GTW7
    • Q8N7J7

    Protein attributes for SELPLG Gene

    Size:
    412 amino acids
    Molecular mass:
    43201 Da
    Quaternary structure:
    • Homodimer; disulfide-linked. Interaction with P-, E- and L-selectins, through their lectin/EGF domains, is required for promoting recruitment and rolling of leukocytes. These interactions require sialyl Lewis X glycan modification but there is a differing dependence for tyrosine sulfations. Sulfation on Tyr-51 of PSGL1 is most important for high affinity L-selectin/SELL binding while P-selectin/SELP requires sulfation on Tyr-48. E-selectin/SELE binds with much lower affinity and requires the sLe(x) epitope, but apparantly not tyrosine sulfation. Dimerization appears not to be required for P-selectin/SELP binding. Interacts with SNX20. Interacts with MSN and SYK; mediates the activation of SYK by SELPLG.
    • (Microbial infection) Interacts with enterovirus 71 capsid proteins.

    Three dimensional structures from OCA and Proteopedia for SELPLG Gene

    Alternative splice isoforms for SELPLG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SELPLG Gene

Post-translational modifications for SELPLG Gene

  • Displays complex, core-2, sialylated and fucosylated O-linked oligosaccharides, at least some of which appear to contain poly-N-acetyllactosamine with varying degrees of substitution. Mainly disialylated or neutral forms of the core-2 tetrasaccharide, Galbeta1-->4GlcNAcbeta1-->6(Galbeta1-->3)GalNAcOH. The GlcN:GalN ratio is approximately 2:1 and the Man:Fuc ratio 3:5. Contains about 14% fucose with alpha-1,3 linkage present in two forms: One species is a disialylated, monofucosylated glycan, and the other, a monosialylated, trifucosylated glycan with a polylactosamine backbone. The fucosylated forms carry the Lewis antigen and are important for interaction with selectins and for functioning in leukocyte rolling. The modification containing the sialyl Lewis X glycan is on Thr-57. No sulfated O-glycans. Some N-glycosylation.
  • Sulfation, in conjunction with the SLe(x)-containing glycan, is necessary for P- and L-selectin binding. High affinity P-selectin binding has a preferred requirement for the isomer sulfated on both Tyr-48 and Tyr-51, whereas L-selectin binding requires predominantly sulfation on Tyr-51 with sulfation on Tyr-48 playing only a minor role. These sulfations play an important role in L- and P-selectin-mediated neutrophil recruitment, and leukocyte rolling.
  • Ubiquitination at Lys386
  • Glycosylation at isoforms=257, Asn65, Asn111, Ser287, and Asn302
  • Modification sites at PhosphoSitePlus

Other Protein References for SELPLG Gene

No data available for DME Specific Peptides for SELPLG Gene

Domains & Families for SELPLG Gene

Gene Families for SELPLG Gene

Protein Domains for SELPLG Gene

ProtoNet:

Suggested Antigen Peptide Sequences for SELPLG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with SELPLG: view

No data available for UniProtKB/Swiss-Prot for SELPLG Gene

Function for SELPLG Gene

Molecular function for SELPLG Gene

GENATLAS Biochemistry:
P-selectin glycoprotein ligand with homology to CD43 and GP1BA
UniProtKB/Swiss-Prot Function:
A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Acts as a receptor for enterovirus 71.

Gene Ontology (GO) - Molecular Function for SELPLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001618 virus receptor activity IEA --
GO:0005102 receptor binding NAS 7505206
GO:0005515 protein binding IPI 11081633
genes like me logo Genes that share ontologies with SELPLG: view
genes like me logo Genes that share phenotypes with SELPLG: view

Animal Models for SELPLG Gene

MGI Knock Outs for SELPLG:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SELPLG Gene

Localization for SELPLG Gene

Subcellular locations from UniProtKB/Swiss-Prot for SELPLG Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SELPLG gene
Compartment Confidence
plasma membrane 5
extracellular 4
cytoskeleton 2
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SELPLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001931 uropod IDA 21696602
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7505206
GO:0016020 membrane IEA,TAS 7505206
GO:0016021 integral component of membrane TAS,IEA 7541799
genes like me logo Genes that share ontologies with SELPLG: view

Pathways & Interactions for SELPLG Gene

genes like me logo Genes that share pathways with SELPLG: view

Pathways by source for SELPLG Gene

1 BioSystems pathway for SELPLG Gene
2 Reactome pathways for SELPLG Gene

SIGNOR curated interactions for SELPLG Gene

Activates:

Gene Ontology (GO) - Biological Process for SELPLG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 7505206
GO:0016032 viral process IEA --
GO:0046718 viral entry into host cell IEA --
GO:0050900 leukocyte migration TAS --
GO:0050901 leukocyte tethering or rolling IDA 25425738
genes like me logo Genes that share ontologies with SELPLG: view

Drugs & Compounds for SELPLG Gene

(15) Drugs for SELPLG Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0

(19) Additional Compounds for SELPLG Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SELPLG: view

Transcripts for SELPLG Gene

Unigene Clusters for SELPLG Gene

Selectin P ligand:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SELPLG Gene

No ASD Table

Relevant External Links for SELPLG Gene

GeneLoc Exon Structure for
SELPLG
ECgene alternative splicing isoforms for
SELPLG

Expression for SELPLG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SELPLG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SELPLG Gene

This gene is overexpressed in Whole Blood (x40.2).

