Free for academic non-profit institutions. Other users need a Commercial license

Aliases for MRPL17 Gene

Aliases for MRPL17 Gene

  • Mitochondrial Ribosomal Protein L17 2 3
  • LYST-Interacting Protein 2 3 4
  • MRP-L17 3 4
  • L17mt 3 4
  • LIP2 3 4
  • LYST-Interacting Protein LIP2 3
  • MRP-L26 3
  • RPL17L 3
  • RPML26 3

External Ids for MRPL17 Gene

Previous GeneCards Identifiers for MRPL17 Gene

  • GC11M007445
  • GC11M007163
  • GC11M006661
  • GC11M006667
  • GC11M006360

Summaries for MRPL17 Gene

Entrez Gene Summary for MRPL17 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

GeneCards Summary for MRPL17 Gene

MRPL17 (Mitochondrial Ribosomal Protein L17) is a Protein Coding gene. Among its related pathways are Organelle biogenesis and maintenance and Viral mRNA Translation. GO annotations related to this gene include protein domain specific binding and structural constituent of ribosome.

Gene Wiki entry for MRPL17 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MRPL17 Gene

Genomics for MRPL17 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MRPL17 Gene

6,680,385 bp from pter
6,683,401 bp from pter
3,017 bases
Minus strand

Genomic View for MRPL17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MRPL17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MRPL17 Gene

Proteins for MRPL17 Gene

  • Protein details for MRPL17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    39S ribosomal protein L17, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • D3DQU3
    • Q6IAH8
    • Q96Q53
    • Q9C066

    Protein attributes for MRPL17 Gene

    175 amino acids
    Molecular mass:
    20050 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAG49441.1; Type=Frameshift; Positions=8; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MRPL17 Gene

neXtProt entry for MRPL17 Gene

Proteomics data for MRPL17 Gene at MOPED

Post-translational modifications for MRPL17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MRPL17 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for MRPL17 Gene

Domains & Families for MRPL17 Gene

Gene Families for MRPL17 Gene

Protein Domains for MRPL17 Gene


Suggested Antigen Peptide Sequences for MRPL17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein L17P family.
  • Belongs to the ribosomal protein L17P family.
genes like me logo Genes that share domains with MRPL17: view

Function for MRPL17 Gene

Gene Ontology (GO) - Molecular Function for MRPL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IBA --
GO:0019904 protein domain specific binding IPI 11984006
genes like me logo Genes that share ontologies with MRPL17: view

Phenotypes for MRPL17 Gene

GenomeRNAi human phenotypes for MRPL17:
genes like me logo Genes that share phenotypes with MRPL17: view

Animal Model Products

miRNA for MRPL17 Gene

miRTarBase miRNAs that target MRPL17

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for MRPL17 Gene

Localization for MRPL17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MRPL17 Gene


Subcellular locations from

Jensen Localization Image for MRPL17 Gene COMPARTMENTS Subcellular localization image for MRPL17 gene
Compartment Confidence
mitochondrion 4
golgi apparatus 2
nucleus 2

Gene Ontology (GO) - Cellular Components for MRPL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005739 mitochondrion --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005762 mitochondrial large ribosomal subunit IBA --
GO:0005840 ribosome --
genes like me logo Genes that share ontologies with MRPL17: view

Pathways & Interactions for MRPL17 Gene

genes like me logo Genes that share pathways with MRPL17: view

Gene Ontology (GO) - Biological Process for MRPL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000002 mitochondrial genome maintenance IBA --
GO:0006412 translation --
GO:0006996 organelle organization TAS --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
genes like me logo Genes that share ontologies with MRPL17: view

No data available for SIGNOR curated interactions for MRPL17 Gene

Drugs & Compounds for MRPL17 Gene

No Compound Related Data Available

Transcripts for MRPL17 Gene

mRNA/cDNA for MRPL17 Gene

Unigene Clusters for MRPL17 Gene

Mitochondrial ribosomal protein L17:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MRPL17

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MRPL17 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b
SP2: -

Relevant External Links for MRPL17 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MRPL17 Gene

mRNA expression in normal human tissues for MRPL17 Gene

Protein differential expression in normal tissues from HIPED for MRPL17 Gene

This gene is overexpressed in Bone (21.8) and Pancreas (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MRPL17 Gene

SOURCE GeneReport for Unigene cluster for MRPL17 Gene Hs.523456

mRNA Expression by UniProt/SwissProt for MRPL17 Gene

Tissue specificity: Detected in adrenal gland, mammary gland and adipose tissue.
genes like me logo Genes that share expression patterns with MRPL17: view

Protein tissue co-expression partners for MRPL17 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for MRPL17 Gene

Orthologs for MRPL17 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MRPL17 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia MRPL17 35
  • 88.5 (n)
  • 89.47 (a)
-- 36
  • 59 (a)
MRPL17 36
  • 89 (a)
(Canis familiaris)
Mammalia MRPL17 35
  • 89.08 (n)
  • 91.81 (a)
MRPL17 36
  • 76 (a)
(Mus musculus)
Mammalia Mrpl17 35
  • 84.97 (n)
  • 85.55 (a)
Mrpl17 16
Mrpl17 36
  • 84 (a)
(Pan troglodytes)
Mammalia MRPL17 35
  • 99.62 (n)
  • 99.43 (a)
MRPL17 36
  • 99 (a)
(Monodelphis domestica)
Mammalia MRPL17 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia MRPL17 36
  • 67 (a)
(Gallus gallus)
Aves MRPL17 35
  • 71.7 (n)
  • 76.73 (a)
MRPL17 36
  • 75 (a)
(Anolis carolinensis)
Reptilia MRPL17 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia mrpl17 35
  • 63.73 (n)
  • 70.44 (a)
Str.6257 35
(Danio rerio)
Actinopterygii Dr.16017 35
mrpl17 35
  • 62.45 (n)
  • 69.62 (a)
mrpl17 36
  • 66 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6245 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001865 35
  • 52.72 (n)
  • 44.44 (a)
fruit fly
(Drosophila melanogaster)
Insecta mRpL17 35
  • 50.71 (n)
  • 42.14 (a)
mRpL17 36
  • 37 (a)
(Caenorhabditis elegans)
Secernentea mrpl-17 36
  • 25 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRPL8 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7023 36
  • 36 (a)
Species with no ortholog for MRPL17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MRPL17 Gene

Gene Tree for MRPL17 (if available)
Gene Tree for MRPL17 (if available)

Paralogs for MRPL17 Gene

No data available for Paralogs for MRPL17 Gene

Variants for MRPL17 Gene

Sequence variations from dbSNP and Humsavar for MRPL17 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs8109 -- 6,682,103(+) TGCAG(A/G)CTCTT utr-variant-3-prime
rs13253 -- 6,682,259(+) GGGAG(A/G)CAATT reference, synonymous-codon
rs1044349 -- 6,682,111(-) TGGAT(C/T)TGAAG utr-variant-3-prime
rs1567135 -- 6,682,661(-) ATTAA(A/C)CTTGG intron-variant
rs1911276 -- 6,684,847(-) aaaac(A/G)acaga upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MRPL17 Gene

Variant ID Type Subtype PubMed ID
nsv7658 CNV Insertion 18451855
nsv832060 CNV Gain 17160897

Variation tolerance for MRPL17 Gene

Residual Variation Intolerance Score: 28.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MRPL17 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MRPL17 Gene

Disorders for MRPL17 Gene

Relevant External Links for MRPL17

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with MRPL17: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for MRPL17 Gene

Publications for MRPL17 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 67
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 67

Products for MRPL17 Gene

Sources for MRPL17 Gene

Back to Top