Aliases for ELMO2 Gene
External Ids for ELMO2 Gene
The protein encoded by this gene interacts with the dedicator of cyto-kinesis 1 protein. Similarity to a C. elegans protein suggests that this protein may function in phagocytosis of apoptotic cells and in cell migration. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
GeneCards Summary for ELMO2 Gene
ELMO2 (Engulfment And Cell Motility 2) is a Protein Coding gene. Among its related pathways are Fcgamma receptor (FCGR) dependent phagocytosis and Fcgamma receptor (FCGR) dependent phagocytosis. GO annotations related to this gene include phospholipid binding and receptor tyrosine kinase binding. An important paralog of this gene is ELMO1.
UniProtKB/Swiss-Prot for ELMO2 Gene
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.