Protein differential expression in normal tissues from HIPED for SELPLG Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.1), Monocytes (14.8), Lymph node (10.4), Cerebral cortex (9.2), and CD8 Tcells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SELPLG Gene



Protein tissue co-expression partners for SELPLG Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SELPLG Gene:

SELPLG

SOURCE GeneReport for Unigene cluster for SELPLG Gene:

Hs.591014

mRNA Expression by UniProt/SwissProt for SELPLG Gene:

Q14242-SELPL_HUMAN
Tissue specificity: Expressed on neutrophils, monocytes and most lymphocytes.

Evidence on tissue expression from TISSUES for SELPLG Gene

  • Blood(4.9)
  • Nervous system(4.9)
  • Spleen(3.4)
  • Lymph node(2.5)
  • Intestine(2.4)
  • Heart(2.3)
  • Lung(2.3)
  • Bone marrow(2.2)
genes like me logo Genes that share expression patterns with SELPLG: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SELPLG Gene

Orthologs for SELPLG Gene

This gene was present in the common ancestor of chordates.

Orthologs for SELPLG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SELPLG 34 35
  • 99.07 (n)
dog
(Canis familiaris)
Mammalia SELPLG 34 35
  • 67.85 (n)
mouse
(Mus musculus)
Mammalia Selplg 34 16 35
  • 67.11 (n)
cow
(Bos Taurus)
Mammalia SELPLG 34 35
  • 64.15 (n)
rat
(Rattus norvegicus)
Mammalia Selplg 34
  • 63.45 (n)
lizard
(Anolis carolinensis)
Reptilia SELPLG 35
  • 19 (a)
OneToOne
Species where no ortholog for SELPLG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SELPLG Gene

ENSEMBL:
Gene Tree for SELPLG (if available)
TreeFam:
Gene Tree for SELPLG (if available)

Paralogs for SELPLG Gene

No data available for Paralogs for SELPLG Gene

Variants for SELPLG Gene

Sequence variations from dbSNP and Humsavar for SELPLG Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000128794 -- 108,634,327(+) TTCTC(A/G)CAGGA intron-variant, upstream-variant-2KB
rs1000325370 -- 108,626,706(+) CTGTT(G/T)TCCAG intron-variant, upstream-variant-2KB
rs1000405654 -- 108,628,905(+) CTCTC(A/T)AAGCC intron-variant
rs1000775473 -- 108,624,687(+) ACTCC(-/TTTTTTCTTT)TTTTT intron-variant
rs1000874064 -- 108,627,761(+) AGTGA(C/G)ATCCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SELPLG Gene

Variant ID Type Subtype PubMed ID
esv2746345 CNV deletion 23290073
esv3630708 CNV loss 21293372
nsv560113 CNV loss 21841781
nsv560114 CNV gain 21841781
nsv883 CNV deletion 18451855

Variation tolerance for SELPLG Gene

Residual Variation Intolerance Score: 95.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.01; 87.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SELPLG Gene

Human Gene Mutation Database (HGMD)
SELPLG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SELPLG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SELPLG Gene

Disorders for SELPLG Gene

MalaCards: The human disease database

(8) MalaCards diseases for SELPLG Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SELPLG

Genetic Association Database (GAD)
SELPLG
Human Genome Epidemiology (HuGE) Navigator
SELPLG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SELPLG
genes like me logo Genes that share disorders with SELPLG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SELPLG Gene

Publications for SELPLG Gene

  1. SELP and SELPLG genetic variation is associated with cell surface measures of SELP and SELPLG: the Atherosclerosis Risk in Communities Carotid MRI Study. (PMID: 19395438) Volcik K.A. … Boerwinkle E. (Clin. Chem. 2009) 3 22 46 64
  2. Human P-selectin glycoprotein ligand-1 is a functional receptor for enterovirus 71. (PMID: 19543284) Nishimura Y. … Shimizu H. (Nat. Med. 2009) 3 4 22 64
  3. SLIC-1/sorting nexin 20: a novel sorting nexin that directs subcellular distribution of PSGL-1. (PMID: 18196517) Schaff U.Y. … Simon S.I. (Eur. J. Immunol. 2008) 3 4 22 64
  4. Specific P-selectin and P-selectin glycoprotein ligand-1 genotypes/haplotypes are associated with risk of incident CHD and ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) study. (PMID: 17420019) Volcik K.A. … Boerwinkle E. (Atherosclerosis 2007) 3 22 46 64
  5. Turkish population data on the factor XIII Val34Leu,glycoprotein (GP)Ibalpha Kozak and P-selectin glycoprotein ligand 1 (PSGL-1) loci. (PMID: 15386532) Hancer V.S. … Nalcaci M. (Cell Biochem. Funct. 2005) 3 22 46 64

Products for SELPLG Gene

Sources for SELPLG Gene

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