Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TSPAN31 Gene

Aliases for TSPAN31 Gene

  • Tetraspanin 31 2 3 5
  • Sarcoma-Amplified Sequence 3 4
  • Tspan-31 3 4
  • SAS 3 4
  • Sarcoma Amplified Sequence 2
  • Transmembrane 4 Protein 3
  • Tetraspanin-31 3

External Ids for TSPAN31 Gene

Previous HGNC Symbols for TSPAN31 Gene

  • SAS

Previous GeneCards Identifiers for TSPAN31 Gene

  • GC12P056426
  • GC12P058138
  • GC12P055175

Summaries for TSPAN31 Gene

Entrez Gene Summary for TSPAN31 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is thought to be involved in growth-related cellular processes. This gene is associated with tumorigenesis and osteosarcoma. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSPAN31 Gene

TSPAN31 (Tetraspanin 31) is a Protein Coding gene. Diseases associated with TSPAN31 include Liposarcoma and Atypical Lipomatous Tumor. An important paralog of this gene is TSPAN13.

Gene Wiki entry for TSPAN31 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN31 Gene

Genomics for TSPAN31 Gene

Regulatory Elements for TSPAN31 Gene

Enhancers for TSPAN31 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G057109 1.5 ENCODE dbSUPER 33.4 -626.8 -626760 3.8 CREB3L1 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 SP3 MCM3 NEMP1 SMARCC2 ENSG00000257740 ANKRD52 BAZ2A NAB2 ENSG00000224713 CTDSP2 LOC283387 RN7SL809P
GH12G056835 1.3 Ensembl ENCODE 12.3 -901.3 -901321 1.4 HDGF CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 FOS SP3 ANKRD52 NEMP1 TSPAN31 ENSG00000212383 BAZ2A GPR182 RDH16 ENSG00000224713 SDR9C7 ENSG00000273536
GH12G057454 1.6 Ensembl ENCODE dbSUPER 9.7 -282.2 -282243 3.5 HDGF PKNOX1 MLX CREB3L1 ARNT ARID4B DMAP1 ZNF2 YY1 ZNF766 NEMP1 ENSG00000224713 LOC283387 BAZ2A RN7SL809P RNU6-343P CTDSP2 RBMS2 TSPAN31 ARHGAP9
GH12G057830 2 FANTOM5 Ensembl ENCODE dbSUPER 7.7 +101.5 101467 17.0 MLX FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC ZNF610 GLIS1 EEF1AKMT3 TSFM ATP23 METTL1 CTDSP2 TSPAN31 CDK4 AGAP2 LOC283387 PIR34053
GH12G057245 1.2 ENCODE dbSUPER 12.3 -492.8 -492781 0.2 PKNOX1 ZNF2 YY2 REST ZNF662 ZNF491 ZNF518A ZNF610 GLIS1 ZNF624 ENSG00000257740 ANKRD52 LOC283387 NAB2 TSPAN31 NXPH4 ZBTB39 NEMP1 ARHGEF25 B4GALNT1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TSPAN31 on UCSC Golden Path with GeneCards custom track

Genomic Location for TSPAN31 Gene

Chromosome:
12
Start:
57,738,013 bp from pter
End:
57,750,211 bp from pter
Size:
12,199 bases
Orientation:
Plus strand

Genomic View for TSPAN31 Gene

Genes around TSPAN31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN31 Gene

Proteins for TSPAN31 Gene

  • Protein details for TSPAN31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12999-TSN31_HUMAN
    Recommended name:
    Tetraspanin-31
    Protein Accession:
    Q12999
    Secondary Accessions:
    • O00577
    • Q53X76

    Protein attributes for TSPAN31 Gene

    Size:
    210 amino acids
    Molecular mass:
    23053 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TSPAN31 Gene

Post-translational modifications for TSPAN31 Gene

  • Glycosylation at isoforms=100, isoforms=109, Asn117, and isoforms=134
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TSPAN31 Gene

Domains & Families for TSPAN31 Gene

Gene Families for TSPAN31 Gene

Protein Domains for TSPAN31 Gene

Graphical View of Domain Structure for InterPro Entry

Q12999

UniProtKB/Swiss-Prot:

TSN31_HUMAN :
  • Belongs to the tetraspanin (TM4SF) family.
Family:
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN31: view

Function for TSPAN31 Gene

Phenotypes for TSPAN31 Gene

genes like me logo Genes that share phenotypes with TSPAN31: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TSPAN31

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPAN31 Gene

Localization for TSPAN31 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN31 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSPAN31 gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TSPAN31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 8134123
GO:0016020 membrane TAS,IEA 8134123
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TSPAN31: view

