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Aliases for BGN Gene

Aliases for BGN Gene

  • Biglycan 2 3
  • Bone/Cartilage Proteoglycan I 3 4
  • Biglycan Proteoglycan 2 3
  • SLRR1A 3 4
  • PG-S1 3 4
  • Dermatan Sulphate Proteoglycan I 3
  • Bone/Cartilage Proteoglycan-I 3
  • Small Leucine-Rich Protein 1A 3
  • DSPG1 3
  • PGI 3

External Ids for BGN Gene

Summaries for BGN Gene

Entrez Gene Summary for BGN Gene

  • The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to two other small proteoglycans, decorin and fibromodulin. The encoded protein and decorin are thought to be the result of a gene duplication. Decorin contains one attached glycosaminoglycan chain, while this protein probably contains two chains. For this reason, this protein is called biglycan. This protein plays a role in assembly of collagen fibrils and muscle regeneration. It interacts with several proteins involved in muscular dystrophy, including alpha-dystroglycan, alpha- and gamma-sarcoglycan and collagen VI, and it is critical for the assembly of the dystrophin-associated protein complex. [provided by RefSeq, Nov 2009]

GeneCards Summary for BGN Gene

BGN (Biglycan) is a Protein Coding gene. Diseases associated with BGN include exposure keratitis. Among its related pathways are Disease and Degradation of the extracellular matrix. GO annotations related to this gene include extracellular matrix structural constituent and extracellular matrix binding. An important paralog of this gene is ECM2.

UniProtKB/Swiss-Prot for BGN Gene

  • May be involved in collagen fiber assembly.

Gene Wiki entry for BGN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BGN Gene

Genomics for BGN Gene

Genomic Location for BGN Gene

Start:
153,494,889 bp from pter
End:
153,509,554 bp from pter
Size:
14,666 bases
Orientation:
Plus strand

Genomic View for BGN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BGN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for BGN Gene

Regulatory Elements for BGN Gene

Proteins for BGN Gene

  • Protein details for BGN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21810-PGS1_HUMAN
    Recommended name:
    Biglycan
    Protein Accession:
    P21810
    Secondary Accessions:
    • D3DWU3
    • P13247

    Protein attributes for BGN Gene

    Size:
    368 amino acids
    Molecular mass:
    41654 Da
    Quaternary structure:
    • Homodimer. Forms a ternary complex with MFAP2 and ELN (By similarity).

neXtProt entry for BGN Gene

Proteomics data for BGN Gene at MOPED

Post-translational modifications for BGN Gene

  • The two attached glycosaminoglycan chains can be either chondroitin sulfate or dermatan sulfate.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Ser42, Ser47, Ser180, Ser198, Asn270, and Asn311

Other Protein References for BGN Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for BGN Gene

Domains for BGN Gene

Gene Families for BGN Gene

HGNC:
  • SLRR :Proteoglycans / Extracellular Matrix : Small leucine-rich repeats

UniProtKB/Swiss-Prot:

PGS1_HUMAN
Family:
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.:
    • P21810
Similarity:
  • Contains 12 LRR (leucine-rich) repeats.:
    • P21810
genes like me logo Genes that share domains with BGN: view

Function for BGN Gene

Molecular function for BGN Gene

GENATLAS Biochemistry: biglycan (small interstitial proteoglycan),leucine-rich repeat (LRR) family
UniProtKB/Swiss-Prot Function: May be involved in collagen fiber assembly.

Gene Ontology (GO) - Molecular Function for BGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005201 extracellular matrix structural constituent NAS 1860845
GO:0005515 protein binding --
GO:0005539 glycosaminoglycan binding IEA --
GO:0050840 extracellular matrix binding IEA --
genes like me logo Genes that share ontologies with BGN: view
genes like me logo Genes that share phenotypes with BGN: view

Animal Models for BGN Gene

MGI Knock Outs for BGN:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for BGN Gene

Localization for BGN Gene

Subcellular locations from UniProtKB/Swiss-Prot for BGN Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for BGN Gene COMPARTMENTS Subcellular localization image for BGN gene
Compartment Confidence
extracellular 5
golgi apparatus 4
lysosome 4
vacuole 4
cytoskeleton 2
cytosol 2
endoplasmic reticulum 2
mitochondrion 2
plasma membrane 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix NAS 1860845
GO:0005622 intracellular --
GO:0005796 Golgi lumen TAS --
GO:0009986 cell surface IDA 2212616
genes like me logo Genes that share ontologies with BGN: view

Pathways for BGN Gene

genes like me logo Genes that share pathways with BGN: view

Pathways by source for BGN Gene

Gene Ontology (GO) - Biological Process for BGN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001974 blood vessel remodeling IEA --
GO:0005975 carbohydrate metabolic process TAS --
GO:0008150 biological_process ND --
GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan IEA --
GO:0030198 extracellular matrix organization TAS --
genes like me logo Genes that share ontologies with BGN: view

Compounds for BGN Gene

(3) Novoseek inferred chemical compound relationships for BGN Gene

Compound -log(P) Hits PubMed IDs
chondroitin 68.4 1
leucine 35.6 1
dexamethasone 27.8 6
genes like me logo Genes that share compounds with BGN: view

