Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TSPAN31 Gene

Aliases for TSPAN31 Gene

  • Tetraspanin 31 2 3 5
  • Sarcoma-Amplified Sequence 3 4
  • Tspan-31 3 4
  • SAS 3 4
  • Sarcoma Amplified Sequence 2
  • Transmembrane 4 Protein 3
  • Tetraspanin-31 3

External Ids for TSPAN31 Gene

Previous HGNC Symbols for TSPAN31 Gene

  • SAS

Previous GeneCards Identifiers for TSPAN31 Gene

  • GC12P056426
  • GC12P058138
  • GC12P055175

Summaries for TSPAN31 Gene

Entrez Gene Summary for TSPAN31 Gene

  • The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is thought to be involved in growth-related cellular processes. This gene is associated with tumorigenesis and osteosarcoma. [provided by RefSeq, Jul 2008]

GeneCards Summary for TSPAN31 Gene

TSPAN31 (Tetraspanin 31) is a Protein Coding gene. Diseases associated with TSPAN31 include Atypical Lipomatous Tumor and Malignant Fibroxanthoma. An important paralog of this gene is TSPAN13.

Gene Wiki entry for TSPAN31 Gene

Additional gene information for TSPAN31 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TSPAN31 Gene

Genomics for TSPAN31 Gene

Regulatory Elements for TSPAN31 Gene

Enhancers for TSPAN31 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H057109 1.5 ENCODE dbSUPER 33.4 -626.8 -626760 3.8 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 SP3 MCM3 MEF2D SSRP1 NEMP1 BAZ2A EEF1AKMT3 ENSG00000257740 SMARCC2 CDK4 CTDSP2 PAN2 ANKRD52 DTX3
GH12H057590 1.1 ENCODE 19.9 -146.6 -146592 1.9 HDGF ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF143 ZNF207 SP3 MXD4 ENSG00000224713 NEMP1 SLC26A10 LOC283387 TSPAN31 TSFM EEF1AKMT3 ARHGEF25 CDK4 CTDSP2
GH12H057516 1.4 ENCODE dbSUPER 11.9 -216.9 -216925 8.8 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC ZFP41 MEF2D NEMP1 BAZ2A RN7SL809P DTX3 ZBTB39 MBD6 ENSG00000224713 CTDSP2 EEF1AKMT3 DCTN2
GH12H057454 1.6 Ensembl ENCODE dbSUPER 9.8 -282.2 -282243 3.5 HDGF PKNOX1 MLX ARNT ARID4B DMAP1 ZNF2 YY1 ZNF766 CBX5 NEMP1 BAZ2A ENSG00000224713 MBD6 SLC26A10 RPL13AP23 LINC02403 RPL21P103 RN7SL809P RNU6-343P
GH12H057279 1.3 Ensembl ENCODE 11.9 -457.7 -457692 2.1 HDGF FOXA2 PKNOX1 ATF1 ARID4B SIN3A GATA2 ZNF143 ZNF207 FOS EEF1AKMT3 NEMP1 PAN2 CDK4 ENSG00000224713 TSPAN31 CTDSP2 LOC283387 SHMT2 NXPH4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TSPAN31 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TSPAN31 Gene

Genomic Locations for TSPAN31 Gene
12,199 bases
Plus strand

Genomic View for TSPAN31 Gene

Genes around TSPAN31 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TSPAN31 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TSPAN31 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TSPAN31 Gene

Proteins for TSPAN31 Gene

  • Protein details for TSPAN31 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • O00577
    • Q53X76

    Protein attributes for TSPAN31 Gene

    210 amino acids
    Molecular mass:
    23053 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TSPAN31 Gene

Post-translational modifications for TSPAN31 Gene

  • Glycosylation at posLast=100100, Asn109, posLast=117117, and Asn134
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TSPAN31 Gene

Domains & Families for TSPAN31 Gene

Gene Families for TSPAN31 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for TSPAN31 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the tetraspanin (TM4SF) family.
  • Belongs to the tetraspanin (TM4SF) family.
genes like me logo Genes that share domains with TSPAN31: view

Function for TSPAN31 Gene

Phenotypes From GWAS Catalog for TSPAN31 Gene

Phenotypes for TSPAN31 Gene

genes like me logo Genes that share phenotypes with TSPAN31: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TSPAN31 Gene

Localization for TSPAN31 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TSPAN31 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TSPAN31 gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for TSPAN31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 8134123
GO:0016020 membrane TAS,IEA 8134123
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TSPAN31: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TSPAN31 Gene

