Aliases for PRDM1 Gene
Aliases for PRDM1 Gene
External Ids for PRDM1 Gene
- HGNC: 9346
- Entrez Gene: 639
- Ensembl: ENSG00000057657
- OMIM: 603423
- UniProtKB: O75626
Previous HGNC Symbols for PRDM1 Gene
- BLIMP1
Previous GeneCards Identifiers for PRDM1 Gene
- GC06P106371
- GC06P106557
- GC06P106579
- GC06P106640
- GC06P103981
- GC06P106534
Summaries for PRDM1 Gene
-
This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008]
GeneCards Summary for PRDM1 Gene
PRDM1 (PR/SET Domain 1) is a Protein Coding gene. Diseases associated with PRDM1 include Adult Lymphoma and Central Nervous System Lymphoma. Among its related pathways are Gene Expression and Regulation of TP53 Activity. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is ZNF683.
UniProtKB/Swiss-Prot for PRDM1 Gene
-
Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (By similarity). Binds specifically to the PRDI element in the promoter of the beta-interferon gene (PubMed:1851123). Drives the maturation of B-lymphocytes into Ig secreting cells (PubMed:12626569). Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (By similarity).
Additional gene information for PRDM1 Gene
- Monarch Initiative
- Search for PRDM1 at DataMed
- Search for PRDM1 at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRDM1 Gene
Genomics for PRDM1 Gene
GeneHancer (GH) Regulatory Elements for PRDM1 Gene
Regulatory Element Products
Genomic Locations for PRDM1 Gene
- chr6:106,086,320-106,109,939
- (GRCh38/hg38)
- Size:
- 23,620 bases
- Orientation:
- Plus strand
- chr6:106,534,195-106,557,814
- (GRCh37/hg19)
Genomic View for PRDM1 Gene
- Cytogenetic band:
-
- 6q21 by Ensembl
- 6q21 by Entrez Gene
- 6q21 by HGNC


RefSeq DNA sequence for PRDM1 Gene
Proteins for PRDM1 Gene
-
Protein details for PRDM1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O75626-PRDM1_HUMAN
- Recommended name:
- PR domain zinc finger protein 1
- Protein Accession:
- O75626
- B2REA6
- E1P5E0
- Q86WM7
Protein attributes for PRDM1 Gene
- Size:
- 825 amino acids
- Molecular mass:
- 91771 Da
- Quaternary structure:
-
- Interacts with PRMT5 (By similarity). Interacts with FBXO10 (PubMed:24613396). Interacts with FBXO11 (PubMed:24613396, PubMed:24968003).
- SequenceCaution:
-
- Sequence=AAO45623.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for PRDM1 Gene
Post-translational modifications for PRDM1 Gene
- Sumoylation at Lys-816 by PIAS1 augments transcriptional repressor activity, and is critical for plasma cell differentiation.
- Ubiquitinated by the SCF(FBXO11) complex, leading to its degradation by the proteasome.
Other Protein References for PRDM1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for PRDM1 (BLIMP1/PRDM1)
- Cell Signaling Technology (CST) Antibodies for PRDM1 (PRDM1)
-
Custom Antibody ServicesOriGene Antibodies for PRDM1
- Novus Biologicals Antibodies for PRDM1
-
Abcam antibodies for PRDM1
-
Cloud-Clone Corp. Antibodies for PRDM1
- Invitrogen Antibodies for PRDM1
- antibodies-online: Search results for 184 available PRDM1 Antibodies ranked by validation data
- Compare Top PRDM1 Antibodies
-
Recommended
- 157 WB Antibodies (anti-human)
- 8 FACS Antibodies (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 68 WB Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 37 WB Antibodies (anti-rat)
- 157 WB Antibodies (anti-human)
- 8 FACS Antibodies (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 68 WB Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 37 WB Antibodies (anti-rat)
- GeneTex PRDM1 antibody for PRDM1
-
Santa Cruz Biotechnology (SCBT) Antibodies for PRDM1
Protein Products
-
OriGene Purified Proteins for PRDM1
- Search Origene for MassSpec and Protein Over-expression Lysates for PRDM1
- Origene Custom Protein Services for PRDM1
-
Cloud-Clone Corp. Proteins for PRDM1
- Search GeneTex for Proteins for PRDM1
-
Abcam proteins for PRDM1
Assay Products
No data available for DME Specific Peptides for PRDM1 Gene
Domains & Families for PRDM1 Gene
Gene Families for PRDM1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for PRDM1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PRDM1 Gene
Graphical View of Domain Structure for InterPro Entry
O75626UniProtKB/Swiss-Prot:
PRDM1_HUMAN :- Belongs to the class V-like SAM-binding methyltransferase superfamily.
