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UBE2O Gene(Protein Coding)

Ubiquitin Conjugating Enzyme E2 O

GCID:
GC17M076389
GIFtS:
54
Genes Participants
UDN Logo

Aliases for UBE2O Gene

Aliases for UBE2O Gene

  • Ubiquitin Conjugating Enzyme E2 O 2 3 5
  • E2/E3 Hybrid Ubiquitin-Protein Ligase UBE2O 3 4
  • Ubiquitin-Conjugating Enzyme E2 Of 230 KDa 3 4
  • Ubiquitin-Conjugating Enzyme E2-230K 3 4
  • Ubiquitin Carrier Protein O 3 4
  • Ubiquitin-Protein Ligase O 3 4
  • (E3-Independent) E2 Ubiquitin-Conjugating Enzyme 3
  • Ubiquitin-Conjugating Enzyme E2 O 4
  • Ubiquitin-Conjugating Enzyme E2O 2
  • Ubiquitin Conjugating Enzyme E2O 3
  • EC 2.3.2.24 4
  • KIAA1734 4
  • E2-230K 3

External Ids for UBE2O Gene

Previous GeneCards Identifiers for UBE2O Gene

  • GC17M071898
  • GC17M074385
  • GC17M069814

Summaries for UBE2O Gene

GeneCards Summary for UBE2O Gene

UBE2O (Ubiquitin Conjugating Enzyme E2 O) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include poly(A) RNA binding and ubiquitin-protein transferase activity. An important paralog of this gene is BIRC6.

UniProtKB/Swiss-Prot for UBE2O Gene

  • E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate Lys-63-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853).

Gene Wiki entry for UBE2O Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2O Gene

Genomics for UBE2O Gene

Products:

  1. Regulatory Element

Regulatory Elements for UBE2O Gene

Enhancers for UBE2O Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G076480 2 FANTOM5 Ensembl ENCODE dbSUPER 13.1 -30.1 -30134 6.1 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARID4B DMAP1 ZNF2 YY1 SLC30A9 RHBDF2 UNK AANAT CDK3 UBE2O ENSG00000267342 ENSG00000267801 TRIM65 GC17P076469 GC17M076496
GH17G075555 1.6 Ensembl ENCODE dbSUPER 12.9 +896.1 896109 3.4 HDGF FOXA2 PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZBTB7B LLGL2 UNK NUP85 NT5C TSEN54 ENSG00000266980 UBE2O MYO15B TMEM94 GC17P075560
GH17G076527 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -77.0 -76963 6.3 HDGF PKNOX1 FOXA2 MLX CREB3L1 ZFP64 ARID4B ZBTB7B YY1 SLC30A9 ENSG00000267543 UNK MFSD11 ENSG00000266980 CYGB METTL23 AANAT UBE2O SNHG16 ST6GALNAC2
GH17G075861 1.5 Ensembl ENCODE dbSUPER 12.9 +591.6 591606 0.8 MLX CREB3L1 ARID4B ZNF48 ZNF302 ZNF143 ZMIZ1 SP3 SP5 REST TRIM65 UBE2O UNK MRPL38 H3F3B TRIM47 WBP2 ENSG00000267801
GH17G075975 1.4 ENCODE dbSUPER 12.9 +473.0 473012 10.1 MLX CREB3L1 ZFP64 YBX1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 UBE2O H3F3B ACOX1 UNK ENSG00000267342 CDK3 NT5C TEN1 FBF1 METTL23
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around UBE2O on UCSC Golden Path with GeneCards custom track

Promoters for UBE2O Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000098570 406 1601 HDGF ATF1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 GLIS2

Transcription factor binding sites by QIAGEN in the UBE2O gene promoter:

Genomic Location for UBE2O Gene

Chromosome:
17
Start:
76,389,451 bp from pter
End:
76,453,206 bp from pter
Size:
63,756 bases
Orientation:
Minus strand

Genomic View for UBE2O Gene

Genes around UBE2O on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2O Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2O Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for UBE2O Gene

Proteins for UBE2O Gene

Products:

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  2. Protein
  3. Assay

  • Protein details for UBE2O Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0C9-UBE2O_HUMAN
    Recommended name:
    (E3-independent) E2 ubiquitin-conjugating enzyme
    Protein Accession:
    Q9C0C9
    Secondary Accessions:
    • A6NDU5
    • Q69YP4
    • Q6PIZ2
    • Q86UA4
    • Q8N425
    • Q8TBN1
    • Q9BSW1
    • Q9H6E6
    • Q9H7E4
    • Q9H9B2

