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Aliases for SRL Gene

Aliases for SRL Gene

  • Sarcalumenin 2 3

External Ids for SRL Gene

Summaries for SRL Gene

GeneCards Summary for SRL Gene

SRL (Sarcalumenin) is a Protein Coding gene. GO annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is EHD1.

UniProtKB/Swiss-Prot for SRL Gene

  • May be involved in the regulation of calcium transport

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SRL Gene

Genomics for SRL Gene

Genomic Location for SRL Gene

Start:
4,189,374 bp from pter
End:
4,242,080 bp from pter
Size:
52,707 bases
Orientation:
Minus strand

Genomic View for SRL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SRL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SRL Gene

Regulatory Elements for SRL Gene

Proteins for SRL Gene

  • Protein details for SRL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86TD4-SRCA_HUMAN
    Recommended name:
    Sarcalumenin
    Protein Accession:
    Q86TD4
    Secondary Accessions:

    Protein attributes for SRL Gene

    Size:
    932 amino acids
    Molecular mass:
    100788 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAD89901.1; Type=Frameshift; Positions=927; Evidence={ECO:0000305};

    Alternative splice isoforms for SRL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SRL Gene

Proteomics data for SRL Gene at MOPED

Post-translational modifications for SRL Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn99, Asn740, and Asn848

Other Protein References for SRL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SRL Gene

Domains for SRL Gene

Protein Domains for SRL Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

SRCA_HUMAN
Domain:
  • Contains 1 dynamin-type G (guanine nucleotide-binding) domain.:
    • Q86TD4
Family:
  • Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.:
    • Q86TD4
genes like me logo Genes that share domains with SRL: view

No data available for Gene Families for SRL Gene

Function for SRL Gene

Molecular function for SRL Gene

UniProtKB/Swiss-Prot Function: May be involved in the regulation of calcium transport

Gene Ontology (GO) - Molecular Function for SRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with SRL: view

Phenotypes for SRL Gene

genes like me logo Genes that share phenotypes with SRL: view

Animal Models for SRL Gene

MGI Knock Outs for SRL:

miRNA for SRL Gene

miRTarBase miRNAs that target SRL

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for SRL Gene

Localization for SRL Gene

Subcellular locations from UniProtKB/Swiss-Prot for SRL Gene

Sarcoplasmic reticulum lumen. Note=Associated through calcium with the membrane. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SRL Gene COMPARTMENTS Subcellular localization image for SRL gene
Compartment Confidence
endoplasmic reticulum 2
extracellular 2

Gene Ontology (GO) - Cellular Components for SRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016529 sarcoplasmic reticulum --
GO:0033018 sarcoplasmic reticulum lumen IEA --
genes like me logo Genes that share ontologies with SRL: view

Pathways for SRL Gene

SuperPathways for SRL Gene

No Data Available

Interacting Proteins for SRL Gene

Gene Ontology (GO) - Biological Process for SRL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
genes like me logo Genes that share ontologies with SRL: view

No data available for Pathways by source for SRL Gene

Compounds for SRL Gene

(1) HMDB Compounds for SRL Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(4) Novoseek inferred chemical compound relationships for SRL Gene

Compound -log(P) Hits PubMed IDs
ryanodine 56.1 2
dihydropyridine 55.7 1
calcium 41.1 8
atp 11.2 1
genes like me logo Genes that share compounds with SRL: view

Transcripts for SRL Gene

mRNA/cDNA for SRL Gene

Unigene Clusters for SRL Gene

Sarcalumenin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SRL Gene

No ASD Table

Relevant External Links for SRL Gene

GeneLoc Exon Structure for
SRL
ECgene alternative splicing isoforms for
SRL

Expression for SRL Gene

mRNA expression in normal human tissues for SRL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SRL Gene

This gene is overexpressed in Muscle - Skeletal (19.4), Heart - Left Ventricle (18.9), and Heart - Atrial Appendage (9.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SRL Gene

SOURCE GeneReport for Unigene cluster for SRL Gene Hs.10041

genes like me logo Genes that share expressions with SRL: view

Orthologs for SRL Gene

This gene was present in the common ancestor of animals.

Orthologs for SRL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SRL 36
  • 99.77 (n)
  • 99.77 (a)
SRL 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SRL 37
  • 52 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SRL 36
  • 90.35 (n)
  • 96.71 (a)
SRL 37
  • 51 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Srl 36
  • 88.64 (n)
  • 96.48 (a)
Srl 16
Srl 37
  • 49 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SRL 37
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 17 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Srl 36
  • 89.18 (n)
  • 96.25 (a)
chicken
(Gallus gallus)
Aves SRL 36
  • 83 (n)
  • 89.62 (a)
SRL 37
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SRL 37
  • 76 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.33138 36
tropical clawed frog
(Silurana tropicalis)
Amphibia srl 36
  • 77.61 (n)
  • 88.55 (a)
Str.1480 36
zebrafish
(Danio rerio)
Actinopterygii srl 36
  • 74.96 (n)
  • 85.07 (a)
srl 37
  • 79 (a)
OneToOne
wufb80c09 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002456 36
  • 55.39 (n)
  • 48.01 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG9297 37
  • 21 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rme-1 37
  • 16 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7643 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9298 37
  • 25 (a)
OneToOne
Species with no ortholog for SRL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SRL Gene

ENSEMBL:
Gene Tree for SRL (if available)
TreeFam:
Gene Tree for SRL (if available)

Paralogs for SRL Gene

Paralogs for SRL Gene

Selected SIMAP similar genes for SRL Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with SRL: view

Variants for SRL Gene

Sequence variations from dbSNP and Humsavar for SRL Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs251787 -- 4,192,098(-) ACTGT(C/G)TGAGA utr-variant-3-prime
rs736836 -- 4,235,077(+) CAGGG(A/G)TCGGA intron-variant
rs736850 -- 4,234,530(+) GGCTG(A/G)AAATA intron-variant
rs868301 -- 4,207,433(+) CGCGA(C/T)GTCAG intron-variant
rs868302 -- 4,207,685(+) CCCAA(A/G)CCCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SRL Gene

Variant ID Type Subtype PubMed ID
esv21490 CNV Gain+Loss 19812545
esv2751608 CNV Gain 17911159
dgv794e1 CNV Complex 17122850
esv2671113 CNV Deletion 23128226
esv2750427 CNV Deletion 23290073
nsv527866 CNV Loss 19592680
esv2750428 CNV Deletion 23290073
nsv524305 CNV Loss 19592680
esv2671997 CNV Deletion 23128226

Relevant External Links for SRL Gene

HapMap Linkage Disequilibrium report
SRL

Disorders for SRL Gene

(1) Novoseek inferred disease relationships for SRL Gene

Disease -log(P) Hits PubMed IDs
muscular dystrophies 50.8 1

Relevant External Links for SRL

Genetic Association Database (GAD)
SRL
genes like me logo Genes that share disorders with SRL: view

No data available for UniProtKB/Swiss-Prot for SRL Gene

Publications for SRL Gene

  1. Molecular cloning and expression of cDNA encoding a lumenal calcium binding glycoprotein from sarcoplasmic reticulum. (PMID: 2762314) Leberer E. … MacLennan D.H. (Proc. Natl. Acad. Sci. U.S.A. 1989) 2 3
  2. Identification of 4370 expressed sequence tags from a 3'-end-specific cDNA library of human skeletal muscle by DNA sequencing and filter hybridization. (PMID: 8681137) Lanfranchi G. … Valle G. (Genome Res. 1996) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3

Products for SRL Gene

Sources for SRL Gene

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