Aliases for PRDM1 Gene
Aliases for PRDM1 Gene
External Ids for PRDM1 Gene
- HGNC: 9346
- Entrez Gene: 639
- Ensembl: ENSG00000057657
- OMIM: 603423
- UniProtKB: O75626
Previous HGNC Symbols for PRDM1 Gene
- BLIMP1
Previous GeneCards Identifiers for PRDM1 Gene
- GC06P106371
- GC06P106557
- GC06P106579
- GC06P106640
- GC06P103981
- GC06P106534
Summaries for PRDM1 Gene
-
This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for PRDM1 Gene
PRDM1 (PR/SET Domain 1) is a Protein Coding gene. Diseases associated with PRDM1 include Adult Lymphoma and Central Nervous System Lymphoma. Among its related pathways are Regulation of TP53 Activity and B Cell Development Pathways. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is ZNF683.
UniProtKB/Swiss-Prot for PRDM1 Gene
-
Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (By similarity). Binds specifically to the PRDI element in the promoter of the beta-interferon gene (PubMed:1851123). Drives the maturation of B-lymphocytes into Ig secreting cells (PubMed:12626569). Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (By similarity).
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRDM1 Gene
Genomics for PRDM1 Gene
Regulatory Elements for PRDM1 Gene
Enhancers for PRDM1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH06G105991 | 1.8 | FANTOM5 Ensembl ENCODE | 40.7 | -91.2 | -91224 | 7.0 | CREB3L1 ARNT SIN3A ARID4B ZNF2 YY1 ZNF766 ZNF143 ZNF207 FOS | PRDM1 GC06M106046 GC06M105873 GC06M105874 |
| GH06G106162 | 1.8 | FANTOM5 Ensembl ENCODE dbSUPER | 39.1 | +77.7 | 77687 | 3.0 | HDGF PKNOX1 TBL1XR1 ZBTB40 RELB ETV6 IKZF2 CREM EGR2 SMAD5 | PRDM1 ENSG00000269919 PIR35075 |
| GH06G105795 | 1.7 | FANTOM5 Ensembl ENCODE dbSUPER | 27.9 | -289.2 | -289212 | 3.4 | FOXA2 ZSCAN4 RAD21 YY1 RCOR1 FOS SMARCC1 NFYA JUNB CEBPB | PRDM1 GC06M105786 LOC105377923 |
| GH06G105803 | 1.8 | FANTOM5 Ensembl ENCODE dbSUPER | 24.5 | -281.7 | -281716 | 2.9 | PKNOX1 ATF1 ARNT SIN3A BRCA1 YY1 TCF12 ZNF766 FOS CAVIN1 | PRDM1 GC06M105786 LOC105377923 |
| GH06G106082 | 1.9 | FANTOM5 Ensembl ENCODE dbSUPER | 23.2 | +0.1 | 109 | 8.1 | CREB3L1 SIN3A ZNF2 ZNF766 CBX5 ZNF207 ZNF143 FOS KLF13 SP3 | PRDM1 RNU6-344P ENSG00000269919 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around PRDM1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the PRDM1 gene promoter:
Regulatory Element Products
Genomic Location for PRDM1 Gene
- Chromosome:
- 6
- Start:
- 106,086,320 bp from pter
- End:
- 106,109,939 bp from pter
- Size:
- 23,620 bases
- Orientation:
- Plus strand
Genomic View for PRDM1 Gene
Genes around PRDM1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q21 by Ensembl
- 6q21 by Entrez Gene
- 6q21 by HGNC
PRDM1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PRDM1 Gene
Proteins for PRDM1 Gene
-
Protein details for PRDM1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O75626-PRDM1_HUMAN
- Recommended name:
- PR domain zinc finger protein 1
- Protein Accession:
- O75626
- B2REA6
- E1P5E0
- Q86WM7
Protein attributes for PRDM1 Gene
- Size:
- 825 amino acids
- Molecular mass:
- 91771 Da
- Quaternary structure:
-
- Interacts with PRMT5 (By similarity). Interacts with FBXO10 (PubMed:24613396). Interacts with FBXO11 (PubMed:24613396, PubMed:24968003).
- SequenceCaution:
-
- Sequence=AAO45623.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for PRDM1 Gene
Post-translational modifications for PRDM1 Gene
- Sumoylation at Lys-816 by PIAS1 augments transcriptional repressor activity, and is critical for plasma cell differentiation.
