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Aliases for RPS23 Gene

Aliases for RPS23 Gene

  • Ribosomal Protein S23 2 3 5
  • Homolog Of Yeast Ribosomal Protein S28 3
  • S23 3

External Ids for RPS23 Gene

Previous GeneCards Identifiers for RPS23 Gene

  • GC05M080389
  • GC05M081796
  • GC05M081608
  • GC05M081655
  • GC05M081607
  • GC05M076778
  • GC05M081569

Summaries for RPS23 Gene

Entrez Gene Summary for RPS23 Gene

  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S12P family of ribosomal proteins. It is located in the cytoplasm. The protein shares significant amino acid similarity with S. cerevisiae ribosomal protein S28. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

GeneCards Summary for RPS23 Gene

RPS23 (Ribosomal Protein S23) is a Protein Coding gene. Among its related pathways are Viral mRNA Translation and Influenza Viral RNA Transcription and Replication. GO annotations related to this gene include poly(A) RNA binding and structural constituent of ribosome.

Gene Wiki entry for RPS23 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RPS23 Gene

Genomics for RPS23 Gene

Regulatory Elements for RPS23 Gene

Enhancers for RPS23 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RPS23 on UCSC Golden Path with GeneCards custom track

Promoters for RPS23 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RPS23 on UCSC Golden Path with GeneCards custom track

Genomic Location for RPS23 Gene

82,273,320 bp from pter
82,278,577 bp from pter
5,258 bases
Minus strand

Genomic View for RPS23 Gene

Genes around RPS23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RPS23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RPS23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RPS23 Gene

Proteins for RPS23 Gene

  • Protein details for RPS23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    40S ribosomal protein S23
    Protein Accession:
    Secondary Accessions:
    • P39028
    • Q6IB08

    Protein attributes for RPS23 Gene

    143 amino acids
    Molecular mass:
    15808 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RPS23 Gene

neXtProt entry for RPS23 Gene

Proteomics data for RPS23 Gene at MOPED

Post-translational modifications for RPS23 Gene

  • Hydroxylation at Pro-62 affects translation termination efficiency.
  • Ubiquitination at Lys 37, Lys 48, and Lys 54
  • Modification sites at PhosphoSitePlus

Other Protein References for RPS23 Gene

No data available for DME Specific Peptides for RPS23 Gene

Domains & Families for RPS23 Gene

Gene Families for RPS23 Gene

Protein Domains for RPS23 Gene

Suggested Antigen Peptide Sequences for RPS23 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ribosomal protein S12P family.
  • Belongs to the ribosomal protein S12P family.
genes like me logo Genes that share domains with RPS23: view

Function for RPS23 Gene

Molecular function for RPS23 Gene

GENATLAS Biochemistry:
60S ribosomal protein S23

Gene Ontology (GO) - Molecular Function for RPS23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20434207
genes like me logo Genes that share ontologies with RPS23: view
genes like me logo Genes that share phenotypes with RPS23: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RPS23 Gene

Localization for RPS23 Gene

Subcellular locations from

Jensen Localization Image for RPS23 Gene COMPARTMENTS Subcellular localization image for RPS23 gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for RPS23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005840 ribosome IEA,NAS 8415000
GO:0015935 small ribosomal subunit IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with RPS23: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RPS23 Gene

Pathways & Interactions for RPS23 Gene

SuperPathways for RPS23 Gene

Superpath Contained pathways
1 Viral mRNA Translation
2 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3 Influenza Viral RNA Transcription and Replication
4 Infectious disease
5 rRNA processing
genes like me logo Genes that share pathways with RPS23: view

Gene Ontology (GO) - Biological Process for RPS23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing TAS --
GO:0006413 translational initiation TAS --
GO:0006415 translational termination TAS --
GO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS --
GO:0016032 viral process TAS --
genes like me logo Genes that share ontologies with RPS23: view

No data available for SIGNOR curated interactions for RPS23 Gene

Drugs & Compounds for RPS23 Gene

No Compound Related Data Available

Transcripts for RPS23 Gene

Unigene Clusters for RPS23 Gene

Ribosomal protein S23:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RPS23 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7
SP1: - - -
SP2: - -
SP4: - -

Relevant External Links for RPS23 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RPS23 Gene

mRNA expression in normal human tissues for RPS23 Gene

Protein differential expression in normal tissues from HIPED for RPS23 Gene

This gene is overexpressed in Nasal epithelium (9.1), Cervix (8.4), and Tlymphocyte (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RPS23 Gene

SOURCE GeneReport for Unigene cluster for RPS23 Gene Hs.527193

genes like me logo Genes that share expression patterns with RPS23: view

Protein tissue co-expression partners for RPS23 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RPS23 Gene

Orthologs for RPS23 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RPS23 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia RPS23 35
  • 92.77 (n)
  • 100 (a)
RPS23 36
  • 100 (a)
(Canis familiaris)
Mammalia RPS23 35
  • 87.65 (n)
  • 100 (a)
RPS23 36
  • 100 (a)
(Mus musculus)
Mammalia Rps23 35
  • 89.74 (n)
  • 100 (a)
Rps23 16
Rps23 36
  • 100 (a)
(Pan troglodytes)
Mammalia RPS23 35
  • 99.3 (n)
  • 100 (a)
RPS23 36
  • 92 (a)
(Rattus norvegicus)
Mammalia Rps23 35
  • 90.68 (n)
  • 100 (a)
(Monodelphis domestica)
Mammalia RPS23 36
  • 100 (a)
(Ornithorhynchus anatinus)
Mammalia RPS23 36
  • 100 (a)
(Gallus gallus)
Aves RPS23 35
  • 83.92 (n)
  • 100 (a)
RPS23 36
  • 100 (a)
(Anolis carolinensis)
Reptilia RPS23 36
  • 100 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rps23 35
  • 82.75 (n)
  • 97.9 (a)
Str.1679 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.25836 35
(Danio rerio)
Actinopterygii rps23 35
  • 84.15 (n)
  • 98.6 (a)
rps23 36
  • 99 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8559 35
fruit fly
(Drosophila melanogaster)
Insecta CG8415 37
  • 90 (a)
RpS23 35
  • 76.46 (n)
  • 90.91 (a)
RpS23 36
  • 91 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012990 35
  • 73.19 (n)
  • 89.51 (a)
(Caenorhabditis elegans)
Secernentea rps-23 37
  • 84 (a)
rps-23 35
  • 71.79 (n)
  • 84.62 (a)
rps-23 36
  • 85 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAR108C 35
  • 65.96 (n)
  • 78.87 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B11231g 35
  • 66.2 (n)
  • 78.17 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPS23A 35
  • 68.31 (n)
  • 78.17 (a)
RPS23A 36
  • 77 (a)
RPS23B 36
  • 77 (a)
RPS23A 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G09680 35
  • 69.95 (n)
  • 76.06 (a)
(Glycine max)
eudicotyledons Gma.15234 35
(Oryza sativa)
Liliopsida Os.9075 35
(Triticum aestivum)
Liliopsida Ta.1335 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5143 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01552 35
  • 69.01 (n)
  • 80.28 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rps23 35
  • 67.37 (n)
  • 75.52 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 86 (a)
Species with no ortholog for RPS23:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RPS23 Gene

Gene Tree for RPS23 (if available)
Gene Tree for RPS23 (if available)

Paralogs for RPS23 Gene

genes like me logo Genes that share paralogs with RPS23: view

No data available for Paralogs for RPS23 Gene

Variants for RPS23 Gene

Sequence variations from dbSNP and Humsavar for RPS23 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs3738 -- 82,273,474(+) AGGGG(A/C)TATGT utr-variant-3-prime
rs3739 -- 82,273,492(+) GTTTC(A/G)TGCAC utr-variant-3-prime
rs9099 -- 82,276,077(-) ATAAA(C/T)TTTCA utr-variant-3-prime
rs1053173 -- 82,273,600(+) ACTAG(C/G)TTTAG utr-variant-3-prime
rs1053252 -- 82,273,930(+) TTTTT(C/T)TTTTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for RPS23 Gene

Variant ID Type Subtype PubMed ID
nsv830364 CNV Loss 17160897
nsv520938 CNV Gain 19592680
esv2676657 CNV Deletion 23128226

Variation tolerance for RPS23 Gene

Residual Variation Intolerance Score: 49.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.02; 0.44% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for RPS23 Gene

Disorders for RPS23 Gene

Relevant External Links for RPS23

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for RPS23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RPS23 Gene

Publications for RPS23 Gene

  1. A map of 75 human ribosomal protein genes. (PMID: 9582194) Kenmochi N. … Page D.C. (Genome Res. 1998) 2 3 4 67
  2. Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control. (PMID: 25817432) Gallina I. … Lisby M. (Nat Commun 2015) 3
  3. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for RPS23 Gene

Sources for RPS23 Gene