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Aliases for FKBPL Gene

Aliases for FKBPL Gene

  • FK506 Binding Protein Like 2 3 5
  • WAF-1/CIP1 Stabilizing Protein 39 2 3 4
  • WISP39 3 4
  • DIR1 3 4
  • NG7 3 4
  • Peptidyl-Prolyl Cis-Trans Isomerase 3
  • FK506-Binding Protein Like 2
  • FK506-Binding Protein-Like 3
  • FKBP4 3

External Ids for FKBPL Gene

Previous GeneCards Identifiers for FKBPL Gene

  • GC06U990246
  • GC06M032117
  • GC06M031867
  • GC06M032167
  • GC06M032204
  • GC06M032098
  • GC06M032099

Summaries for FKBPL Gene

Entrez Gene Summary for FKBPL Gene

  • The protein encoded by this gene has similarity to the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The encoded protein is thought to have a potential role in the induced radioresistance. Also it appears to have some involvement in the control of the cell cycle. [provided by RefSeq, Jul 2008]

GeneCards Summary for FKBPL Gene

FKBPL (FK506 Binding Protein Like) is a Protein Coding gene. Among its related pathways are Regulation of PLK1 Activity at G2/M Transition and Cell Cycle, Mitotic. GO annotations related to this gene include peptidyl-prolyl cis-trans isomerase activity and FK506 binding.

UniProtKB/Swiss-Prot for FKBPL Gene

  • May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21.

Gene Wiki entry for FKBPL Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FKBPL Gene

Genomics for FKBPL Gene

Regulatory Elements for FKBPL Gene

Enhancers for FKBPL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G031567 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +551.9 551890 22.2 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YBX1 YY1 SLC30A9 ZNF143 DDX39B TNF LY6G5B LSM2 DHX16 ATF6B TCF19 PPP1R10 VARS CSNK2B
GH06G031792 2 FANTOM5 Ensembl ENCODE dbSUPER 10.3 +334.6 334614 6.7 CREB3L1 AGO1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC MEF2D SSRP1 SKIV2L ATF6B LSM2 LY6G5B DDX39B BAG6 C4A VARS HLA-DRB5 RPL3P2
GH06G032080 1.6 FANTOM5 ENCODE dbSUPER 10.7 +47.8 47808 3.9 HDGF ATF1 PKNOX1 ARID4B DMAP1 ZNF48 ZNF2 TCF12 SLC30A9 GLIS2 HLA-DRB1 ATF6B CYP21A1P FKBPL TNXB PPT2 LY6G6C RNA5SP206
GH06G031829 1.4 ENCODE dbSUPER 10.3 +296.2 296152 9.1 CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 MEF2D LSM2 LY6G5B ATF6B DDX39B SKIV2L VARS LY6G6C GTF2H4 CSNK2B BAG6
GH06G032126 1.2 ENCODE 11 +1.2 1215 4.5 CREB3L1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 NFYC LSM2 DDX39B LY6G5B BRD2 ATF6B SKIV2L PPT2 VARS C4A TCF19
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FKBPL on UCSC Golden Path with GeneCards custom track

Promoters for FKBPL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000320270 -92 1201 HDGF PKNOX1 CREB3L1 ARNT WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B

Genomic Location for FKBPL Gene

Chromosome:
6
Start:
32,128,707 bp from pter
End:
32,130,308 bp from pter
Size:
1,602 bases
Orientation:
Minus strand

Genomic View for FKBPL Gene

Genes around FKBPL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FKBPL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FKBPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FKBPL Gene

Proteins for FKBPL Gene

  • Protein details for FKBPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UIM3-FKBPL_HUMAN
    Recommended name:
    FK506-binding protein-like
    Protein Accession:
    Q9UIM3
    Secondary Accessions:
    • A8K5V3
    • B0UYX8
    • Q9H5G3

    Protein attributes for FKBPL Gene

    Size:
    349 amino acids
    Molecular mass:
    38176 Da
    Quaternary structure:
    • Forms a ternary complex with CDKN1A/p21 and HSP90AB1/Hsp90.
    SequenceCaution:
    • Sequence=BAB15663.1; Type=Frameshift; Positions=201, 205, 319; Evidence={ECO:0000305}; Sequence=CAG33655.1; Type=Frameshift; Positions=201; Evidence={ECO:0000305};

neXtProt entry for FKBPL Gene

Post-translational modifications for FKBPL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FKBPL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FKBPL Gene

Domains & Families for FKBPL Gene

Protein Domains for FKBPL Gene

Suggested Antigen Peptide Sequences for FKBPL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FKBPL: view

No data available for UniProtKB/Swiss-Prot for FKBPL Gene

Function for FKBPL Gene

Molecular function for FKBPL Gene

UniProtKB/Swiss-Prot Function:
May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21.

