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Aliases for FKBPL Gene

Aliases for FKBPL Gene

  • FK506 Binding Protein Like 2 3 5
  • WAF-1/CIP1 Stabilizing Protein 39 2 3 4
  • FK506-Binding Protein Like 2 3
  • WISP39 3 4
  • DIR1 3 4
  • NG7 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase 3
  • FKBP4 3

External Ids for FKBPL Gene

Previous GeneCards Identifiers for FKBPL Gene

  • GC06U990246
  • GC06M032117
  • GC06M031867
  • GC06M032167
  • GC06M032204
  • GC06M032098
  • GC06M032099

Summaries for FKBPL Gene

Entrez Gene Summary for FKBPL Gene

  • The protein encoded by this gene has similarity to the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The encoded protein is thought to have a potential role in the induced radioresistance. Also it appears to have some involvement in the control of the cell cycle. [provided by RefSeq, Jul 2008]

GeneCards Summary for FKBPL Gene

FKBPL (FK506 Binding Protein Like) is a Protein Coding gene. Among its related pathways are Cellular response to heat stress and Cellular Senescence. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and FK506 binding.

UniProtKB/Swiss-Prot for FKBPL Gene

  • May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21.

Gene Wiki entry for FKBPL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FKBPL Gene

Genomics for FKBPL Gene

Regulatory Elements for FKBPL Gene

Promoters for FKBPL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FKBPL on UCSC Golden Path with GeneCards custom track

Genomic Location for FKBPL Gene

Chromosome:
6
Start:
32,128,707 bp from pter
End:
32,130,308 bp from pter
Size:
1,602 bases
Orientation:
Minus strand

Genomic View for FKBPL Gene

Genes around FKBPL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FKBPL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FKBPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for FKBPL Gene

  • Protein details for FKBPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIM3-FKBPL_HUMAN
    Recommended name:
    FK506-binding protein-like
    Protein Accession:
    Q9UIM3
    Secondary Accessions:
    • A8K5V3
    • B0UYX8
    • Q9H5G3

    Protein attributes for FKBPL Gene

    Size:
    349 amino acids
    Molecular mass:
    38176 Da
    Quaternary structure:
    • Forms a ternary complex with CDKN1A/p21 and HSP90AB1/Hsp90.
    SequenceCaution:
    • Sequence=BAB15663.1; Type=Frameshift; Positions=201, 205, 319; Evidence={ECO:0000305}; Sequence=CAG33655.1; Type=Frameshift; Positions=201; Evidence={ECO:0000305};

neXtProt entry for FKBPL Gene

Proteomics data for FKBPL Gene at MOPED

Post-translational modifications for FKBPL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FKBPL Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FKBPL Gene

Domains & Families for FKBPL Gene

Protein Domains for FKBPL Gene

Suggested Antigen Peptide Sequences for FKBPL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UIM3

UniProtKB/Swiss-Prot:

FKBPL_HUMAN :
  • Contains 3 TPR repeats.
Similarity:
  • Contains 3 TPR repeats.
genes like me logo Genes that share domains with FKBPL: view

Function for FKBPL Gene

Molecular function for FKBPL Gene

UniProtKB/Swiss-Prot Function:
May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21.

Gene Ontology (GO) - Molecular Function for FKBPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 25036637
genes like me logo Genes that share ontologies with FKBPL: view
genes like me logo Genes that share phenotypes with FKBPL: view

Animal Model Products

miRNA for FKBPL Gene

miRTarBase miRNAs that target FKBPL

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FKBPL Gene

Localization for FKBPL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FKBPL Gene COMPARTMENTS Subcellular localization image for FKBPL gene
Compartment Confidence
cytosol 3
endoplasmic reticulum 3
nucleus 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FKBPL Gene

Pathways & Interactions for FKBPL Gene

genes like me logo Genes that share pathways with FKBPL: view

Gene Ontology (GO) - Biological Process for FKBPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000413 protein peptidyl-prolyl isomerization IBA --
GO:0050821 protein stabilization TAS --
GO:0061077 chaperone-mediated protein folding IBA --
genes like me logo Genes that share ontologies with FKBPL: view

No data available for SIGNOR curated interactions for FKBPL Gene

Drugs & Compounds for FKBPL Gene

No Compound Related Data Available

Transcripts for FKBPL Gene

mRNA/cDNA for FKBPL Gene

Unigene Clusters for FKBPL Gene

FK506 binding protein like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FKBPL Gene

