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Aliases for RXRG Gene

Aliases for RXRG Gene

  • Retinoid X Receptor, Gamma 2 3
  • Nuclear Receptor Subfamily 2 Group B Member 3 2 3 4
  • NR2B3 3 4
  • Retinoic Acid Receptor RXR-Gamma 3
  • Retinoid X Receptor Gamma 4
  • RXRC 3

External Ids for RXRG Gene

Summaries for RXRG Gene

Entrez Gene Summary for RXRG Gene

  • This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]

GeneCards Summary for RXRG Gene

RXRG (Retinoid X Receptor, Gamma) is a Protein Coding gene. Diseases associated with RXRG include non-functioning pituitary adenoma and functioning pituitary adenoma. Among its related pathways are Pathways in cancer and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include sequence-specific DNA binding and 9-cis retinoic acid receptor activity. An important paralog of this gene is NR2E1.

UniProtKB/Swiss-Prot for RXRG Gene

  • Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5-AGGTCA-3 sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).

Tocris Summary for RXRG Gene

  • Retinoid X receptors (RXR) are members of the NR2B family of nuclear receptors and are common binding partners to many other nuclear receptors, including PPARs, liver X receptors (LXRs) and vitamin D receptors (VDR). RXR heterodimers act as ligand-dependent transcriptional regulators and increase the DNA-binding efficiency of its partner. Despite numerous studies, the physiological role of RXRs have yet to been fully elucidated and, as they can also exist as homodimers, there is the possibility that an independent RXR signaling pathway exists. There are three RXR subtypes; RXRalpha, RXRbeta and RXRgamma, each with two major isoforms (1 and 2). RXRalpha is expressed in the liver, kidney, epidermis and intestine, RXRbeta is widely distributed and RXRgamma is restricted to muscle, pituitary gland and certain parts of the brain.

Gene Wiki entry for RXRG Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RXRG Gene

Genomics for RXRG Gene

Genomic Location for RXRG Gene

Start:
165,400,917 bp from pter
End:
165,445,355 bp from pter
Size:
44,439 bases
Orientation:
Minus strand

Genomic View for RXRG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RXRG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RXRG Gene

Regulatory Elements for RXRG Gene

Proteins for RXRG Gene

  • Protein details for RXRG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48443-RXRG_HUMAN
    Recommended name:
    Retinoic acid receptor RXR-gamma
    Protein Accession:
    P48443
    Secondary Accessions:
    • A6NIP1
    • Q6IBU7

    Protein attributes for RXRG Gene

    Size:
    463 amino acids
    Molecular mass:
    50871 Da
    Quaternary structure:
    • Homodimer. Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer.

    Three dimensional structures from OCA and Proteopedia for RXRG Gene

neXtProt entry for RXRG Gene

Proteomics data for RXRG Gene at MOPED

Post-translational modifications for RXRG Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys418

Other Protein References for RXRG Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RXRG Gene

Domains for RXRG Gene

Gene Families for RXRG Gene

HGNC:
  • NR :Nuclear hormone receptors
IUPHAR :

UniProtKB/Swiss-Prot:

RXRG_HUMAN
Domain:
  • Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.:
    • P48443
  • Contains 1 nuclear receptor DNA-binding domain.:
    • P48443
Family:
  • Belongs to the nuclear hormone receptor family. NR2 subfamily.:
    • P48443
genes like me logo Genes that share domains with RXRG: view

Function for RXRG Gene

Molecular function for RXRG Gene

GENATLAS Biochemistry: retinoic acid X receptor binding and activated by 9-cis-retinoic acid,only (9-cis-RA),gamma subunit,obligate member of heterodimeric nuclear receptors,steroid/thyroid/retinoic receptor superfamily
UniProtKB/Swiss-Prot Function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5-AGGTCA-3 sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).

Gene Ontology (GO) - Molecular Function for RXRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0003707 steroid hormone receptor activity IEA --
GO:0004886 9-cis retinoic acid receptor activity IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with RXRG: view
genes like me logo Genes that share phenotypes with RXRG: view

Animal Models for RXRG Gene

MGI Knock Outs for RXRG:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for RXRG Gene

Localization for RXRG Gene

Subcellular locations from UniProtKB/Swiss-Prot for RXRG Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RXRG Gene COMPARTMENTS Subcellular localization image for RXRG gene
Compartment Confidence
nucleus 4
peroxisome 1

Gene Ontology (GO) - Cellular Components for RXRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with RXRG: view

Pathways for RXRG Gene

genes like me logo Genes that share pathways with RXRG: view

Gene Ontology (GO) - Biological Process for RXRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0007422 peripheral nervous system development IEA --
GO:0007507 heart development IEA --
GO:0007519 skeletal muscle tissue development IEA --
genes like me logo Genes that share ontologies with RXRG: view

Compounds for RXRG Gene

(5) Tocris Compounds for RXRG Gene

Compound Action Cas Number
CD 3254 Potent and selective RXRalpha agonist. [196961-43-0]
Fluorobexarotene RXR agonist [1190848-23-7]
HX 531 RXR antagonist [188844-34-0]
SR 11237 Pan RXR agonist [146670-40-8]
UVI 3003 RXR antagonist [847239-17-2]

(2) HMDB Compounds for RXRG Gene

Compound Synonyms Cas Number PubMed IDs
9-cis-Retinoic acid
  • Tretinoin [usan:ban:inn]
Not Available
Retinoic acid
  • Retinoate
302-79-4

