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Aliases for BID Gene

Aliases for BID Gene

  • BH3 Interacting Domain Death Agonist 2 3 5
  • P22 BID 3 4
  • Human BID Coding Sequence 3
  • Apoptic Death Agonist 3
  • BID Isoform ES(1b) 3
  • Desmocollin Type 4 3
  • BID Isoform L(2) 3
  • BID Isoform Si6 3
  • FP497 3

External Ids for BID Gene

Previous GeneCards Identifiers for BID Gene

  • GC22M015157
  • GC22M016591
  • GC22M016592
  • GC22M018216
  • GC22M002030

Summaries for BID Gene

Entrez Gene Summary for BID Gene

  • This gene encodes a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. The encoded protein is a member of the BCL-2 family of cell death regulators. It is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]

GeneCards Summary for BID Gene

BID (BH3 Interacting Domain Death Agonist) is a Protein Coding gene. Diseases associated with BID include cat eye syndrome. Among its related pathways are Gene Expression and Integrated Pancreatic Cancer Pathway. GO annotations related to this gene include ubiquitin protein ligase binding and death receptor binding.

UniProtKB/Swiss-Prot for BID Gene

  • The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.

Gene Wiki entry for BID Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BID Gene

Genomics for BID Gene

Regulatory Elements for BID Gene

Promoters for BID Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around BID on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the BID gene promoter:

Genomic Location for BID Gene

Chromosome:
22
Start:
17,734,138 bp from pter
End:
17,774,770 bp from pter
Size:
40,633 bases
Orientation:
Minus strand

Genomic View for BID Gene

Genes around BID on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
BID Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for BID Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BID Gene

Proteins for BID Gene

  • Protein details for BID Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55957-BID_HUMAN
    Recommended name:
    BH3-interacting domain death agonist
    Protein Accession:
    P55957
    Secondary Accessions:
    • Q549M7
    • Q71T04
    • Q7Z4M9
    • Q8IY86

    Protein attributes for BID Gene

    Size:
    195 amino acids
    Molecular mass:
    21995 Da
    Quaternary structure:
    • Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein Bcl-2 (By similarity). p15 BID interacts with ITCH.
    SequenceCaution:
    • Sequence=AAH22072.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for BID Gene

    Alternative splice isoforms for BID Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for BID Gene

Proteomics data for BID Gene at MOPED

Post-translational modifications for BID Gene

  • p15 BID is ubiquitinated by ITCH; ubiquitination results in proteasome-dependent degradation.
  • TNF-alpha induces a caspase-mediated cleavage of p22 BID into a major p15 and minor p13 and p11 products.
  • Ubiquitination at Lys 158
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for BID Gene

Domains & Families for BID Gene

Gene Families for BID Gene

Protein Domains for BID Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P55957

UniProtKB/Swiss-Prot:

BID_HUMAN :
  • Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
Domain:
  • Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.
genes like me logo Genes that share domains with BID: view

Function for BID Gene

Molecular function for BID Gene

GENATLAS Biochemistry:
BH3 interacting domain,death agonist (inducing apoptosis),highly expressed in adult heart and liver,heterodimerizing with either agonists (BAX) or antagonists (BCL2),murine Bid homolog,inducing mitochondrial damage by caspase-8 cleavage,expressed in cytosol and translocated to mitochondria after proteolytic activation
UniProtKB/Swiss-Prot Function:
The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.
genes like me logo Genes that share phenotypes with BID: view

Animal Models for BID Gene

MGI Knock Outs for BID:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for BID Gene

Localization for BID Gene

Subcellular locations from UniProtKB/Swiss-Prot for BID Gene

Cytoplasm. Mitochondrion membrane. Note=When uncleaved, it is predominantly cytoplasmic. {ECO:0000269 PubMed:14583606}.
BH3-interacting domain death agonist p15: Mitochondrion membrane. Note=Translocates to mitochondria as an integral membrane protein. {ECO:0000250}.
BH3-interacting domain death agonist p13: Mitochondrion membrane. Note=Associated with the mitochondrial membrane. {ECO:0000250}.
Isoform 1: Cytoplasm.
Isoform 3: Cytoplasm.
Isoform 2: Mitochondrion membrane. Note=A significant proportion of isoform 2 localizes to mitochondria, it may be cleaved constitutively.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BID Gene COMPARTMENTS Subcellular localization image for BID gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 5
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BID Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 mitochondrial outer membrane TAS --
genes like me logo Genes that share ontologies with BID: view

Pathways & Interactions for BID Gene

genes like me logo Genes that share pathways with BID: view

SIGNOR curated interactions for BID Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for BID Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006626 protein targeting to mitochondrion IEA --
GO:0006915 apoptotic process TAS --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA --
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors TAS 9727491
GO:0008637 apoptotic mitochondrial changes TAS 9727492
genes like me logo Genes that share ontologies with BID: view

Drugs & Compounds for BID Gene

(39) Drugs for BID Gene - From: Novoseek and ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Peginterferon alfa-2a Approved, Investigational Pharma 537
Ribavirin Approved Pharma 948
Anti-Infective Agents Pharma 17220
Antimetabolites Pharma 9454
Antiviral Agents Pharma 8071

(23) Additional Compounds for BID Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with BID: view

Transcripts for BID Gene

Unigene Clusters for BID Gene

BH3 interacting domain death agonist:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BID Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e · 8f
SP1: -
SP2: - -
SP3: -
SP4: - - -
SP5: - - -
SP6: - - - -
SP7: - - -
SP8: - - - - -

Relevant External Links for BID Gene

GeneLoc Exon Structure for
BID
ECgene alternative splicing isoforms for
BID

Expression for BID Gene

mRNA expression in normal human tissues for BID Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BID Gene

This gene is overexpressed in Whole Blood (x6.9).

