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Aliases for SERPINB4 Gene

Aliases for SERPINB4 Gene

  • Serpin Family B Member 4 2 3
  • Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 4 2 3 5
  • Squamous Cell Carcinoma Antigen 2 2 3 4
  • Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 4 2 3
  • Peptidase Inhibitor 11 3 4
  • LEUPIN 3 4
  • SCCA-2 3 4
  • SCCA2 3 4
  • PI11 3 4
  • Protease Inhibitor (Leucine-Serpin) 3
  • Squamous Cell Carcinoma Antigen 1 3
  • SCCA2/SCCA1 Fusion Protein 3
  • SCCA1 3
  • PI-11 4

External Ids for SERPINB4 Gene

Previous HGNC Symbols for SERPINB4 Gene

  • SCCA2

Previous GeneCards Identifiers for SERPINB4 Gene

  • GC18M061143
  • GC18M061277
  • GC18M059456
  • GC18M059419
  • GC18M059458
  • GC18M059459
  • GC18M058004

Summaries for SERPINB4 Gene

GeneCards Summary for SERPINB4 Gene

SERPINB4 (Serpin Family B Member 4) is a Protein Coding gene. Diseases associated with SERPINB4 include inverted papilloma and cervical squamous cell carcinoma. Among its related pathways are Amoebiasis. GO annotations related to this gene include enzyme binding and protease binding. An important paralog of this gene is SERPINB12.

UniProtKB/Swiss-Prot for SERPINB4 Gene

  • May act as a protease inhibitor to modulate the host immune response against tumor cells.

Gene Wiki entry for SERPINB4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SERPINB4 Gene

Genomics for SERPINB4 Gene

Regulatory Elements for SERPINB4 Gene

Genomic Location for SERPINB4 Gene

Chromosome:
18
Start:
63,637,259 bp from pter
End:
63,644,319 bp from pter
Size:
7,061 bases
Orientation:
Minus strand

Genomic View for SERPINB4 Gene

Genes around SERPINB4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SERPINB4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SERPINB4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SERPINB4 Gene

Proteins for SERPINB4 Gene

  • Protein details for SERPINB4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48594-SPB4_HUMAN
    Recommended name:
    Serpin B4
    Protein Accession:
    P48594
    Secondary Accessions:
    • A8K847

    Protein attributes for SERPINB4 Gene

    Size:
    390 amino acids
    Molecular mass:
    44854 Da
    Quaternary structure:
    No Data Available

neXtProt entry for SERPINB4 Gene

Proteomics data for SERPINB4 Gene at MOPED

Post-translational modifications for SERPINB4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SERPINB4 Gene

Antibody Products

No data available for DME Specific Peptides for SERPINB4 Gene

Domains & Families for SERPINB4 Gene

Gene Families for SERPINB4 Gene

Protein Domains for SERPINB4 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P48594

UniProtKB/Swiss-Prot:

SPB4_HUMAN :
  • Belongs to the serpin family. Ov-serpin subfamily.
Family:
  • Belongs to the serpin family. Ov-serpin subfamily.
genes like me logo Genes that share domains with SERPINB4: view

Function for SERPINB4 Gene

Molecular function for SERPINB4 Gene

UniProtKB/Swiss-Prot Function:
May act as a protease inhibitor to modulate the host immune response against tumor cells.

Gene Ontology (GO) - Molecular Function for SERPINB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 21857942
genes like me logo Genes that share ontologies with SERPINB4: view

Phenotypes for SERPINB4 Gene

GenomeRNAi human phenotypes for SERPINB4:
MGI mutant phenotypes for SERPINB4:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with SERPINB4: view

Animal Models for SERPINB4 Gene

MGI Knock Outs for SERPINB4:

Animal Model Products

  • Taconic Biosciences Mouse Models for SERPINB4

CRISPR Products

miRNA for SERPINB4 Gene

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SERPINB4 Gene

Localization for SERPINB4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SERPINB4 Gene

