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Aliases for ELMO2 Gene

Aliases for ELMO2 Gene

  • Engulfment And Cell Motility 2 2 3
  • Protein Ced-12 Homolog A 3 4
  • HCed-12A 3 4
  • CED12 3 6
  • Engulfment And Cell Motility 2 (Ced-12 Homolog, C. Elegans) 2
  • Engulfment And Cell Motility Protein 2 3
  • PH Domain Protein CED12A 3
  • Ced-12 Homolog 2 3
  • KIAA1834 4
  • CED-12 3
  • ELMO-2 3
  • CED12A 4

External Ids for ELMO2 Gene

Summaries for ELMO2 Gene

Entrez Gene Summary for ELMO2 Gene

  • The protein encoded by this gene interacts with the dedicator of cyto-kinesis 1 protein. Similarity to a C. elegans protein suggests that this protein may function in phagocytosis of apoptotic cells and in cell migration. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for ELMO2 Gene

ELMO2 (Engulfment And Cell Motility 2) is a Protein Coding gene. Among its related pathways are Fcgamma receptor (FCGR) dependent phagocytosis and Fcgamma receptor (FCGR) dependent phagocytosis. GO annotations related to this gene include phospholipid binding and receptor tyrosine kinase binding. An important paralog of this gene is ELMO1.

UniProtKB/Swiss-Prot for ELMO2 Gene

  • Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

Gene Wiki entry for ELMO2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ELMO2 Gene

Genomics for ELMO2 Gene

Genomic Location for ELMO2 Gene

Start:
46,366,049 bp from pter
End:
46,432,985 bp from pter
Size:
66,937 bases
Orientation:
Minus strand

Genomic View for ELMO2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ELMO2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ELMO2 Gene

Regulatory Elements for ELMO2 Gene

Proteins for ELMO2 Gene

  • Protein details for ELMO2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JJ3-ELMO2_HUMAN
    Recommended name:
    Engulfment and cell motility protein 2
    Protein Accession:
    Q96JJ3
    Secondary Accessions:
    • E1P5T3
    • Q5JVZ6
    • Q7Z5G9
    • Q96CJ2
    • Q96ME5
    • Q96PA9
    • Q9H938
    • Q9H9L5
    • Q9HAH0
    • Q9NQQ6

    Protein attributes for ELMO2 Gene

    Size:
    720 amino acids
    Molecular mass:
    82615 Da
    Quaternary structure:
    • Interacts with the SH3-domain of DOCK1 via its SH3-binding site. Probably part of a complex with DOCK1 and RAC1. Probably part of a complex with DOCK1 and CRK isoform CRK-II. Interacts with ARHGEF16, DOCK4 and EPHA2; mediates activation of RAC1 by EPHA2.
    SequenceCaution:
    • Sequence=BAB13879.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14210.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14405.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB47463.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ELMO2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ELMO2 Gene

Proteomics data for ELMO2 Gene at MOPED

Post-translational modifications for ELMO2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys532 and Lys542

Other Protein References for ELMO2 Gene

No data available for DME Specific Peptides for ELMO2 Gene

Domains for ELMO2 Gene

Gene Families for ELMO2 Gene

HGNC:
  • ELMO :Engulfment and cell motility proteins

Protein Domains for ELMO2 Gene

UniProtKB/Swiss-Prot:

ELMO2_HUMAN
Domain:
  • Contains 1 ELMO domain.:
    • Q96JJ3
  • Contains 1 PH domain.:
    • Q96JJ3
genes like me logo Genes that share domains with ELMO2: view

Function for ELMO2 Gene

Molecular function for ELMO2 Gene

UniProtKB/Swiss-Prot Function: Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.

Gene Ontology (GO) - Molecular Function for ELMO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005488 binding --
GO:0005515 protein binding IPI 20679435
GO:0017124 SH3 domain binding IEA --
GO:0030971 receptor tyrosine kinase binding IPI 20679435
genes like me logo Genes that share ontologies with ELMO2: view

Phenotypes for ELMO2 Gene

GenomeRNAi human phenotypes for ELMO2:
genes like me logo Genes that share phenotypes with ELMO2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ELMO2 Gene

Localization for ELMO2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ELMO2 Gene

Cytoplasm. Cytoplasm, cytosol. Membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ELMO2 Gene COMPARTMENTS Subcellular localization image for ELMO2 gene
Compartment Confidence
cytosol 5
cytoskeleton 2
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ELMO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0016020 membrane IDA 20679435
genes like me logo Genes that share ontologies with ELMO2: view

Pathways for ELMO2 Gene

genes like me logo Genes that share pathways with ELMO2: view

Pathways by source for ELMO2 Gene

Gene Ontology (GO) - Biological Process for ELMO2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006909 phagocytosis --
GO:0006915 apoptotic process IEA --
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS --
GO:0045087 innate immune response TAS --
GO:0048010 vascular endothelial growth factor receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with ELMO2: view

