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Aliases for SELE Gene

Aliases for SELE Gene

  • Selectin E 2 3 5
  • Leukocyte-Endothelial Cell Adhesion Molecule 2 3 4
  • Endothelial Leukocyte Adhesion Molecule 1 3 4
  • CD62 Antigen-Like Family Member E 3 4
  • Endothelial Adhesion Molecule 1 2 3
  • ELAM-1 3 4
  • LECAM2 3 4
  • ELAM1 3 4
  • Leukocyte Endothelial Cell Adhesion Molecule 2 3
  • CD62E Antigen 4
  • CD62E 3
  • ESEL 3
  • ELAM 3

External Ids for SELE Gene

Previous HGNC Symbols for SELE Gene

  • ELAM1
  • ELAM

Previous GeneCards Identifiers for SELE Gene

  • GC01M167320
  • GC01M165342
  • GC01M166181
  • GC01M166671
  • GC01M166879
  • GC01M166423
  • GC01M167958
  • GC01M169691
  • GC01M140914

Summaries for SELE Gene

Entrez Gene Summary for SELE Gene

  • The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008]

GeneCards Summary for SELE Gene

SELE (Selectin E) is a Protein Coding gene. Diseases associated with SELE include atherosclerosis and leukocyte adhesion deficiency. Among its related pathways are Platelet activation, signaling and aggregation and Cell adhesion_Cell-matrix glycoconjugates. GO annotations related to this gene include transmembrane signaling receptor activity and phospholipase binding. An important paralog of this gene is CSMD3.

UniProtKB/Swiss-Prot for SELE Gene

  • Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.

Tocris Summary for SELE Gene

  • Cell adhesion molecules (CAMs) are a large family of transmembrane proteins that are involved in the binding of a cell to another cell or to the extracellular matrix. They have roles in cell proliferation, differentiation, motility, trafficking, apoptosis and tissue architecture.

Gene Wiki entry for SELE Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SELE Gene

Genomics for SELE Gene

Regulatory Elements for SELE Gene

Genomic Location for SELE Gene

Chromosome:
1
Start:
169,722,640 bp from pter
End:
169,764,705 bp from pter
Size:
42,066 bases
Orientation:
Minus strand

Genomic View for SELE Gene

Genes around SELE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SELE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SELE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SELE Gene

Proteins for SELE Gene

  • Protein details for SELE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P16581-LYAM2_HUMAN
    Recommended name:
    E-selectin
    Protein Accession:
    P16581
    Secondary Accessions:
    • A2RRD6
    • P16111

    Protein attributes for SELE Gene

    Size:
    610 amino acids
    Molecular mass:
    66655 Da
    Quaternary structure:
    • Interacts with PSGL1/SELPLG and PODXL2 through the sialyl Lewis X epitope. PSGL1 sulfation appears not to be required for this interaction.

    Three dimensional structures from OCA and Proteopedia for SELE Gene

neXtProt entry for SELE Gene

Proteomics data for SELE Gene at MOPED

Post-translational modifications for SELE Gene

  • Glycosylation at Asn 25, Asn 145, Asn 160, Asn 179, Asn 199, Asn 203, Asn 265, Asn 312, Asn 332, Asn 503, and Asn 527
  • Modification sites at PhosphoSitePlus

Other Protein References for SELE Gene

Antibody Products

  • R&D Systems Antibodies for SELE (E-Selectin/CD62E)

No data available for DME Specific Peptides for SELE Gene

Domains & Families for SELE Gene

Suggested Antigen Peptide Sequences for SELE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P16581

UniProtKB/Swiss-Prot:

LYAM2_HUMAN :
  • Contains 1 C-type lectin domain.
  • Belongs to the selectin/LECAM family.
Domain:
  • Contains 1 C-type lectin domain.
  • Contains 1 EGF-like domain.
  • Contains 6 Sushi (CCP/SCR) domains.
Family:
  • Belongs to the selectin/LECAM family.
genes like me logo Genes that share domains with SELE: view

Function for SELE Gene

Molecular function for SELE Gene

GENATLAS Biochemistry:
E selectin,leucocyte adhesion molecule,107-115kDa,expressed in endothelial cells,induced by IL1B,TNFA. Mutations of the gene may be a risk factor in atherosclerosis
UniProtKB/Swiss-Prot Function:
Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with PSGL1/SELPLG. May have a role in capillary morphogenesis.