- Family:
-
- Belongs to the class V-like SAM-binding methyltransferase superfamily.
Function for PRDM1 Gene
Molecular function for PRDM1 Gene
- GENATLAS Biochemistry:
- PR domain containing 1,B-lymphocyte maturation promoting transcription factor,repressing the expression of IFNB promoter,and the transcription by recruiting a complex of Groucho family proteins to DNA,deleted in several B-cell non Hodgkin lymphoma and other cancers
- UniProtKB/Swiss-Prot Function:
- Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (By similarity). Binds specifically to the PRDI element in the promoter of the beta-interferon gene (PubMed:1851123). Drives the maturation of B-lymphocytes into Ig secreting cells (PubMed:12626569). Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (By similarity).
Enzyme Numbers (IUBMB) for PRDM1 Gene
Phenotypes From GWAS Catalog for PRDM1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 1851123 |
GO:0001078 | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 1851123 |
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003677 | DNA binding | IEA | -- |
GO:0003700 | DNA binding transcription factor activity | TAS | 1851123 |
Phenotypes for PRDM1 Gene
- MGI mutant phenotypes for PRDM1:
-
inferred from 15 alleles
- normal phenotype
- homeostasis/metabolism phenotype
- muscle phenotype
- cardiovascular system phenotype
- mortality/aging
- immune system phenotype
- cellular phenotype
- growth/size/body region phenotype
- neoplasm
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- embryo phenotype
- hematopoietic system phenotype
- renal/urinary system phenotype
- liver/biliary system phenotype
- craniofacial phenotype
- no phenotypic analysis
- limbs/digits/tail phenotype
- GenomeRNAi human phenotypes for PRDM1:
Animal Models for PRDM1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PRDM1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for PRDM1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PRDM1 gene
- Search ViGene Biosciences for PRDM1
CRISPR Products
-
OriGene CRISPR knockouts for PRDM1
- genomics-online: gRNA clones - Search results for available PRDM1 gene related products
- Applied Biological Materials CRISPR for PRDM1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRDM1
- GenScript: Design CRISPR guide RNA sequences for PRDM1
miRNA for PRDM1 Gene
- miRTarBase miRNAs that target PRDM1
-
- hsa-let-7a-5p (MIRT001936)
- hsa-mir-9-5p (MIRT001937)
- hsa-mir-127-3p (MIRT004279)
- hsa-mir-125b-5p (MIRT004533)
- hsa-let-7b-5p (MIRT005513)
- hsa-let-7f-5p (MIRT005514)
- hsa-mir-30a-5p (MIRT007218)
- hsa-mir-877-3p (MIRT037062)
- hsa-mir-223-3p (MIRT054801)
- hsa-mir-30c-5p (MIRT167508)
- hsa-mir-30d-5p (MIRT167509)
- hsa-mir-30b-5p (MIRT167510)
- hsa-mir-30e-5p (MIRT167511)
- hsa-mir-125a-3p (MIRT217176)
- hsa-mir-374a-5p (MIRT217179)
- hsa-mir-129-5p (MIRT217240)
- hsa-mir-125a-5p (MIRT437582)
- hsa-mir-140-5p (MIRT437596)
- hsa-mir-874-3p (MIRT610586)
- hsa-mir-3157-3p (MIRT610587)
- hsa-mir-6886-3p (MIRT610588)
- hsa-mir-938 (MIRT610589)
- hsa-mir-222-3p (MIRT731781)
- hsa-mir-101-3p (MIRT731782)
- hsa-mir-320c (MIRT732833)
Targeted motifs for PRDM1 Gene
- Consensus sequence: ACTTTCACTTTC Submotif: canonical Cell Type: Hela GEO ID: GSE31477
miRNA Products
- Search ViGene Biosciences for PRDM1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PRDM1
- Browse OriGene Inhibitory RNA Products For PRDM1
- genomics-online: shRNA clones - Search results for available PRDM1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PRDM1 gene
Clone Products
- Sino Biological Human cDNA Clone for PRDM1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PRDM1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PRDM1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PRDM1
- genomics-online: cdna clones - Search results for available PRDM1 gene related products
- orf clones - Search results for available PRDM1 gene related products
- Applied Biological Materials Clones for PRDM1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PRDM1
-
ViGene Biosciences adenoviral particle packaged cDNA for PRDM1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PRDM1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PRDM1 gene
No data available for Human Phenotype Ontology and Transcription Factor Targets for PRDM1 Gene
Localization for PRDM1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PRDM1 Gene
- Nucleus. Cytoplasm.