- Ubiquitinated by the SCF(FBXO11) complex, leading to its degradation by the proteasome.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for PRDM1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for PRDM1
- R&D Systems Antibodies for PRDM1 (BLIMP1/PRDM1)
- Cell Signaling Technology (CST) Antibodies for PRDM1 (PRDM1)
-
Custom Antibody ServicesOriGene Antibodies for PRDM1
- Novus Biologicals Antibodies for PRDM1
-
Cloud-Clone Corp. Antibodies for PRDM1
- Invitrogen Antibodies for PRDM1
- antibodies-online Antibodies for PRDM1: See all 167
- GeneTex PRDM1 antibody for PRDM1
-
Custom Antibody ServicesProSci Antibodies for PRDM1
-
Santa Cruz Biotechnology (SCBT) Antibodies for PRDM1
Protein Products
-
OriGene Purified Proteins for PRDM1
- Search Origene for MassSpec and Protein Over-expression Lysates for PRDM1
- Origene Custom Protein Services for PRDM1
-
Cloud-Clone Corp. Proteins for PRDM1
- antibodies-online Proteins for PRDM1: See all 9
- Search antibodies-online for peptides
- Search GeneTex for Proteins for PRDM1
Assay Products
- antibodies-online Kits for PRDM1: See all 3
No data available for DME Specific Peptides for PRDM1 Gene
Domains & Families for PRDM1 Gene
Gene Families for PRDM1 Gene
Protein Domains for PRDM1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PRDM1 Gene
Graphical View of Domain Structure for InterPro Entry
O75626UniProtKB/Swiss-Prot:
PRDM1_HUMAN :- Belongs to the class V-like SAM-binding methyltransferase superfamily.
- Family:
-
- Belongs to the class V-like SAM-binding methyltransferase superfamily.
Function for PRDM1 Gene
Molecular function for PRDM1 Gene
- GENATLAS Biochemistry:
- PR domain containing 1,B-lymphocyte maturation promoting transcription factor,repressing the expression of IFNB promoter,and the transcription by recruiting a complex of Groucho family proteins to DNA,deleted in several B-cell non Hodgkin lymphoma and other cancers
- UniProtKB/Swiss-Prot Function:
- Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (By similarity). Binds specifically to the PRDI element in the promoter of the beta-interferon gene (PubMed:1851123). Drives the maturation of B-lymphocytes into Ig secreting cells (PubMed:12626569). Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (By similarity).
Enzyme Numbers (IUBMB) for PRDM1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | IDA | 1851123 |
| GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | IDA | 1851123 |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | TAS | 1851123 |
Phenotypes for PRDM1 Gene
- MGI mutant phenotypes for PRDM1:
-
inferred from 15 alleles
- mortality/aging
- cellular phenotype
- normal phenotype
- growth/size/body region phenotype
- immune system phenotype
- muscle phenotype
- homeostasis/metabolism phenotype
- cardiovascular system phenotype
- neoplasm
- reproductive system phenotype
- endocrine/exocrine gland phenotype
- limbs/digits/tail phenotype
- embryo phenotype
- hematopoietic system phenotype
- renal/urinary system phenotype
- liver/biliary system phenotype
- craniofacial phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for PRDM1:
Animal Models for PRDM1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PRDM1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PRDM1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PRDM1 gene
- Search ViGene Biosciences for PRDM1
CRISPR Products
-
OriGene CRISPR knockouts for PRDM1
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRDM1
- GenScript: Design CRISPR guide RNA sequences for PRDM1
miRNA for PRDM1 Gene
- miRTarBase miRNAs that target PRDM1
-
- hsa-let-7a-5p (MIRT001936)
- hsa-mir-9-5p (MIRT001937)
- hsa-mir-127-3p (MIRT004279)
- hsa-mir-125b-5p (MIRT004533)
- hsa-let-7b-5p (MIRT005513)
- hsa-let-7f-5p (MIRT005514)
- hsa-mir-30a-5p (MIRT007218)
- hsa-mir-877-3p (MIRT037062)
- hsa-mir-223-3p (MIRT054801)
- hsa-mir-30c-5p (MIRT167508)
- hsa-mir-30d-5p (MIRT167509)
- hsa-mir-30b-5p (MIRT167510)
- hsa-mir-30e-5p (MIRT167511)
- hsa-mir-374a-5p (MIRT217179)
- hsa-mir-129-5p (MIRT217240)
- hsa-mir-125a-5p (MIRT437582)
- hsa-mir-140-5p (MIRT437596)
- hsa-mir-874-3p (MIRT610586)
- hsa-mir-3157-3p (MIRT610587)
- hsa-mir-6886-3p (MIRT610588)
- hsa-mir-938 (MIRT610589)
Targeted motifs for PRDM1 Gene
HOMER Transcription Factor Regulatory Elements motif PRDM1
- Consensus sequence: ACTTTCACTTTC Submotif: canonical Cell Type: Hela GEO ID: GSE31477
miRNA Products
- Search ViGene Biosciences for PRDM1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for PRDM1
- Browse OriGene Inhibitory RNA Products For PRDM1
-
ViGene Biosciences ready-to-package AAV shRNAs for PRDM1 gene
Clone Products
- Sino Biological Human cDNA Clone for PRDM1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for PRDM1
- VectorBuilder custom plasmid, inducible vectors for PRDM1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PRDM1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for PRDM1
-
ViGene Biosciences adenoviral particle packaged cDNA for PRDM1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PRDM1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PRDM1 gene
Flow Cytometry Products
No data available for Human Phenotype Ontology and Transcription Factor Targets for PRDM1 Gene
Localization for PRDM1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PRDM1 Gene
- Nucleus. Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 1 |
| extracellular | 1 |
| endoplasmic reticulum | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IDA | 21421998 |
Pathways & Interactions for PRDM1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Gene Expression |
.48
|
|
| 2 | Regulation of TP53 Activity | ||
| 3 | Regulation of TP53 Expression and Degradation | ||
| 4 | NF-kappaB Signaling | ||
| 5 | B Cell Development Pathways | ||
Pathways by source for PRDM1 Gene
1 Cell Signaling Technology pathway for PRDM1 Gene
3 BioSystems pathways for PRDM1 Gene
6 Reactome pathways for PRDM1 Gene
2 R&D Systems pathways for PRDM1 Gene
Interacting Proteins for PRDM1 Gene
Selected Interacting proteins:
O75626-PRDM1_HUMAN
ENSP00000358092
for PRDM1 Gene via
IID
STRING
UniProtKB
MINT
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | IDA | 1851123 |
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0001763 | morphogenesis of a branching structure | IEA | -- |
| GO:0001892 | embryonic placenta development | IEA | -- |
| GO:0001893 | maternal placenta development | IEA | -- |
Transcripts for PRDM1 Gene
mRNA/cDNA for PRDM1 Gene
- (7) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (76) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PRDM1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for PRDM1
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRDM1
- GenScript: Design CRISPR guide RNA sequences for PRDM1
miRNA Products
- Search ViGene Biosciences for PRDM1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for PRDM1
- Browse OriGene Inhibitory RNA Products For PRDM1
-
ViGene Biosciences ready-to-package AAV shRNAs for PRDM1 gene
Clone Products
- Sino Biological Human cDNA Clone for PRDM1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for PRDM1
- VectorBuilder custom plasmid, inducible vectors for PRDM1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PRDM1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP9: | - | ||||||||||||||||||||||||||||||||||||||||
| SP10: | - |
Expression for PRDM1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Gonad
- Primordial Germ Cell Precursors Epiblast
- Primordial Germ Cells Primitive Gonad
- Primordial Germ Cells Allantois
- XY Germ Cells Testis Cord
- Germ-like cells(Panula S et. al. 2011)
- Ovary (Reproductive System)
- NULL (Uncategorized)
- Germ Cells (Reproductive System)
-
Eye (Sensory Organs)
- Early Photoreceptor Precursor Cells Retinal Neuroblastic Layer
- Late Photoreceptor Precursor Cells Retinal Neuroblastic Layer
-
Neurons
- Early Photoreceptor Precursor Cells Retinal Neuroblastic Layer
- Late Photoreceptor Precursor Cells Retinal Neuroblastic Layer
-
Hair (Integumentary System)
- Sebocyte Progenitor Cells Sebaceous Gland
-
Epiblast (Early Embryonic Tissues)
- Primordial Germ Cell Precursors Epiblast
-
Limb (Muscoskeletal System)
- Limb Bud Mesenchyme Cells Limb Bud
-
Mesoderm (Gastrulation Derivatives)
- Limb Bud Mesenchyme Cells Limb Bud
-
Heart (Cardiovascular System)
- Cardiomyocytes Myocardium
-
Placenta (Extraembryonic Tissues)
- Primordial Germ Cells Allantois
-
Testis (Reproductive System)
- XY Germ Cells Testis Cord
- Endoderm (Gastrulation Derivatives)
- Primitive Streak (Early Embryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for PRDM1 Gene
This gene is overexpressed in Esophagus - Mucosa (x7.8) and Whole Blood (x4.2).