No ASD Table

Relevant External Links for FKBPL Gene

GeneLoc Exon Structure for
FKBPL
ECgene alternative splicing isoforms for
FKBPL

Expression for FKBPL Gene

mRNA expression in normal human tissues for FKBPL Gene

Protein differential expression in normal tissues from HIPED for FKBPL Gene

This gene is overexpressed in Peripheral blood mononuclear cells (35.8), CD8 Tcells (9.1), Pancreas (7.9), Testis (7.5), and Urinary Bladder (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FKBPL Gene



SOURCE GeneReport for Unigene cluster for FKBPL Gene Hs.520042

mRNA Expression by UniProt/SwissProt for FKBPL Gene

Q9UIM3-FKBPL_HUMAN
Tissue specificity: Ubiquitously expressed with higher levels in testis.
genes like me logo Genes that share expression patterns with FKBPL: view

Protein tissue co-expression partners for FKBPL Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for FKBPL Gene

Orthologs for FKBPL Gene

This gene was present in the common ancestor of chordates.

Orthologs for FKBPL Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia FKBPL 35
  • 86.63 (n)
  • 83.67 (a)
chimpanzee
(Pan troglodytes)
Mammalia FKBPL 35
  • 99.81 (n)
  • 99.71 (a)
FKBPL 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fkbpl 35
  • 80.92 (n)
  • 76.59 (a)
cow
(Bos Taurus)
Mammalia FKBPL 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fkbpl 36
  • 74 (a)
OneToOne
Fkbpl 16
Fkbpl 35
  • 81.21 (n)
  • 73.99 (a)
lizard
(Anolis carolinensis)
Reptilia FKBPL 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fkbpl 35
  • 47.33 (n)
  • 39.6 (a)
zebrafish
(Danio rerio)
Actinopterygii FKBPL 36
  • 25 (a)
OneToOne
Species with no ortholog for FKBPL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FKBPL Gene

ENSEMBL:
Gene Tree for FKBPL (if available)
TreeFam:
Gene Tree for FKBPL (if available)

Paralogs for FKBPL Gene

No data available for Paralogs for FKBPL Gene

Variants for FKBPL Gene

Sequence variations from dbSNP and Humsavar for FKBPL Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
VAR_061546 -
rs6457482 -- 32,130,733(+) aaaaa(A/G)aaaAG upstream-variant-2KB
rs4947254 -- 32,130,708(+) ctcaa(A/C)caaaa upstream-variant-2KB
rs9267802 -- 32,132,040(+) CATAA(A/G)CCGTA upstream-variant-2KB
rs9281653 -- 32,131,332(+) GGGGG(-/G)AGGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FKBPL Gene

Variant ID Type Subtype PubMed ID
dgv1929e1 CNV Complex 17122850
nsv830629 CNV Loss 17160897
nsv884701 CNV Gain 21882294
nsv884702 CNV Loss 21882294

Variation tolerance for FKBPL Gene

Residual Variation Intolerance Score: 32.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.24; 76.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FKBPL Gene

HapMap Linkage Disequilibrium report
FKBPL
Human Gene Mutation Database (HGMD)
FKBPL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FKBPL Gene

Disorders for FKBPL Gene

Relevant External Links for FKBPL

Genetic Association Database (GAD)
FKBPL
Human Genome Epidemiology (HuGE) Navigator
FKBPL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FKBPL

No disorders were found for FKBPL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FKBPL Gene

Publications for FKBPL Gene

  1. A novel human stress response-related gene with a potential role in induced radioresistance. (PMID: 10521921) Robson T. … Hirst D.G. (Radiat. Res. 1999) 3 4 23 67
  2. FKBPL regulates estrogen receptor signaling and determines response to endocrine therapy. (PMID: 20103631) McKeen H.D. … Robson T. (Cancer Res. 2010) 3 23
  3. A novel FK506-like binding protein interacts with the glucocorticoid receptor and regulates steroid receptor signaling. (PMID: 18669603) McKeen H.D. … Robson T. (Endocrinology 2008) 3 23
  4. Gene regulation by low-dose ionizing radiation in a normal human lung epithelial cell line. (PMID: 9056895) Robson T.A. … Arrand J.E. (Biochem. Soc. Trans. 1997) 2 3
  5. FKBPL is a critical antiangiogenic regulator of developmental and pathological angiogenesis. (PMID: 25767277) Yakkundi A. … Robson T. (Arterioscler. Thromb. Vasc. Biol. 2015) 3

Products for FKBPL Gene

Sources for FKBPL Gene

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