    Protein attributes for UBE2O Gene

    Size:
    1292 amino acids
    Molecular mass:
    141293 Da
    Quaternary structure:
    • Interacts with CPNE1 (via VWFA domain) and CPNE4 (via VWFA domain).
    SequenceCaution:
    • Sequence=AAH22237.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH25977.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH36820.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH51868.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14320.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14948.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15313.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB21825.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for UBE2O Gene

Protein Expression for UBE2O Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for UBE2O Gene

  • Phosphorylated. Phosphorylation affects subcellular location.
  • Ubiquitinated: autoubiquitinates, possibly affecting its subcellular location.
  • Ubiquitination at posLast=132132, posLast=212212, Lys283, Lys373, posLast=521521, posLast=620620, Lys815, posLast=819819, isoforms=825, isoforms=866, and posLast=990990
  • Modification sites at PhosphoSitePlus

Other Protein References for UBE2O Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for UBE2O (UBE2O)
  • Santa Cruz Biotechnology (SCBT) Antibodies for UBE2O

No data available for DME Specific Peptides for UBE2O Gene

Domains & Families for UBE2O Gene

Protein Domains for UBE2O Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for UBE2O Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9C0C9

UniProtKB/Swiss-Prot:

UBE2O_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2O: view

No data available for Gene Families for UBE2O Gene

Function for UBE2O Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for UBE2O Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot EnzymeRegulation:
inhibited by phenylarsine oxide (PAO).
UniProtKB/Swiss-Prot Function:
E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate Lys-63-linked ubiquitination of WASHC1, leading to promote endosomal F-actin assembly (PubMed:23452853).

Enzyme Numbers (IUBMB) for UBE2O Gene

Gene Ontology (GO) - Molecular Function for UBE2O Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22681889
GO:0004842 ubiquitin-protein transferase activity IDA 23455153
GO:0005515 protein binding IPI 23455153
GO:0005524 ATP binding IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with UBE2O: view
genes like me logo Genes that share phenotypes with UBE2O: view

Animal Models for UBE2O Gene

MGI Knock Outs for UBE2O:

Animal Model Products

  • Taconic Biosciences Mouse Models for UBE2O

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBE2O Gene

Localization for UBE2O Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2O Gene

Cytoplasm. Nucleus. Note=Mainly localizes to the cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UBE2O gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for UBE2O Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 24703950
GO:0005737 cytoplasm IDA 24703950
GO:0005829 cytosol IEA --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with UBE2O: view

Pathways & Interactions for UBE2O Gene

genes like me logo Genes that share pathways with UBE2O: view

UniProtKB/Swiss-Prot Q9C0C9-UBE2O_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for UBE2O Gene

Inactivates:

Gene Ontology (GO) - Biological Process for UBE2O Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006513 protein monoubiquitination IDA 23455153
GO:0006810 transport IEA --
GO:0016567 protein ubiquitination IEA --
GO:0030513 positive regulation of BMP signaling pathway IDA 23455153
GO:0042147 retrograde transport, endosome to Golgi IMP 23452853
genes like me logo Genes that share ontologies with UBE2O: view

Drugs & Compounds for UBE2O Gene

Products:

  1. Drug

(3) Drugs for UBE2O Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for UBE2O Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
 14000-31-8
genes like me logo Genes that share compounds with UBE2O: view

Transcripts for UBE2O Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for UBE2O Gene

(4) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(233) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UBE2O Gene

Ubiquitin-conjugating enzyme E2O:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2O Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18
SP1: - -
SP2: -
SP3: -
SP4:

Relevant External Links for UBE2O Gene

GeneLoc Exon Structure for
UBE2O
ECgene alternative splicing isoforms for
UBE2O

Expression for UBE2O Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UBE2O Gene

mRNA expression in normal human tissues for UBE2O Gene
mRNA expression by BioGPS for UBE2O GenemRNA expression by GTEx for UBE2O Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBE2O Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.8) and Heart (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for UBE2O Gene



Protein tissue co-expression partners for UBE2O Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of UBE2O Gene:

UBE2O

SOURCE GeneReport for Unigene cluster for UBE2O Gene:

Hs.16130

mRNA Expression by UniProt/SwissProt for UBE2O Gene:

Q9C0C9-UBE2O_HUMAN
Tissue specificity: Predominantly expressed in skeletal muscle and heart.