(6) Drugbank Compounds for RXRG Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Acitretin
55079-83-9 target agonist
Adapalene
  • Adapaleno [INN-Spanish]
106685-40-9 target agonist
Alitretinoin
  • 9-cis-Retinoic acid
5300-03-8 target agonist
Bexarotene
153559-49-0 target agonist
Etretinate
54350-48-0 target agonist

(2) IUPHAR Ligand for RXRG Gene

Ligand Type Action Affinity Pubmed IDs
9-cis-retinoic acid Agonist Agonist 9.7
bexarotene Agonist Agonist 7.54

(5) Novoseek inferred chemical compound relationships for RXRG Gene

Compound -log(P) Hits PubMed IDs
retinoic acid 51.3 2
retinoid 49.9 2
vitamin d 33.1 1
lipid 0 2
glucose 0 1
genes like me logo Genes that share compounds with RXRG: view

Transcripts for RXRG Gene

Unigene Clusters for RXRG Gene

Retinoid X receptor, gamma:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RXRG Gene

No ASD Table

Relevant External Links for RXRG Gene

GeneLoc Exon Structure for
RXRG
ECgene alternative splicing isoforms for
RXRG

Expression for RXRG Gene

mRNA expression in normal human tissues for RXRG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RXRG Gene

This gene is overexpressed in Pituitary (7.3), Brain - Putamen (basal ganglia) (5.6), Muscle - Skeletal (5.1), Brain - Caudate (basal ganglia) (4.5), and Brain - Nucleus accumbens (basal ganglia) (4.2).

SOURCE GeneReport for Unigene cluster for RXRG Gene Hs.26550

genes like me logo Genes that share expressions with RXRG: view

Orthologs for RXRG Gene

This gene was present in the common ancestor of animals.

Orthologs for RXRG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RXRG 36
  • 99.64 (n)
  • 100 (a)
RXRG 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RXRG 36
  • 92.15 (n)
  • 98.7 (a)
RXRG 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RXRG 36
  • 91.72 (n)
  • 97.84 (a)
RXRG 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rxrg 36
  • 90.21 (n)
  • 98.27 (a)
Rxrg 16
Rxrg 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RXRG 37
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rxrg 36
  • 90.35 (n)
  • 97.62 (a)
chicken
(Gallus gallus)
Aves RXRG 36
  • 78.79 (n)
  • 85.71 (a)
RXRG 37
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.878 36
tropical clawed frog
(Silurana tropicalis)
Amphibia rxrg 36
  • 71.15 (n)
  • 77.22 (a)
zebrafish
(Danio rerio)
Actinopterygii rxrga 36
  • 74.6 (n)
  • 82.71 (a)
rxrgb 37
  • 73 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta usp 37
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10537 37
  • 51 (a)
OneToMany
Species with no ortholog for RXRG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RXRG Gene

ENSEMBL:
Gene Tree for RXRG (if available)
TreeFam:
Gene Tree for RXRG (if available)

Paralogs for RXRG Gene

Paralogs for RXRG Gene

genes like me logo Genes that share paralogs with RXRG: view

Variants for RXRG Gene

Sequence variations from dbSNP and Humsavar for RXRG Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs100537 -- 165,444,407(+) ATCCC(A/G)GGAAC intron-variant
rs113471 -- 165,428,878(-) TACAC(A/G)GATAC utr-variant-5-prime, reference, synonymous-codon
rs157861 -- 165,408,924(+) TTCTC(C/G)TCTTT intron-variant
rs157862 -- 165,412,371(+) ACAAC(A/T)AAACA intron-variant
rs157863 -- 165,414,166(+) AGGGT(A/G)AATGG intron-variant

Relevant External Links for RXRG Gene

HapMap Linkage Disequilibrium report
RXRG
Human Gene Mutation Database (HGMD)
RXRG

No data available for Structural Variations from Database of Genomic Variants (DGV) for RXRG Gene

Disorders for RXRG Gene

(2) Novoseek inferred disease relationships for RXRG Gene

Disease -log(P) Hits PubMed IDs
hyperlipidemia familial combined 69.3 1
tumors 0 3

Relevant External Links for RXRG

Genetic Association Database (GAD)
RXRG
Human Genome Epidemiology (HuGE) Navigator
RXRG
genes like me logo Genes that share disorders with RXRG: view

No data available for UniProtKB/Swiss-Prot for RXRG Gene

Publications for RXRG Gene

  1. Chromosomal localization of the human retinoid X receptors. (PMID: 8034312) Almasan A. … Evans R.M. (Genomics 1994) 2 3 23
  2. Type 2 diabetes susceptibility genes on chromosome 1q21-24. (PMID: 18269685) Hasstedt S.J. … Elbein S.C. (Ann. Hum. Genet. 2008) 3 23 49
  3. Retinoid X receptor-gamma and peroxisome proliferator-activated receptor-gamma expression predicts thyroid carcinoma cell response to retinoid and thiazolidinedione treatment. (PMID: 15299084) Klopper J.P. … Haugen B.R. (Mol. Cancer Ther. 2004) 3 23
  4. High frequency of a retinoid X receptor gamma gene variant in familial combined hyperlipidemia that associates with atherogenic dyslipidemia. (PMID: 17272748) Nohara A. … Mabuchi H. (Arterioscler. Thromb. Vasc. Biol. 2007) 3 23
  5. Structural variants in the retinoid receptor genes in patients with schizophrenia and other psychiatric diseases. (PMID: 15635645) Feng J. … Sommer S.S. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2005) 3 49

Products for RXRG Gene

  • Addgene plasmids for RXRG

Sources for RXRG Gene

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