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Aliases for CLIP1 Gene

Aliases for CLIP1 Gene

  • CAP-Gly Domain Containing Linker Protein 1 2 3 5
  • Restin (Reed-Steinberg Cell-Expressed Intermediate Filament-Associated Protein) 2 3
  • Cytoplasmic Linker Protein 170 Alpha-2 3 4
  • Cytoplasmic Linker Protein 1 3 4
  • CLIP-170 3 4
  • Restin 2 4
  • CYLN1 3 4
  • RSN 3 4
  • Reed-Sternberg Intermediate Filament-Associated Protein 4
  • Cytoplasmic Linker Protein CLIP-170 3
  • CLIP170 3
  • CLIP 3

External Ids for CLIP1 Gene

Previous HGNC Symbols for CLIP1 Gene

  • RSN

Previous GeneCards Identifiers for CLIP1 Gene

  • GC12M121322
  • GC12M121205
  • GC12M122755
  • GC12M119716

Summaries for CLIP1 Gene

Entrez Gene Summary for CLIP1 Gene

  • The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for CLIP1 Gene

CLIP1 (CAP-Gly Domain Containing Linker Protein 1) is a Protein Coding gene. Diseases associated with CLIP1 include extratemporal epilepsy and distal hereditary motor neuropathy, type ii. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include nucleic acid binding and microtubule binding. An important paralog of this gene is CLIP4.

UniProtKB/Swiss-Prot for CLIP1 Gene

  • Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking.

Gene Wiki entry for CLIP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CLIP1 Gene

Genomics for CLIP1 Gene

Regulatory Elements for CLIP1 Gene

Promoters for CLIP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CLIP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CLIP1 Gene

Chromosome:
12
Start:
122,271,432 bp from pter
End:
122,422,632 bp from pter
Size:
151,201 bases
Orientation:
Minus strand

Genomic View for CLIP1 Gene

Genes around CLIP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CLIP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CLIP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CLIP1 Gene

Proteins for CLIP1 Gene

  • Protein details for CLIP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30622-CLIP1_HUMAN
    Recommended name:
    CAP-Gly domain-containing linker protein 1
    Protein Accession:
    P30622
    Secondary Accessions:
    • A0AVD3
    • Q17RS4
    • Q29RG0

    Protein attributes for CLIP1 Gene

    Size:
    1438 amino acids
    Molecular mass:
    162246 Da
    Quaternary structure:
    • Interacts with MTOR; phosphorylates and regulates CLIP1. Interacts (via CAP-Gly domains) with tubulin. Interacts with SLAIN2. Interacts (via zinc finger) with DCTN1. Interacts with MAPRE1 and MAPRE3.

    Three dimensional structures from OCA and Proteopedia for CLIP1 Gene

    Alternative splice isoforms for CLIP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CLIP1 Gene

Proteomics data for CLIP1 Gene at MOPED

Post-translational modifications for CLIP1 Gene

  • Phosphorylated. Phosphorylation by MTOR may positively regulate CLIP1 association with microtubules.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CLIP1 (Restin)

No data available for DME Specific Peptides for CLIP1 Gene

Domains & Families for CLIP1 Gene

Protein Domains for CLIP1 Gene

Graphical View of Domain Structure for InterPro Entry

P30622

UniProtKB/Swiss-Prot:

CLIP1_HUMAN :
  • Intramolecular interaction between the zinc finger domain and the CAP-Gly domains may inhibit interaction with tubulin.
  • Contains 1 CCHC-type zinc finger.
Domain:
  • Intramolecular interaction between the zinc finger domain and the CAP-Gly domains may inhibit interaction with tubulin.
  • Contains 2 CAP-Gly domains.
Similarity:
  • Contains 1 CCHC-type zinc finger.
genes like me logo Genes that share domains with CLIP1: view

No data available for Gene Families for CLIP1 Gene

Function for CLIP1 Gene

Molecular function for CLIP1 Gene

UniProtKB/Swiss-Prot Function:
Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking.

Gene Ontology (GO) - Molecular Function for CLIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity TAS 15928712
genes like me logo Genes that share ontologies with CLIP1: view
genes like me logo Genes that share phenotypes with CLIP1: view

Human Phenotype Ontology for CLIP1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CLIP1 Gene

MGI Knock Outs for CLIP1:

Animal Model Products

miRNA for CLIP1 Gene

miRTarBase miRNAs that target CLIP1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CLIP1 Gene

Localization for CLIP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CLIP1 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle. Note=Associated with the cytoskeleton. Detected at the plus ends of microtubules in the cytosol, and close to plasma membrane ruffles. Associates with the membranes of intermediate macropinocytic vesicles. {ECO:0000269 PubMed:12433698, ECO:0000269 PubMed:17889670, ECO:0000269 PubMed:21646404}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CLIP1 Gene COMPARTMENTS Subcellular localization image for CLIP1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
endosome 5
nucleus 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CLIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005768 endosome TAS 1356075
GO:0005829 cytosol TAS --
GO:0005874 microtubule IEA,ISS --
GO:0005881 cytoplasmic microtubule IEA --
genes like me logo Genes that share ontologies with CLIP1: view

Pathways & Interactions for CLIP1 Gene

genes like me logo Genes that share pathways with CLIP1: view

SIGNOR curated interactions for CLIP1 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for CLIP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001578 microtubule bundle formation IMP 17889670
GO:0007062 sister chromatid cohesion TAS --
genes like me logo Genes that share ontologies with CLIP1: view

Drugs & Compounds for CLIP1 Gene

(3) Drugs for CLIP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(4) Additional Compounds for CLIP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CLIP1: view

Transcripts for CLIP1 Gene

Unigene Clusters for CLIP1 Gene

CAP-GLY domain containing linker protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CLIP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^
SP1: - - - -
SP2: - - - - -
SP3: - - -
SP4:
SP5:
SP6: - -
SP7:
SP8:
SP9:

ExUns: 20 ^ 21 ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27a · 27b · 27c · 27d
SP1: - - -
SP2: - - -
SP3:
SP4: - - -
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for CLIP1 Gene

GeneLoc Exon Structure for
CLIP1
ECgene alternative splicing isoforms for
CLIP1

Expression for CLIP1 Gene

mRNA expression in normal human tissues for CLIP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CLIP1 Gene

This gene is overexpressed in Muscle - Skeletal (x8.4).

Protein differential expression in normal tissues from HIPED for CLIP1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CLIP1 Gene



SOURCE GeneReport for Unigene cluster for CLIP1 Gene Hs.524809

mRNA Expression by UniProt/SwissProt for CLIP1 Gene

P30622-CLIP1_HUMAN
Tissue specificity: Detected in dendritic cells (at protein level). Highly expressed in the Reed-Sternberg cells of Hodgkin disease.
genes like me logo Genes that share expression patterns with CLIP1: view

Protein tissue co-expression partners for CLIP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CLIP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CLIP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CLIP1 35
  • 98.97 (n)
  • 98.99 (a)
CLIP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CLIP1 36
  • 92 (a)
OneToOne
CLIP1 35
  • 89.39 (n)
  • 91.95 (a)
dog
(Canis familiaris)
Mammalia CLIP1 35
  • 89.7 (n)
  • 91.45 (a)
CLIP1 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Clip1 16
Clip1 35
  • 87.11 (n)
  • 89.79 (a)
Clip1 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CLIP1 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 91 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
chicken
(Gallus gallus)
Aves CLIP1 35
  • 75.1 (n)
  • 74.04 (a)
CLIP1 36
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CLIP1 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia clip1 35
  • 63.72 (n)
  • 60.02 (a)
zebrafish
(Danio rerio)
Actinopterygii CLIP1 (2 of 2) 36
  • 60 (a)
OneToMany
clip1a 36
  • 50 (a)
OneToMany
clip1a 35
  • 55.52 (n)
  • 48.59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CLIP-190 36
  • 23 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
OneToOne
Species with no ortholog for CLIP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CLIP1 Gene

ENSEMBL:
Gene Tree for CLIP1 (if available)
TreeFam:
Gene Tree for CLIP1 (if available)

Paralogs for CLIP1 Gene

Paralogs for CLIP1 Gene

genes like me logo Genes that share paralogs with CLIP1: view

Variants for CLIP1 Gene

Sequence variations from dbSNP and Humsavar for CLIP1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1129167 - 122,327,956(-) GCCGA(C/G)AAAGC reference, missense
VAR_036446 A breast cancer sample
rs3741447 - 122,340,866(+) TTTCC(A/G)AAGTG reference, missense
rs17883517 - 122,333,033(+) AGAAG(A/G)GTTAT reference, missense
rs17881033 - 122,279,123(+) ATCTG(A/C/T)GTCTT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CLIP1 Gene

Variant ID Type Subtype PubMed ID
esv2672169 CNV Deletion 23128226
dgv324e199 CNV Deletion 23128226

Variation tolerance for CLIP1 Gene

Residual Variation Intolerance Score: 4.49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 19.86; 98.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CLIP1 Gene

HapMap Linkage Disequilibrium report
CLIP1
Human Gene Mutation Database (HGMD)
CLIP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CLIP1 Gene

Disorders for CLIP1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CLIP1 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
extratemporal epilepsy
distal hereditary motor neuropathy, type ii
  • distal hereditary motor neuronopathy, type ii
autosomal recessive non-syndromic intellectual disability
  • autosomal recessive mental retardation
- elite association - COSMIC cancer census association via MalaCards
Search CLIP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CLIP1

Genetic Association Database (GAD)
CLIP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CLIP1
genes like me logo Genes that share disorders with CLIP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CLIP1 Gene

Publications for CLIP1 Gene

  1. Structural basis for tubulin recognition by cytoplasmic linker protein 170 and its autoinhibition. (PMID: 17563362) Mishima M. … Hakoshima T. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 4 23 67
  2. Localization of the gene (RSN) coding for restin, a marker for Reed-Sternberg cells in Hodgkin's disease, to human chromosome band 12q24.3 and YAC cloning of the locus. (PMID: 8222754) Hilliker C. … Van den Berghe H. (Cytogenet. Cell Genet. 1994) 2 3 23
  3. Microtubule plus-end tracking by CLIP-170 requires EB1. (PMID: 19126680) Dixit R. … Holzbaur E.L. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23
  4. The membrane-tubulating potential of amphiphysin 2/BIN1 is dependent on the microtubule-binding cytoplasmic linker protein 170 (CLIP-170). (PMID: 19004523) Meunier B. … Leprince C. (Eur. J. Cell Biol. 2009) 3 23
  5. Cdc2-mediated phosphorylation of CLIP-170 is essential for its inhibition of centrosome reduplication. (PMID: 19687009) Yang X. … Liu X. (J. Biol. Chem. 2009) 3 23

Products for CLIP1 Gene

Sources for CLIP1 Gene

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