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Aliases for UBE2O Gene

Aliases for UBE2O Gene

  • Ubiquitin-Conjugating Enzyme E2O 2 3
  • Ubiquitin-Conjugating Enzyme E2 Of 230 KDa 3 4
  • Ubiquitin-Conjugating Enzyme E2-230K 3 4
  • Ubiquitin Carrier Protein O 3 4
  • Ubiquitin-Protein Ligase O 3 4
  • E2/E3 Hybrid Ubiquitin-Protein Ligase UBE2O 3
  • Ubiquitin-Conjugating Enzyme E2 O 4
  • EC 6.3.2.19 4
  • EC 6.3.2.- 4
  • KIAA1734 4
  • E2-230K 3

External Ids for UBE2O Gene

Previous GeneCards Identifiers for UBE2O Gene

  • GC17M071898
  • GC17M074385
  • GC17M069814

Summaries for UBE2O Gene

GeneCards Summary for UBE2O Gene

UBE2O (Ubiquitin-Conjugating Enzyme E2O) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is BIRC6.

UniProtKB/Swiss-Prot for UBE2O Gene

  • E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate Lys-63-linked ubiquitination of WASH1, leading to promote endosomal F-actin assembly (PubMed:23452853).

Gene Wiki entry for UBE2O Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UBE2O Gene

Genomics for UBE2O Gene

Regulatory Elements for UBE2O Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for UBE2O Gene

Start:
76,389,451 bp from pter
End:
76,453,206 bp from pter
Size:
63,756 bases
Orientation:
Minus strand

Genomic View for UBE2O Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for UBE2O Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UBE2O Gene

Proteins for UBE2O Gene

  • Protein details for UBE2O Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0C9-UBE2O_HUMAN
    Recommended name:
    E2/E3 hybrid ubiquitin-protein ligase UBE2O
    Protein Accession:
    Q9C0C9
    Secondary Accessions:
    • A6NDU5
    • Q69YP4
    • Q6PIZ2
    • Q86UA4
    • Q8N425
    • Q8TBN1
    • Q9BSW1
    • Q9H6E6
    • Q9H7E4
    • Q9H9B2

    Protein attributes for UBE2O Gene

    Size:
    1292 amino acids
    Molecular mass:
    141293 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH22237.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH25977.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH36820.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH51868.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14320.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14948.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15313.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB21825.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for UBE2O Gene

Proteomics data for UBE2O Gene at MOPED

Post-translational modifications for UBE2O Gene

  • Phosphorylated. Phosphorylation affects subcellular location.
  • Ubiquitinated: autoubiquitinates, possibly affecting its subcellulat location.
  • Ubiquitination at Lys132, Lys212, Lys283, Lys373, Lys521, Lys620, Lys815, Lys819, Lys825, Lys866, and Lys990
  • Modification sites at PhosphoSitePlus

Other Protein References for UBE2O Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for UBE2O Gene

Domains for UBE2O Gene

Protein Domains for UBE2O Gene

Suggested Antigen Peptide Sequences for UBE2O Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9C0C9

UniProtKB/Swiss-Prot:

UBE2O_HUMAN :
  • Q9C0C9
Family:
  • Belongs to the ubiquitin-conjugating enzyme family.
genes like me logo Genes that share domains with UBE2O: view

No data available for Gene Families for UBE2O Gene

Function for UBE2O Gene

Molecular function for UBE2O Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.
UniProtKB/Swiss-Prot EnzymeRegulation:
inhibited by phenylarsine oxide (PAO).
UniProtKB/Swiss-Prot Function:
E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin-associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate Lys-63-linked ubiquitination of WASH1, leading to promote endosomal F-actin assembly (PubMed:23452853).

Enzyme Numbers (IUBMB) for UBE2O Gene

Gene Ontology (GO) - Molecular Function for UBE2O Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 23455153
GO:0005515 protein binding IPI 23455153
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
GO:0016881 acid-amino acid ligase activity --
genes like me logo Genes that share ontologies with UBE2O: view

Phenotypes for UBE2O Gene

GenomeRNAi human phenotypes for UBE2O:
genes like me logo Genes that share phenotypes with UBE2O: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBE2O

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for UBE2O Gene

Localization for UBE2O Gene

Subcellular locations from UniProtKB/Swiss-Prot for UBE2O Gene

Cytoplasm. Nucleus. Note=Mainly localizes to the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for UBE2O Gene COMPARTMENTS Subcellular localization image for UBE2O gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for UBE2O Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 24703950
genes like me logo Genes that share ontologies with UBE2O: view

