Aliases for CLIP1 Gene
External Ids for CLIP1 Gene
Previous HGNC Symbols for CLIP1 Gene
Previous GeneCards Identifiers for CLIP1 Gene
The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
GeneCards Summary for CLIP1 Gene
CLIP1 (CAP-Gly Domain Containing Linker Protein 1) is a Protein Coding gene. Diseases associated with CLIP1 include Autosomal Recessive Non-Syndromic Intellectual Disability and Extratemporal Epilepsy. Among its related pathways are mTOR signaling pathway (Pathway Interaction Database) and Remodeling of Adherens Junctions. GO annotations related to this gene include nucleic acid binding and microtubule binding. An important paralog of this gene is CLIP2.
UniProtKB/Swiss-Prot for CLIP1 Gene
Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking.