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Aliases for CCL7 Gene

Aliases for CCL7 Gene

  • C-C Motif Chemokine Ligand 7 2 3 5
  • Monocyte Chemoattractant Protein 3 2 3 4
  • Monocyte Chemotactic Protein 3 2 3 4
  • Small Inducible Cytokine A7 (Monocyte Chemotactic Protein 3) 2 3
  • Chemokine (C-C Motif) Ligand 7 2 3
  • Small-Inducible Cytokine A7 3 4
  • SCYA6 3 4
  • SCYA7 3 4
  • MCP-3 3 4
  • MCP3 3 4
  • NC28 3 4
  • C-C Motif Chemokine 7 3
  • MARC 3
  • FIC 3

External Ids for CCL7 Gene

Previous HGNC Symbols for CCL7 Gene

  • SCYA6
  • SCYA7

Previous GeneCards Identifiers for CCL7 Gene

  • GC17P032366
  • GC17P034636
  • GC17P032742
  • GC17P029621
  • GC17P032597
  • GC17P028782

Summaries for CCL7 Gene

Entrez Gene Summary for CCL7 Gene

  • This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family members on chromosome 17q. [provided by RefSeq, Jul 2008]

GeneCards Summary for CCL7 Gene

CCL7 (C-C Motif Chemokine Ligand 7) is a Protein Coding gene. Diseases associated with CCL7 include Status Asthmaticus and Stachybotrys Chartarum. Among its related pathways are PEDF Induced Signaling and TGF-Beta Pathway. GO annotations related to this gene include heparin binding and CCR1 chemokine receptor binding. An important paralog of this gene is CCL2.

UniProtKB/Swiss-Prot for CCL7 Gene

  • Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3.

Gene Wiki entry for CCL7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CCL7 Gene

Genomics for CCL7 Gene

Regulatory Elements for CCL7 Gene

Enhancers for CCL7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G034237 1.7 FANTOM5 Ensembl ENCODE dbSUPER 37.1 -29.3 -29331 7.2 RAD21 RARA GATA2 ETV6 RELB IKZF2 EGR2 CBFB JUNB GATAD2B CCL7 CCL8 CCL1 ASIC2 CCL2 GC17M034278 GC17P034213
GH17G034299 1.3 FANTOM5 Ensembl ENCODE 36.7 +30.4 30381 2.5 CTCF MXI1 JUN MAX CEBPG RAD21 YY1 POLR2A SMC3 FOS CCL7 CCL8 CCL1 CCL2 CCL11
GH17G034245 1.8 FANTOM5 Ensembl ENCODE dbSUPER 23.9 -17.3 -17306 14.0 PKNOX1 CBX3 SIN3A GLIS2 GATA2 ZSCAN5C FOS CREM CBFB JUNB CCL7 CCL11 CCL8 CCL1 ASIC2 CCL2 GC17M034278
GH17G034306 1.3 FANTOM5 Ensembl ENCODE 19.9 +36.9 36895 1.5 CTCF REST EBF1 RAD21 RELA JUND NFIC IKZF1 SMC3 FOS CCL7 CCL11 CCL1 ASIC2 CCL8
GH17G034399 1.3 FANTOM5 ENCODE dbSUPER 19.6 +129.0 129005 0.4 ATF1 CBX3 PKNOX1 L3MBTL2 NR4A1 MAX CEBPG ZNF592 CBX5 HMBOX1 CCL7 CCL1 CCL8 CCL2 GC17M034364 GC17P034446
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CCL7 on UCSC Golden Path with GeneCards custom track

Genomic Location for CCL7 Gene

Chromosome:
17
Start:
34,270,216 bp from pter
End:
34,272,242 bp from pter
Size:
2,027 bases
Orientation:
Plus strand

Genomic View for CCL7 Gene

Genes around CCL7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CCL7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CCL7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CCL7 Gene

