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Aliases for BCAN Gene

Aliases for BCAN Gene

  • Brevican 2 3 5
  • Chondroitin Sulfate Proteoglycan 7 2 3 4
  • Brain-Enriched Hyaluronan-Binding Protein 3 4
  • BEHAB 3 4
  • CSPG7 3 4
  • Chondroitin Sulfate Proteoglycan BEHAB 3
  • Brevican Proteoglycan 2

External Ids for BCAN Gene

Previous GeneCards Identifiers for BCAN Gene

  • GC01P154481
  • GC01P152377
  • GC01P153390
  • GC01P153828
  • GC01P153424
  • GC01P154878
  • GC01P156611
  • GC01P127969

Summaries for BCAN Gene

Entrez Gene Summary for BCAN Gene

  • This gene encodes a member of the lectican family of chondroitin sulfate proteoglycans that is specifically expressed in the central nervous system. This protein is developmentally regulated and may function in the formation of the brain extracellular matrix. This protein is highly expressed in gliomas and may promote the growth and cell motility of brain tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

GeneCards Summary for BCAN Gene

BCAN (Brevican) is a Protein Coding gene. Among its related pathways are Degradation of the extracellular matrix and Metabolism. GO annotations related to this gene include carbohydrate binding and hyaluronic acid binding. An important paralog of this gene is HAPLN2.

UniProtKB/Swiss-Prot for BCAN Gene

  • May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans.

Gene Wiki entry for BCAN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BCAN Gene

Genomics for BCAN Gene

Regulatory Elements for BCAN Gene

Genomic Location for BCAN Gene

Chromosome:
1
Start:
156,641,390 bp from pter
End:
156,659,532 bp from pter
Size:
18,143 bases
Orientation:
Plus strand

Genomic View for BCAN Gene

Genes around BCAN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BCAN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BCAN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BCAN Gene

Proteins for BCAN Gene

  • Protein details for BCAN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GW7-PGCB_HUMAN
    Recommended name:
    Brevican core protein
    Protein Accession:
    Q96GW7
    Secondary Accessions:
    • D3DVC2
    • Q5SZ10
    • Q5T3I5
    • Q8TBB9
    • Q9HBK1
    • Q9HBK4

    Protein attributes for BCAN Gene

    Size:
    911 amino acids
    Molecular mass:
    99118 Da
    Quaternary structure:
    • Interacts with TNR.

    Alternative splice isoforms for BCAN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BCAN Gene

Proteomics data for BCAN Gene at MOPED

Post-translational modifications for BCAN Gene

  • Contains mostly chondroitin sulfate (By similarity). O-glycosylated with a core 1 or possibly core 8 glycan.
  • Glycosylation at Asn 130, Asn 337, Thr 540, Ser 905, and Ser 906
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for BCAN Gene

Domains & Families for BCAN Gene

Suggested Antigen Peptide Sequences for BCAN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96GW7

UniProtKB/Swiss-Prot:

PGCB_HUMAN :
  • Contains 1 C-type lectin domain.
  • Belongs to the aggrecan/versican proteoglycan family.
Domain:
  • Contains 1 C-type lectin domain.
  • Contains 1 EGF-like domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Contains 2 Link domains.
  • Contains 1 Sushi (CCP/SCR) domain.
Family:
  • Belongs to the aggrecan/versican proteoglycan family.
genes like me logo Genes that share domains with BCAN: view

Function for BCAN Gene

Molecular function for BCAN Gene

UniProtKB/Swiss-Prot Function:
May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans.

Gene Ontology (GO) - Molecular Function for BCAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005201 extracellular matrix structural constituent IBA --
GO:0005540 hyaluronic acid binding IEA,IBA --
genes like me logo Genes that share ontologies with BCAN: view
genes like me logo Genes that share phenotypes with BCAN: view

Animal Models for BCAN Gene

MGI Knock Outs for BCAN:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BCAN Gene

Localization for BCAN Gene

Subcellular locations from UniProtKB/Swiss-Prot for BCAN Gene

Isoform 1: Secreted, extracellular space, extracellular matrix.
Isoform 2: Membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BCAN Gene COMPARTMENTS Subcellular localization image for BCAN gene
Compartment Confidence
extracellular 5
lysosome 5
vacuole 5
golgi apparatus 4
plasma membrane 3
cytosol 2
mitochondrion 2
nucleus 2
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for BCAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005796 Golgi lumen TAS --
GO:0030425 dendrite IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with BCAN: view

Pathways & Interactions for BCAN Gene

genes like me logo Genes that share pathways with BCAN: view

Pathways by source for BCAN Gene

1 GeneGo (Thomson Reuters) pathway for BCAN Gene

Gene Ontology (GO) - Biological Process for BCAN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0007155 cell adhesion IEA,IBA --
GO:0007417 central nervous system development IBA --
GO:0021766 hippocampus development IEA --
GO:0022617 extracellular matrix disassembly TAS --
genes like me logo Genes that share ontologies with BCAN: view

