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Aliases for SELE Gene

Aliases for SELE Gene

  • Selectin E 2 3 5
  • Endothelial Leukocyte Adhesion Molecule 1 3 4
  • CD62 Antigen-Like Family Member E 3 4
  • Endothelial Adhesion Molecule 1 2 3
  • ELAM-1 3 4
  • LECAM2 3 4
  • ELAM1 3 4
  • Leukocyte Endothelial Cell Adhesion Molecule 2 3
  • Leukocyte-Endothelial Cell Adhesion Molecule 2 4
  • CD62E Antigen 4
  • E-Selectin 3
  • CD62E 3
  • ESEL 3
  • ELAM 3

External Ids for SELE Gene

Previous HGNC Symbols for SELE Gene

  • ELAM1
  • ELAM

Previous GeneCards Identifiers for SELE Gene

  • GC01M167320
  • GC01M165342
  • GC01M166181
  • GC01M166671
  • GC01M166879
  • GC01M166423
  • GC01M167958
  • GC01M169691
  • GC01M140914

Summaries for SELE Gene

Entrez Gene Summary for SELE Gene

  • The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for SELE Gene

SELE (Selectin E) is a Protein Coding gene. Diseases associated with SELE include Atherosclerosis and Rheumatoid Vasculitis. Among its related pathways are Cell adhesion_Cell-matrix glycoconjugates and Cell surface interactions at the vascular wall. GO annotations related to this gene include transmembrane signaling receptor activity and phospholipase binding. An important paralog of this gene is SELP.

UniProtKB/Swiss-Prot for SELE Gene

  • Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.

Tocris Summary for SELE Gene

  • Cell adhesion molecules (CAMs) are a large family of transmembrane proteins that are involved in the binding of a cell to another cell or to the extracellular matrix. They have roles in cell proliferation, differentiation, motility, trafficking, apoptosis and tissue architecture.

Gene Wiki entry for SELE Gene

Additional gene information for SELE Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELE Gene

Genomics for SELE Gene

Regulatory Elements for SELE Gene

Enhancers for SELE Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H169571 1.2 FANTOM5 ENCODE 9.7 +192.4 192373 1 ELF3 TBP FOXA2 RARA MIXL1 THAP11 PPARG KAT8 SSRP1 MIER3 F5 C1orf112 METTL18 SELE SCYL3 GC01P169565
GH01H169604 1 Ensembl ENCODE dbSUPER 10.2 +159.7 159704 1 CTCF POLR2A ZNF24 REST PRDM1 SELP SELE SELL F5
GH01H169565 0.8 ENCODE 10.4 +198.9 198888 0 FOXA2 SAP130 ARID4B FEZF1 CEBPG ZSCAN9 RARA GATAD1 HOMEZ CREM SELE GC01P169565 F5
GH01H169546 0.8 ENCODE 10 +218.3 218258 0 CTCF MAX ZNF2 RAD21 RFX5 YY1 CC2D1A GATA3 SCRT2 SMC3 ENSG00000213062 SLC19A2 F5 CCDC181 SELE GC01P169565 GC01P169489
GH01H169547 0.8 ENCODE 10 +218.1 218138 0 CTCF ZNF2 RAD21 RFX5 YY1 CC2D1A GATA3 SCRT2 SMC3 ZNF143 ENSG00000213062 SLC19A2 F5 CCDC181 SELE GC01P169565 GC01P169489
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SELE on UCSC Golden Path with GeneCards custom track

Genomic Location for SELE Gene

Chromosome:
1
Start:
169,722,640 bp from pter
End:
169,764,705 bp from pter
Size:
42,066 bases
Orientation:
Minus strand

Genomic View for SELE Gene

Genes around SELE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELE Gene

Proteins for SELE Gene

  • Protein details for SELE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16581-LYAM2_HUMAN
    Recommended name:
    E-selectin
    Protein Accession:
    P16581
    Secondary Accessions:
    • A2RRD6
    • P16111

    Protein attributes for SELE Gene

    Size:
    610 amino acids
    Molecular mass:
    66655 Da
    Quaternary structure:
    • Interacts with PSGL1/SELPLG and PODXL2 through the sialyl Lewis X epitope. PSGL1 sulfation appears not to be required for this interaction.