This gene is overexpressed in Serum (37.1) and Pancreas (27.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRDM1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of PRDM1 Gene:
PRDM1SOURCE GeneReport for Unigene cluster for PRDM1 Gene:
Hs.436023Evidence on tissue expression from TISSUES for PRDM1 Gene
- Bone marrow(3)
- Blood(2.7)
- Lymph node(2.6)
- Spleen(2.4)
Primer Products
-
OriGene qPCR primer pairs for PRDM1
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRDM1 Gene
Orthologs for PRDM1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PRDM1 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Prdm1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Prdm1 34 |
|
||
| cow (Bos Taurus) |
Mammalia | PRDM1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | PRDM1 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PRDM1 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PRDM1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PRDM1 34 |
|
||
| BLIMP-1 35 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | PRDM1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | prdm1 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | prdm1-prov 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | prdm1a 34 35 |
|
||
| ubo 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CG5249 36 |
|
|
|
| Blimp-1 35 |
|
OneToOne | |||
| worm (Caenorhabditis elegans) |
Secernentea | odd-3 36 |
|
|
- Species where no ortholog for PRDM1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for PRDM1 Gene
(64) SIMAP similar genes for PRDM1 Gene using alignment to 6 proteins:
- DKFZp666P0310
- ZNF818P
- DKFZp434J0650
- ZNF55
- ZNF78L1
- ZNF
- zf30
- ZKSCAN1
- ZFS-4
- ZFS-2
- ZNF468
- A-328A3.4
- DKFZp762K012
- DKFZp434G1930
- kr-znf3
- ZNF83
- ZNF32
- DKFZp666C237
- ZNF625
- DKFZp570I0164
- ZNF844
- HZF36
- HZF30
- DKFZp686O1631
- DKFZp666M039
- ZNF72
- PLAGL1
- Nbla00121
- smap-7
- ZNF778
- ZNF697
- ZNF664
- ZNF600
- HZF16
- ZNF833P
- ZNF702P
- ZNF282
- ZNF234
- ZFS-5
- HZF40
- DKFZp686N0199
- ZNF808
- ZNF75A
- ZNF323
- ZNF22
- ZNF146
- DKFZp686M04222
- DKFZp313M0722
- ZNF501
- ZNF138
- ZFS-6
- ZNF137P
- ZNF331
- ZFP64
- MST154
- ZNFN1A2
- HZF17
- ZNF589
- ZFP41
- PLZF
- HZF28
- ZNF726P1
- ZFS-3
- DKFZp547H249
Variants for PRDM1 Gene
| SNP ID | Clin | Chr 06 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs139718143 | untested | 106,107,241(+) | AGGAC(A/G)TGGAG | reference, missense | |
| rs141465160 | untested | 106,105,508(+) | GCAAT(C/G/T)TCCTC | reference, missense | |
| rs143040512 | untested | 106,105,221(+) | TCACA(A/G)CAGCC | reference, missense | |
| rs144524449 | untested | 106,105,382(+) | ACAAC(C/G/T)CTCAC | reference, missense | |
| rs149024185 | untested | 106,104,971(+) | CTAAC(A/G)TTTCA | reference, missense |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv6134n100 | CNV | gain | 25217958 |
| nsv1025231 | CNV | gain | 25217958 |
| nsv5429 | CNV | insertion | 18451855 |
| nsv830755 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
55.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.10;
84.51% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for PRDM1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRDM1 Gene
Disorders for PRDM1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| adult lymphoma |
|
|
| central nervous system lymphoma |
|
|
| hodgkin lymphoma |
|
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| oral hairy leukoplakia |
|
|
| b-cell lymphomas |
|
Search PRDM1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for PRDM1
No data available for UniProtKB/Swiss-Prot and Genatlas for PRDM1 Gene
Publications for PRDM1 Gene
- Identification and characterization of a novel repressor of beta- interferon gene expression. (PMID: 1851123) Keller A.D. … Maniatis T. (Genes Dev. 1991) 2 3 4 22 64
- Lack of evidence of a role of XBP1 and PRDM1 polymorphisms in Spanish patients with immunoglobulin A deficiency. (PMID: 19735688) del Pozo N. … NA_A+ez C. (Hum. Immunol. 2009) 3 22 46 64
- Identification of a functionally impaired positive regulatory domain I binding factor 1 transcription repressor in myeloma cell lines. (PMID: 12626569) Gyory I. … Wright K.L. (J. Immunol. 2003) 3 4 22 64
- SUMOylation of Blimp-1 is critical for plasma cell differentiation. (PMID: 22555612) Ying H.Y. … Lin K.I. (EMBO Rep. 2012) 3 4 64
- NANOS3 function in human germ cell development. (PMID: 21421998) Julaton V.T. … Reijo Pera R.A. (Hum. Mol. Genet. 2011) 3 4 64
Products for PRDM1 Gene
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for PRDM1 Gene
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