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Aliases for RPS27 Gene

Aliases for RPS27 Gene

  • Ribosomal Protein S27 2 3
  • MPS1 3 4 6
  • Metallopan-Stimulin 1 3 4
  • Metallopanstimulin 1 2 3
  • MPS-1 3 4
  • Ribosomal Protein S27 (Metallopanstimulin 1) 2
  • 40S Ribosomal Protein S27 3
  • S27 3

External Ids for RPS27 Gene

Summaries for RPS27 Gene

Entrez Gene Summary for RPS27 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S27E family of ribosomal proteins. It contains a C4-type zinc finger domain that can bind to zinc. The encoded protein has been shown to be able to bind to nucleic acid. It is located in the cytoplasm as a ribosomal component, but it has also been detected in the nucleus. Studies in rat indicate that ribosomal protein S27 is located near ribosomal protein S18 in the 40S subunit and is covalently linked to translation initiation factor eIF3. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS27 Gene

RPS27 (Ribosomal Protein S27) is a Protein Coding gene. Among its related pathways are Disease and Cell Cycle, Mitotic. GO annotations related to this gene include structural constituent of ribosome. An important paralog of this gene is RPS27L.

Gene Wiki entry for RPS27 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS27 Gene

Genomics for RPS27 Gene

Genomic Location for RPS27 Gene

Start:
153,990,759 bp from pter
End:
153,992,155 bp from pter
Size:
1,397 bases
Orientation:
Plus strand

Genomic View for RPS27 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RPS27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS27 Gene

Proteins for RPS27 Gene

  • Protein details for RPS27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42677-RS27_HUMAN
    Recommended name:
    40S ribosomal protein S27
    Protein Accession:
    P42677
    Secondary Accessions:
    • Q5T4L6

    Protein attributes for RPS27 Gene

    Size:
    84 amino acids
    Molecular mass:
    9461 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS27 Gene

neXtProt entry for RPS27 Gene

Proteomics data for RPS27 Gene at MOPED

Post-translational modifications for RPS27 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys5 and Lys16

Other Protein References for RPS27 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for RPS27 Gene

Domains for RPS27 Gene

Gene Families for RPS27 Gene

HGNC:
  • RPS :S ribosomal proteins

Protein Domains for RPS27 Gene

UniProtKB/Swiss-Prot:

RS27_HUMAN
Family:
  • Belongs to the ribosomal protein S27e family.:
    • P42677
genes like me logo Genes that share domains with RPS27: view

Function for RPS27 Gene

Molecular function for RPS27 Gene

GENATLAS Biochemistry: 60S ribosomal protein S27

Gene Ontology (GO) - Molecular Function for RPS27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding NAS 8908372
GO:0003735 structural constituent of ribosome IEA --
GO:0005515 protein binding IPI 21170087
GO:0008270 zinc ion binding NAS 8407955
GO:0044822 poly(A) RNA binding IDA 22681889
genes like me logo Genes that share ontologies with RPS27: view

Phenotypes for RPS27 Gene

genes like me logo Genes that share phenotypes with RPS27: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for RPS27 Gene

Localization for RPS27 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RPS27 Gene COMPARTMENTS Subcellular localization image for RPS27 gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RPS27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 8407955
GO:0005829 cytosol TAS --
GO:0005840 ribosome NAS 8908372
GO:0022627 cytosolic small ribosomal subunit IDA 15883184
genes like me logo Genes that share ontologies with RPS27: view

Pathways for RPS27 Gene

SuperPathways for RPS27 Gene

Superpath Contained pathways
1 Influenza Viral RNA Transcription and Replication
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Cell Cycle, Mitotic
.62
4 Mitotic Metaphase and Anaphase
5 CFTR translational fidelity (class I mutations)
.54
genes like me logo Genes that share pathways with RPS27: view

Pathways by source for RPS27 Gene

1 GeneGo (Thomson Reuters Life Sciences Research) pathway for RPS27 Gene
1 BioSystems pathway for RPS27 Gene
1 KEGG pathway for RPS27 Gene

Gene Ontology (GO) - Biological Process for RPS27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0006412 translation TAS --
GO:0006413 translational initiation TAS --
GO:0006414 translational elongation TAS --
genes like me logo Genes that share ontologies with RPS27: view

Compounds for RPS27 Gene

(1) HMDB Compounds for RPS27 Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic AMP
  • Cyclic AMP
60-92-4

(1) Novoseek inferred chemical compound relationships for RPS27 Gene

Compound -log(P) Hits PubMed IDs
zinc 55.8 10
genes like me logo Genes that share compounds with RPS27: view

Transcripts for RPS27 Gene

mRNA/cDNA for RPS27 Gene

Unigene Clusters for RPS27 Gene

Ribosomal protein S27:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPS27 Gene

No ASD Table

Relevant External Links for RPS27 Gene

GeneLoc Exon Structure for
RPS27
ECgene alternative splicing isoforms for
RPS27

Expression for RPS27 Gene

mRNA expression in normal human tissues for RPS27 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for RPS27 Gene

SOURCE GeneReport for Unigene cluster for RPS27 Gene Hs.546291

mRNA Expression by UniProt/SwissProt for RPS27 Gene

P42677-RS27_HUMAN
Tissue specificity: Expressed in a wide variety of actively proliferating cells and tumor tissues
genes like me logo Genes that share expressions with RPS27: view

Orthologs for RPS27 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RPS27 36
  • 100 (n)
  • 100 (a)
RPS27 37
  • 100 (a)
OneToMany
RPS27 37
  • 100 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 37
  • 95 (a)
OneToMany
RPS27 36
  • 94.84 (n)
  • 100 (a)
RPS27 37
  • 100 (a)
OneToMany
dog
(Canis familiaris)
Mammalia RPS27 36
  • 88.89 (n)
  • 100 (a)
RPS27 37
  • 100 (a)
OneToMany
RPS27 37
  • 98 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm9846 37
  • 100 (a)
OneToMany
Rps27 16
Rps27 37
  • 100 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia RPS27 37
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rps27 36
  • 96.03 (n)
  • 100 (a)
lizard
(Anolis carolinensis)
Reptilia RPS27 37
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rps27 36
  • 80.16 (n)
  • 96.43 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 36
rps27.1 37
  • 96 (a)
ManyToMany
rps27.2 36
  • 80.95 (n)
  • 97.62 (a)
rps27.2 37
  • 98 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007157 36
  • 74.21 (n)
  • 85.71 (a)
fruit fly
(Drosophila melanogaster)
Insecta RpS27 36
  • 73.98 (n)
  • 85.37 (a)
RpS27 37
  • 82 (a)
OneToMany
CG10423 38
  • 85 (a)
worm
(Caenorhabditis elegans)
Secernentea rps-27 36
  • 68.27 (n)
  • 79.52 (a)
rps-27 37
  • 78 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR065C 36
  • 61.79 (n)
  • 74.39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS27A 37
  • 70 (a)
ManyToMany
RPS27B 36
  • 62.6 (n)
  • 71.95 (a)
RPS27B 37
  • 71 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E11661g 36
  • 58.94 (n)
  • 71.95 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7575 36
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G47930 36
  • 71.86 (n)
  • 81.82 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.190 36
corn
(Zea mays)
Liliopsida Zm.7093 36
rice
(Oryza sativa)
Liliopsida Os02g0478700 36
  • 72.29 (n)
  • 83.12 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00618 36
  • 65.85 (n)
  • 79.27 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps27 36
  • 67.07 (n)
  • 75.9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10862 37
  • 96 (a)
OneToMany
Species with no ortholog for RPS27:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RPS27 Gene

ENSEMBL:
Gene Tree for RPS27 (if available)
TreeFam:
Gene Tree for RPS27 (if available)

Paralogs for RPS27 Gene

Paralogs for RPS27 Gene

Selected SIMAP similar genes for RPS27 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RPS27: view

Variants for RPS27 Gene

Sequence variations from dbSNP and Humsavar for RPS27 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2632 -- 153,991,545(+) AAAAA(A/T)GTTAT intron-variant
rs2633 -- 153,991,514(+) AAGTG(A/C)AGGAA intron-variant
rs6668510 -- 153,989,878(+) caaga(C/G)caaaa upstream-variant-2KB
rs12563539 -- 153,989,308(+) gcagc(A/G)gcgcg upstream-variant-2KB
rs12563772 -- 153,989,749(+) tagcc(A/G)ggcat upstream-variant-2KB

Relevant External Links for RPS27 Gene

HapMap Linkage Disequilibrium report
RPS27

No data available for Structural Variations from Database of Genomic Variants (DGV) for RPS27 Gene

Disorders for RPS27 Gene

(7) Novoseek inferred disease relationships for RPS27 Gene

Disease -log(P) Hits PubMed IDs
hnscc 58.6 7
tumors 19.9 11
carcinoma squamous cell 17.8 3
cancer 17.2 11
melanoma 17.2 7
genes like me logo Genes that share disorders with RPS27: view

No data available for UniProtKB/Swiss-Prot for RPS27 Gene

Publications for RPS27 Gene

  1. A growth factor-inducible gene encodes a novel nuclear protein with zinc finger structure. (PMID: 8407955) Fernandez-Pol J.A. … Hamilton P.D. (J. Biol. Chem. 1993) 2 3 4 23
  2. Primary structures and sequence analysis of human ribosomal proteins L39 and S27. (PMID: 8908372) Tsui S.K.W. … Lee C.Y. (Biochem. Mol. Biol. Int. 1996) 2 3 4 23
  3. Metallopanstimulin gene product produced in a baculovirus expression system is a nuclear phosphoprotein that binds to DNA. (PMID: 7986747) Fernandez-Pol J.A. … Hamilton P.D. (Cell Growth Differ. 1994) 3 23
  4. Extraribosomal function of metallopanstimulin-1: reducing paxillin in head and neck squamous cell carcinoma and inhibiting tumor growth. (PMID: 19642098) Dai Y. … Stack B.C. (Int. J. Cancer 2010) 3 23
  5. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 3 4

Products for RPS27 Gene

Sources for RPS27 Gene

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