- Nucleoli (2)
- Nucleus (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IEA | -- |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IDA,IEA | 21421998 |
Pathways & Interactions for PRDM1 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Gene Expression |
.48
|
|
2 | Regulation of TP53 Activity | ||
3 | Regulation of TP53 Expression and Degradation | ||
4 | NF-kappaB Signaling | ||
5 | B Cell Development Pathways |
Pathways by source for PRDM1 Gene
1 Cell Signaling Technology pathway for PRDM1 Gene
3 BioSystems pathways for PRDM1 Gene
6 Reactome pathways for PRDM1 Gene
1 R&D Systems pathway for PRDM1 Gene
Interacting Proteins for PRDM1 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IDA | 1851123 |
GO:0001701 | in utero embryonic development | IEA | -- |
GO:0001763 | morphogenesis of a branching structure | IEA | -- |
GO:0001892 | embryonic placenta development | IEA | -- |
GO:0001893 | maternal placenta development | IEA | -- |
Transcripts for PRDM1 Gene
mRNA/cDNA for PRDM1 Gene
- (7) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (76) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PRDM1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for PRDM1
- genomics-online: gRNA clones - Search results for available PRDM1 gene related products
- Applied Biological Materials CRISPR for PRDM1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRDM1
- GenScript: Design CRISPR guide RNA sequences for PRDM1
miRNA Products
- Search ViGene Biosciences for PRDM1
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PRDM1
- Browse OriGene Inhibitory RNA Products For PRDM1
- genomics-online: shRNA clones - Search results for available PRDM1 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for PRDM1 gene
Clone Products
- Sino Biological Human cDNA Clone for PRDM1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PRDM1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PRDM1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PRDM1
- genomics-online: cdna clones - Search results for available PRDM1 gene related products
- orf clones - Search results for available PRDM1 gene related products
- Applied Biological Materials Clones for PRDM1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | · | 11c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||||||||||
SP7: | - | ||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | |||||||||||||||||||||||||||||||||||||||
SP9: | - | ||||||||||||||||||||||||||||||||||||||||
SP10: | - |
Expression for PRDM1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Gonad
- Primordial Germ Cell Precursors Epiblast
- Primordial Germ Cells Primitive Gonad
- Primordial Germ Cells Allantois
- XY Germ Cells Testis Cord
- Germ-like cells(Panula S et. al. 2011)
- Ovary (Reproductive System)
- NULL (Uncategorized)
- Germ Cells (Reproductive System)
-
Eye (Sensory Organs)
- Early Photoreceptor Precursor Cells Retinal Neuroblastic Layer
- Late Photoreceptor Precursor Cells Retinal Neuroblastic Layer
-
Neurons
- Early Photoreceptor Precursor Cells Retinal Neuroblastic Layer
- Late Photoreceptor Precursor Cells Retinal Neuroblastic Layer
-
Hair (Integumentary System)
- Sebocyte Progenitor Cells Sebaceous Gland
-
Epiblast (Early Embryonic Tissues)
- Primordial Germ Cell Precursors Epiblast
-
Limb (Muscoskeletal System)
- Limb Bud Mesenchyme Cells Limb Bud
-
Mesoderm (Gastrulation Derivatives)
- Limb Bud Mesenchyme Cells Limb Bud
-
Heart (Cardiovascular System)
- Cardiomyocytes Myocardium
-
Placenta (Extraembryonic Tissues)
- Primordial Germ Cells Allantois
-
Testis (Reproductive System)
- XY Germ Cells Testis Cord
- Endoderm (Gastrulation Derivatives)
- Primitive Streak (Early Embryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for PRDM1 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PRDM1 Gene
NURSA nuclear receptor signaling pathways regulating expression of PRDM1 Gene:
PRDM1SOURCE GeneReport for Unigene cluster for PRDM1 Gene:
Hs.436023Evidence on tissue expression from TISSUES for PRDM1 Gene
- Bone marrow(3)
- Blood(2.7)
- Lymph node(2.6)
- Spleen(2.4)
Primer Products
-
OriGene qPCR primer pairs for PRDM1
