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Aliases for SERPINB4 Gene

Aliases for SERPINB4 Gene

  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 4 2 3
  • Squamous Cell Carcinoma Antigen 2 2 3 4
  • SCCA2 3 4 6
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 4 2 3
  • Peptidase Inhibitor 11 3 4
  • LEUPIN 3 4
  • SCCA-2 3 4
  • PI11 3 4
  • Protease Inhibitor (Leucine-Serpin) 3
  • Squamous Cell Carcinoma Antigen 1 3
  • SCCA2/SCCA1 Fusion Protein 3
  • Serpin B4 3
  • SCCA1 3
  • PI-11 4

External Ids for SERPINB4 Gene

Previous Symbols for SERPINB4 Gene

  • SCCA2

Summaries for SERPINB4 Gene

GeneCards Summary for SERPINB4 Gene

SERPINB4 (Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 4) is a Protein Coding gene. Diseases associated with SERPINB4 include inverted papilloma and burns. Among its related pathways are Amoebiasis. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is SERPINB12.

UniProtKB/Swiss-Prot for SERPINB4 Gene

  • May act as a protease inhibitor to modulate the host immune response against tumor cells

Gene Wiki entry for SERPINB4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINB4 Gene

Genomics for SERPINB4 Gene

Genomic Location for SERPINB4 Gene

Start:
63,637,259 bp from pter
End:
63,644,298 bp from pter
Size:
7,040 bases
Orientation:
Minus strand

Genomic View for SERPINB4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SERPINB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINB4 Gene

Regulatory Elements for SERPINB4 Gene

Proteins for SERPINB4 Gene

  • Protein details for SERPINB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48594-SPB4_HUMAN
    Recommended name:
    Serpin B4
    Protein Accession:
    P48594
    Secondary Accessions:
    • A8K847

    Protein attributes for SERPINB4 Gene

    Size:
    390 amino acids
    Molecular mass:
    44854 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SERPINB4 Gene

Proteomics data for SERPINB4 Gene at MOPED

Post-translational modifications for SERPINB4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERPINB4 Gene

No data available for DME Specific Peptides for SERPINB4 Gene

Domains for SERPINB4 Gene

Gene Families for SERPINB4 Gene

HGNC:
  • SERPIN :Serine (or cysteine) peptidase inhibitors

Protein Domains for SERPINB4 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

SPB4_HUMAN
Family:
  • Belongs to the serpin family. Ov-serpin subfamily.:
    • P48594
genes like me logo Genes that share domains with SERPINB4: view

Function for SERPINB4 Gene

Molecular function for SERPINB4 Gene

UniProtKB/Swiss-Prot Function: May act as a protease inhibitor to modulate the host immune response against tumor cells

Gene Ontology (GO) - Molecular Function for SERPINB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 21857942
GO:0004867 serine-type endopeptidase inhibitor activity NAS 7589435
GO:0019899 enzyme binding IPI 23382074
genes like me logo Genes that share ontologies with SERPINB4: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SERPINB4 Gene

Localization for SERPINB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINB4 Gene

Cytoplasm. Note=Seems to also be secreted in plasma by cancerous cells but at a low level.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERPINB4 Gene COMPARTMENTS Subcellular localization image for SERPINB4 gene
Compartment Confidence
extracellular 3
cytosol 2
nucleus 2
golgi apparatus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for SERPINB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IBA --
GO:0005622 intracellular IDA 21857942
GO:0005737 cytoplasm IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with SERPINB4: view

Pathways for SERPINB4 Gene

SuperPathways for SERPINB4 Gene

Superpath Contained pathways
1 Amoebiasis
genes like me logo Genes that share pathways with SERPINB4: view

Pathways by source for SERPINB4 Gene

1 KEGG pathway for SERPINB4 Gene

Gene Ontology (GO) - Biological Process for SERPINB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010466 negative regulation of peptidase activity IDA 12949073
GO:0010951 negative regulation of endopeptidase activity IBA --
GO:0030162 regulation of proteolysis NAS 7589435
GO:0042270 protection from natural killer cell mediated cytotoxicity IMP 21857942
genes like me logo Genes that share ontologies with SERPINB4: view

Compounds for SERPINB4 Gene

(3) Novoseek inferred chemical compound relationships for SERPINB4 Gene

Compound -log(P) Hits PubMed IDs
scca1 99.4 138
serine 66.8 21
cysteine 59.8 21
genes like me logo Genes that share compounds with SERPINB4: view

Transcripts for SERPINB4 Gene

Unigene Clusters for SERPINB4 Gene

Serpin peptidase inhibitor, clade B (ovalbumin), member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB4 Gene

No ASD Table

Relevant External Links for SERPINB4 Gene

GeneLoc Exon Structure for
SERPINB4
ECgene alternative splicing isoforms for
SERPINB4

Expression for SERPINB4 Gene

mRNA expression in normal human tissues for SERPINB4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SERPINB4 Gene

This gene is overexpressed in Vagina (20.0), Esophagus - Mucosa (13.4), Cervix - Ectocervix (12.7), and Minor Salivary Gland (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SERPINB4 Gene

SOURCE GeneReport for Unigene cluster for SERPINB4 Gene Hs.123035

mRNA Expression by UniProt/SwissProt for SERPINB4 Gene

P48594-SPB4_HUMAN
Tissue specificity: Squamous cells
genes like me logo Genes that share expressions with SERPINB4: view