    Three dimensional structures from OCA and Proteopedia for SELE Gene

neXtProt entry for SELE Gene

Post-translational modifications for SELE Gene

  • Glycosylation at isoforms=25, Asn145, Asn160, Asn179, isoforms=199, isoforms=203, Asn265, Asn312, Asn332, isoforms=503, and Asn527
  • Modification sites at PhosphoSitePlus

Other Protein References for SELE Gene

Protein Products

Assay Products

  • Abcam assays for SELE

No data available for DME Specific Peptides for SELE Gene

Domains & Families for SELE Gene

Gene Families for SELE Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Candidate cardiovascular disease genes
  • CD markers
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for SELE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P16581

UniProtKB/Swiss-Prot:

LYAM2_HUMAN :
  • Belongs to the selectin/LECAM family.
Family:
  • Belongs to the selectin/LECAM family.
genes like me logo Genes that share domains with SELE: view

Function for SELE Gene

Molecular function for SELE Gene

GENATLAS Biochemistry:
E selectin,leucocyte adhesion molecule,107-115kDa,expressed in endothelial cells,induced by IL1B,TNFA. Mutations of the gene may be a risk factor in atherosclerosis
UniProtKB/Swiss-Prot Function:
Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.

Phenotypes From GWAS Catalog for SELE Gene

Gene Ontology (GO) - Molecular Function for SELE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IMP 12960351
GO:0005515 protein binding IPI 18606703
GO:0030246 carbohydrate binding IEA --
GO:0033691 sialic acid binding IDA 7680663
GO:0043274 phospholipase binding IDA 12960351
genes like me logo Genes that share ontologies with SELE: view
genes like me logo Genes that share phenotypes with SELE: view

Animal Models for SELE Gene

MGI Knock Outs for SELE:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SELE
  • Applied Biological Materials Clones for SELE
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SELE Gene

Localization for SELE Gene

Subcellular locations from UniProtKB/Swiss-Prot for SELE Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SELE gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 5
nucleus 2
cytosol 2
mitochondrion 1
peroxisome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for SELE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 9290466
GO:0005886 plasma membrane TAS --
GO:0005901 caveola IDA 12960351
GO:0005905 clathrin-coated pit IDA 18029551
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with SELE: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SELE Gene

Pathways & Interactions for SELE Gene

genes like me logo Genes that share pathways with SELE: view

SIGNOR curated interactions for SELE Gene

Is activated by:

Gene Ontology (GO) - Biological Process for SELE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002092 positive regulation of receptor internalization IDA 9312078
GO:0002523 leukocyte migration involved in inflammatory response TAS 18029551
GO:0006954 inflammatory response TAS 2466335
GO:0007155 cell adhesion IEA --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP 18029551
genes like me logo Genes that share ontologies with SELE: view

Drugs & Compounds for SELE Gene

(88) Drugs for SELE Gene - From: DrugBank, PharmGKB, ApexBio, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carvedilol Approved, Investigational Pharma Antagonist, Target, inhibitor 170
Capecitabine Approved, Investigational Pharma RNA processing inhibitor and thymidylate synthase inhibitor, F-pyrimidines 1362
Fluorouracil Approved Pharma RNA processing inhibitor and thymidylate synthase inhibitor 1904
Oxaliplatin Approved, Investigational Pharma Antitumor agent, Platinum 1504
leucovorin Approved Nutra 3323,1162

(65) Additional Compounds for SELE Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ac2-26
151988-33-9
Echistatin, alpha1 isoform
154303-05-6
Heparin sodium salt
9041-08-1

(5) Tocris Compounds for SELE Gene

Compound Action Cas Number
Ac2-26 Annexin/lipocortin 1-mimetic; inhibits leukocyte extravasation 151988-33-9
BIO 5192 Highly potent and selective inhibitor of integrin alpha4beta1 327613-57-0
Echistatin, alpha1 isoform alphaVbeta3 and glycoprotein IIb/IIIa (integrin alphaIIbbeta3) inhibitor 154303-05-6
Heparin sodium salt Anticoagulant 9041-08-1
RGDS peptide Integrin binding sequence; inhibits integrin receptor function 91037-65-9

(2) ApexBio Compounds for SELE Gene

Compound Action Cas Number
A 205804 E-selectin/ICAM-1 expression inhibitor 251992-66-2
Thiolutin RNA polymerase inhibitor,antibiotic 1987-11-6
genes like me logo Genes that share compounds with SELE: view

Drug Products

Transcripts for SELE Gene

Unigene Clusters for SELE Gene

Selectin E:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for SELE
  • Applied Biological Materials Clones for SELE
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for SELE Gene

No ASD Table

Relevant External Links for SELE Gene

GeneLoc Exon Structure for
SELE
ECgene alternative splicing isoforms for
SELE

Expression for SELE Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SELE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SELE Gene

This gene is overexpressed in Fallopian Tube (x8.9) and Adipose - Visceral (Omentum) (x6.5).