- genomics-online: primer clones - Search results for available PRDM1 gene related products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PRDM1 Gene
Orthologs for PRDM1 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | PRDM1 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Prdm1 33 16 34 |
|
||
rat (Rattus norvegicus) |
Mammalia | Prdm1 33 |
|
||
cow (Bos Taurus) |
Mammalia | PRDM1 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | PRDM1 33 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | PRDM1 34 |
|
OneToOne | |
platypus (Ornithorhynchus anatinus) |
Mammalia | PRDM1 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | PRDM1 33 |
|
||
BLIMP-1 34 |
|
OneToOne | |||
lizard (Anolis carolinensis) |
Reptilia | PRDM1 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | prdm1 33 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | prdm1-prov 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | prdm1a 33 34 |
|
||
ubo 33 |
|
||||
fruit fly (Drosophila melanogaster) |
Insecta | CG5249 35 |
|
|
|
Blimp-1 34 |
|
OneToOne | |||
worm (Caenorhabditis elegans) |
Secernentea | odd-3 35 |
|
|
- Species where no ortholog for PRDM1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for PRDM1 Gene
(64) SIMAP similar genes for PRDM1 Gene using alignment to 6 proteins:
- DKFZp666P0310
- ZNF818P
- DKFZp434J0650
- ZNF55
- ZNF78L1
- ZNF
- zf30
- ZKSCAN1
- ZFS-4
- ZFS-2
- ZNF468
- A-328A3.4
- DKFZp762K012
- DKFZp434G1930
- kr-znf3
- ZNF83
- ZNF32
- DKFZp666C237
- ZNF625
- DKFZp570I0164
- ZNF844
- HZF36
- HZF30
- DKFZp686O1631
- DKFZp666M039
- ZNF72
- PLAGL1
- Nbla00121
- smap-7
- ZNF778
- ZNF697
- ZNF664
- ZNF600
- HZF16
- ZNF833P
- ZNF702P
- ZNF282
- ZNF234
- ZFS-5
- HZF40
- DKFZp686N0199
- ZNF808
- ZNF75A
- ZNF323
- ZNF22
- ZNF146
- DKFZp686M04222
- DKFZp313M0722
- ZNF501
- ZNF138
- ZFS-6
- ZNF137P
- ZNF331
- ZFP64
- MST154
- ZNFN1A2
- HZF17
- ZNF589
- ZFP41
- PLZF
- HZF28
- ZNF726P1
- ZFS-3
- DKFZp547H249
Variants for PRDM1 Gene
SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs139718143 | not-provided, not specified | 106,107,241(+) | G/A | coding_sequence_variant, missense_variant | |
rs141465160 | not-provided, not specified | 106,105,508(+) | C/G/T | coding_sequence_variant, missense_variant | |
rs143040512 | not-provided, not specified | 106,105,221(+) | G/A | coding_sequence_variant, missense_variant | |
rs144524449 | not-provided, not specified | 106,105,382(+) | G/C/T | coding_sequence_variant, missense_variant | |
rs149024185 | not-provided, not specified | 106,104,971(+) | A/G | coding_sequence_variant, missense_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv6134n100 | CNV | gain | 25217958 |
nsv1025231 | CNV | gain | 25217958 |
nsv5429 | CNV | insertion | 18451855 |
nsv830755 | CNV | loss | 17160897 |
Additional Variant Information for PRDM1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRDM1 Gene
Disorders for PRDM1 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
adult lymphoma |
|
|
central nervous system lymphoma |
|
|
oral hairy leukoplakia |
|
|
diffuse large b-cell lymphoma |
|
|
b-cell lymphomas |
|
Additional Disease Information for PRDM1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PRDM1 Gene
Publications for PRDM1 Gene
- Identification and characterization of a novel repressor of beta-interferon gene expression. (PMID: 1851123) Keller AD … Maniatis T (Genes & development 1991) 2 3 4 22 58
- Lack of evidence of a role of XBP1 and PRDM1 polymorphisms in Spanish patients with immunoglobulin A deficiency. (PMID: 19735688) del Pozo N … Núñez C (Human immunology 2009) 3 22 44 58
- Identification of a functionally impaired positive regulatory domain I binding factor 1 transcription repressor in myeloma cell lines. (PMID: 12626569) Györy I … Wright KL (Journal of immunology (Baltimore, Md. : 1950) 2003) 3 4 22 58
- SUMOylation of Blimp-1 is critical for plasma cell differentiation. (PMID: 22555612) Ying HY … Lin KI (EMBO reports 2012) 3 4 58
- NANOS3 function in human germ cell development. (PMID: 21421998) Julaton VT … Reijo Pera RA (Human molecular genetics 2011) 3 4 58