Proteins for CCL7 Gene

  • Protein details for CCL7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P80098-CCL7_HUMAN
    Recommended name:
    C-C motif chemokine 7
    Protein Accession:
    P80098
    Secondary Accessions:
    • Q569J6

    Protein attributes for CCL7 Gene

    Size:
    99 amino acids
    Molecular mass:
    11200 Da
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=CAA50405.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA50406.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA51055.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CCL7 Gene

neXtProt entry for CCL7 Gene

Post-translational modifications for CCL7 Gene

Other Protein References for CCL7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CCL7 (CCL7/MCP-3/MARC)
  • Abcam antibodies for CCL7

No data available for DME Specific Peptides for CCL7 Gene

Domains & Families for CCL7 Gene

Gene Families for CCL7 Gene

Protein Domains for CCL7 Gene

Suggested Antigen Peptide Sequences for CCL7 Gene

Graphical View of Domain Structure for InterPro Entry

P80098

UniProtKB/Swiss-Prot:

CCL7_HUMAN :
  • Belongs to the intercrine beta (chemokine CC) family.
Family:
  • Belongs to the intercrine beta (chemokine CC) family.
genes like me logo Genes that share domains with CCL7: view

Function for CCL7 Gene

Molecular function for CCL7 Gene

UniProtKB/Swiss-Prot Function:
Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3.

Gene Ontology (GO) - Molecular Function for CCL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008009 chemokine activity IDA,TAS 10072545
GO:0008201 heparin binding IEA --
GO:0031726 CCR1 chemokine receptor binding IPI 7545673
genes like me logo Genes that share ontologies with CCL7: view
genes like me logo Genes that share phenotypes with CCL7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CCL7

miRNA for CCL7 Gene

miRTarBase miRNAs that target CCL7

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CCL7 Gene

Localization for CCL7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CCL7 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CCL7 gene
Compartment Confidence
extracellular 5
cytosol 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CCL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA,TAS --
GO:0005623 cell IEA --
genes like me logo Genes that share ontologies with CCL7: view

Pathways & Interactions for CCL7 Gene

genes like me logo Genes that share pathways with CCL7: view

Gene Ontology (GO) - Biological Process for CCL7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002548 monocyte chemotaxis IC 10660125
GO:0006874 cellular calcium ion homeostasis TAS 10770925
GO:0006935 chemotaxis TAS 9780207
GO:0006954 inflammatory response IEA,IBA --
GO:0006955 immune response IEA --
genes like me logo Genes that share ontologies with CCL7: view

No data available for SIGNOR curated interactions for CCL7 Gene

Drugs & Compounds for CCL7 Gene

(15) Drugs for CCL7 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bindarit Pharma 0

(15) Additional Compounds for CCL7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for CCL7 Gene

Compound Action Cas Number
Bindarit 130641-38-2
genes like me logo Genes that share compounds with CCL7: view

Transcripts for CCL7 Gene

mRNA/cDNA for CCL7 Gene

Unigene Clusters for CCL7 Gene

Chemokine (C-C motif) ligand 7:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CCL7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c
SP1: -
SP2:
SP3: - -

Relevant External Links for CCL7 Gene

GeneLoc Exon Structure for
CCL7
ECgene alternative splicing isoforms for
CCL7

Expression for CCL7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CCL7 Gene

mRNA differential expression in normal tissues according to GTEx for CCL7 Gene

This gene is overexpressed in Brain - Substantia nigra (x5.6) and Lung (x4.7).