Gene Ontology (GO) - Molecular Function for FKBPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25036637
genes like me logo Genes that share ontologies with FKBPL: view
genes like me logo Genes that share phenotypes with FKBPL: view

Animal Models for FKBPL Gene

MGI Knock Outs for FKBPL:

Animal Model Products

CRISPR Products

miRNA for FKBPL Gene

miRTarBase miRNAs that target FKBPL

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FKBPL Gene

Localization for FKBPL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FKBPL gene
Compartment Confidence
cytosol 5
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FKBPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FKBPL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FKBPL Gene

Pathways & Interactions for FKBPL Gene

genes like me logo Genes that share pathways with FKBPL: view

Gene Ontology (GO) - Biological Process for FKBPL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009314 response to radiation NAS 10521921
GO:0050821 protein stabilization TAS --
genes like me logo Genes that share ontologies with FKBPL: view

No data available for SIGNOR curated interactions for FKBPL Gene

Drugs & Compounds for FKBPL Gene

No Compound Related Data Available

Transcripts for FKBPL Gene

mRNA/cDNA for FKBPL Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(77) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FKBPL Gene

FK506 binding protein like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FKBPL Gene

No ASD Table

Relevant External Links for FKBPL Gene

GeneLoc Exon Structure for
FKBPL
ECgene alternative splicing isoforms for
FKBPL

Expression for FKBPL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FKBPL Gene

Protein differential expression in normal tissues from HIPED for FKBPL Gene

This gene is overexpressed in Peripheral blood mononuclear cells (35.8), CD8 Tcells (9.1), Pancreas (7.9), Testis (7.5), and Urinary Bladder (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FKBPL Gene



Protein tissue co-expression partners for FKBPL Gene

NURSA nuclear receptor signaling pathways regulating expression of FKBPL Gene:

FKBPL

SOURCE GeneReport for Unigene cluster for FKBPL Gene:

Hs.520042

mRNA Expression by UniProt/SwissProt for FKBPL Gene:

Q9UIM3-FKBPL_HUMAN
Tissue specificity: Ubiquitously expressed with higher levels in testis.

Evidence on tissue expression from TISSUES for FKBPL Gene

  • Intestine(4.1)
  • Lung(4)
genes like me logo Genes that share expression patterns with FKBPL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FKBPL Gene

Orthologs for FKBPL Gene

This gene was present in the common ancestor of chordates.

Orthologs for FKBPL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FKBPL 34 35
  • 99.81 (n)
dog
(Canis familiaris)
Mammalia FKBPL 34
  • 86.63 (n)
mouse
(Mus musculus)
Mammalia Fkbpl 34 16 35
  • 81.21 (n)
cow
(Bos Taurus)
Mammalia FKBPL 35
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fkbpl 34
  • 80.92 (n)
lizard
(Anolis carolinensis)
Reptilia FKBPL 35
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fkbpl 34
  • 47.33 (n)
zebrafish
(Danio rerio)
Actinopterygii FKBPL 35
  • 25 (a)
OneToOne
Species where no ortholog for FKBPL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FKBPL Gene

ENSEMBL:
Gene Tree for FKBPL (if available)
TreeFam:
Gene Tree for FKBPL (if available)

Paralogs for FKBPL Gene

No data available for Paralogs for FKBPL Gene

Variants for FKBPL Gene

Sequence variations from dbSNP and Humsavar for FKBPL Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000439018 -- 32,131,347(+) GGCGG(C/G)GGGGG upstream-variant-2KB
rs1000814463 -- 32,129,672(+) CTGCT(A/G)CCTAA upstream-variant-2KB, reference, stop-gained
rs1000881764 -- 32,131,577(+) CGTCT(-/CAAACAAA)CAAAC upstream-variant-2KB
rs1001180453 -- 32,131,495(+) ATGGC(A/G)TGAAC upstream-variant-2KB
rs1001729851 -- 32,131,089(+) TTAGC(C/T)GGGCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FKBPL Gene

Variant ID Type Subtype PubMed ID
dgv10404n54 CNV loss 21841781
dgv10463n54 CNV loss 21841781
dgv10472n54 CNV loss 21841781
esv2759415 CNV gain+loss 17122850
nsv1028506 CNV gain 25217958
nsv1073969 CNV deletion 25765185
nsv1112900 CNV deletion 24896259
nsv1126749 CNV deletion 24896259
nsv602104 CNV loss 21841781
nsv830629 CNV loss 17160897

Variation tolerance for FKBPL Gene

Residual Variation Intolerance Score: 32.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.24; 76.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FKBPL Gene

Human Gene Mutation Database (HGMD)
FKBPL
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FKBPL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FKBPL Gene

Disorders for FKBPL Gene

Relevant External Links for FKBPL

Genetic Association Database (GAD)
FKBPL
Human Genome Epidemiology (HuGE) Navigator
FKBPL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FKBPL

No disorders were found for FKBPL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FKBPL Gene

Publications for FKBPL Gene

  1. A novel human stress response-related gene with a potential role in induced radioresistance. (PMID: 10521921) Robson T. … Hirst D.G. (Radiat. Res. 1999) 3 4 22 64
  2. FKBPL regulates estrogen receptor signaling and determines response to endocrine therapy. (PMID: 20103631) McKeen H.D. … Robson T. (Cancer Res. 2010) 3 22 64
  3. Alterations in the steroid hormone receptor co-chaperone FKBPL are associated with male infertility: a case-control study. (PMID: 20210997) Sunnotel O. … Walsh C.P. (Reprod. Biol. Endocrinol. 2010) 3 46 64
  4. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos L.F. … Criswell L.A. (PLoS Genet. 2009) 3 46 64
  5. A novel FK506-like binding protein interacts with the glucocorticoid receptor and regulates steroid receptor signaling. (PMID: 18669603) McKeen H.D. … Robson T. (Endocrinology 2008) 3 22 64

Products for FKBPL Gene

Sources for FKBPL Gene

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