Evidence on tissue expression from TISSUES for UBE2O Gene

  • Nervous system(4.8)
  • Liver(4.2)
  • Skin(4.2)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with UBE2O: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for UBE2O Gene

Orthologs for UBE2O Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2O Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia UBE2O 34 35
  • 99.54 (n)
dog
(Canis familiaris)
 Mammalia UBE2O 34 35
  • 90.83 (n)
cow
(Bos Taurus)
 Mammalia UBE2O 34 35
  • 90.48 (n)
rat
(Rattus norvegicus)
 Mammalia Ube2o 34
  • 88.92 (n)
mouse
(Mus musculus)
 Mammalia Ube2o 34 16 35
  • 88.55 (n)
oppossum
(Monodelphis domestica)
 Mammalia UBE2O 35
  • 88 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia UBE2O 35
  • 83 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves UBE2O 34 35
  • 77.46 (n)
lizard
(Anolis carolinensis)
 Reptilia UBE2O 35
  • 74 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia ube2o 34
  • 70.17 (n)
zebrafish
(Danio rerio)
 Actinopterygii UBE2O 35
  • 73 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta CG10254 35
  • 25 (a)
 OneToOne
barley
(Hordeum vulgare)
 Liliopsida Hv.2300 34
corn
(Zea mays)
 Liliopsida Zm.2040 34
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 41 (a)
 OneToOne
Species where no ortholog for UBE2O was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBE2O Gene

ENSEMBL:
Gene Tree for UBE2O (if available)
TreeFam:
Gene Tree for UBE2O (if available)

Paralogs for UBE2O Gene

Paralogs for UBE2O Gene

(5) SIMAP similar genes for UBE2O Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with UBE2O: view

Variants for UBE2O Gene

Sequence variations from dbSNP and Humsavar for UBE2O Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000048822 -- 76,400,869(+) TTATC(C/T)CCAAA intron-variant
rs1000086364 -- 76,444,400(+) ATTTT(A/T)AAAAG intron-variant
rs1000119220 -- 76,423,373(+) AGACC(C/G)TATCT intron-variant
rs1000166377 -- 76,422,330(+) CCAGG(C/T)TGAGC intron-variant
rs1000171761 -- 76,428,325(+) ATTCT(C/T)GTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2O Gene

Variant ID Type Subtype PubMed ID
esv3397284 CNV duplication 20981092
esv3399280 CNV duplication 20981092
esv3582913 CNV loss 25503493
esv3641287 CNV loss 21293372
esv3641288 CNV loss 21293372
esv3641289 CNV insertion 21293372
nsv1143862 CNV deletion 24896259
nsv2145 CNV deletion 18451855
nsv833547 CNV loss 17160897
nsv833549 CNV gain 17160897
nsv978463 CNV duplication 23825009

Variation tolerance for UBE2O Gene

Residual Variation Intolerance Score: 5.89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.80; 93.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for UBE2O Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
UBE2O

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2O Gene

Disorders for UBE2O Gene

Relevant External Links for UBE2O

Human Genome Epidemiology (HuGE) Navigator
UBE2O
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBE2O

No disorders were found for UBE2O Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBE2O Gene

Publications for UBE2O Gene

  1. Identification, tissue expression, and chromosomal position of a novel gene encoding human ubiquitin-conjugating enzyme E2-230k. (PMID: 11311559) Yokota T. … Emi M. (Gene 2001) 2 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  3. Autodeubiquitination protects the tumor suppressor BAP1 from cytoplasmic sequestration mediated by the atypical ubiquitin ligase UBE2O. (PMID: 24703950) Mashtalir N. … Affar E.B. (Mol. Cell 2014) 3 4 64
  4. Regulation of WASH-dependent actin polymerization and protein trafficking by ubiquitination. (PMID: 23452853) Hao Y.H. … Potts P.R. (Cell 2013) 3 4 64
  5. UBE2O negatively regulates TRAF6-mediated NF-I_B activation by inhibiting TRAF6 polyubiquitination. (PMID: 23381138) Zhang X. … ten Dijke P. (Cell Res. 2013) 3 4 64

Products for UBE2O Gene

Sources for UBE2O Gene

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