Pathways & Interactions for TSPAN31 Gene

SuperPathways for TSPAN31 Gene

No Data Available

Interacting Proteins for TSPAN31 Gene

Gene Ontology (GO) - Biological Process for TSPAN31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0008284 positive regulation of cell proliferation TAS 8134123
genes like me logo Genes that share ontologies with TSPAN31: view

No data available for Pathways by source and SIGNOR curated interactions for TSPAN31 Gene

Transcripts for TSPAN31 Gene

Unigene Clusters for TSPAN31 Gene

Tetraspanin 31:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN31 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - -
SP6: - -
SP7:
SP8: -

Relevant External Links for TSPAN31 Gene

GeneLoc Exon Structure for
TSPAN31
ECgene alternative splicing isoforms for
TSPAN31

Expression for TSPAN31 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSPAN31 Gene

Protein differential expression in normal tissues from HIPED for TSPAN31 Gene

This gene is overexpressed in Pancreas (30.3), Colon (12.1), and Fetal gut (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TSPAN31 Gene



NURSA nuclear receptor signaling pathways regulating expression of TSPAN31 Gene:

TSPAN31

SOURCE GeneReport for Unigene cluster for TSPAN31 Gene:

Hs.632708

Evidence on tissue expression from TISSUES for TSPAN31 Gene

  • Nervous system(3.2)
genes like me logo Genes that share expression patterns with TSPAN31: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSPAN31 Gene

Orthologs for TSPAN31 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN31 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TSPAN31 34 35
  • 99.84 (n)
dog
(Canis familiaris)
Mammalia TSPAN31 34
  • 94.13 (n)
SAS 35
  • 85 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TSPAN31 34 35
  • 93.81 (n)
mouse
(Mus musculus)
Mammalia Tspan31 34 16 35
  • 86.51 (n)
rat
(Rattus norvegicus)
Mammalia Tspan31 34
  • 85.87 (n)
lizard
(Anolis carolinensis)
Reptilia TSPAN31 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tspan31 34
  • 67.15 (n)
Str.10756 34
zebrafish
(Danio rerio)
Actinopterygii sas 35 34
  • 65.87 (n)
OneToOne
zgc56710 34
fruit fly
(Drosophila melanogaster)
Insecta Tsp97E 35
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10763 35
  • 42 (a)
OneToMany
Species where no ortholog for TSPAN31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSPAN31 Gene

ENSEMBL:
Gene Tree for TSPAN31 (if available)
TreeFam:
Gene Tree for TSPAN31 (if available)

Paralogs for TSPAN31 Gene

Paralogs for TSPAN31 Gene

(2) SIMAP similar genes for TSPAN31 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with TSPAN31: view

Variants for TSPAN31 Gene

Sequence variations from dbSNP and Humsavar for TSPAN31 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs113625101 Likely benign 57,748,004(+) CCCAA(C/T)GTGCT utr-variant-3-prime
rs115576923 Likely benign 57,748,603(+) GGGTT(A/G)AAAGT downstream-variant-500B, reference, synonymous-codon
rs2069511 Likely benign 57,748,315(-) GGTAT(A/G)TTCCC downstream-variant-500B, utr-variant-3-prime
rs2227954 Uncertain significance 57,748,551(-) ATCTA(C/T)ATAAG downstream-variant-500B, reference, missense
rs587779897 Uncertain significance 57,748,575(-) CCTTT(A/C/G)GAGCT downstream-variant-500B, reference, synonymous-codon, missense

Structural Variations from Database of Genomic Variants (DGV) for TSPAN31 Gene

Variant ID Type Subtype PubMed ID
nsv470296 CNV loss 18288195
nsv470297 CNV gain 18288195
nsv510601 CNV deletion 20534489
nsv559045 CNV loss 21841781
nsv819021 CNV loss 19587683
nsv826384 CNV gain 20364138
nsv826386 CNV gain 20364138

Variation tolerance for TSPAN31 Gene

Residual Variation Intolerance Score: 32.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSPAN31 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TSPAN31

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN31 Gene

Disorders for TSPAN31 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TSPAN31 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
liposarcoma
atypical lipomatous tumor
  • liposarcoma, well differentiated
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TSPAN31

Genetic Association Database (GAD)
TSPAN31
Human Genome Epidemiology (HuGE) Navigator
TSPAN31
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TSPAN31
genes like me logo Genes that share disorders with TSPAN31: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSPAN31 Gene

Publications for TSPAN31 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Amplification of CDK4, MDM2, SAS and GLI genes in leiomyosarcoma, alveolar and embryonal rhabdomyosarcoma. (PMID: 15024701) Ragazzini P. … Benassi M.S. (Histol. Histopathol. 2004) 3 22 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers. (PMID: 9192850) Elkahloun A.G. … Meltzer P.S. (Genomics 1997) 3 4 64

Products for TSPAN31 Gene

Sources for TSPAN31 Gene

Content
Loading form....