Pathways & Interactions for TSPAN31 Gene

SuperPathways for TSPAN31 Gene

No Data Available

Interacting Proteins for TSPAN31 Gene

Gene Ontology (GO) - Biological Process for TSPAN31 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IBA --
GO:0008284 positive regulation of cell proliferation TAS 8134123
genes like me logo Genes that share ontologies with TSPAN31: view

No data available for Pathways by source and SIGNOR curated interactions for TSPAN31 Gene

Drugs & Compounds for TSPAN31 Gene

No Compound Related Data Available

Transcripts for TSPAN31 Gene

Unigene Clusters for TSPAN31 Gene

Tetraspanin 31:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TSPAN31 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - - -
SP5: - - -
SP6: - -
SP8: -

Relevant External Links for TSPAN31 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TSPAN31 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TSPAN31 Gene

Protein differential expression in normal tissues from HIPED for TSPAN31 Gene

This gene is overexpressed in Pancreas (30.3), Colon (12.1), and Fetal gut (10.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TSPAN31 Gene

NURSA nuclear receptor signaling pathways regulating expression of TSPAN31 Gene:


SOURCE GeneReport for Unigene cluster for TSPAN31 Gene:


Evidence on tissue expression from TISSUES for TSPAN31 Gene

  • Nervous system(3.2)
genes like me logo Genes that share expression patterns with TSPAN31: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TSPAN31 Gene

Orthologs for TSPAN31 Gene

This gene was present in the common ancestor of animals.

Orthologs for TSPAN31 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TSPAN31 33 34
  • 99.84 (n)
(Canis familiaris)
Mammalia TSPAN31 33
  • 94.13 (n)
SAS 34
  • 85 (a)
(Bos Taurus)
Mammalia TSPAN31 33 34
  • 93.81 (n)
(Mus musculus)
Mammalia Tspan31 33 16 34
  • 86.51 (n)
(Rattus norvegicus)
Mammalia Tspan31 33
  • 85.87 (n)
(Anolis carolinensis)
Reptilia TSPAN31 34
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tspan31 33
  • 67.15 (n)
Str.10756 33
(Danio rerio)
Actinopterygii sas 33 34
  • 65.87 (n)
zgc56710 33
fruit fly
(Drosophila melanogaster)
Insecta Tsp97E 34
  • 35 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10763 34
  • 42 (a)
Species where no ortholog for TSPAN31 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TSPAN31 Gene

Gene Tree for TSPAN31 (if available)
Gene Tree for TSPAN31 (if available)

Paralogs for TSPAN31 Gene

Paralogs for TSPAN31 Gene

(2) SIMAP similar genes for TSPAN31 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with TSPAN31: view

Variants for TSPAN31 Gene

Sequence variations from dbSNP and Humsavar for TSPAN31 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs113625101 Likely benign 57,748,004(+) CCCAA(C/T)GTGCT utr-variant-3-prime
rs115576923 Likely benign 57,748,603(+) GGGTT(A/G)AAAGT downstream-variant-500B, reference, synonymous-codon
rs2069511 Likely benign 57,748,315(-) GGTAT(A/G)TTCCC downstream-variant-500B, utr-variant-3-prime
rs2227954 Uncertain significance 57,748,551(-) ATCTA(C/T)ATAAG downstream-variant-500B, reference, missense
rs587779897 Uncertain significance 57,748,575(-) CCTTT(A/C/G)GAGCT downstream-variant-500B, reference, synonymous-codon, missense

Structural Variations from Database of Genomic Variants (DGV) for TSPAN31 Gene

Variant ID Type Subtype PubMed ID
nsv470296 CNV loss 18288195
nsv470297 CNV gain 18288195
nsv510601 CNV deletion 20534489
nsv559045 CNV loss 21841781
nsv819021 CNV loss 19587683
nsv826384 CNV gain 20364138
nsv826386 CNV gain 20364138

Variation tolerance for TSPAN31 Gene

Residual Variation Intolerance Score: 32.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.26; 5.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TSPAN31 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TSPAN31 Gene

Disorders for TSPAN31 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TSPAN31 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
atypical lipomatous tumor
  • liposarcoma, well differentiated
malignant fibroxanthoma
  • fibrous histiocytoma, malignant
  • cutaneous fibrous histiocytoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TSPAN31

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TSPAN31: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TSPAN31 Gene

Publications for TSPAN31 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Amplification of CDK4, MDM2, SAS and GLI genes in leiomyosarcoma, alveolar and embryonal rhabdomyosarcoma. (PMID: 15024701) Ragazzini P … Benassi MS (Histology and histopathology 2004) 3 22 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers. (PMID: 9192850) Elkahloun AG … Meltzer PS (Genomics 1997) 3 4 60

Products for TSPAN31 Gene

Sources for TSPAN31 Gene

Loading form....