Products for PRDM1 Gene
- R&D Systems Antibodies for PRDM1 (BLIMP1/PRDM1)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for PRDM1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for PRDM1
- Search Origene for MassSpec and Protein Over-expression Lysates for PRDM1
- Origene Custom Protein Services for PRDM1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PRDM1
- Browse OriGene Inhibitory RNA Products For PRDM1
- OriGene qPCR primer pairs for PRDM1
- OriGene CRISPR knockouts for PRDM1
- OriGene ORF clones in human for PRDM1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PRDM1
- GenScript: Next-day shipping of latest version cDNA ORF clones for PRDM1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for PRDM1
- GenScript Custom Assay Services for PRDM1
- GenScript Custom overexpressing Cell Line Services for PRDM1
- GenScript: Design CRISPR guide RNA sequences for PRDM1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for PRDM1
- Cell Signaling Technology (CST) Antibodies for PRDM1 (PRDM1)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for PRDM1
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse Sino Biological ELISA Kits
- Browse Sino Biological ELISA Pair Sets
- Browse Sino Biological CRO Services
- Browse Sino Biological Control Vectors
- Sino Biological Transfection Reagent
- Sino Biological Anti-His Tag Antibody
- Novus Biologicals Antibodies for PRDM1
- Novus Biologicals lysates and proteins for PRDM1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for PRDM1
- Abcam proteins for PRDM1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Cloud-Clone Corp. Antibodies for PRDM1
- Cloud-Clone Corp. Proteins for PRDM1
- Browse Assay Kits at Cloud-Clone Corp.
- Browse Knockouts at Cloud-Clone Corp.
- Browse Knockins at Cloud-Clone Corp.
- Cloud-Clone Corp. disease models service
- Browse cDNA clones at Cloud-Clone Corp.
- Browse primers at Cloud-Clone Corp.
- Cloud-Clone Corp. primary cells service
- Invitrogen Antibodies for PRDM1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Cyagen custom Knockout/knockin (KOKI) mouse models for PRDM1
- VectorBuilder custom plasmid, inducible vectors for PRDM1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PRDM1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for PRDM1
- antibodies-online: Search results for 184 available PRDM1 Antibodies ranked by validation data
- Compare Top PRDM1 Antibodies
- Recommended
- 157 WB Antibodies (anti-human)
- 8 FACS Antibodies (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 68 WB Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 37 WB Antibodies (anti-rat)
- 157 WB Antibodies (anti-human)
- 8 FACS Antibodies (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 68 WB Antibodies (anti-mouse)
- 2 FACS Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 37 WB Antibodies (anti-rat)
- antibodies-online: Search results for 3 available PRDM1 Elisa Kits ranked by validation data
- Compare Top PRDM1 Elisa Kits
- antibodies-online: Search results for 9 available PRDM1 Proteins ranked by validation data
- Compare Top PRDM1 Proteins
- GeneTex PRDM1 antibody for PRDM1
- Search GeneTex for Proteins for PRDM1
- ViGene Biosciences adenoviral particle packaged cDNA for PRDM1 gene
- ViGene Biosciences lentiviral particle packaged cDNA for PRDM1 gene
- ViGene Biosciences ready-to-package AAV shRNAs for PRDM1 gene
- Search ViGene Biosciences for PRDM1
- Santa Cruz Biotechnology (SCBT) Antibodies for PRDM1
- Search Santa Cruz Biotechnology (SCBT) for PRDM1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PRDM1
- Horizon Cell Lines for PRDM1
- genomics-online: cdna clones - Search results for available PRDM1 gene related products
- orf clones - Search results for available PRDM1 gene related products
- genomics-online: gRNA clones - Search results for available PRDM1 gene related products
- genomics-online: primer clones - Search results for available PRDM1 gene related products
- genomics-online: shRNA clones - Search results for available PRDM1 gene related products
Sources for PRDM1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew