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Aliases for RPS29 Gene

Aliases for RPS29 Gene

  • Ribosomal Protein S29 2 3 5
  • DBA13 3
  • S29 3

External Ids for RPS29 Gene

Previous GeneCards Identifiers for RPS29 Gene

  • GC14M047365
  • GC14M043840
  • GC14M048034
  • GC14M048040
  • GC14M049114
  • GC14M049120
  • GC14M049119
  • GC14M050043
  • GC14M030161

Summaries for RPS29 Gene

Entrez Gene Summary for RPS29 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit and a member of the S14P family of ribosomal proteins. The protein, which contains a C2-C2 zinc finger-like domain that can bind to zinc, can enhance the tumor suppressor activity of Ras-related protein 1A (KREV1). It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]

GeneCards Summary for RPS29 Gene

RPS29 (Ribosomal Protein S29) is a Protein Coding gene. Diseases associated with RPS29 include diamond-blackfan anemia 13 and diamond-blackfan anemia. Among its related pathways are Gene Expression and Metabolism. GO annotations related to this gene include structural constituent of ribosome.

Gene Wiki entry for RPS29 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS29 Gene

Genomics for RPS29 Gene

Regulatory Elements for RPS29 Gene

Promoters for RPS29 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPS29 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPS29 Gene

Chromosome:
14
Start:
49,570,984 bp from pter
End:
49,599,164 bp from pter
Size:
28,181 bases
Orientation:
Minus strand

Genomic View for RPS29 Gene

Genes around RPS29 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS29 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS29 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS29 Gene

Proteins for RPS29 Gene

  • Protein details for RPS29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62273-RS29_HUMAN
    Recommended name:
    40S ribosomal protein S29
    Protein Accession:
    P62273
    Secondary Accessions:
    • A8MZ73
    • P30054

    Protein attributes for RPS29 Gene

    Size:
    56 amino acids
    Molecular mass:
    6677 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS29 Gene

    Alternative splice isoforms for RPS29 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RPS29 Gene

Proteomics data for RPS29 Gene at MOPED

Post-translational modifications for RPS29 Gene

  • Ubiquitination at Lys 33 and Lys 48
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS29 Gene

Antibody Products

No data available for DME Specific Peptides for RPS29 Gene

Domains & Families for RPS29 Gene

Gene Families for RPS29 Gene

Protein Domains for RPS29 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RPS29 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P62273

UniProtKB/Swiss-Prot:

RS29_HUMAN :
  • Belongs to the ribosomal protein S14P family.
Family:
  • Belongs to the ribosomal protein S14P family.
genes like me logo Genes that share domains with RPS29: view

Function for RPS29 Gene

Molecular function for RPS29 Gene

GENATLAS Biochemistry:
40S ribosomal protein S29
genes like me logo Genes that share phenotypes with RPS29: view

Human Phenotype Ontology for RPS29 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

miRNA for RPS29 Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS29 Gene

Localization for RPS29 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS29 Gene COMPARTMENTS Subcellular localization image for RPS29 gene
Compartment Confidence
cytosol 5
extracellular 5
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for RPS29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
GO:0015935 small ribosomal subunit IDA 15883184
GO:0022627 cytosolic small ribosomal subunit IDA 8706699
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with RPS29: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS29 Gene

Pathways & Interactions for RPS29 Gene

SuperPathways for RPS29 Gene

Superpath Contained pathways
1 Viral mRNA Translation
.60
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 Infectious disease
.48
5 rRNA processing
genes like me logo Genes that share pathways with RPS29: view

Pathways by source for RPS29 Gene

1 BioSystems pathway for RPS29 Gene
1 KEGG pathway for RPS29 Gene
1 GeneGo (Thomson Reuters) pathway for RPS29 Gene

Gene Ontology (GO) - Biological Process for RPS29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0006412 translation IEA,IC 8706699
GO:0006413 translational initiation TAS --
GO:0006415 translational termination TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
genes like me logo Genes that share ontologies with RPS29: view

No data available for SIGNOR curated interactions for RPS29 Gene

Drugs & Compounds for RPS29 Gene

No Compound Related Data Available

Transcripts for RPS29 Gene

Unigene Clusters for RPS29 Gene

Ribosomal protein S29:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPS29 Gene

No ASD Table

Relevant External Links for RPS29 Gene

GeneLoc Exon Structure for
RPS29
ECgene alternative splicing isoforms for
RPS29

Expression for RPS29 Gene

mRNA expression in normal human tissues for RPS29 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RPS29 Gene

This gene is overexpressed in Tlymphocyte (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS29 Gene



SOURCE GeneReport for Unigene cluster for RPS29 Gene Hs.156367

genes like me logo Genes that share expression patterns with RPS29: view

Protein tissue co-expression partners for RPS29 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS29 Gene

Orthologs for RPS29 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS29 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RPS29 35
  • 91.07 (n)
  • 98.21 (a)
RPS29 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RPS29 35
  • 89.29 (n)
  • 98.21 (a)
mouse
(Mus musculus)
Mammalia Rps29 35
  • 85.71 (n)
  • 98.21 (a)
Rps29 16
Gm10126 36
  • 85 (a)
OneToMany
Rps29 36
  • 96 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia RPS29 35
  • 98.99 (n)
  • 100 (a)
RPS29 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rps29 35
  • 86.9 (n)
  • 98.21 (a)
oppossum
(Monodelphis domestica)
Mammalia RPS29 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves RPS29 35
  • 80.95 (n)
  • 98.21 (a)
RPS29 36
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rps29 35
  • 80.95 (n)
  • 98.21 (a)
zebrafish
(Danio rerio)
Actinopterygii wufa11f02 35
rps29 36
  • 93 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8386 35
fruit fly
(Drosophila melanogaster)
Insecta RpS29 36
  • 75 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rps-29 36
  • 71 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS29A 36
  • 64 (a)
OneToMany
RPS29B 36
  • 63 (a)
OneToMany
RPS29A 38
wheat
(Triticum aestivum)
Liliopsida Ta.17501 35
Species with no ortholog for RPS29:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS29 Gene

ENSEMBL:
Gene Tree for RPS29 (if available)
TreeFam:
Gene Tree for RPS29 (if available)

Paralogs for RPS29 Gene

genes like me logo Genes that share paralogs with RPS29: view

No data available for Paralogs for RPS29 Gene

Variants for RPS29 Gene

Sequence variations from dbSNP and Humsavar for RPS29 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
VAR_071328 Diamond-Blackfan anemia 13 (DBA13)
VAR_071329 Diamond-Blackfan anemia 13 (DBA13)
rs2354440 -- 49,577,771(+) GGCTT(C/T)GCGAG utr-variant-3-prime
rs2354441 -- 49,577,844(+) ACAGC(C/T)CAGGT reference, missense
rs1804416 -- 49,583,637(-) CGGGG(A/C)ATCTA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RPS29 Gene

Variant ID Type Subtype PubMed ID
esv28926 CNV Gain+Loss 19812545

Variation tolerance for RPS29 Gene

Residual Variation Intolerance Score: 50.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.06; 1.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RPS29 Gene

HapMap Linkage Disequilibrium report
RPS29
Human Gene Mutation Database (HGMD)
RPS29

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RPS29 Gene

Disorders for RPS29 Gene

MalaCards: The human disease database

(4) MalaCards diseases for RPS29 Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
diamond-blackfan anemia 13
  • dba13
diamond-blackfan anemia
  • blackfan - diamond syndrome
west nile fever
pierre robin syndrome
  • pierre robin sequence
- elite association - COSMIC cancer census association via MalaCards
Search RPS29 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

RS29_HUMAN
  • Diamond-Blackfan anemia 13 (DBA13) [MIM:615909]: A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. {ECO:0000269 PubMed:24829207}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for RPS29

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RPS29
genes like me logo Genes that share disorders with RPS29: view

No data available for Genatlas for RPS29 Gene

Publications for RPS29 Gene

  1. The S29 ribosomal protein increases tumor suppressor activity of K rev-1 gene on v-K ras-transformed NIH3T3 cells. (PMID: 8781548) Kondoh N. … Oikawa T. (Biochim. Biophys. Acta 1996) 2 3 4 23 67
  2. Low content of protein S29 in ribosomes of human lung cancer cell line a549: detected by two-dimensional electrophoresis. (PMID: 12625830) Zhou Z.D. … Liu W.Y. (Protein Pept. Lett. 2003) 3 23
  3. Regulation of the quiescence-induced genes: quiescin Q6, decorin, and ribosomal protein S29. (PMID: 10708601) Coppock D.L. … Cina-Poppe D.A. (Biochem. Biophys. Res. Commun. 2000) 3 23
  4. Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs. (PMID: 7772601) Frigerio J.-M. … Iovanna J.L. (Biochim. Biophys. Acta 1995) 2 3
  5. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3

Products for RPS29 Gene

Sources for RPS29 Gene

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