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Aliases for RXRG Gene

Aliases for RXRG Gene

  • Retinoid X Receptor Gamma 2 3 4 5
  • Nuclear Receptor Subfamily 2 Group B Member 3 2 3 4
  • Retinoid X Receptor, Gamma 2 3
  • NR2B3 3 4
  • RXRC 3

External Ids for RXRG Gene

Previous GeneCards Identifiers for RXRG Gene

  • GC01M163005
  • GC01M161021
  • GC01M162066
  • GC01M162557
  • GC01M162102
  • GC01M163636
  • GC01M165370
  • GC01M136616

Summaries for RXRG Gene

Entrez Gene Summary for RXRG Gene

  • This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]

GeneCards Summary for RXRG Gene

RXRG (Retinoid X Receptor Gamma) is a Protein Coding gene. Diseases associated with RXRG include hyperlipidemia, familial combined and lung cancer. Among its related pathways are Gene Expression and Signaling by GPCR. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is NR2F1.

UniProtKB/Swiss-Prot for RXRG Gene

  • Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5-AGGTCA-3 sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).

Tocris Summary for RXRG Gene

  • Retinoid X receptors (RXR) are members of the NR2B nuclear receptor family and are common binding partners to many other nuclear receptors, including PPARs, liver X receptors (LXRs) and vitamin D receptors (VDRs). There are three RXR subtypes; alpha, beta and gamma.

Gene Wiki entry for RXRG Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RXRG Gene

Genomics for RXRG Gene

Regulatory Elements for RXRG Gene

Genomic Location for RXRG Gene

Chromosome:
1
Start:
165,400,917 bp from pter
End:
165,445,355 bp from pter
Size:
44,439 bases
Orientation:
Minus strand

Genomic View for RXRG Gene

Genes around RXRG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RXRG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RXRG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RXRG Gene

Proteins for RXRG Gene

  • Protein details for RXRG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48443-RXRG_HUMAN
    Recommended name:
    Retinoic acid receptor RXR-gamma
    Protein Accession:
    P48443
    Secondary Accessions:
    • A6NIP1
    • Q6IBU7

    Protein attributes for RXRG Gene

    Size:
    463 amino acids
    Molecular mass:
    50871 Da
    Quaternary structure:
    • Homodimer. Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer.

    Three dimensional structures from OCA and Proteopedia for RXRG Gene

neXtProt entry for RXRG Gene

Proteomics data for RXRG Gene at MOPED

Post-translational modifications for RXRG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RXRG Gene

Antibody Products

  • R&D Systems Antibodies for RXRG (RXR gamma/NR2B3)
  • Cell Signaling Technology (CST) Antibodies for RXRG (RXRG)

No data available for DME Specific Peptides for RXRG Gene

Domains & Families for RXRG Gene

Gene Families for RXRG Gene

Graphical View of Domain Structure for InterPro Entry

P48443

UniProtKB/Swiss-Prot:

RXRG_HUMAN :
  • Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • Belongs to the nuclear hormone receptor family. NR2 subfamily.
Domain:
  • Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • Contains 1 nuclear receptor DNA-binding domain.
Family:
  • Belongs to the nuclear hormone receptor family. NR2 subfamily.
genes like me logo Genes that share domains with RXRG: view

Function for RXRG Gene

Molecular function for RXRG Gene

GENATLAS Biochemistry:
retinoic acid X receptor binding and activated by 9-cis-retinoic acid,only (9-cis-RA),gamma subunit,obligate member of heterodimeric nuclear receptors,steroid/thyroid/retinoic receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5-AGGTCA-3 sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).

Gene Ontology (GO) - Molecular Function for RXRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003707 steroid hormone receptor activity IEA --
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with RXRG: view
genes like me logo Genes that share phenotypes with RXRG: view

Animal Models for RXRG Gene

MGI Knock Outs for RXRG:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for RXRG Gene

Localization for RXRG Gene

Subcellular locations from UniProtKB/Swiss-Prot for RXRG Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RXRG Gene COMPARTMENTS Subcellular localization image for RXRG gene
Compartment Confidence
nucleus 5
peroxisome 2

No data available for Gene Ontology (GO) - Cellular Components for RXRG Gene

Pathways & Interactions for RXRG Gene

genes like me logo Genes that share pathways with RXRG: view

SIGNOR curated interactions for RXRG Gene

Is activated by:

Gene Ontology (GO) - Biological Process for RXRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0010467 gene expression TAS --
GO:0051289 protein homotetramerization IEA --
GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus IEA --
genes like me logo Genes that share ontologies with RXRG: view

Drugs & Compounds for RXRG Gene

(10) Drugs for RXRG Gene - From: DGIdb, DrugBank, HMDB, Tocris, FDA Approved Drugs, Novoseek, IUPHAR, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bexarotene Approved, Investigational Pharma Agonist, agonist, Target Others 43
Adapalene Approved Pharma binder, Target, agonist RAR尾 and RAR纬 agonist 71
Acitretin Approved Pharma Target, agonist Metabolite of etretinate 30
Tretinoin Approved, Investigational Nutra Full agonist, Agonist, binder, Target, agonist 210
Alitretinoin Approved, Investigational Pharma agonist, Target 15