Protein differential expression in normal tissues from HIPED for CCL7 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CCL7 Gene



Protein tissue co-expression partners for CCL7 Gene

NURSA nuclear receptor signaling pathways regulating expression of CCL7 Gene:

CCL7

SOURCE GeneReport for Unigene cluster for CCL7 Gene:

Hs.251526

Evidence on tissue expression from TISSUES for CCL7 Gene

  • Blood(4.7)
  • Intestine(4.3)
  • Bone marrow(2)
genes like me logo Genes that share expression patterns with CCL7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CCL7 Gene

Orthologs for CCL7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CCL7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCL7 34 35
  • 99.33 (n)
dog
(Canis familiaris)
Mammalia CCL7 34 35
  • 82.83 (n)
mouse
(Mus musculus)
Mammalia Ccl7 35
  • 60 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 45 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
-- 35
  • 19 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 44 (a)
ManyToMany
-- 35
  • 44 (a)
ManyToMany
Species where no ortholog for CCL7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CCL7 Gene

ENSEMBL:
Gene Tree for CCL7 (if available)
TreeFam:
Gene Tree for CCL7 (if available)

Paralogs for CCL7 Gene

genes like me logo Genes that share paralogs with CCL7: view

Variants for CCL7 Gene

Sequence variations from dbSNP and Humsavar for CCL7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000045109 -- 34,269,532(+) TTCCA(C/T)CTGGT upstream-variant-2KB
rs1001040406 -- 34,272,004(+) TTGGT(A/G)GGTTT utr-variant-3-prime
rs1001717241 -- 34,268,347(+) GGTCT(C/T)TCCAT upstream-variant-2KB
rs1002017945 -- 34,270,718(+) CGGGA(G/T)ACCCA intron-variant
rs1002070512 -- 34,270,959(+) CACAG(C/T)CCATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CCL7 Gene

Variant ID Type Subtype PubMed ID
dgv3141n100 CNV gain 25217958
esv3572553 CNV gain 25503493
nsv517423 CNV gain+loss 19592680
nsv519297 CNV gain 19592680
nsv574714 CNV gain 21841781

Variation tolerance for CCL7 Gene

Residual Variation Intolerance Score: 66.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 5.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CCL7 Gene

Human Gene Mutation Database (HGMD)
CCL7
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CCL7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CCL7 Gene

Disorders for CCL7 Gene

MalaCards: The human disease database

(8) MalaCards diseases for CCL7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
status asthmaticus
  • asthma with status asthmaticus
stachybotrys chartarum
  • stachybotrys atra
nephrogenic systemic fibrosis
  • nephrogenic fibrosing dermopathy
acute contagious conjunctivitis
  • contagious opthalmia
pulmonary eosinophilia
  • asthmatic pulmonary eosinophilia
- elite association - COSMIC cancer census association via MalaCards
Search CCL7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CCL7

Genetic Association Database (GAD)
CCL7
Human Genome Epidemiology (HuGE) Navigator
CCL7
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CCL7
genes like me logo Genes that share disorders with CCL7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CCL7 Gene

Publications for CCL7 Gene

  1. Human monocyte chemotactic protein-3 (MCP-3): molecular cloning of the cDNA and comparison with other chemokines. (PMID: 8461011) Opdenakker G. … van Damme J. (Biochem. Biophys. Res. Commun. 1993) 2 3 4 22 64
  2. Association analysis of monocyte chemotactic protein-3 (MCP3) polymorphisms with asthmatic phenotypes. (PMID: 15715950) Park B.L. … Shin H.D. (J. Biochem. Mol. Biol. 2005) 3 22 46 64
  3. Determination of the three-dimensional structure of CC chemokine monocyte chemoattractant protein 3 by 1H two-dimensional NMR spectroscopy. (PMID: 9109648) Meunier S. … Darbon H. (Biochemistry 1997) 3 4 22 64
  4. Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3. (PMID: 8898111) Kim K.-S. … Sykes B.D. (FEBS Lett. 1996) 3 4 22 64
  5. The human MCP-3 gene (SCYA7): cloning, sequence analysis, and assignment to the C-C chemokine gene cluster on chromosome 17q11.2- q12. (PMID: 7916328) Opdenakker G. … van Damme J. (Genomics 1994) 3 4 22 64

Products for CCL7 Gene

Sources for CCL7 Gene

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