Pathways for UBE2O Gene

genes like me logo Genes that share pathways with UBE2O: view

UniProtKB/Swiss-Prot Q9C0C9-UBE2O_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for UBE2O Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006513 protein monoubiquitination IDA 23455153
GO:0030513 positive regulation of BMP signaling pathway IDA 23455153
GO:0042147 retrograde transport, endosome to Golgi IMP 23452853
GO:0070534 protein K63-linked ubiquitination IMP 23452853
genes like me logo Genes that share ontologies with UBE2O: view

Compounds for UBE2O Gene

(4) HMDB Compounds for UBE2O Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8
genes like me logo Genes that share compounds with UBE2O: view

Transcripts for UBE2O Gene

Unigene Clusters for UBE2O Gene

Ubiquitin-conjugating enzyme E2O:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for UBE2O

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for UBE2O Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18
SP1: - -
SP2: -
SP3: -
SP4:

Relevant External Links for UBE2O Gene

GeneLoc Exon Structure for
UBE2O
ECgene alternative splicing isoforms for
UBE2O

Expression for UBE2O Gene

mRNA expression in normal human tissues for UBE2O Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for UBE2O Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.8) and Heart (12.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for UBE2O Gene

SOURCE GeneReport for Unigene cluster for UBE2O Gene Hs.16130

mRNA Expression by UniProt/SwissProt for UBE2O Gene

Q9C0C9-UBE2O_HUMAN
Tissue specificity: Predominantly expressed in skeletal muscle and heart.
genes like me logo Genes that share expressions with UBE2O: view

Expression partners for UBE2O Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for UBE2O Gene

Orthologs for UBE2O Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UBE2O Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia UBE2O 35
  • 90.48 (n)
  • 95.87 (a)
UBE2O 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia UBE2O 35
  • 90.83 (n)
  • 95.27 (a)
UBE2O 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ube2o 35
  • 88.55 (n)
  • 94.57 (a)
Ube2o 16
Ube2o 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia UBE2O 35
  • 99.54 (n)
  • 99.91 (a)
UBE2O 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ube2o 35
  • 88.92 (n)
  • 94.89 (a)
oppossum
(Monodelphis domestica)
Mammalia UBE2O 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia UBE2O 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves UBE2O 35
  • 77.46 (n)
  • 83.45 (a)
UBE2O 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia UBE2O 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ube2o 35
  • 70.17 (n)
  • 71.63 (a)
zebrafish
(Danio rerio)
Actinopterygii UBE2O 36
  • 73 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10254 36
  • 25 (a)
OneToOne
barley
(Hordeum vulgare)
Liliopsida Hv.2300 35
corn
(Zea mays)
Liliopsida Zm.2040 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToOne
Species with no ortholog for UBE2O:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for UBE2O Gene

ENSEMBL:
Gene Tree for UBE2O (if available)
TreeFam:
Gene Tree for UBE2O (if available)

Paralogs for UBE2O Gene

Paralogs for UBE2O Gene

Selected SIMAP similar genes for UBE2O Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with UBE2O: view

Variants for UBE2O Gene

Sequence variations from dbSNP and Humsavar for UBE2O Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs346807 -- 76,411,964(+) AGGCG(C/T)GAGCC intron-variant
rs346808 -- 76,409,204(+) acctc(A/G)tgatc intron-variant
rs346809 -- 76,409,198(+) ctcct(A/G)acctc intron-variant
rs346810 -- 76,409,032(+) ggcgc(A/G)atctc intron-variant
rs346811 -- 76,407,844(+) CCACC(C/T)CACCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for UBE2O Gene

Variant ID Type Subtype PubMed ID
nsv833547 CNV Loss 17160897
nsv2145 CNV Loss 18451855
nsv833549 CNV Gain 17160897

Relevant External Links for UBE2O Gene

HapMap Linkage Disequilibrium report
UBE2O

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UBE2O Gene

Disorders for UBE2O Gene

Relevant External Links for UBE2O

Human Genome Epidemiology (HuGE) Navigator
UBE2O

No disorders were found for UBE2O Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for UBE2O Gene

Publications for UBE2O Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Identification, tissue expression, and chromosomal position of a novel gene encoding human ubiquitin-conjugating enzyme E2-230k. (PMID: 11311559) Yokota T. … Emi M. (Gene 2001) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Autodeubiquitination protects the tumor suppressor BAP1 from cytoplasmic sequestration mediated by the atypical ubiquitin ligase UBE2O. (PMID: 24703950) Mashtalir N. … Affar E.B. (Mol. Cell 2014) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for UBE2O Gene

Sources for UBE2O Gene

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