Gene Ontology (GO) - Molecular Function for SELE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043274 phospholipase binding IDA 12960351
GO:0070492 oligosaccharide binding IDA 7680663
genes like me logo Genes that share ontologies with SELE: view
genes like me logo Genes that share phenotypes with SELE: view

Animal Models for SELE Gene

MGI Knock Outs for SELE:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SELE Gene

Localization for SELE Gene

Subcellular locations from UniProtKB/Swiss-Prot for SELE Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SELE Gene COMPARTMENTS Subcellular localization image for SELE gene
Compartment Confidence
cytoskeleton 5
extracellular 5
plasma membrane 5
cytosol 2
nucleus 2
golgi apparatus 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SELE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005905 coated pit IDA 18029551
GO:0048471 perinuclear region of cytoplasm IDA 12960351
genes like me logo Genes that share ontologies with SELE: view

Pathways & Interactions for SELE Gene

genes like me logo Genes that share pathways with SELE: view

SIGNOR curated interactions for SELE Gene

Is activated by:

Gene Ontology (GO) - Biological Process for SELE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002092 positive regulation of receptor internalization IDA 9312078
GO:0007155 cell adhesion IEA --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP 18029551
GO:0007202 activation of phospholipase C activity IMP 12960351
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with SELE: view

Drugs & Compounds for SELE Gene

(79) Drugs for SELE Gene - From: Novoseek, PharmGKB, DGIdb, DrugBank, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Carvedilol Approved, Investigational Pharma Antagonist, Target, inhibitor 153
Capecitabine Approved, Investigational Pharma RNA processing inhibitor and thymidylate synthase inhibitor, F-pyrimidines 1220
Fluorouracil Approved Pharma RNA processing inhibitor and thymidylate synthase inhibitor 1684
leucovorin Approved Pharma 952
Oxaliplatin Approved, Investigational Pharma Antitumor agent, Platinum 1322

(72) Additional Compounds for SELE Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ac2-12
256447-08-2
Ac2-26
151988-33-9
GR 144053 trihydrochloride
1215333-48-4
Thiolutin
  • Acetopyrrothine
  • Farcinicine
  • N-Acetylpyrrothine
  • Thiolutin
87-11-6
genes like me logo Genes that share compounds with SELE: view

Transcripts for SELE Gene

Unigene Clusters for SELE Gene

Selectin E:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SELE Gene

No ASD Table

Relevant External Links for SELE Gene

GeneLoc Exon Structure for
SELE
ECgene alternative splicing isoforms for
SELE

Expression for SELE Gene

mRNA expression in normal human tissues for SELE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SELE Gene

This gene is overexpressed in Fallopian Tube (x8.9) and Adipose - Visceral (Omentum) (x6.5).

SOURCE GeneReport for Unigene cluster for SELE Gene Hs.82848

genes like me logo Genes that share expression patterns with SELE: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for SELE Gene

Orthologs for SELE Gene

This gene was present in the common ancestor of animals.

Orthologs for SELE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SELE 36
  • 99 (a)
OneToOne
SELE 35
  • 99.34 (n)
  • 99.18 (a)
cow
(Bos Taurus)
Mammalia SELE 36
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SELE 35
  • 81.2 (n)
  • 75.59 (a)
SELE 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Sele 16
Sele 35
  • 77.74 (n)
  • 73.36 (a)
Sele 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SELE 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SELE 36
  • 58 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sele 35
  • 74.01 (n)
  • 71.19 (a)
chicken
(Gallus gallus)
Aves SELE 35
  • 57.98 (n)
  • 50.21 (a)
SELE 36
  • 51 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii selp 36
  • 28 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta hig 36
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T07H6.4 36
  • 12 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 7 (a)
ManyToMany
-- 36
  • 9 (a)
ManyToMany
-- 36
  • 12 (a)
ManyToMany
-- 36
  • 7 (a)
ManyToMany
-- 36
  • 10 (a)
ManyToMany
CSA.10017 36
  • 21 (a)
ManyToMany
CSA.10029 36
  • 8 (a)
ManyToMany
Species with no ortholog for SELE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for SELE Gene