Cytoplasm. Note=Seems to also be secreted in plasma by cancerous cells but at a low level.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SERPINB4 Gene COMPARTMENTS Subcellular localization image for SERPINB4 gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2
golgi apparatus 1
lysosome 1
plasma membrane 1
vacuole 1

Gene Ontology (GO) - Cellular Components for SERPINB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with SERPINB4: view

Pathways & Interactions for SERPINB4 Gene

SuperPathways for SERPINB4 Gene

Superpath Contained pathways
1 Amoebiasis
genes like me logo Genes that share pathways with SERPINB4: view

Pathways by source for SERPINB4 Gene

1 KEGG pathway for SERPINB4 Gene

Gene Ontology (GO) - Biological Process for SERPINB4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010951 negative regulation of endopeptidase activity NAS 7589435
GO:0030162 regulation of proteolysis NAS 7589435
genes like me logo Genes that share ontologies with SERPINB4: view

No data available for SIGNOR curated interactions for SERPINB4 Gene

Drugs & Compounds for SERPINB4 Gene

(2) Drugs for SERPINB4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for SERPINB4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SERPINB4: view

Transcripts for SERPINB4 Gene

Unigene Clusters for SERPINB4 Gene

Serpin peptidase inhibitor, clade B (ovalbumin), member 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SERPINB4 Gene

No ASD Table

Relevant External Links for SERPINB4 Gene

GeneLoc Exon Structure for
SERPINB4
ECgene alternative splicing isoforms for
SERPINB4

Expression for SERPINB4 Gene

mRNA expression in normal human tissues for SERPINB4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SERPINB4 Gene

This gene is overexpressed in Vagina (x20.0), Esophagus - Mucosa (x13.4), Cervix - Ectocervix (x12.7), and Minor Salivary Gland (x5.2).

Protein differential expression in normal tissues from HIPED for SERPINB4 Gene

This gene is overexpressed in Cervix (24.7), Nasal epithelium (19.0), and Stomach (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SERPINB4 Gene



SOURCE GeneReport for Unigene cluster for SERPINB4 Gene Hs.123035

mRNA Expression by UniProt/SwissProt for SERPINB4 Gene

P48594-SPB4_HUMAN
Tissue specificity: Squamous cells.
genes like me logo Genes that share expression patterns with SERPINB4: view

Protein tissue co-expression partners for SERPINB4 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SERPINB4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for SERPINB4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SERPINB4 35
  • 98.03 (n)
  • 97.17 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 66 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
-- 36
  • 68 (a)
ManyToMany
-- 36
  • 64 (a)
ManyToMany
SERPINB4 36
  • 66 (a)
ManyToMany
LOC100337240 35
  • 75.32 (n)
  • 66.96 (a)
dog
(Canis familiaris)
Mammalia SERPINB4 35
  • 77.69 (n)
  • 68.22 (a)
-- 36
  • 63 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Serpinb3a 36
  • 61 (a)
ManyToMany
Serpinb3b 36
  • 59 (a)
ManyToMany
Serpinb3c 36
  • 58 (a)
ManyToMany
Serpinb3d 36
  • 60 (a)
ManyToMany
Serpinb3a 35
  • 71.68 (n)
  • 60.88 (a)
Serpinb3a 16
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 52 (a)
ManyToMany
-- 36
  • 52 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 52 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Serpinb3a 35
  • 71.16 (n)
  • 60.1 (a)
chicken
(Gallus gallus)
Aves OVALY 35
  • 56.88 (n)
  • 45.71 (a)
OVALY 36
  • 45 (a)
ManyToMany
SERPINB14 36
  • 38 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 50 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490314 35
  • 55.07 (n)
  • 43.3 (a)
fruit fly
(Drosophila melanogaster)
Insecta Spn42Dd 35
  • 49.38 (n)
  • 39.6 (a)
CG6687 37
  • 27 (a)
CG6717 37
  • 30 (a)
CG7722 37
  • 28 (a)
CG9455 37
  • 34 (a)
CG9460 37
  • 33 (a)
nec 37
  • 28 (a)
serpin-27A 37
  • 34 (a)
Spn1 37
  • 36 (a)
Spn2 37
  • 34 (a)
Spn3 37
  • 33 (a)
Spn4 37
  • 37 (a)
Spn43Aa 37
  • 32 (a)
Spn43Ab 37
  • 27 (a)
Spn5 37
  • 29 (a)
Spn6 37
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea srp-1 37
  • 29 (a)
srp-6 37
  • 29 (a)
srp-7 37
  • 32 (a)
srp-5 35
  • 49.09 (n)
  • 38.18 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons SRP3 35
  • 47.47 (n)
  • 37.15 (a)
rice
(Oryza sativa)
Liliopsida Os03g0610700 35
  • 47.62 (n)
  • 42.35 (a)
Species with no ortholog for SERPINB4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SERPINB4 Gene