Protein differential expression in normal tissues from HIPED for BID Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.7) and Monocytes (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for BID Gene



SOURCE GeneReport for Unigene cluster for BID Gene Hs.591054

mRNA Expression by UniProt/SwissProt for BID Gene

P55957-BID_HUMAN
Tissue specificity: Isoform 2 and isoform 3 are expressed in spleen, bone marrow, cerebral and cerebellar cortex. Isoform 2 is expressed in spleen, pancreas and placenta (at protein level). Isoform 3 is expressed in lung, pancreas and spleen (at protein level). Isoform 4 is expressed in lung and pancreas (at protein level).
genes like me logo Genes that share expression patterns with BID: view

Protein tissue co-expression partners for BID Gene

In Situ Assay Products

Orthologs for BID Gene

This gene was present in the common ancestor of chordates.

Orthologs for BID Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BID 35
  • 99.45 (n)
  • 100 (a)
BID 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BID1 36
  • 57 (a)
OneToOne
BID 35
  • 71.87 (n)
  • 59.37 (a)
dog
(Canis familiaris)
Mammalia BID 35
  • 75.77 (n)
  • 68.56 (a)
BID 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bid 16
Bid 36
  • 63 (a)
OneToOne
Bid 35
  • 75.79 (n)
  • 67.37 (a)
oppossum
(Monodelphis domestica)
Mammalia BID 36
  • 33 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BID 36
  • 43 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bid 35
  • 73.37 (n)
  • 62.37 (a)
chicken
(Gallus gallus)
Aves BID 35
  • 52.02 (n)
  • 42.2 (a)
BID 36
  • 37 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BID 36
  • 37 (a)
OneToOne
Species with no ortholog for BID:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BID Gene

ENSEMBL:
Gene Tree for BID (if available)
TreeFam:
Gene Tree for BID (if available)

Paralogs for BID Gene

No data available for Paralogs for BID Gene

Variants for BID Gene

Sequence variations from dbSNP and Humsavar for BID Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs8190315 - 17,743,998(-) GTTCC(A/G)GCCTC intron-variant, reference, missense, utr-variant-5-prime
rs17853595 - 17,738,107(+) GGCGT(G/T)TGACT reference, missense
rs59225839 - 17,735,587(+) AGTCC(A/G)TCCCC reference, missense
rs367672 -- 17,742,470(+) ACACC(C/T)Ccccc intron-variant
rs375985 -- 17,774,254(+) CTCCT(A/C)TGGCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for BID Gene

Variant ID Type Subtype PubMed ID
nsv526826 CNV Gain 19592680
nsv428385 CNV Gain+Loss 18775914
nsv914151 CNV Gain 21882294
nsv914152 CNV Loss 21882294
nsv834119 CNV Loss 17160897
nsv834120 CNV Loss 17160897
esv2662076 CNV Deletion 23128226
nsv914153 CNV Loss 21882294
dgv4819n71 CNV Loss 21882294

Variation tolerance for BID Gene

Residual Variation Intolerance Score: 79.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for BID Gene

HapMap Linkage Disequilibrium report
BID

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BID Gene

Disorders for BID Gene

MalaCards: The human disease database

(1) MalaCards diseases for BID Gene - From: GeneCards

Disorder Aliases PubMed IDs
cat eye syndrome
  • ces
- elite association - COSMIC cancer census association via MalaCards
Search BID in MalaCards View complete list of genes associated with diseases

Relevant External Links for BID

Genetic Association Database (GAD)
BID
Human Genome Epidemiology (HuGE) Navigator
BID
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
BID
genes like me logo Genes that share disorders with BID: view

No data available for UniProtKB/Swiss-Prot and Genatlas for BID Gene

Publications for BID Gene

  1. The gene for death agonist BID maps to the region of human 22q11.2 duplicated in cat eye syndrome chromosomes and to mouse chromosome 6. (PMID: 9721221) Footz T.K. … McDermid H.E. (Genomics 1998) 2 3 4 67
  2. Activity of protein kinase CK2 uncouples Bid cleavage from caspase-8 activation. (PMID: 20356928) Hellwig C.T. … Rehm M. (J. Cell. Sci. 2010) 3 23
  3. Knockdown of human bid gene expression enhances survival of CD8+ T cells. (PMID: 19046991) Lei X.Y. … Yang A.G. (Immunol. Lett. 2009) 3 23
  4. Cleavage of Bid by executioner caspases mediates feed forward amplification of mitochondrial outer membrane permeabilization during genotoxic stress-induced apoptosis in Jurkat cells. (PMID: 19233849) Shelton S.N. … Robertson J.D. (J. Biol. Chem. 2009) 3 23
  5. Lysosomal serine protease CLN2 regulates tumor necrosis factor-alpha-mediated apoptosis in a Bid-dependent manner. (PMID: 19246452) Autefage H. … Andrieu-Abadie N. (J. Biol. Chem. 2009) 3 23

Products for BID Gene

Sources for BID Gene

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