ENSEMBL:
Gene Tree for SELE (if available)
TreeFam:
Gene Tree for SELE (if available)

Paralogs for SELE Gene

Paralogs for SELE Gene

(2) SIMAP similar genes for SELE Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with SELE: view

Variants for SELE Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SELE Gene

P16581-LYAM2_HUMAN
A polymorphism in position 149 is associated with a higher risk of coronary artery disease (CAD). A significantly higher mutation frequency (Arg-149) is observed in patients with angiographically proven severe atherosclerosis compared with an unselected population (Ser-149).

Sequence variations from dbSNP and Humsavar for SELE Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs5361 - 169,731,919(-) CCTGC(A/C)GTGGC reference, missense
rs5360 - 169,732,646(+) AGGTG(C/G)AGCAA reference, missense
rs5364 - 169,729,506(-) ACAAC(A/C/G)AGAAG reference, missense
rs5366 - 169,728,076(-) ACAAC(A/C/G)AGAAG reference, missense
rs5368 - 169,727,805(-) AATTA(C/T)ATGGA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for SELE Gene

Variant ID Type Subtype PubMed ID
nsv872541 CNV Loss 21882294

Variation tolerance for SELE Gene

Residual Variation Intolerance Score: 59.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.50; 82.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SELE Gene

HapMap Linkage Disequilibrium report
SELE
Human Gene Mutation Database (HGMD)
SELE

Disorders for SELE Gene

MalaCards: The human disease database

(46) MalaCards diseases for SELE Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
atherosclerosis
  • arteriosclerosis
leukocyte adhesion deficiency
  • leukocyte adhesion deficiency, type iii
systemic scleroderma
  • diffuse scleroderma
limb ischemia
heterophyiasis
  • heterophyes infectious disease
- elite association - COSMIC cancer census association via MalaCards
Search SELE in MalaCards View complete list of genes associated with diseases

Relevant External Links for SELE

Genetic Association Database (GAD)
SELE
Human Genome Epidemiology (HuGE) Navigator
SELE
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SELE
genes like me logo Genes that share disorders with SELE: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SELE Gene

Publications for SELE Gene

  1. E-selectin polymorphism associated with myocardial infarction causes enhanced leukocyte-endothelial interactions under flow conditions. (PMID: 12649084) Yoshida M. … Kimura A. (Arterioscler. Thromb. Vasc. Biol. 2003) 3 4 48 67
  2. Increase in E-selectin expression in umbilical vein endothelial cells by anticancer drugs and inhibition by cimetidine. (PMID: 19885579) Kawase J. … Ueda M. (Oncol. Rep. 2009) 3 23
  3. [Galectin-9 isoforms influence the adhesion between colon carcinoma LoVo cells and human umbilical vein endothelial cells in vitro by regulating the expression of E-selectin in LoVo cells]. (PMID: 19538882) Zhang F. … Liu B.Y. (Zhonghua Zhong Liu Za Zhi 2009) 3 23
  4. Clinical significance of nailfold capillaroscopy in systemic lupus erythematosus: correlation with endothelial cell activation markers and disease activity. (PMID: 18991188) Kuryliszyn-Moskal A. … Sierakowski S. (Scand. J. Rheumatol. 2009) 3 23
  5. Differential dose-dependent effects of prednisolone on shedding of endothelial adhesion molecules during human endotoxemia. (PMID: 18930765) Lemaire L.C. … van der Poll T. (Immunol. Lett. 2008) 3 23

Products for SELE Gene

Sources for SELE Gene

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