ENSEMBL:
Gene Tree for SERPINB4 (if available)
TreeFam:
Gene Tree for SERPINB4 (if available)

Paralogs for SERPINB4 Gene

genes like me logo Genes that share paralogs with SERPINB4: view

Variants for SERPINB4 Gene

Sequence variations from dbSNP and Humsavar for SERPINB4 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs471015 -- 63,645,044(+) atgtt(A/G/T)ttgga upstream-variant-2KB
rs642038 -- 63,645,121(-) ctgag(A/G)cttat upstream-variant-2KB
rs1829798 -- 63,645,275(+) CTTTT(A/T)CTTGC upstream-variant-2KB
rs1829799 -- 63,645,296(+) TATGT(C/T)TTTAT upstream-variant-2KB
rs3760573 -- 63,644,604(+) CAAAA(A/C)CAAAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SERPINB4 Gene

Variant ID Type Subtype PubMed ID
nsv833672 CNV Gain 17160897
esv2313855 CNV Deletion 18987734
esv2717205 CNV Deletion 23290073

Variation tolerance for SERPINB4 Gene

Residual Variation Intolerance Score: 77.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.17; 39.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SERPINB4 Gene

HapMap Linkage Disequilibrium report
SERPINB4
Human Gene Mutation Database (HGMD)
SERPINB4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SERPINB4 Gene

Disorders for SERPINB4 Gene

MalaCards: The human disease database

(3) MalaCards diseases for SERPINB4 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
inverted papilloma
  • inverted papilloma, squamous cell
cervical squamous cell carcinoma
  • squamous cell carcinoma of cervix
chromosome 18q deletion syndrome
  • de grouchy syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SERPINB4

Human Genome Epidemiology (HuGE) Navigator
SERPINB4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SERPINB4
genes like me logo Genes that share disorders with SERPINB4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SERPINB4 Gene

Publications for SERPINB4 Gene

  1. A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene. (PMID: 7724531) Schneider S.S. … Silverman G.A. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 4 23 67
  2. The squamous cell carcinoma antigen 2 inhibits the cysteine proteinase activity of a major mite allergen, Der p 1. (PMID: 14630915) Sakata Y. … Izuhara K. (J. Biol. Chem. 2004) 2 3 23
  3. Update of the human and mouse SERPIN gene superfamily. (PMID: 24172014) Heit C. … Vasiliou V. (Hum. Genomics 2013) 2 3
  4. Heparin enhances serpin inhibition of the cysteine protease cathepsin L. (PMID: 19959474) Higgins W.J. … Worrall D.M. (J. Biol. Chem. 2010) 3 23
  5. New horny layer marker proteins for evaluating skin condition in atopic dermatitis. (PMID: 19339807) Yamane Y. … Miyazaki K. (Int. Arch. Allergy Immunol. 2009) 3 23

Products for SERPINB4 Gene

Sources for SERPINB4 Gene

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