Orthologs for SERPINB4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SERPINB4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERPINB4 36
  • 98.03 (n)
  • 97.17 (a)
cow
(Bos Taurus)
Mammalia -- 37
  • 66 (a)
ManyToMany
-- 37
  • 64 (a)
ManyToMany
-- 37
  • 68 (a)
ManyToMany
-- 37
  • 64 (a)
ManyToMany
LOC100337240 36
  • 75.32 (n)
  • 66.96 (a)
SERPINB4 37
  • 66 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 63 (a)
OneToMany
SERPINB4 36
  • 77.69 (n)
  • 68.22 (a)
mouse
(Mus musculus)
Mammalia Serpinb3a 36
  • 71.68 (n)
  • 60.88 (a)
Serpinb3a 37
  • 61 (a)
ManyToMany
Serpinb3b 37
  • 59 (a)
ManyToMany
Serpinb3c 16
Serpinb3c 37
  • 58 (a)
ManyToMany
Serpinb3d 37
  • 60 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 52 (a)
ManyToMany
-- 37
  • 52 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 52 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Serpinb3a 36
  • 71.16 (n)
  • 60.1 (a)
chicken
(Gallus gallus)
Aves OVALY 36
  • 56.88 (n)
  • 45.71 (a)
OVALY 37
  • 45 (a)
ManyToMany
SERPINB14 37
  • 38 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 50 (a)
ManyToMany
-- 37
  • 49 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490314 36
  • 55.07 (n)
  • 43.3 (a)
fruit fly
(Drosophila melanogaster)
Insecta Spn42Dd 36
  • 49.38 (n)
  • 39.6 (a)
Spn43Ab 38
  • 27 (a)
serpin-27A 38
  • 34 (a)
Spn5 38
  • 29 (a)
Spn3 38
  • 33 (a)
Spn2 38
  • 34 (a)
Spn43Aa 38
  • 32 (a)
CG9455 38
  • 34 (a)
CG9460 38
  • 33 (a)
CG6687 38
  • 27 (a)
Spn1 38
  • 36 (a)
nec 38
  • 28 (a)
CG6717 38
  • 30 (a)
Spn6 38
  • 34 (a)
CG7722 38
  • 28 (a)
Spn4 38
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea srp-5 36
  • 49.09 (n)
  • 38.18 (a)
srp-7 38
  • 32 (a)
srp-1 38
  • 29 (a)
srp-6 38
  • 29 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons SRP3 36
  • 47.47 (n)
  • 37.15 (a)
rice
(Oryza sativa)
Liliopsida Os03g0610700 36
  • 47.62 (n)
  • 42.35 (a)
Species with no ortholog for SERPINB4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SERPINB4 Gene

ENSEMBL:
Gene Tree for SERPINB4 (if available)
TreeFam:
Gene Tree for SERPINB4 (if available)

Paralogs for SERPINB4 Gene

genes like me logo Genes that share paralogs with SERPINB4: view

Variants for SERPINB4 Gene

Sequence variations from dbSNP and Humsavar for SERPINB4 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs471015 -- 63,645,044(+) atgtt(A/G/T)ttgga upstream-variant-2KB
rs642038 -- 63,645,121(-) ctgag(A/G)cttat upstream-variant-2KB
rs690543 -- 63,637,379(+) AAATT(A/C/G/T)GAAGA utr-variant-3-prime
rs1829798 -- 63,645,275(+) CTTTT(A/T)CTTGC upstream-variant-2KB
rs1829799 -- 63,645,296(+) TATGT(C/T)TTTAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SERPINB4 Gene

Variant ID Type Subtype PubMed ID
nsv833672 CNV Gain 17160897
esv2313855 CNV Deletion 18987734
esv2717205 CNV Deletion 23290073

Relevant External Links for SERPINB4 Gene

HapMap Linkage Disequilibrium report
SERPINB4
Human Gene Mutation Database (HGMD)
SERPINB4

Disorders for SERPINB4 Gene

(11) Novoseek inferred disease relationships for SERPINB4 Gene

Disease -log(P) Hits PubMed IDs
carcinoma squamous cell 79.4 37
squamous cell cancer 52.2 2
cervical cancer 34.3 6
tumors 23.5 15
cancer 21.5 11

Relevant External Links for SERPINB4

Human Genome Epidemiology (HuGE) Navigator
SERPINB4
genes like me logo Genes that share disorders with SERPINB4: view

No data available for UniProtKB/Swiss-Prot for SERPINB4 Gene

Publications for SERPINB4 Gene

  1. A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene. (PMID: 7724531) Schneider S.S. … Silverman G.A. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4 23
  2. Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells. (PMID: 10956412) Uemura Y. … Silverman G.A. (Int. J. Cancer 2000) 3 4 23
  3. Molecular cloning of human squamous cell carcinoma antigen 1 gene and characterization of its promoter. (PMID: 11267667) Hamada K. … Ito M. (Biochim. Biophys. Acta 2001) 3 4 23
  4. The squamous cell carcinoma antigen 2 inhibits the cysteine proteinase activity of a major mite allergen, Der p 1. (PMID: 14630915) Sakata Y. … Izuhara K. (J. Biol. Chem. 2004) 2 3 23
  5. Identification of a novel human serpin gene; cloning sequencing and expression of leupin. (PMID: 7589435) Barnes R.C. … Worrall D.M. (FEBS Lett. 1995) 3 4 23

Products for SERPINB4 Gene

Sources for SERPINB4 Gene

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