NURSA nuclear receptor signaling pathways regulating expression of SELE Gene:

SELE

SOURCE GeneReport for Unigene cluster for SELE Gene:

Hs.82848

Evidence on tissue expression from TISSUES for SELE Gene

  • Heart(4.7)
  • Blood(3.3)
  • Liver(3.2)
  • Lung(2.7)
  • Skin(2.7)
  • Intestine(2.5)
  • Nervous system(2.3)
  • Bone marrow(2.1)
  • Kidney(2)
genes like me logo Genes that share expression patterns with SELE: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SELE Gene

Orthologs for SELE Gene

This gene was present in the common ancestor of animals.

Orthologs for SELE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SELE 33 34
  • 99.34 (n)
dog
(Canis familiaris)
Mammalia SELE 33 34
  • 81.2 (n)
mouse
(Mus musculus)
Mammalia Sele 33 16 34
  • 77.74 (n)
rat
(Rattus norvegicus)
Mammalia Sele 33
  • 74.01 (n)
oppossum
(Monodelphis domestica)
Mammalia SELE 34
  • 63 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SELE 34
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SELE 34
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves SELE 33 34
  • 57.98 (n)
zebrafish
(Danio rerio)
Actinopterygii selp 34
  • 28 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta hig 34
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T07H6.4 34
  • 12 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10017 34
  • 21 (a)
ManyToMany
-- 34
  • 12 (a)
ManyToMany
-- 34
  • 10 (a)
ManyToMany
-- 34
  • 9 (a)
ManyToMany
CSA.10029 34
  • 8 (a)
ManyToMany
-- 34
  • 7 (a)
ManyToMany
-- 34
  • 7 (a)
ManyToMany
Species where no ortholog for SELE was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SELE Gene

ENSEMBL:
Gene Tree for SELE (if available)
TreeFam:
Gene Tree for SELE (if available)

Paralogs for SELE Gene

Paralogs for SELE Gene

(2) SIMAP similar genes for SELE Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SELE: view

Variants for SELE Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SELE Gene

LYAM2_HUMAN-P16581
A polymorphism in position 149 is associated with a higher risk of coronary artery disease (CAD). A significantly higher mutation frequency (Arg-149) is observed in patients with angiographically proven severe atherosclerosis compared with an unselected population (Ser-149).

Sequence variations from dbSNP and Humsavar for SELE Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs5368 Uncertain significance 169,727,805(-) AATTA(C/T)ATGGA reference, missense
rs1000173481 -- 169,727,068(+) ATAAA(C/T)ACTGC intron-variant
rs1000690421 -- 169,731,381(+) TACAC(A/G)GCTAG intron-variant
rs1000718380 -- 169,724,042(+) AAGTT(A/C)TAATA utr-variant-3-prime
rs1000725733 -- 169,731,078(+) GCACT(C/G)TCTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SELE Gene

Variant ID Type Subtype PubMed ID
nsv1078878 OTHER inversion 25765185

Variation tolerance for SELE Gene

Residual Variation Intolerance Score: 59.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.50; 82.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SELE Gene

Human Gene Mutation Database (HGMD)
SELE
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SELE

Disorders for SELE Gene

MalaCards: The human disease database

(72) MalaCards diseases for SELE Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
atherosclerosis
  • arteriosclerosis
rheumatoid vasculitis
boutonneuse fever
  • african tick typhus
coarctation of aorta
  • aorta coarctation
leukocyte adhesion deficiency
  • leukocyte adhesion deficiency 1
- elite association - COSMIC cancer census association via MalaCards
Search SELE in MalaCards View complete list of genes associated with diseases

Relevant External Links for SELE

Genetic Association Database (GAD)
SELE
Human Genome Epidemiology (HuGE) Navigator
SELE
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SELE
genes like me logo Genes that share disorders with SELE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SELE Gene

Publications for SELE Gene

  1. The common variants of E-selectin gene in Graves' disease. (PMID: 18094708) Chen H … Ning G (Genes and immunity 2008) 3 22 45 60
  2. Risks of human limb deficiency anomalies associated with 29 SNPs of genes involved in homocysteine metabolism, coagulation, cell-cell interactions, inflammatory response, and blood pressure regulation. (PMID: 17036337) Carmichael SL … Lammer EJ (American journal of medical genetics. Part A 2006) 3 22 45 60
  3. Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery. (PMID: 16820586) Podgoreanu MV … Perioperative Genetics and Safety Outcomes Study (PEGASUS) Investigative Team (Circulation 2006) 3 22 45 60
  4. E-selectin genotypes and risk of type 2 diabetes in women. (PMID: 15833936) Meigs JB … Manson JE (Obesity research 2005) 3 22 45 60
  5. Ser128Arg gene polymorphism for E-selectin and severity of atherosclerotic arterial disease. (PMID: 15179350) Ghilardi G … Scorza R (The Journal of cardiovascular surgery 2004) 3 22 45 60

Products for SELE Gene

  • Addgene plasmids for SELE

Sources for SELE Gene

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