Aliases for SDCBP Gene
External Ids for SDCBP Gene
Previous GeneCards Identifiers for SDCBP Gene
The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for SDCBP Gene
SDCBP (Syndecan Binding Protein (Syntenin)) is a Protein Coding gene. Diseases associated with SDCBP include asthenopia and melanoma. Among its related pathways are L1CAM interactions and Syndecan-4-mediated signaling events. GO annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is SDCBP2.
UniProtKB/Swiss-Prot for SDCBP Gene
Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.