Transcripts for BGN Gene

Unigene Clusters for BGN Gene

Biglycan:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for BGN Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b · 11c ^
SP1: -
SP2: - - -
SP3: - - - - - -
SP4: - - - - -
SP5: -
SP6:
SP7: - - - - - - - - - - - - - -
SP8: - - - - - - - - - -
SP9: -
SP10: - -
SP11: - - - - - - -

ExUns: 12a · 12b · 12c · 12d
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11: -

Relevant External Links for BGN Gene

GeneLoc Exon Structure for
BGN
ECgene alternative splicing isoforms for
BGN

Expression for BGN Gene

mRNA expression in normal human tissues for BGN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for BGN Gene

This gene is overexpressed in Artery - Aorta (14.8), Artery - Coronary (8.7), and Artery - Tibial (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for BGN Gene

SOURCE GeneReport for Unigene cluster for BGN Gene Hs.821

mRNA Expression by UniProt/SwissProt for BGN Gene

P21810-PGS1_HUMAN
Tissue specificity: Found in several connective tissues, especially in articular cartilages
genes like me logo Genes that share expressions with BGN: view

Orthologs for BGN Gene

This gene was present in the common ancestor of chordates.

Orthologs for BGN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BGN 36
  • 99.01 (n)
  • 99.67 (a)
BGN 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BGN 36
  • 90.85 (n)
  • 94.84 (a)
BGN 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BGN 36
  • 91.85 (n)
  • 94.84 (a)
BGN 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bgn 36
  • 88.59 (n)
  • 95.92 (a)
Bgn 16
Bgn 37
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 89 (a)
OneToMany
-- 37
  • 89 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Bgn 36
  • 88.59 (n)
  • 95.65 (a)
lizard
(Anolis carolinensis)
Reptilia BGN 37
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.939 36
tropical clawed frog
(Silurana tropicalis)
Amphibia bgn 36
  • 70.38 (n)
  • 77.45 (a)
zebrafish
(Danio rerio)
Actinopterygii bgna 37
  • 66 (a)
OneToMany
bgnb 36
  • 69.66 (n)
  • 72.47 (a)
bgnb 37
  • 69 (a)
OneToMany
Dr.16232 36
Species with no ortholog for BGN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for BGN Gene

ENSEMBL:
Gene Tree for BGN (if available)
TreeFam:
Gene Tree for BGN (if available)

Paralogs for BGN Gene

Paralogs for BGN Gene

Selected SIMAP similar genes for BGN Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with BGN: view

Variants for BGN Gene

Sequence variations from dbSNP and Humsavar for BGN Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs4833 -- 153,504,772(+) ACCTC(A/G)GGCGT synonymous-codon, reference
rs17678 -- 153,509,269(-) GTTTT(G/T)TGGGC utr-variant-3-prime
rs743641 -- 153,508,696(+) CTCCC(A/T)CCACA utr-variant-3-prime
rs743642 -- 153,508,763(+) CCAAG(G/T)CTCCA utr-variant-3-prime
rs880414 -- 153,502,355(+) GCAGG(A/G)GCATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for BGN Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV Gain+Loss 17666407
nsv522600 CNV Gain 19592680

Relevant External Links for BGN Gene

HapMap Linkage Disequilibrium report
BGN
Human Gene Mutation Database (HGMD)
BGN
Locus Specific Mutation Databases (LSDB)
BGN

Disorders for BGN Gene

(1) MalaCards Diseases for BGN Gene

Search for BGN Gene in MalaCards »

(4) University of Copenhagen DISEASES for BGN Gene

Relevant External Links for BGN

Genetic Association Database (GAD)
BGN
Human Genome Epidemiology (HuGE) Navigator
BGN
genes like me logo Genes that share disorders with BGN: view

No data available for UniProtKB/Swiss-Prot for BGN Gene

Publications for BGN Gene

  1. Smad4/DPC4-dependent regulation of biglycan gene expression by transforming growth factor-beta in pancreatic tumor cells. (PMID: 12140283) Chen W.B. … Ungefroren H. (J. Biol. Chem. 2002) 3 23
  2. Regulation of biglycan gene expression by transforming growth factor-beta requires MKK6-p38 mitogen-activated protein Kinase signaling downstream of Smad signaling. (PMID: 12538652) Ungefroren H. … Kalthoff H. (J. Biol. Chem. 2003) 3 23
  3. Fine mapping of the human biglycan (BGN) gene within the Xq28 region employing a hybrid cell panel. (PMID: 1612609) Traupe H. … Ropers H.H. (Genomics 1992) 2 3
  4. Human biglycan gene. Putative promoter, intron-exon junctions, and chromosomal localization. (PMID: 1860845) Fisher L.W. … Young M.F. (J. Biol. Chem. 1991) 3 4
  5. Dermatan sulphate proteoglycans of human articular cartilage. The properties of dermatan sulphate proteoglycans I and II. (PMID: 2590169) Roughley P.J. … White R.J. (Biochem. J. 1989) 3 4

Products for BGN Gene

Sources for BGN Gene

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