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Aliases for SCT Gene

Aliases for SCT Gene

  • Secretin 2 3 3 5
  • Prepro-Secretin 2 3

External Ids for SCT Gene

Previous GeneCards Identifiers for SCT Gene

  • GC11P001116
  • GC11P000936
  • GC11P000573
  • GC11M000616
  • GC11M000441

Summaries for SCT Gene

Entrez Gene Summary for SCT Gene

  • This gene encodes a member of the glucagon family of peptides. The encoded preproprotein is secreted by endocrine S cells in the proximal small intestinal mucosa as a prohormone, then proteolytically processed to generate the mature peptide hormone. The release of this active peptide hormone is stimulated by either fatty acids or acidic pH in the duodenum. This hormone stimulates the secretion of bile and bicarbonate in the duodenum, pancreatic and biliary ducts. [provided by RefSeq, Feb 2016]

GeneCards Summary for SCT Gene

SCT (Secretin) is a Protein Coding gene. Diseases associated with SCT include Zollinger-Ellison Syndrome and Exocrine Pancreatic Insufficiency. Among its related pathways are Presynaptic function of Kainate receptors and Peptide ligand-binding receptors. GO annotations related to this gene include hormone activity.

UniProtKB/Swiss-Prot for SCT Gene

  • Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach.

Gene Wiki entry for SCT Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCT Gene

Genomics for SCT Gene

Regulatory Elements for SCT Gene

Enhancers for SCT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G000628 1.4 FANTOM5 Ensembl ENCODE 8.6 -1.8 -1770 1.9 PKNOX1 ATF1 FEZF1 ZNF366 IKZF2 CREM ZNF263 ZEB2 TBX21 ZFP69B TMEM80 SCT DRD4 IRF7 GC11P000637
GH11G000632 0.4 ENCODE 0.4 -5.7 -5721 0.8 BHLHE40 ZNF18 GC11P000637 SCT
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SCT on UCSC Golden Path with GeneCards custom track

Genomic Location for SCT Gene

Chromosome:
11
Start:
624,989 bp from pter
End:
627,240 bp from pter
Size:
2,252 bases
Orientation:
Minus strand

Genomic View for SCT Gene

Genes around SCT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SCT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SCT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCT Gene

Proteins for SCT Gene

  • Protein details for SCT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09683-SECR_HUMAN
    Recommended name:
    Secretin
    Protein Accession:
    P09683

    Protein attributes for SCT Gene

    Size:
    121 amino acids
    Molecular mass:
    13016 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SCT Gene

Post-translational modifications for SCT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SCT Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for SCT Gene

Domains & Families for SCT Gene

Gene Families for SCT Gene

Protein Domains for SCT Gene

Suggested Antigen Peptide Sequences for SCT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P09683

UniProtKB/Swiss-Prot:

SECR_HUMAN :
  • Belongs to the glucagon family.
Family:
  • Belongs to the glucagon family.
genes like me logo Genes that share domains with SCT: view

Function for SCT Gene

Molecular function for SCT Gene

UniProtKB/Swiss-Prot Function:
Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach.

LifeMap Function Summary for SCT Gene

It affects the following cells:

Gene Ontology (GO) - Molecular Function for SCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity NAS 11060443
GO:0047485 protein N-terminus binding IEA --
genes like me logo Genes that share ontologies with SCT: view
genes like me logo Genes that share phenotypes with SCT: view

Animal Model Products

  • Taconic Biosciences Mouse Models for SCT

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SCT Gene

Localization for SCT Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCT Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SCT gene
Compartment Confidence
extracellular 5
plasma membrane 2
nucleus 2
cytoskeleton 1
mitochondrion 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with SCT: view

Pathways & Interactions for SCT Gene

genes like me logo Genes that share pathways with SCT: view

Gene Ontology (GO) - Biological Process for SCT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007420 brain development IEA --
GO:0030157 pancreatic juice secretion NAS 11060443
GO:0030819 positive regulation of cAMP biosynthetic process IEA --
GO:0048566 embryonic digestive tract development IEA --
GO:0090187 positive regulation of pancreatic juice secretion IEA --
genes like me logo Genes that share ontologies with SCT: view

No data available for SIGNOR curated interactions for SCT Gene

Drugs & Compounds for SCT Gene

(131) Drugs for SCT Gene - From: ClinicalTrials, ApexBio, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Fludarabine Approved Pharma DNA synthsis inhibitor 1154,1154
Pyridoxine Approved, Vet_approved Nutra 188,188
Cyclosporine Approved, Investigational, Vet_approved Pharma Antagonist Immunosuppressant drug, Immunosuppressive agent, Calcineurin inhibitor 922
Azacitidine Approved, Investigational Pharma 529
Belinostat Approved, Investigational Pharma Histone deacetylase (HDAC)inhibitors 42

(50) Additional Compounds for SCT Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for SCT Gene

Compound Action Cas Number
Secretin (rat) 121028-49-7
genes like me logo Genes that share compounds with SCT: view

Transcripts for SCT Gene

mRNA/cDNA for SCT Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for SCT Gene

Secretin:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCT Gene

No ASD Table

Relevant External Links for SCT Gene

GeneLoc Exon Structure for
SCT
ECgene alternative splicing isoforms for
SCT

Expression for SCT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SCT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCT Gene

This gene is overexpressed in Muscle - Skeletal (x8.4), Spleen (x5.1), and Testis (x4.7).

NURSA nuclear receptor signaling pathways regulating expression of SCT Gene:

SCT

SOURCE GeneReport for Unigene cluster for SCT Gene:

Hs.632324

Evidence on tissue expression from TISSUES for SCT Gene

  • Intestine(3.5)
  • Pancreas(3.2)
  • Blood(2.9)
  • Stomach(2.7)
  • Gall bladder(2.3)
  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with SCT: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SCT Gene

Orthologs for SCT Gene

This gene was present in the common ancestor of mammals.

Orthologs for SCT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SCT 34 35
  • 98.62 (n)
mouse
(Mus musculus)
Mammalia Sct 35
  • 56 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SCT 35
  • 55 (a)
OneToOne
Species where no ortholog for SCT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for SCT Gene

ENSEMBL:
Gene Tree for SCT (if available)
TreeFam:
Gene Tree for SCT (if available)

Paralogs for SCT Gene

No data available for Paralogs for SCT Gene

Variants for SCT Gene

Sequence variations from dbSNP and Humsavar for SCT Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000226608 -- 627,628(+) ATCAT(G/T)CGGTG upstream-variant-2KB, utr-variant-5-prime
rs1000541351 -- 626,871(+) CCCCC(A/C)CCCCA intron-variant, upstream-variant-2KB
rs1000660706 -- 627,853(+) CCCGT(C/T)CTCCC upstream-variant-2KB
rs1000789412 -- 627,041(+) GGGCC(C/T)GGGGG intron-variant, upstream-variant-2KB
rs1001696040 -- 627,333(+) CTCGG(C/T)CGGCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SCT Gene

Variant ID Type Subtype PubMed ID
dgv1522n54 CNV loss 21841781
dgv1523n54 CNV gain 21841781
dgv182e199 CNV deletion 23128226
esv2668299 CNV deletion 23128226
esv2759794 CNV loss 17122850
esv2762889 CNV loss 21179565
nsv1039558 CNV gain 25217958
nsv1053964 CNV gain 25217958
nsv1143528 CNV deletion 24896259
nsv1159791 CNV deletion 26073780
nsv467635 CNV loss 19166990
nsv469923 CNV loss 18288195
nsv552861 CNV loss 21841781
nsv552865 CNV loss 21841781
nsv552866 CNV loss 21841781
nsv951270 CNV deletion 24416366

Variation tolerance for SCT Gene

Gene Damage Index Score: 0.44; 9.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SCT Gene

Human Gene Mutation Database (HGMD)
SCT
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SCT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCT Gene

Disorders for SCT Gene

MalaCards: The human disease database

(44) MalaCards diseases for SCT Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
zollinger-ellison syndrome
  • gastrinoma
exocrine pancreatic insufficiency
gastrinoma
  • gastrin cell tumour
steatorrhea
  • fatty stool
pervasive developmental disorder
  • pervasive development disorder
- elite association - COSMIC cancer census association via MalaCards
Search SCT in MalaCards View complete list of genes associated with diseases

Relevant External Links for SCT

Genetic Association Database (GAD)
SCT
Human Genome Epidemiology (HuGE) Navigator
SCT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SCT
genes like me logo Genes that share disorders with SCT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SCT Gene

Publications for SCT Gene

  1. Human secretin (SCT): gene structure, chromosome location, and distribution of mRNA. (PMID: 11060443) Whitmore T.E. … Lok S. (Cytogenet. Cell Genet. 2000) 3 4 22 64
  2. Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients. (PMID: 20398908) Saus E. … Estivill X. (J Psychiatr Res 2010) 3 46 64
  3. Secretin inhibits cholangiocarcinoma growth via dysregulation of the cAMP-dependent signaling mechanisms of secretin receptor. (PMID: 19904746) Onori P. … Glaser S.S. (Int. J. Cancer 2010) 3 22 64
  4. Peptic ulceration may be a hormonal deficiency disease. (PMID: 18280672) Love J.W. (Med. Hypotheses 2008) 3 22 64
  5. Retinoic acid-induced human secretin gene expression in neuronal cells is mediated by cyclin-dependent kinase 1. (PMID: 16888198) Lee L.T. … Chow B.K. (Ann. N. Y. Acad. Sci. 2006) 3 22 64

Products for SCT Gene

Sources for SCT Gene

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