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UBE2O Gene(Protein Coding)

Ubiquitin Conjugating Enzyme E2 O

GCID:
GC17M076389
GIFtS:
55
Genes Participants
UDN Logo

Aliases for UBE2O Gene

Aliases for UBE2O Gene

  • Ubiquitin Conjugating Enzyme E2 O 2 3
  • E2/E3 Hybrid Ubiquitin-Protein Ligase UBE2O 3 4
  • Ubiquitin-Conjugating Enzyme E2 Of 230 KDa 3 4
  • Ubiquitin-Conjugating Enzyme E2-230K 3 4
  • Ubiquitin-Conjugating Enzyme E2O 2 3
  • Ubiquitin Conjugating Enzyme E2O 3 5
  • Ubiquitin Carrier Protein O 3 4
  • Ubiquitin-Protein Ligase O 3 4
  • Ubiquitin-Conjugating Enzyme E2 O 4
  • EC 2.3.2.24 4
  • KIAA1734 4
  • E2-230K 3

External Ids for UBE2O Gene

Previous GeneCards Identifiers for UBE2O Gene

  • GC17M071898
  • GC17M074385
  • GC17M069814

Summaries for UBE2O Gene

GeneCards Summary for UBE2O Gene

UBE2O (Ubiquitin Conjugating Enzyme E2 O) is a Protein Coding gene. Among its related pathways are Antigen processing- Ubiquitination and Proteasome degradation and Immune System. GO annotations related to this gene include poly(A) RNA binding and ubiquitin-protein transferase activity. An important paralog of this gene is UBE2Z.

UniProtKB/Swiss-Prot for UBE2O Gene

  • E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate Lys-63-linked ubiquitination of WASH1, leading to promote endosomal F-actin assembly (PubMed:23452853).

Gene Wiki entry for UBE2O Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2O Gene

Genomics for UBE2O Gene

Products:

  1. Regulatory Element

Regulatory Elements for UBE2O Gene

Enhancers for UBE2O Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around UBE2O on UCSC Golden Path with GeneCards custom track

Promoters for UBE2O Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around UBE2O on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the UBE2O gene promoter:

Genomic Location for UBE2O Gene

Chromosome:
17
Start:
76,389,451 bp from pter
End:
76,453,206 bp from pter
Size:
63,756 bases
Orientation:
Minus strand

Genomic View for UBE2O Gene

Genes around UBE2O on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UBE2O Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UBE2O Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for UBE2O Gene

Proteins for UBE2O Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for UBE2O Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0C9-UBE2O_HUMAN
    Recommended name:
    (E3-independent) E2 ubiquitin-conjugating enzyme
    Protein Accession:
    Q9C0C9
    Secondary Accessions:
    • A6NDU5
    • Q69YP4
    • Q6PIZ2
    • Q86UA4
    • Q8N425
    • Q8TBN1
    • Q9BSW1
    • Q9H6E6
    • Q9H7E4
    • Q9H9B2

    Protein attributes for UBE2O Gene

    Size:
    1292 amino acids
    Molecular mass:
    141293 Da
    Quaternary structure:
    • Interacts with CPNE1 (via VWFA domain) and CPNE4 (via VWFA domain).
    SequenceCaution:
    • Sequence=AAH22237.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH25977.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH36820.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH51868.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14320.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14948.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15313.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB21825.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for UBE2O Gene

Proteomics data for UBE2O Gene at MOPED

Protein Expression for UBE2O Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for UBE2O Gene

  • Phosphorylated. Phosphorylation affects subcellular location.
  • Ubiquitinated: autoubiquitinates, possibly affecting its subcellulat location.
  • Ubiquitination at Lys 132, Lys 212, Lys 283, Lys 373, Lys 521, Lys 620, Lys 815, Lys 819, Lys 825, Lys 866, and Lys 990
  • Modification sites at PhosphoSitePlus

Other Protein References for UBE2O Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UBE2O Gene

Domains & Families for UBE2O Gene

Protein Domains for UBE2O Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for UBE2O Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9C0C9

UniProtKB/Swiss-Prot:

UBE2O_HUMAN :
  • Belongs to the ubiquitin-conjugating enzyme family.
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2O: view

No data available for Gene Families for UBE2O Gene

Function for UBE2O Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for UBE2O Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N(6)-monoubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot EnzymeRegulation:
inhibited by phenylarsine oxide (PAO).
UniProtKB/Swiss-Prot Function:
E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate Lys-63-linked ubiquitination of WASH1, leading to promote endosomal F-actin assembly (PubMed:23452853).

Enzyme Numbers (IUBMB) for UBE2O Gene

Gene Ontology (GO) - Molecular Function for UBE2O Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 23455153
GO:0061630 ubiquitin protein ligase activity IDA 23455153
genes like me logo Genes that share ontologies with UBE2O: view

Phenotypes for UBE2O Gene

MGI mutant phenotypes for UBE2O:
inferred from 1 alleles
GenomeRNAi human phenotypes for UBE2O:
genes like me logo Genes that share phenotypes with UBE2O: view

Animal Models for UBE2O Gene

MGI Knock Outs for UBE2O:

Animal Model Products

  • Taconic Biosciences Mouse Models for UBE2O

miRNA for UBE2O Gene

miRTarBase miRNAs that target UBE2O

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UBE2O Gene

Localization for UBE2O Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2O Gene

Cytoplasm. Nucleus. Note=Mainly localizes to the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2O Gene COMPARTMENTS Subcellular localization image for UBE2O gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for UBE2O Gene

Pathways & Interactions for UBE2O Gene

genes like me logo Genes that share pathways with UBE2O: view

UniProtKB/Swiss-Prot Q9C0C9-UBE2O_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for UBE2O Gene

Inactivates:

Gene Ontology (GO) - Biological Process for UBE2O Gene

None

Drugs & Compounds for UBE2O Gene

Products:

  1. Drug

(3) Drugs for UBE2O Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(1) Additional Compounds for UBE2O Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
 7664-38-2
genes like me logo Genes that share compounds with UBE2O: view

Transcripts for UBE2O Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for UBE2O Gene

(5) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(233) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UBE2O Gene

Ubiquitin-conjugating enzyme E2O:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2O Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18
SP1: - -
SP2: -
SP3: -
SP4:

Relevant External Links for UBE2O Gene

GeneLoc Exon Structure for
UBE2O
ECgene alternative splicing isoforms for
UBE2O

Expression for UBE2O Gene

Products:

  1. Primer

mRNA expression in normal human tissues for UBE2O Gene

mRNA expression in normal human tissues for UBE2O Gene
mRNA expression by BioGPS for UBE2O GenemRNA expression by GTEx for UBE2O Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for UBE2O Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.8) and Heart (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE2O Gene



SOURCE GeneReport for Unigene cluster for UBE2O Gene Hs.16130

mRNA Expression by UniProt/SwissProt for UBE2O Gene

Q9C0C9-UBE2O_HUMAN
Tissue specificity: Predominantly expressed in skeletal muscle and heart.
genes like me logo Genes that share expression patterns with UBE2O: view

Protein tissue co-expression partners for UBE2O Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for UBE2O Gene

Orthologs for UBE2O Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2O Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia UBE2O 35
  • 90.48 (n)
  • 95.87 (a)
UBE2O 36
  • 95 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia UBE2O 35
  • 90.83 (n)
  • 95.27 (a)
UBE2O 36
  • 96 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Ube2o 35
  • 88.55 (n)
  • 94.57 (a)
Ube2o 16
Ube2o 36
  • 94 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia UBE2O 35
  • 99.54 (n)
  • 99.91 (a)
UBE2O 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Ube2o 35
  • 88.92 (n)
  • 94.89 (a)
oppossum
(Monodelphis domestica)
 Mammalia UBE2O 36
  • 88 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia UBE2O 36
  • 83 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves UBE2O 35
  • 77.46 (n)
  • 83.45 (a)
UBE2O 36
  • 78 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia UBE2O 36
  • 74 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia ube2o 35
  • 70.17 (n)
  • 71.63 (a)
zebrafish
(Danio rerio)
 Actinopterygii UBE2O 36
  • 73 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta CG10254 36
  • 25 (a)
 OneToOne
barley
(Hordeum vulgare)
 Liliopsida Hv.2300 35
corn
(Zea mays)
 Liliopsida Zm.2040 35
sea squirt
(Ciona savignyi)
 Ascidiacea -- 36
  • 41 (a)
 OneToOne
Species with no ortholog for UBE2O:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBE2O Gene

ENSEMBL:
Gene Tree for UBE2O (if available)
TreeFam:
Gene Tree for UBE2O (if available)

Paralogs for UBE2O Gene

Paralogs for UBE2O Gene

(5) SIMAP similar genes for UBE2O Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with UBE2O: view

Variants for UBE2O Gene

Sequence variations from dbSNP and Humsavar for UBE2O Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs3803739 - 76,391,203(+) CAGGC(C/T)CTGGG reference, missense
rs435892 -- 76,402,424(-) GCCTA(A/T)TTCTG intron-variant
rs443112 -- 76,417,817(+) TCAGC(A/G)TCCGC intron-variant
rs444896 -- 76,425,254(+) AAGTA(A/G)AAGAA intron-variant
rs445683 -- 76,405,440(-) ACCTC(A/G)CACTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2O Gene

Variant ID Type Subtype PubMed ID
nsv833547 CNV Loss 17160897
nsv2145 CNV Loss 18451855
nsv833549 CNV Gain 17160897

Variation tolerance for UBE2O Gene

Residual Variation Intolerance Score: 5.89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.80; 93.40% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for UBE2O Gene

Disorders for UBE2O Gene

Relevant External Links for UBE2O

Human Genome Epidemiology (HuGE) Navigator
UBE2O
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
UBE2O

No disorders were found for UBE2O Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UBE2O Gene

Publications for UBE2O Gene

  1. Identification, tissue expression, and chromosomal position of a novel gene encoding human ubiquitin-conjugating enzyme E2-230k. (PMID: 11311559) Yokota T. … Emi M. (Gene 2001) 2 3 4 67
  2. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for UBE2O Gene

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