(8) Additional Compounds for RXRG Gene - From: Tocris, IUPHAR, HMDB, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
9-cis-retinoic acid
  • 15-Apo-beta-caroten-15-oate
  • 15-Apo-beta-caroten-15-oic acid
  • 9-cis-Retinoate
  • 9-cis-Retinoic acid
  • 9-cis-Tretinoin
Agonist
retinoic acid
302-79-4
CD 3254
196961-43-0
Fluorobexarotene
1190848-23-7
SR 11237
146670-40-8
genes like me logo Genes that share compounds with RXRG: view

Transcripts for RXRG Gene

Unigene Clusters for RXRG Gene

Retinoid X receptor, gamma:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for RXRG Gene

No ASD Table

Relevant External Links for RXRG Gene

GeneLoc Exon Structure for
RXRG
ECgene alternative splicing isoforms for
RXRG

Expression for RXRG Gene

mRNA expression in normal human tissues for RXRG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RXRG Gene

This gene is overexpressed in Pituitary (x7.3), Brain - Putamen (basal ganglia) (x5.6), Muscle - Skeletal (x5.1), Brain - Caudate (basal ganglia) (x4.5), and Brain - Nucleus accumbens (basal ganglia) (x4.2).

SOURCE GeneReport for Unigene cluster for RXRG Gene Hs.26550

genes like me logo Genes that share expression patterns with RXRG: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for RXRG Gene

Orthologs for RXRG Gene

This gene was present in the common ancestor of animals.

Orthologs for RXRG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RXRG 35
  • 99.64 (n)
  • 100 (a)
RXRG 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RXRG 36
  • 99 (a)
OneToOne
RXRG 35
  • 92.15 (n)
  • 98.7 (a)
dog
(Canis familiaris)
Mammalia RXRG 35
  • 91.72 (n)
  • 97.84 (a)
RXRG 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rxrg 36
  • 98 (a)
OneToOne
Rxrg 16
Rxrg 35
  • 90.21 (n)
  • 98.27 (a)
oppossum
(Monodelphis domestica)
Mammalia RXRG 36
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rxrg 35
  • 90.35 (n)
  • 97.62 (a)
chicken
(Gallus gallus)
Aves RXRG 36
  • 85 (a)
OneToOne
RXRG 35
  • 78.79 (n)
  • 85.71 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.878 35
tropical clawed frog
(Silurana tropicalis)
Amphibia rxrg 35
  • 71.15 (n)
  • 77.22 (a)
zebrafish
(Danio rerio)
Actinopterygii rxrgb 36
  • 73 (a)
OneToOne
rxrga 35
  • 74.6 (n)
  • 82.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta usp 36
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10537 36
  • 51 (a)
OneToMany
Species with no ortholog for RXRG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RXRG Gene

ENSEMBL:
Gene Tree for RXRG (if available)
TreeFam:
Gene Tree for RXRG (if available)

Paralogs for RXRG Gene

Paralogs for RXRG Gene

genes like me logo Genes that share paralogs with RXRG: view

Variants for RXRG Gene

Sequence variations from dbSNP and Humsavar for RXRG Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs190770 -- 165,402,279(+) caggt(C/T)tttgc intron-variant
rs283690 -- 165,401,520(+) TAAAA(A/G)AGCTG intron-variant
rs283691 -- 165,418,227(+) CCCAG(A/G)CAGGG intron-variant
rs283692 -- 165,408,152(+) ACCAA(C/T)AACAT intron-variant
rs283693 -- 165,407,807(+) atctc(A/G)gtgaa intron-variant

Variation tolerance for RXRG Gene

Residual Variation Intolerance Score: 8.17% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RXRG Gene

HapMap Linkage Disequilibrium report
RXRG
Human Gene Mutation Database (HGMD)
RXRG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for RXRG Gene

Disorders for RXRG Gene

MalaCards: The human disease database

(2) MalaCards diseases for RXRG Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hyperlipidemia, familial combined
  • combined hyperlipidemia, familial
lung cancer
  • lung cancer, protection against
- elite association - COSMIC cancer census association via MalaCards
Search RXRG in MalaCards View complete list of genes associated with diseases

Relevant External Links for RXRG

Genetic Association Database (GAD)
RXRG
Human Genome Epidemiology (HuGE) Navigator
RXRG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RXRG
genes like me logo Genes that share disorders with RXRG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RXRG Gene

Publications for RXRG Gene

  1. Type 2 diabetes susceptibility genes on chromosome 1q21-24. (PMID: 18269685) Hasstedt S.J. … Elbein S.C. (Ann. Hum. Genet. 2008) 3 23 48 67
  2. Chromosomal localization of the human retinoid X receptors. (PMID: 8034312) Almasan A. … Evans R.M. (Genomics 1994) 2 3 23
  3. A phase I study of bexarotene, a retinoic X receptor agonist, in non-M3 acute myeloid leukemia. (PMID: 18765556) Tsai D.E. … Carroll M. (Clin. Cancer Res. 2008) 25 26
  4. High frequency of a retinoid X receptor gamma gene variant in familial combined hyperlipidemia that associates with atherogenic dyslipidemia. (PMID: 17272748) Nohara A. … Mabuchi H. (Arterioscler. Thromb. Vasc. Biol. 2007) 3 23
  5. Bexarotene (LGD1069, Targretin), a selective retinoid X receptor agonist, prevents and reverses gemcitabine resistance in NSCLC cells by modulating gene amplification. (PMID: 17483357) Tooker P. … Hermann T.W. (Cancer Res. 2007) 25 26

Products for RXRG Gene

Sources for RXRG Gene

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