No data available for SIGNOR curated interactions for BCAN Gene

Drugs & Compounds for BCAN Gene

(1) Drugs for BCAN Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hyaluronan Approved Pharma 362
genes like me logo Genes that share compounds with BCAN: view

Transcripts for BCAN Gene

Unigene Clusters for BCAN Gene

Brevican:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BCAN Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^
SP1: - - -
SP2: -
SP3: -
SP4: - -
SP5: -
SP6: -
SP7:
SP8: -
SP9:
SP10: - - - - - - - - -
SP11: - - - -
SP12:

ExUns: 18a · 18b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for BCAN Gene

GeneLoc Exon Structure for
BCAN
ECgene alternative splicing isoforms for
BCAN

Expression for BCAN Gene

mRNA expression in normal human tissues for BCAN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BCAN Gene

This gene is overexpressed in Brain - Amygdala (x7.3), Brain - Caudate (basal ganglia) (x5.2), Brain - Hippocampus (x5.2), Brain - Putamen (basal ganglia) (x5.1), Brain - Nucleus accumbens (basal ganglia) (x5.0), Brain - Anterior cingulate cortex (BA24) (x4.1), and Brain - Substantia nigra (x4.0).

Protein differential expression in normal tissues from HIPED for BCAN Gene

This gene is overexpressed in Frontal cortex (30.7), Brain (19.6), and Cerebrospinal fluid (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for BCAN Gene



SOURCE GeneReport for Unigene cluster for BCAN Gene Hs.516904

genes like me logo Genes that share expression patterns with BCAN: view

Protein tissue co-expression partners for BCAN Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for BCAN Gene

Orthologs for BCAN Gene

This gene was present in the common ancestor of animals.

Orthologs for BCAN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia BCAN 35
  • 89.27 (n)
  • 89.89 (a)
BCAN 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BCAN 35
  • 87.78 (n)
  • 88.23 (a)
BCAN 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bcan 35
  • 83.37 (n)
  • 84.35 (a)
Bcan 16
Bcan 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia BCAN 35
  • 99.51 (n)
  • 99.66 (a)
BCAN 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bcan 35
  • 83.49 (n)
  • 85.16 (a)
oppossum
(Monodelphis domestica)
Mammalia BCAN 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 52 (a)
ManyToMany
chicken
(Gallus gallus)
Aves BCAN 35
  • 70.81 (n)
  • 66.83 (a)
BCAN 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BCAN 36
  • 38 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486298 35
  • 58.77 (n)
  • 56.59 (a)
zebrafish
(Danio rerio)
Actinopterygii bcan 35
  • 59.01 (n)
  • 55.74 (a)
bcan 36
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea clec-149 36
  • 23 (a)
OneToMany
Species with no ortholog for BCAN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for BCAN Gene

ENSEMBL:
Gene Tree for BCAN (if available)
TreeFam:
Gene Tree for BCAN (if available)

Paralogs for BCAN Gene

Paralogs for BCAN Gene

genes like me logo Genes that share paralogs with BCAN: view

Variants for BCAN Gene

Sequence variations from dbSNP and Humsavar for BCAN Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_019551 -
VAR_050123 -
rs1105300 -- 156,640,685(+) ATGCT(A/G)GGATT upstream-variant-2KB
rs1016423 -- 156,644,500(+) CAATG(C/T)CTGGA intron-variant
rs1361744 -- 156,640,896(-) CAGTG(C/T)CATGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for BCAN Gene

Variant ID Type Subtype PubMed ID
nsv523181 CNV Loss 19592680
nsv872473 CNV Loss 21882294
nsv521401 CNV Loss 19592680
nsv521552 CNV Loss 19592680

Variation tolerance for BCAN Gene

Residual Variation Intolerance Score: 15.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.82; 86.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BCAN Gene

HapMap Linkage Disequilibrium report
BCAN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BCAN Gene

Disorders for BCAN Gene

Relevant External Links for BCAN

Genetic Association Database (GAD)
BCAN
Human Genome Epidemiology (HuGE) Navigator
BCAN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BCAN

No disorders were found for BCAN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for BCAN Gene

Publications for BCAN Gene

  1. cDNA cloning, chromosomal localization, and expression analysis of human BEHAB/brevican, a brain specific proteoglycan regulated during cortical development and in glioma. (PMID: 11054543) Gary S.C. … Hockfield S. (Gene 2000) 2 3 4 67
  2. Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23. (PMID: 11873941) Nomoto H. … Ninomiya Y. (Acta Med. Okayama 2002) 2 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Brevican, neurocan, tenascin-C and versican are mainly responsible for the invasiveness of low-grade astrocytoma. (PMID: 21997179) Varga I. … Klekner A. (Pathol. Oncol. Res. 2012) 3
  5. Genome-wide methylation screen in low-grade breast cancer identifies novel epigenetically altered genes as potential biomarkers for tumor diagnosis. (PMID: 22930747) Faryna M. … Gerhauser C. (FASEB J. 2012) 3

Products for BCAN Gene

Sources for BCAN Gene

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