Compounds for ELMO2 Gene

(3) HMDB Compounds for ELMO2 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with ELMO2: view

Transcripts for ELMO2 Gene

Unigene Clusters for ELMO2 Gene

Engulfment and cell motility 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ELMO2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^
SP1: - - -
SP2: - - - - - -
SP3: - -
SP4: - - - - -
SP5: - - - -
SP6:
SP7: - - - - - -
SP8: - - - - -
SP9: - - - - - -
SP10: - - - - - - -
SP11: - - - - -
SP12: - - -
SP13: - - -
SP14: - -
SP15: - -
SP16: - - - - - - -
SP17: - - -
SP18: - - - - - - -
SP19: - - - -
SP20:
SP21:
SP22:

ExUns: 14 ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25
SP1: - - -
SP2: - - -
SP3: - - -
SP4: -
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: -
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

Relevant External Links for ELMO2 Gene

GeneLoc Exon Structure for
ELMO2
ECgene alternative splicing isoforms for
ELMO2

Expression for ELMO2 Gene

mRNA expression in normal human tissues for ELMO2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ELMO2 Gene

SOURCE GeneReport for Unigene cluster for ELMO2 Gene Hs.210469

mRNA Expression by UniProt/SwissProt for ELMO2 Gene

Q96JJ3-ELMO2_HUMAN
Tissue specificity: Widely expressed, with a higher expression in skeletal muscle, kidney and placenta.
genes like me logo Genes that share expressions with ELMO2: view

Orthologs for ELMO2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ELMO2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ELMO2 36
  • 99.68 (n)
  • 100 (a)
ELMO2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ELMO2 36
  • 91.99 (n)
  • 99.31 (a)
ELMO2 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ELMO2 36
  • 93.52 (n)
  • 99.44 (a)
ELMO2 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Elmo2 36
  • 89.4 (n)
  • 98.75 (a)
Elmo2 16
Elmo2 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ELMO2 37
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ELMO2 37
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Elmo2 36
  • 89.95 (n)
  • 98.61 (a)
chicken
(Gallus gallus)
Aves ELMO2 36
  • 83.7 (n)
  • 96.94 (a)
ELMO2 37
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ELMO2 37
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68475 36
tropical clawed frog
(Silurana tropicalis)
Amphibia elmo1 36
  • 78.43 (n)
  • 89.31 (a)
zebrafish
(Danio rerio)
Actinopterygii ELMO2 37
  • 79 (a)
OneToOne
LOC100006857 36
  • 75.49 (n)
  • 82.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ced-12 37
  • 44 (a)
OneToMany
Ced-12 38
  • 44 (a)
worm
(Caenorhabditis elegans)
Secernentea ced-12 37
  • 19 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU03264 36
  • 43.92 (n)
  • 26.9 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3186 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 47 (a)
ManyToMany
-- 37
  • 57 (a)
ManyToMany
Species with no ortholog for ELMO2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ELMO2 Gene

ENSEMBL:
Gene Tree for ELMO2 (if available)
TreeFam:
Gene Tree for ELMO2 (if available)

Paralogs for ELMO2 Gene

Paralogs for ELMO2 Gene

Selected SIMAP similar genes for ELMO2 Gene using alignment to 10 proteins:

Pseudogenes.org Pseudogenes for ELMO2 Gene

genes like me logo Genes that share paralogs with ELMO2: view

Variants for ELMO2 Gene

Sequence variations from dbSNP and Humsavar for ELMO2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs365819 -- 46,406,389(+) GACGA(A/G)CCGGC intron-variant
rs378277 -- 46,407,564(+) CACTT(A/G)TAGGC upstream-variant-2KB
rs388837 -- 46,408,369(+) TTGGC(A/G)GAGCT upstream-variant-2KB
rs401379 -- 46,406,574(+) GCTCC(C/T)GCTCC utr-variant-5-prime
rs423820 -- 46,408,969(+) ggagc(A/G)cagca upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ELMO2 Gene

Variant ID Type Subtype PubMed ID
nsv820217 CNV Loss 19587683

Relevant External Links for ELMO2 Gene

HapMap Linkage Disequilibrium report
ELMO2

Disorders for ELMO2 Gene

Relevant External Links for ELMO2

Genetic Association Database (GAD)
ELMO2
Human Genome Epidemiology (HuGE) Navigator
ELMO2
genes like me logo Genes that share disorders with ELMO2: view

No data available for UniProtKB/Swiss-Prot for ELMO2 Gene

Publications for ELMO2 Gene

  1. CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration. (PMID: 11595183) Gumienny T.L. … Ravichandran K.S. (Cell 2001) 2 3 4
  2. The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway. (PMID: 11703939) Zhou Z. … Horvitz H.R. (Dev. Cell 2001) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ELMO2 Gene

Sources for ELMO2 Gene

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